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  • Shobhit Institute of Engineering and Technology Meerut
  • Shobhit Institute of Engineering and Technology, Meerut

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Rudraksha (Elaeocarpusganitrus) owes an important status both in Ayurveda as well as in Hindu mythology for its curative and spiritual benefits, respectively. Physical wearing of Rudraksha has been cited for its pharmacological actions against vast range of medical ailments including anxiety, lack of concentration, insomnia, depression, hypertension, palpitation, infertility, rheumatism and asthma. The present review aims to investigate the scientific evidences available in literature for their biochemical and compositional properties, in-vitro and in-vivo activities, as well as clinical analysis.It clearly identifies the need to carry out in-depth research in the multiple domains such as physical, pharmacological, and clinical studies in order to understand and disseminate the medical benefits of Rudraksha for the welfare of mankind. The present work sums the current state of knowledge concerning the ethno pharmacology, physical properties chemical composition, pharmacology and toxicology of E. ganitrus.
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Pb. Univ. Res. J (Sci.) Vol. 68, 2018, pp 1-6
Durg V. Rai*, Shiva Sharma and Manisha Rastogi
Department of Biomedical Engineering, School of Biological Engineering and Sciences,
Shobhit University, NH-58, Modipuram, Meerut-250110, India.
Rudraksha (Elaeocarpusganitrus) owes an important status both in Ayurveda as well as in Hindu mythology for its curative and spiritual
benefits, respectively. Physical wearing of Rudraksha has been cited for its pharmacological actions against vast range of medical ailments
including anxiety, lack of concentration, insomnia, depression, hypertension, palpitation, infertility, rheumatism and asthma. The present
review aims to investigate the scientific evidences available in literature for their biochemical and compositional properties, in-vitro and in-
vivo activities, as well as clinical analysis.It clearly identifies the need to carry out in-depth research in the multiple domains such as
physical, pharmacological, and clinical studies in order to understand and disseminate the medical benefits of Rudraksha for the welfare of
mankind. The present work sums the current state of knowledge concerning the ethno pharmacology, physical properties chemical
composition, pharmacology and toxicology of E. ganitrus.
Keywords: Rudraksha, Biochemical, Physical, Mineralogical, Clinical Trials.
Rudraksha or Elaeocarpusganitrus roxb. (Syn. E.
sphaericus Gaertn; Family Elaeocarpaceae) fruits are
popular from ancient times for their mythological,
aesthetic and medicinal importance Joshi et al.
(2014). Elaeocarpusganitrusroxb.trees grow to ~20 m
and are found from the Gangetic plain in the foothills of
the Himalayas to China, South and Southeast Asia, parts
of Australia, and Guam and Hawaii.Rudraksha trees are
commonly found in mountain and hilly areas of Nepal,
Indonesia Javaand Sumatra. Dried Rudrakasha bead is
obtained from the ripe fruit of Elaeocarpus ganitrus
roxb.. Microscopic studies revealed the presence of a
hard endocarp with lignified isodiametric sclereids,
seeds with membranous seed coat, which enclosed a
dense cellular endosperm comprising of calcium oxalate
druses (Singh 2010).
Rudraksha fruits are generally categorized based upon
the number of segments or grooves or popularly mukhis
present over the fruit beads Tilak et al. (2017).
Figure 1 shows various stages related toRudraksha
bead.Rudraksha beads (size ~ 25 mm) have between 1
and 21 lines (mukhi). Most of rudrakshas have four, five
or six lines. Rudraksha beads are white, red, brown
(most common) yellow, and black.
Rudraksha seeds are covered with a blue outer husk
when fully ripe and are also known as blueberry beads.
The blue color is not derived from pigment but is
structural(Lee, 1991).
(a) (b)
(c) (d)
Figure 1: (a) Inflorescence on Rudraksha tree, (b)
Fruit on Rudraksha tree, (c) Ripen fruit and (d) Dried
Rudraksha bead (six mukhi).
*Corresponding Author:
MS Received: October 8, 2018, Accepted: December 21, 2018
Pharmacologically, Rudraksha beads have been reported
for their therapeutic potential against several disorders
like stress, anxiety, depression, palpitation, nerve pain,
epilepsy, migraine, lack of concentration, asthma,
hypertension, diabetes, arthritis and liver diseases Jain et
al. (2014). Further, in our traditional system of medicine,
Rudraksha beads have been reported to exert multiple
pharmacological actions when applied in several forms
such as physical wearing of Rudraksha rosary, oral
intake of Rudraksha dipped water or Rudraksha powder.
Moreover, it has also been mentioned that the specificity
in their therapeutic properties differs based upon the type
of grooves or Mukhis Shah et al. (2010); Tripathi et al.
(2016-a); Dadhich et al. (2014); Sharma et al. (2015);
Tilak et al. (2017); Jain et al. (2014); Tripathi et al.
One of the major mechanisms of action of Rudraksha
beads through which it influences the systemic
physiology is its electromagnetic property. It has been
repeatedly mentioned in the published literature that
Rudraksha beads pose inductive, resistive, dielectric,
paramagnetic and diamagnetic properties due to which
variable signals were emitted by different
mukhiRudraksha thereby attributing positive beneficial
effect on overall systemic physiology Ravishankar et al.
(2007). However, scientific evidences regarding the
electromagnetic properties of Rudraksha beads are
almost nil. Single evidence regarding the bioelectric
energy of Rudraksha was found where the authors
reported that 108 beads Rudraksha rosary stabilized the
flocculation of current applied on two medicinal plants
Tripathy et al. (2016-a). Further, it has been
hypothesized that the composition of Rudraksha beads
may influence its electromagnetic property and
therefore, play key role in its therapeutic benefits.
Previous studies revealed presence of several bioactive
phytoconstituents including alkaloids, flavonoids,
tannins, steroids, triterpenoids, carbohydrates and
cardiac glycosides as the major components. In-addition,
other studies also reported presence of isoelaeocarpicine,
elaeocapine, isoelaeocarpine and quercetin, gallic,
ellagic acids and rudrakine as biomarker components in
Rudraksha bead.
The current review aims to assess the available scientific
evidences of Rudraksha bead with special reference to
their biochemical and compositional properties,
electromagnetic property, in-vitro and in-vivo activities,
and clinical studies.
Several reports related to biochemical constituents in
Rudraksha bead are availablein literature Jain et al.
(2014). These revealed presence of glycosides, alkaloids,
minerals, vitamins, steroids, flavanoid, gallic acid,
ellagic acid andquercetin in Rudraksha. Hardainiyan et
al. (2015) evaluated the ethanolic fruit extract of
Rudraksha and reported the presence of alkaloids,
glycosides, phenolic compounds, flavonoids, saponins,
carbohydrates and fixed oils, but protein and amino
acids were absent in this extract. Tripathi et al.
(2016-c), screened the presence of phytochemical in
hexane, chloroform, ethyl acetate, acetone and
methanol extracts of Rudraksha. Results showed the
presence of alkaloids, glycoside, phytosterols,
carbohydrate, tannin, flavanoid, amino acid, saponin,
and terpenoids. In another study Tripathi et al.
(2016-d), performed spectroscopic analysis on the
methanol seed extract of E. ganitrus. Analysis was
performed using FTIR and UV-VIS for the
phytochemical analysis. Results showed the presence
of phenolic compound and flavanoid at 318nm and
245nm, respectively, in UV-VIS whereas in whereas
FTIR spectra was obtained at the peak at 3363.97cm-
1 for OH group. Das (2017),reported the presence of
many significant phytochemicals like saponins,
tannins, cardiac glycosides, flavanoidsand steroids in
aqueous, ethanolic and methanolic extract of
Rudraksha. Singh et al. (2016; 2018) studied the
overall mechanical and compressive strength of
Rudraksha bead and revealed good compressive
strength in both the vertical and horizontal planes.
Electromagnetic properties in Rudrakshahave been
reported by several reviewers Joshi et al. (2014);
Jain et al. (2014); Arivu et al. (2017); Hardainiyan et
al. (2015),where Rudraksha was mentioned as a
famous electromagnetic bead helpful in curing
several chronic disorders. Tripathy et al. (2016-
b)stated the healing mechanism of Rudraksha due to
its electromagnetic property. The study reported that
the electromagnetic properties of Rudrakshabeads
activate body’s energy wheel, which in turn
influences the bioelectrical properties of human body
and heals various chronic diseases like blood
pressure, heart rate, diabetes, gynaecological
problem, neurological disorders, mental problem,
insomnia and rheumatism. In another report Tripathy
et al. (2016-a) mentioned that rotation of Rudraksha
between two copper coins is an evidence of its
electromagnetic property. The activity needs to be
confirmed with reasoning. Further, it explains the
electromagnetic and piezoelectric properties of
Rudraksha and their mechanism of action in
treatment. The authors stated that wearing of
Rudraksha works on electromagnetism and controls
bioelectric energy of human body, which in turn is
responsible for mind-body coordination and its
induced health benefits. Moreover, the authors
reported that chanting using Rudraksha mala has its
natural piezoelectric effects that would generate a
charge in response to applied mechanical stress and
work similar to acupressure therapy. In-addition,
diamagnetic and paramagnetic characteristics of the
Rudraksha further help in balancing the impaired
functioning by restoring the subatomic and
bioenergetics homeostasis. Prajapati et al. (2016)
RAI et al.
reported the electromagnetic characteristics of
Rudraksha on dracaena plant. Authors divided each plant
into two zones,i.e., Positive region (stem) and Negative
region (plant leave). To record the parameters Cu
electrodes were connected to the plant leaves and Zn
electrode to plant stem. Variations in the electrical
potential of the plant were observed from 1.1 to 0.8 mV
without Rudraksha, which got stabilized to 0.8 mV after
wearing of Rudraksha. Based upon the study outcomes,
the authors reported the presence of capacitive, resistive
and inductive properties in Rudraksha. Tilak et al.
(2017), reviewed the potential benefits of physical
wearing of Rudraksha due to its electromagnetic
properties. Authors reported that physical wearing of
Rudraksha exerted implausible power control over
electromagnetic impulses brain and focus human brain
on a single target. The study stated that
electromagnetism of Rudraksha affects grey and white
matter in brain, thereby influencing our sixth sense.
Sharma et al. (2018) reported thequantitative electrical
properties of Rudraksha bead and the possible
biochemical and mineralogical components responsible
for its bioelectrical property. Results of this study
indicate the presence of 27 important minerals with
variable electrical properties.
The antimicrobial, antioxidant, anti-cancerous, and
immunomodulatory activities of different solvent
mediated Rudraksha extracts have been studied.
Chemically the extracts showed the presence of
phytosterols, fats, alkaloids, flavonoids, carbohydrates,
proteins and tannins (Singh 2010). Kumar et. al. (2014)
isolated several bioactive compound from the different
parts of the plant and were analysed pharmacologically.
E. ganitrus was reported to exhibit antimicrobial,
antiulcerogenic and antioxidant activity. Dharmalingam
et al. (2017) studied antimicrobial activities of hexane,
chloroform, ethylacetate and aqueous alcohol extracts of
Rudraksha against gram-positive and gram-negative
bacteria. The microbial load such as total bacterial count
and fungal count (Enterobacteria, Escherichia coli,
Salmonella species, Staphylococcus aureus and
Pseudomonas aeruginosa) and antibacterial activity were
measured using serial dilution method and Kirby bauer
method, respectively, for selective pathogens. The study
results demonstrated potent antibacterial activity of all E.
ganitrus extract against gram-positive and gram-
negative bacteria. Jayashree et al. (2016), evaluated the
antimicrobial activities for acetone, methanol and water
extracts of Rudraksha (leaf, stem, bark and Rudraksha
bead) against four bacterial species (Shigellasonnei,
Salmonella typhi, Staphylococcus aureus and Klebsiella
pneumonia) and a fungal species (Candida albicans)
using the agar well diffusion method. Results showed
that plant extracts exhibited a dose-dependent inhibition
of microorganisms, especially the acetone and methanol
extracts of leaf and stem bark displayed maximum
antibacterial activity against all the bacterial species
studied. Dalei et al.(2016) investigated antimicrobial
activity of methanol, and acetone extracts of pulp
and bead of E. ganitrus. The extracts exhibited
antimicrobial activities with zones of inhibition
ranging from 9.5 mm to 21.0mm and 10.5 mm to 22
mm for methanol and acetone extracts respectively.
All extracts exhibited appreciable activity against the
fungal species. Tripathy et al. (2016-c) studied
antibacterial potential of Rudraksha against two
gram positive and five gram negative bacteria at
three concentration (220, 330, 550 μg/Disc) through
disc diffusion method. Results showed zone of
inhibition in the range of 6 to 12 mm with highest
zone of inhibition at 12mm for Escherichia Coli at
550 μg/Disc. These findings demonstrated
antibacterial activity of E.ganitrusextract. Das et al.
(2015) evaluated antioxidant activities of Rudraksha
where comparable results were obtained with
standard ascorbic acid. In DPPH antioxidant analysis
while standard Ascorbic acid showedEC50 value at
25.53 μg/ml, methanolic extract of E. serratus
showed EC50 at 75.47 μg/ml.
Barveet al. (2014) examined antihypertensive effect
of E. ganitrus on male Wistar rats. To perform the
analysis, powdered seeds were extracted by
maceration using water in copper (E1) and glass
vessel (E2) and analyzed for antihypertensive
activity in cadmium chloride (1 mg/kg
intraperitoneally; for a period of 15 days) induced
rats. E1 was administered at dose of 5, 10, and 15
mg/kg and E2 at dose of 10, 20, and 30 mg/kg. E1
and E2 did not show any toxicity at dose of 5 g/kg in
rats. It was found that 15 mg/kg of E1 and 30 mg/kg
of E2 decreases the blood pressure by ~30 mmHg in
hypertensive rats. Overall results showed effective
antihypertensive activity using water extract of
Dadhich et al. (2014) evaluated antidepressant
effects of Rudraksha Bead extract (75% ethanol) in
albino mice. Study was carried out on Group I
(Untreated Control received vehicle (Distilled
water)), Group II (Control (Fluoxetine) 20 mg/kg
body weight) and Group III (Control (Imipramine)
15 mg/kg) administrated orally with distilled water.
Group IV, V, VI and VII were administered orally
with different doses (20, 40, 60 and 80 mg/kg body
weight) of E. ganitrusfruit extract (EGFE).
Antidepressant effect of EGFE was assessed by
forced swim test. EGFE (20 and 40mg/kg)
significantly decreased the immobility time and
increased climbing and swimming time significantly.
Duration of immobility of mice increased at high
dose (80mg/kg) as compared to vehicle. It is
concluded that while EGFE exhibited antidepressant
effect at low dose, at high dose it was sedative.
Tripathy et al. (2016-e) investigated antidepressant
activity of ethanolic extract of E. ganitrusat 250mg/kg
dose in mice. Antidepressant activity of ethanolic extract
of E. ganitruswas carried out using hole cross test, open
field test and thiopental induced sleeping time test in
swiss albino mice. The extract increased the locomotor
activity of mice in open field and hole cross test
significantly (p<0.05). The findings demonstrated that
the seed extract of E. ganitrushave significant
antidepressant activity.
Kakalij et al. (2017) evaluated ameliorative effect of E.
ganitruson gentamicin (GM)-induced nephrotoxicity in
rats. E. ganitrus(100, 200, and 400 mg/kg body weight)
was administered orally to male wistar rats. Results
revealed that co- administration of E.
ganitrussignificantly reduced elevated levels of serum
creatinine, BUN, uric acid and albuminuria,alongwith
considerable increase in the serum albumin and urine
creatinine. Furthermore, E. ganitrus noticeably increased
serum total protein and antioxidant enzyme levels with
significant alterationin phagocytic index and neutrophil
adhesion assay when compared with GM treated group
in a dose dependent manner. This study revealed that
ethanolic extract of E. ganitrus had immunomodulatory
and nephroprotective activity. Tripathy et al. (2016-c),
investigated hypoglycemicactivity of methanol and
water (ratio70:30) extract of E. ganitrus seeds in alloxan
induced diabetic rats. The extract of E.Ganitrus seed
significantly (P<0.05) reduced blood glucose level in
alloxan induced diabetic rats after twelve hours of
administration. Results supported traditional uses of
E.ganitrus seed for the management of diabetic sores.
Tripathy et al. (2016-c) alsoexamined antihyperglycemic
effect of methanolic seed extracts of E. ganitrusroxb.
instreptozotocin induced diabetes. The methanolic seed
extract exhibited potent antidiabetic activity comparable
to the standard drug glybenclamide.
Jain et al. (2017) screened anti-atherosclerotic ethanolic
crude (70%) extract of E.ganitrus seed in kidney of
cholesterol induced atherogenic rabbits. The ethanolic
extract, when administered at a dose level of 250 mg/kg
and 500 mg/kg (p.o) daily for 60 days to cholesterol-fed
rabbits, rectified the altered histology by restoring the
normal histology. Study concluded that the ethanolic
extract of E. ganitrus seed may serve as a potent agent
against cardiovascular diseases and resultant chronic
kidney disease.
Jain et al. (2016) also experimentedanti-atherosclerotic
activity of E. ganitrus extract at dose level of 250 and
500 mg/kg in New Zealand white male rabbits fed with
high cholesterol diet for 120 days. The study reported
significant corrections in (p≤0.01, ≤0.001) disturbed
lipid profile on the extract treatment in a dose-dependent
manner during the 60 days of the treatment period. A
significant reduction in lipid peroxidation and a
considerable increase in glutathione, catalase, and
superoxide dismutase levels (p≤0.01, ≤0.001) were
observed inthe post-treatment cholesterol-fed rabbits.
The histopathological modifications such as
accumulation of foam cells, atheromatous plaque
formation and lumen size reduction supported the
successful induction of atherosclerosis in rabbits.
TheE. ganitrus extract treated rabbits showed
significant lowering of cholesterol deposition and
increased lumen size when compared to cholesterol-
fed group.
Bagewadi et al. (2015) evaluated anti-parkinsonian
effect of E. ganitrus in rota rod and catalepsy bar
tests. Assessment of oxidative stress was done by
measuring the malondialdehyde (MDA) and reduced
glutathione (GSH) levels in the striatal region of the
brain. E. ganitrus (200 and 400 mg/kg, p.o.) showed
significant anti-oxidative effect by causing a
decrease in brain MDA levels (p<0.001) and a
significant increase in GSH levels (p<0.001) that
further plays a vital role in the pathophysiology of
PD. Overall this study conclusively shows
E.ganitrushas anti-oxidant and neuroprotective
activity in haloperidol experimental model of PD.
Tripathi et al. (2016) assessed the immunomodulatory
properties of E. ganitrus (Rudraksha). This
experiment was conducted on two groups of 15 male
candidates each. The Group-1 served as control
without wearing the Rudraksha and Group-2 people
were regularly wearing Rudraksha as necklace.
Specimen blood was collected by puncturing vein of
arm and morning first urine samples were collected
from group-1 and group-2 for biochemical analysis.
Results showed people, who were regularly wearing
Rudraksha beads, were healthy and their CBC and
urine tests show that their haemoglobin, RBC, DLC
and TLC are in excellent condition as compared to
the people who do not wear Rudraksha bead rosary.
Makhija et al. (2015) assessed the efficacy of an
ayurvedic formulation containing Rudraksha in the
management of mental retardation in 15 mentally
retarded children between age group of 8 months to
12 years. A combination of Vacha, Rudraksha,
Haridra andHinguwas administered twice daily for
90 days. Findings of the study revealed that
treatment was highly effective over behavioural
disorders, but very minimal response to treatment
was noticed over mental age and social age. Also
significant improvement was observed over
psychological, psychomotor and biological factors.
Considering the importance of Rudraksha beads as
given in our ancient Indian system of medicine
against multiple disorders, it is concluded that
scientific evidences regarding its pharmacological
properties generated through standard in vitro, in-
vivo, and clinical studies as well as its mechanism of
action are highly insufficient. There is a strong need
RAI et al.
to conduct in-depth research studies in order to prove its
efficacy as cost-effective, user friendly, easily
accessible, safe and holistic therapeutic approach to
ameliorate adverse effects of chronic diseases.
We acknowledge the help and guidance from
Mahamandeleshwar Swami Martandpuriji and also for
providing traditional knowledge about Rudraksha and
motivation to generate scientific evidences for Ayurvedic
system of Medicine.
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RAI et al.
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Elaeocarpus ganitrus, popularly known as Rudraksha is among the revered medicinal plants in India used for treatment and management of multiple chronic disease conditions. Rudraksha beads were reported to exhibit immense medicinal value due to its electromagnetic properties, although scientific evidences pertaining to its compositional analysis responsible for its electromagnetic effect are highly sparse. The present study aims to investigate the bioelectrical and mineralogical components of Rudraksha beads which may contribute in their electromagnetic properties of therapeutic importance. Two hundred Rudraksha fruits were randomly collected from University medicinal garden, de-pulped, dried, and powdered under aseptic conditions for biochemical, physical and mineralogical analyses. Samples were analyzed in triplicate and data was represented as Mean and SD. Results indicated the presence of protein, carbohydrates, fat, moisture and mineral content in Rudraksha bead powder. Moreover electrical properties like resistance, reactance, capacitance and inductance were also observed in Rudraksha beads. The results of this paper provide the background to justify that biochemical and mineralogical composition are associated with the electrical behavior of Rudraksha beads. Such associations may be exploited for the development of targeted alternative healing using Rudraksha.
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In the present study 70% ethanolic crude extract of Elaeocarpus ganitrus seed has been screened for its anti-atherosclerotic and antioxidant activity in liver of cholesterol induced atherogenic rabbits. Lipid profile, lipid peroxidation level as well as histological changes in liver were investigated. The statistical analysis were carried out by using one way ANOVA followed by Tukey’s multiple comparison test. Cholesterol feeding produced a significant increase in total cholesterol, phospholipids and triglycerides in liver. It also increases lipid peroxidation as well as showed severe fatty changes in liver. E. ganitrus extract was administered at a dose level of 250 mg/kg and 500 mg/kg (p.o) daily for 60 days to cholesterol-fed rabbits rectified the disturbed lipid profile significantly and a considerable decrease in lipid peroxidation (P ≤ 0.01, ≤ 0.001) was observed. Normal histology of liver regained in cholesterol fed animals given E. ganitrus extract compared to the cholesterol fed animals. The phytochemical analysis of ethanolic extract of E. ganitrus indicated strong presence of alkaloids, flavanoids, tannins, phenols, saponins and fatty acids that may be responsible for the significant antiatherosclerotic as well as antioxidant activity. Our study exhibited that the ethanol extract of E. ganitrus seed is a potent agent and contribute remarkably in developing novel herbal medicines to improve the lives of patients suffering from cardiovascular diseases around the word. KEYWORDS: Atherosclerosis, Hyperlipidaemic, Phytoconstituents, Cholesterol.
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Our body is work as a circuit to flow of bioelectric energy from the one organ to another organ this bioelectric energy is generated from circulation of blood, heartbeats, muscles fiber relaxing and contraction. It's mainly produced by sensory and moter nerve conduction and every body parts or organs have a special type of bioelectric energy which is necessary for their organs proper working if it's disturb by any types then the organ functioning is also disturb. Bioelectric energy is also produced the formation of bio chemicals like the secretion of harmones & enzymes.
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Since time immemorial plants have played a vital role in the field of health care and medicines. There are many plants with high medicinal values among which Elaeocarpus ganitrus (Rudraksh) holds utmost importance, both scientifically as well as spiritually. The different parts of a rudraksh tree have high concentrations of important phytochemical constituents thus adding to its medicinal value. This work is focused on phytochemical screening of methanolic extracts from the epicarp, endocarp of the seed and bark sample of rudraksh tree and their comparison to justify the high medicinal efficacy of the plant.
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ABSTRACT Elaeocarpus ganitrus (syn: Elaeocarpus sphaericus; Elaeocarpaceae) is a large evergreen big-leaved tree. Elaeocarpus ganitrus is a medium sized tree occurring in Nepal, Bihar, Bengal, Assam, Madhya Pradesh and Bombay, and cultivated as an ornamental tree in various parts of India. Hindu mythology believes that, anyone who wears Rudraksha beads get the mental and physical prowess to get spiritual illumination. According to Ayurvedic medicine Rudraksha is used in the managing of blood pressure, asthma, mental disorders, diabetes, gynecological disorders and neurological disorders. The Elaeocarpus ganitrus is an inhabitant shrub that has a good rich history of traditional uses in medicine. Present review has been attempting to make to collect the botanical, ethnomedicinal, pharmacological information and therapeutic utility of Elaeocarpus ganitrus on the basis of current science. Keywords: Elaeocarpus ganitrus, Antidepressant, Rudraksha, Pharmacological activity.
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In the present review, an attempt has been made to congregate the botanical, phytochemical, ethno medicinal, pharmacological information on Elaeocarpus ganitrus Roxb. belongs to family Elaeocarpaceae. It is prevalent for its fascinating fruit stones and medicinal properties. It procures a remarkable position in Hinduism and Ayurveda, the indigenous system of medicine. In Hindi it is recognized as Rudraksha, is a large evergreen broad-leaved tree whose seed is conventionally used for prayer beads in Hindu religion. In traditional system of medicine, different parts (beads, bark, leaves and outer shell of beads) of Rudraksha are taken for the alleviation of various health problems such as mental disorders, headache, fever, skin diseases, and for healing the wounds. Ayurvedic texts categorise Rudraksha fruits as thermogenic, sedative, cough alleviator and are useful for the treatment of bronchitis, neuralgia, cephalagia, anorexia, migraine, manic conditions and other brain disorders. It is employed in folk medicine as a counter agent of stress, anxiety, depression, palpitation, nerve pain, epilepsy, lack of concentration, asthma, hypertension, arthritis and liver diseases. Furthermore it is retrieve to exhibit multifarious pharmacological activities like anti-inflammatory, analgesic, hypoglycemic, antiulcerogenic and very high antimicrobial activity. Phytosterols, fats, alkaloids, flavonoids, carbohydrates, proteins and tannins have been found to be largely responsible for the therapeutic potential of E. ganitrus. Aqueous extract of leaves contains glycosides also. Ethanolic extract of leaves contains gallic acid, ellagic acid & quercetin. This review provides a scientific basis for pharmacological/medicinal properties and therapeutic uses of Elaeocarpus ganitrus Roxb.
Background: Elaeocarpus sphaericus is known for its medicinal and spiritual values in India, since long back. Pinus wallichiana, a conifer is known for its timber wood and rich phenolics in the needle. However still, there is no report on the phytoconstituents and biological activities of the leaves of these plants from Uttarakhand region of India. Aim and Objectives: To identify the phytochemicals, antioxidant, and antibacterial properties of methanolic and aqueous extracts of leaves of E. sphaericus Roxb and P. wallichiana for exploring their potential for medicinal use. Materials and Methods: Leaves were used for extraction in aqueous and hydro-methanolic solvents through soxhlet method. Extracts were examined for the presence of phenolics and flavonoids. Antioxidant properties were explored by scavenging assays for 2, 2-diphenyl-2-picryl hydrazyl, nitric oxide, H2O2. Agar well diffusion assay was applied for the antimicrobial potential of the extracts against pathogenic bacteria. Experiments were done in triplicates, and average values with standard deviations are shown. Results: Hydro-methanolic extracts were rich in phenols and flavonoids. E. sphaericus extract has shown better antioxidant property than that of P. wallichiana. Hydro-methanolic extracts have shown antioxidant potential better than aqueous extracts. Only, hydro-methanolic extracts showed antibacterial activities. E. sphaericus have shown better antibacterial activities than that of P. wallichiana. Conclusion: Hydro-methanolic extracts of E. sphaericus and P. wallichiana are rich in phenolics and flavonoids and possess good antioxidant and antibacterial properties. Leaf extract of E. sphaericus has promising antioxidant and antibacterial potential.
In this present study, in vitro antimicrobial activity of methanol, and acetone extracts of epicarp and endocarp of Elaeocarpus ganitrus were investigated. The extracts exhibited antimicrobial activities with zones of inhibition ranging from 9.5mm to 21.0mm and 10.5mm to 22 mm for methanol and acetone extracts respectively. The minimum inhibitory concentration (MIC) of the epicarp acetone extract against different microorganisms was ranged between 0.5 to 0.8 mgml-1, while that of the endocarp acetone extract ranged between 0.6 to 1.0 mgml-1. Again all the extracts exhibited appreciable activity against the fungal species were investigated. The zones of inhibition exhibited by the extracts against the test fungal species ranged between 9 to18mm and 10 to 21 mm for methanol and acetonic extracts respectively. Phytochemical screening revealed the presence of tannin, glycosides, alkaloids, quinines, steroid, cumarins, phenols and flavonoids in the extracts. The ability of the crude epicarp and endocarp extracts of E.ganitrus to inhibit the growth of bacteria and fungi is an indication for its broad spectrum antimicrobial potential which may be employed in the management of microbial infections.
The Methanolic extract of Elaeocarpus sphaericus fruits at the dose of 200 mg/kg increased the percentage of time-spent and the percentage of arm entries in the open arms of the elevated plus-maze (EPM) and decreased the percentage of time-spent in the closed arms of EPM. Moreover, it prolonged the ketamine-induced latency to sleep but had no significant effects on total sleeping time induced by ketamine. Also, the locomotor activity was affected but not to the same extent as observed for diazepam. The anxiolytic effects of methanol extract Elaeocarpus sphaericus fruits may be related to their content of flavonoids. This study validates the traditional use of the plant in management of anxiety.