showed that six-month preventive administration of N-acetylcysteine (NAC, precursor of glutathione),
significantly reduced the incidence of clinically apparent influenza and influenza-like episodes, especially in
elderly high-risk individuals. In addition, pathophysiological conditions such as lung cell injury and
inflammation found in patients with severe ARDS represents the targets for effective treatment by NAC
Own observations of COVID-19 cases
Our research team from Kursk State Medical University is involved in the project on genetics of
redox homeostasis in type 2 diabetes mellitus (T2D) since December, 2016 .In April 2020, four
patients from the control group, examined in February 2020, contacted with persons with COVID-19
confirmed diagnosis (3 patients were quarantined at home and 1 patient was hospitalized in Kursk
infectious hospital).Blood samples have been collected from the patients and used to measure total
plasma ROS and GSH levels immediately after blood sampling).All four cases were females, non-
smokers, without chronic diseases and with confirmed positive PCR-test for COVID-19.Description of
the cases is presented below.
1.-Patient-M.-(age-34), BMI-23.8 kg/m2. Symptoms (fever-38°C, mild myalgia) appeared on the
8th-day after contact with a COVID-19 positive patient and disappeared on the 6th-day of disease
without treatment. GSH-0.712 μmol/L, ROS-2.075 μmol/L, ROS/GSH-ratio-2.9.
2.-Patient P.-(age-47), BMI 21.0-kg/m2. Symptoms (fever-37.3°C, mild fatigue) appeared on the
10th-day after contact with a COVID-19 positive patient and disappeared on the 4th-day of disease
without treatment. GSH-0.933 μmol/L, ROS-1.143 μmol/L, ROS/GSH-ratio-1.2.
3.-Patient C.-(age-44), BMI 22.5-kg/m2, family history (FH) for diabetes. First symptoms such as
fever 37.7°C and air hunger appeared on the 4th-day after contact with a COVID-19 positive patient.
Daily fever between 37.1 and 38.5°C, dry cough, hoarseness, significant myalgia and fatigue are
persisting to date for 13-days. GSH-0.079- (!)-μmol/L, ROS-2.73-μmol/L, ROS/GSH ratio-34.6-(!).
4.-Patient-R.-(age 56), BMI-33.0-kg/m2, PH for diabetes. Symptoms (fever 39°C, severe dry
cough, dyspnea, significant fatigue and tachycardia) appeared on the 7th-day after contact with a