The following thesis is an interdisciplinary investigation of architectural transitions cast as a composite of space and experience in time. Dispersed between philosophy, architecture and cognitive neuroscience, the thesis also attempts to provide an empirically plausible neuroscientific framework that best explains the human experience of architectural transitions. Accordingly, the thesis is neither a pure study of space nor of the human, but instead, an investigation of the dynamics that emerge between the body and space during transitions. To this end, a falsifiable hypothesis is derived from the framework and tested to assess the quality of the framework.