The purpose of this paper is to examine university mergers, their motives, problems and challenges that emerge during process implementation, as well as their effects. Research results have shown that rarely there is one motive for merging insititutions of higher education, but there are, most often, multiple motives. Furthermore, research results have shown that the efficiency of university mergers is different and that more successful mergers among institutions of different sizes, as well as among complementary institutions. Additionaly, research results have shown that the most important challenge related to the implementation of university mergers refers to the conservatism of traditional academic cultures and the existence of strong employee resistance toward change. Finally, research results have shown that the key factors of the success of university mergers are successful management of human resources, leadership quality, communication on important aspects of changes, achieving cultural compliance of integrated institutions.