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Comparision of antiglycemic and antilipidemic effects of Apium graveolens with Cinnamomum verum on male diabetic rats

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Abstract

Comparision of antiglycemic and antilipidemic effects of Apium graveolens with Cinnamomum verum on male diabetic rats Introduction: Celery (Apium graveolens L.) is a vegetable, more specifically a biennial plant belonging to the order Umbelliferae (Apiales). Cinnamomum verum is a small evergreen tree belonging to the family Lauraceae. Among other species, its inner bark is used to make cinnamon. In herbal medicine hypothesis mentioned antiglycemic and antilipidemic effects for both of these two plants. The objective of this study was to examine this hypothesis Marerials and methods: 30 Samples were chosen from male rats (220–250 gr). Rats were randomly devided to 3 groups. All 30 rats, were fasted for 12 hours before an intramuscular injection of streptozotocin 50 mg/kg. Two days after STZ treatment, the rats were considered diabetic. The first group rats fed with 1 mL of physiologic saline daily for 3 weeks. The second group rats fed with C.verum oil(100 mg/kg) daily for 3 weeks. The third group rats fed with A.graveolens oil(200 mg/kg) daily for 3 weeks. Plasma glucose and TG level were compared in 3 groups with ANOVA test. Results: Both C.verum and A.gravelens decreased plasma glucose compared with control group and there was signigicant diffrence between these reductions: 33.2% reduction in C.verum group versus 24.7% reduction in A.graveolens group. There was no diffrence in plasma TG level between control and C.verum group, However A.graveolens decreased plasma TG level 11.2%. Discussion:This study showed that C.verum has better effect on blood glucose than A.graveolens; C.verum has no effect on blood TG level however A.graveolens decreases TG level. More studies are suggested to find their mechanism of action on reducing plasma glucose and TG level.
Comparision of antiglycemic and antilipidemic effects of Apium
graveolens with Cinnamomum verum on male diabetic rats
Introduction: Celery (Apium graveolens L.) is a vegetable, more specifically
a biennial plant belonging to the order Umbelliferae (Apiales). Cinnamomum
verum is a small evergreen tree belonging to the family Lauraceae. Among other
species, its inner bark is used to make cinnamon. In herbal medicine hypothesis
mentioned antiglycemic and antilipidemic effects for both of these two plants. The
objective of this study was to examine this hypothesis
Marerials and methods: 30 Samples were chosen from male rats (220–250 gr).
Rats were randomly devided to 3 groups. All 30 rats, were fasted for 12 hours
before an intramuscular injection of streptozotocin 50 mg/kg. Two days after STZ
treatment, the rats were considered diabetic. The first group rats fed with 1 mL of
physiologic saline daily for 3 weeks. The second group rats fed with C.verum
oil(100 mg/kg) daily for 3 weeks. The third group rats fed with A.graveolens
oil(200 mg/kg) daily for 3 weeks. Plasma glucose and TG level were compared in
3 groups with ANOVA test.
Results: Both C.verum and A.gravelens decreased plasma glucose compared with
control group and there was signigicant diffrence between these reductions: 33.2%
reduction in C.verum group versus 24.7% reduction in A.graveolens group. There
was no diffrence in plasma TG level between control and C.verum group, However
A.graveolens decreased plasma TG level 11.2%.
Discussion:This study showed that C.verum has better effect on blood glucose
than A.graveolens; C.verum has no effect on blood TG level however A.graveolens
decreases TG level. More studies are suggested to find their mechanism of action
on reducing plasma glucose and TG level.
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