Rationale: This brief reflects on the key scientific contributions of the recent publication of the report 'Towards a Sustainable Food System' by the Chief Scientific Advisors (Scientific Advice Mechanism-SAM) 1 and the SAPEA (Science Advice for Policy by European Academies) Evidence Review Report on 'Sustainable Food Systems for the EU' 2 that informed it. This is done with a view towards advancing food sovereignty and agroecology in the Farm to Fork Strategy. Context: Vulnerable food systems Covid-19 has exposed even more limits and dysfunctions in our globalized food systems: from our reliance on underpaid farm and food sector workers operating in poor working conditions (most often women and migrants), the risks associated with intensive animal farming, including zoonoses, to barriers facing small-scale producers when trying to access local markets, to gender inequalities and the additional risks faced by people with pre-existing diet-related health conditions. Covid-19 is also set to aggravate other shocks (e.g. crop failures or abrupt changes in food prices due to climate change and other extreme events), and threats (e.g. biocultural erosion, degrading soil fertility, ageing farm population, land concentration, lack of farm renewal). These shocks and threats reveal the fragility of the European food systems, which the SAPEA report makes clear is even more vulnerable due to its interdependent nature and the fact that 1