Celery’s (Apium graveolens) antiglycemic effect on diabetic rats
Introduction:Celery (Apium graveolens) is a vegetable, more specifically
a biennial plant belonging to the order Umbelliferae (Apiales). It has a furrowed
stalk with wedge-shaped leaves, the whole plant having a coarse, rank taste, and a
peculiar smell. It has so many confirmed positive effects like its beneficial role in
lowering testicular damage, The objective of this study was to examine the
hypothesis that intake of celery can reduce plasma glucose level.
Materials and methods: Samples were chosen from Male rats (220–250 gr). Rats
were randomly assigned accordingly to 2 groups; each one contains 10 rats. All 20
rats, were fasted for 12 hours before an intramuscular injection of streptozotocin 50
mg/kg dissolved in citrate buffer at pH 4.5. Two days after STZ treatment, the rats
were considered diabetic (nonfasting blood glucose level of >300 mg/dL). The
control group rats fed daily for 3 weeks, with 1 mL of physiologic saline alone
administered by the intragastric route; howerver The case group rats, fed daily for
3 weeks, with Celery oil(200 mg/kg) administered by the intragastric route. After 3
weeks, plasma glucose was measured by commercial kits 2 times:1-before starting
the test 2-at the end of test
Results: The body weight gain of diabetic rats fed celery oil and control rats were
similar; but water and food intake were 34.3% lower in case groups(P value<
0.05). Ingestion of Celery oil significantly reduced plasma glucose concentration
by 31.7% in diabetic rats compared with control diabetic rats.
Discussion: The present study found that using of celery oil can reduce plasma
glucose level in diabetic rats; more studies are needed to find its mechanism of
action on reducing plasma glucose level.