The bench press is a multi-joint exercise commonly used to improve upper body strength. Previous investigations have analyzed kinetic and kinematic variables during different bench press variations. However, no known studies have examined the effect of foot position on force output and muscle activity. The purpose of this investigation was to examine the effects of 3 different foot placements on isometric bench press force and muscle activity. Twenty-one recreationally trained males (age: 22.57 ± 1.36 years; height: 176.95 ± 6.80 cm; body mass: 85.15 ± 12.54 kg) participated in this investigation. Self-reported one-repetition maximum (1RM) of at least body mass was used as inclusion criteria (self-reported absolute 1RM: 119.37 ± 26.44 kg; relative 1RM: 1.40 ± 0.22). Subjects performed the isometric bench press with a normal foot placement with both feet down on the ground (FD), both feet up on the edge of the bench (FU), and both feet resting on an adjacent bench parallel to the ground (FO) in a randomized order. After 2 familiarization trials with FD placement, subjects performed 3 maximum voluntary isometric contractions for approximately 3 s each. Peak force (PF) and average integrated electromyography (avgIEMG) values were recorded for the pectoralis major (PM), anterior deltoid (AD), triceps brachii (TB), vastus lateralis (VL), biceps femoris (BF), and gastrocnemius (G) muscles. PF output for FD, FU, and FO was 1134 ± 295 N, 1182 ± 247 N, and 1161 ± 249 N, respectively. The avgIEMG for the PM with the feet down, up, and out was 1.25 ± 0.50 mV, 1.19 ± 0.46 mV, and 1.20 ± 0.47 mV respectively. The avgIEMG for AD for feet down, up, and out was 3.20 ± 1.18 mV, 3.18 ± 1.23 mV, and 3.12 ± 1.18 mV, respectively. The avgIEMG for TB for feet down, up, and out was 2.26 ± 0.97 mV, 2.17 ± 0.93 mV, and 2.18 ± 0.89 mV, respectively. The avgIEMG for VL for feet up, down, and out was 0.26 ± 0.30 mV, 0.11 ± 0.01 mV, and 0.24 ± 0.25 mV, respectively. The avgIEMG for BF for feet down, up, and out was 0.21 ± 0.22 mV, 0.12 ± 0.05 mV, and 0.16 ± 0.10 mV, respectively. The avgIEMG for G for feet down, up, and out was 0.25 ± 0.14 mV, 0.23 ± 0.11 mV, and 0.20 ± 0.06 mV, respectively. A repeated measures general linear model returned no significant differences between conditions for force or muscle activity. Additionally, a Pearson correlation coefficient of 0.54 (sig. = 0.01) indicates a strong relationship between self-reported 1RM and isometric bench press in the foot down position. Different foot positions do not have a significant effect on peak force or muscle activity of upper and lower body muscles during the isometric bench press. In this investigation, the bar was attached to a rack which did not permit lateral, anterior, or posterior motion of the bar. In a free weight bench press where these types of motion are possible, the results may be different. Although force output and muscle activity were not different between isometric conditions, stability may be increased with both feet on the ground during a dynamic movement.