The objective of our program is to study the interplay between massive stars and the ISM in HII regions. Our sample of Galactic and Extragalactic HII regions spans a wide range in metallicity, density, mass and age. We will use the IRS to determine the general properties of the regions using line ratios, the strength of the PAH features, and the H2 column density at numerous locations within the
... [Show full abstract] clusters. In addition we will use IRAC and MIPS for mapping of the PAH features (IRAC) over a larger field and the detection of massive, embedded stellar sources (MIPS).