Six novel clerodane diterpenes have been isolated from the bark of Casearia tremula. They were characterized by extensive use of Heteronuclear Multiple Bond Coherence NMR spectroscopy as rel-18(S),19(R)-diacetoxy-18,19-epoxy-6(R)-methoxy-2(S)-(2ξ-methylbutanoyloxy)5(R),8(S),9(S),10(R)-cleroda-3,13(16),14-triene,
... [Show full abstract] rel-18(S),19(R)-diacetoxy-18,19-epoxy-2(S)-(2ξ-methylbutanoyloxy)-5(R),8(S),9(S),10(R)-cleroda-3,13(16),14-triene, rel-18(S),19(R)-diacetoxy-18,19-epoxy-2(R)-hexanoyloxy-5(R),8(S),9(S),10(R)-cleroda-3,13(16),14-triene, rel-18(S),19(R)-diacetoxy-18,19-epoxy-6(R)-hydroxy-2(S)-octanoyloxy-5(R),8(S),9(S),10(R)-cleroda-3,13(16),14-triene and rel-18(S),19(R)-diacetoxy-18,19-epoxy-6(R)-hydroxy-2(S)-undecanoyloxy-5(R),8(S),9(S),10(R)-cleroda-3,13(16),14-triene, rel-18(S),19(R)-diacetoxy-18,19-epoxy-6(R)-hydroxy2(S)-(2ξ-methylbutanoyloxy)-5(R),8(S),9(S),10(R)-cleroda-3,13(16),14-triene and rel-18(S),19(R)-diacetoxy-18,19-epoxy-6(R)-hydroxy-2(S)-(3ξ-hydroxyoctanoyloxy)-5(R),8(S),9(S), 10(R)-cleroda-3,13(16),14-triene.