... Coping skills for negative emotions (e.g., skills for coping with anxiety), Positive Valence Systems (PVS) includes Motivation to change behavior (e.g., self-reinforcement), Drug-free activities (e.g., information on healthy leisure offers existing in the city), Knowledge about drug reward (e.g., immediate rewards against personal values), Social Processes (SP) includes Social skills (e.g., communication skills), Social attitudes and selfperception for drugs (e.g., modifying attitude towards using drug), Social norms (e.g., personalized normative feedback), Social pressure resisting skills (e.g., refusal skills), Changing self/other perspective (perception of self and other), Self-related awareness and self-efficacy skills (e.g., belief in one's ability to overcome drug temptation), Self-monitoring (e.g., personal self-management), Drug effects on body and brain (e.g., accurate insight towards harmful effects of substances), Cognitive System (CS) includes Cognitive-management skills (e.g., problem solving), Cognitive empowerment skills (e.g., goal-setting), Cognitive-control skills (e.g., self-control skills), Arousal and Regulatory Systems (ARS) includes Stress management (e.g., coping skills for stress) References (In alphabetical order of the interventions): Alerta Alcohol program (Martinez-Montilla et al., 2020), Alcohol Misuse Prevention Study (AMPS) (Shope et al., 2001), Brief alcohol intervention (Giles et al., 2016;, WISEteens (Brief intervention for poly-drug use) (Arnaud et al., 2012), Climate Schools (now known as OurFutures) (Vogl et al., 2009;Slade et al., 2021), CognitionMotivation-Emotional Intelligence-Resistance Skills (CMER) (Guo et al., 2010), Drug education program (Midford et al., 2012), eCHECKUP TO GO (Doumas et al., 2020), IPSY (Spaeth et al., 2010), keepin' it REAL (Kulis et al., 2007), Kripalu Yoga in the Schools (KYIS) curriculum (Butzer et al., 2017), Life skills training (LST) (Seal, 2006;Botvin et al., 1990), Motivational interviewing-oriented brief alcohol interventions (MIBAI) (Gmel et al., 2012), MobileCoach Alcohol (Haug et al., 2014), Preventure (Barrett et al., 2015;Conrad, 2016), Project Toward No Drug Abuse (TND) (Sussman et al., 2011) Ready4life (Haug et al., 2021), Reconnecting Youth (Hallfors et al., 2006), RealTeen (Schwinn et al., 2010), these risk factors show some specificity in reducing risk for substance misuse and clinically significant levels of anxiety disorders and major depression (O'Leary- Barrett et al., 2013). The other example of a multi-dimensional program is life skill programs (LSPs) which target intra-and interpersonal skills (e.g., communication skills, empathy, assertiveness, problem solving and decision-making skills, coping with emotions and stress), as well as training substance-related skills (e.g., resistance skills), changing attitude, and improving substance-related knowledge (e.g., norms) (Wenzel et al., 2009). ...