This paper demonstrates the performance characteristics of Photovoltaic Cell Electro-Fenton oxidation for treatment of refinery wastewater. The photovoltaic electro-oxidation was constructed and deliberates the extent of its custom in purifying this wastewater, which is a photovoltaic cell, DC to AC convertor, a battery and an electric – oxidation reactor. Throughout electrochemical treatment, many operating limits were examined, such as hydrogen peroxide, electrolysis time, current density and total organic carbon in addition to energy consumption and cost. The effects of the operational variables counting the current (0.5-2 mA), H2O2 concentration (10-50 ppm) and the electrolysis time (10-30 min) and were deliberate by using reply surface methodology (RSM) and Minitab-17. The agitation speed, pH and NaCL of the solution had remained occupied as 250 rpm, 3, 0.25 g correspondingly. Fast recovery and mineralization of organics and their middle reaction crops were stated. Underneath the best standards of the working variables more than 98% elimination competence of organic content and 39.67 kWh/m3for the consumption of energy was got.