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Nigella sativa, anthemis hyaline and natural honey for promising COVID-19 treatment

Authors:
  • Sohag University in Egypt, Taibah Univesity in Saudi Arabia
American Journal of Public Health Research, 2020, Vol. 8, No. 2, 54-60
Available online at http://pubs.sciepub.com/ajphr/8/2/3
Published by Science and Education Publishing
DOI:10.12691/ajphr-8-2-3
TaibUVID for Minimizing COVID-19 Fatalities
and Morbidity: An Evidence-based Approach
for Better Outcomes (A Treatment Protocol)
Salah Mohamed El Sayed1,2,3,*, Hamdi H. Almaramhy4, Yasmeen Talal Aljehani5, Ahmed M. Okashah6,
Mariam E. El-Anzi7, Mansour Barakah AlHarbi8, Rehab El-Tahlawi9,10, Manal Mohamed Helmy11,
Moutassim Aboonq12, Osama Hamouda3, Osama Alhadramy13
1Department of Clinical Biochemistry and Molecular Medicine, Taibah Faculty of Medicine, Taibah University,
Al-Madinah Al-Munawwarah, Saudi Arabia
2Department of Medical Biochemistry, Sohag Faculty of Medicine, Sohag University, Egypt
3Integrative Medicine and Prophetic Medicine Course and Research, Taibah Faculty of Medicine, Taibah University,
Al-Madinah Al-Munawwarah, Saudi Arabia
4Department of surgery, Taibah Faculty of Medicine, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia
5Family medicine programme & Ministry of health affairs & Sayed Al-shuhada primary health care center,
Al-Madinah Al-Munawwarah, Saudi Arabia
6Academic Affairs Director And Consultant Clinical Immunologist, Al-Madinah Directorate of Health, Al-Madinah Al-Munawwarah,
Ministry of Health, Saudi Arabia
7Diabetic Center in King Fahd Hospital & Said Alshohada Primary Health Care Center, Al-Madinah Al-Munawwarah, Saudi Arabia
8Head of training and academic affairs and Designated Institutional Official (DIO), KFH, Al-Madinah and Leader of training and
academic affairs taskforce in Al-madinah
9Department of Microbiology, College of Medicine, Taibah University, Saudi Arabia
10Department of Microbiology, Faculty of Medicine, Zagazig University, Egypt
11Division of Pediatric Cardiology, Pediatrics Department, Maternity and children hospital, Hail, Saudi Arabia
12Department of Medical Physiology, Taibah Faculty of Medicine, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia
13Division of Cardiology, Department of Medicine, Taibah College of Medicine, Taibah University,
Al-Madinah Al-Munawwarah, Saudi Arabia
*Corresponding author: salahfazara@yahoo.com
Received February 28, 2020; Revised March 29, 2020; Accepted April 06, 2020
Abstract With the continuously expanding terrible pandemic of COVID-19 infection, globally increasing
numbers of COVID-19 patients and contacts progressively jump to heavy burdens beyond capabilities. Developing
and poor countries may face humanity disasters in the next few days unless urgent measures are rapidly performed.
Standard anti-COVID-19 treatment should inhibit COVID-19 replication, repair virus-induced tissue damage and
enhance patients' immunity. Unfortunately, such criteria are still lacking in current treatments resulting in relatively
high viral infectivity, morbidity and mortality. Based on previous prophetic medicine research experience and the
literature, we introduce TaibUVID therapy as a novel medicinal nutrition formulation. TaibUVID stands for Taibah
University anti-COVID-19 treatment as a novel evidence-based approach (using natural products) for treating
COVID-19 patients. A single TaibUVID dose includes: 1 large spoonful of nigella sativa oil (or 2 gram nigella
sativa seeds) mixed with 1 gram of grinded anthemis hyaline and 1 large spoonful of natural honey. This mixture is
to be chewed in the mouth and swallowed orally for both COVID-19 contacts and patients. We adjusted dosing
regimen and period of treatment into three clinical levels including contacts or prophylaxis, mild cases and severe
case. We also introduce novel nigella sativa oil (or nigella sativa decoction) nebulization for local treatment of
pneumonia or bronchopneumonia that is faced in severe COVID-19 cases. The wonderful report by Ulasli et al.
(Ulasli et al. Mol Biol Rep. 2014;41:1703-11) deserves a lot of interest where nigella sativa and Anthemis hyalina
(chamomile) were confirmed to inhibit corona virus replication maximally. In addition, nigella sativa enhances
immunity, exerts tissue protective effects and effectively treats co-morbidities. Oral honey exerts potent antiviral
effects, enhances immunity and exerts tissue protective effects. Our suggested TaibUVID is a promising evidence-
based approach to rescue lives, decrease fatalities and put a rapid end to COVID-19 pandemic.
Keywords: COVID-19, TaibUVID, nigella sativa, anthemis hyalina, oral honey and citrus sinensis
Cite This Article: Salah Mohamed El Sayed, Hamdi H. Almaramhy, Yasmeen Talal Aljehani, Ahmed M.
Okashah, Mariam E. El-Anzi, Mansour Barakah AlHarbi, Rehab El-Tahlawi, Manal Mohamed Helmy,
Moutassim Aboonq, Osama Hamouda, and Osama Alhadramy, TaibUVID for Minimizing COVID-19 Fatalities
American Journal of Public Health Research 55
and Morbidity: An Evidence-based Approach for Better Outcomes (A Treatment Protocol).” American Journal of
Public Health Research, vol. 8, no. 2 (2020): 54-60. doi: 10.12691/ajphr-8-2-3.
1. Introduction
With the continuously expanding terrible pandemic of
COVID-19 infection, globally increasing numbers of
COVID-19 patients and contacts progressively jump to
heavy burdens beyond capabilities. Developing and poor
countries may face humanity disasters in the next few
days unless urgent measures are rapidly performed. As
worldwide health authorities and hospitals are currently
overloaded, home treatment of contacts and mild
COVID-19 cases may become a fact necessitating some
evidence-based suggested measures in addition to some
health advices. No single country is an exception away
from COVID-19 infection. Revising the current treatment
policies and guidelines is mandatory as hospitals
capacities may be exceeded soon resulting in more
threatening mortality rates.
2. COVID-19 Pandemic and Future
Concerns
Unfortunately, ideal anti-COVID-19 medications are
not existing so far. An ideal anti-COVID-19 medication
(or a combination of agents) should be safe for such
patients while conferring three basic therapeutic effects
(and/or preventive health benefits): enhancing the antiviral
immunity, tissue-protection (and tissue repair) and
exerting potent antiviral effects. Revising the current
global treatment modalities provided for COVID-19
patients and contacts clearly confirms that current
COVID-19 remedies may be still far from those targets.
Most available treatments are supportive rather than
curative. Based on previous prophetic medicine research
and experience, we introduce Taibuvid (TaibUVID) as a
novel evidence-based approach (using natural products)
for treating COVID-19 patients. TaibUVID stands for
Taibah university anti-COVID-19 therapy.
3. How to Protect Patients' Lives
from Coronaviruses?
Natural products e.g. nigella sativa and anthemis
hyaline (chamomile) proved effective in decreasing
coronaviruses replication by about 92% and 100%,
respectively in in-vitro cultures [1]. Natural honey is a
prophetic medicine remedy with proven potent antiviral
and tissue protection effects. Both nigella sativa and
natural honey are prophetic medicine remedies that gain
popularity and public acceptability in Saudi Arabia and
worldwide. The well-documented therapeutic benefits of
nigella sativa (lung protection, increasing immunity and
repair of tissue damage) are urgently needed to combat
COVID-19 pandemic.
Coronaviruses are members of the Coronaviridae family
that are enveloped viruses that contain non-segmented,
positive-stranded genomic RNA [2,3,4,5,6]. Ultrastructural
analysis of Coronaviruses have revealed that they form
pleomorphic particles that are roughly spherical but show
variations in size (80-120 nm in diameter) and shape
[7,8,9,10].
In spring 2003, a new human Coronavirus has been
causing an epidemic outbreak in South East Asia and
Canada [11]. At the time, the accused virus was rapidly
identified as the SARS-CoV but it did not look like the
human Coronaviruses. The SARS-CoV alarmed the world
because it sickened more than 8,000 people and killed
nearly 800 of them [12]. Recently, a novel coronavirus
caused respiratory infectious disease with high mortality.
The virus is called Middle East respiratory syndrome
coronavirus (MERS-CoV). This novel MERS-CoV was
first reported in Saudi Arabia and eight other countries in
2012 [13]. Currently, there are no approved drugs against
Coronaviruses but some potential therapies have been
proposed.
4. COVID-19 Infection
The world is currently witnessing an outbreak of a new
coronavirus spreading quickly across China and affecting
at least 80 other countries. With almost less than half a
million infection, a worldwide death toll of at least 63,000
(as of 5 April 2020), and with the potential to affect up to
two-thirds of the world population, COVID-19 is
considered by the World Health Organization (WHO) to
be a global health emergency. The speed of spread and
infectivity of COVID-19 (also known as Wuhan-2019-
nCoV) are dramatically exceeding those of the Middle
East respiratory syndrome coronavirus (MERS-CoV) and
severe acute respiratory syndrome coronavirus (SARS-
CoV). In fact, since September 2012, the WHO has been
notified of 2494 laboratory-confirmed cases of infection
with MERS-CoV, whereas the 2002-2003 epidemic of
SARS affected 26 countries and resulted in more than
8000 cases. Therefore, although SARS-Cov, MERS-Cov,
and COVID-19 are all the result of coronaviral infections,
the causes of the coronaviruses differ dramatically in their
transmissibility. It is likely that these differences in
infectivity of coronaviruses can be attributed to the
differences in the rigidity of their shells which can be
evaluated using computational tools for predicting
intrinsic disorder predisposition of the corresponding viral
proteins [14].
5. Nigella Sativa as a Potential Safe and
Effective Treatment for COVID-19
Natural products are simple, cheap, economic, available,
easy to administer and effective remedies. Natural
products are widely accepted by the public Nigella sativa
(NS) exhibits the rescue triad: immune stimulation, tissues
(e.g. lung) protection and potent antiviral effects. NS is a
confirmed remedy in prophetic medicine. NS can be
56 American Journal of Public Health Research
administered as intact seeds or powder (grinded seeds).
Intact seeds can be crushed in the mouth and swallowed or
be added to food or juices.
NS was reported as a strong stimulant and potentiator
of the natural immunity and the immune system. NS was
reported to increase splenocyte proliferation, suppress the
secretion of inflammatory cytokines (TNF-α and Il-6),
enhance the natural killer cytotoxic activities, increase
bone marrow cellularity and increase the number of white
blood cells. NS was also reported to increase the
resistance against lethal infections, decrease lung
pathological changes due to ovalbumin sensitization and
enhance the production of INF-gamma [15].
NS conferred lung and tracheal protection in many
research studies. NS was reported to protect against
tracheal contractions induced by leukotriene B4, induce
tracheal relaxant effects, exert antispasmodic and
mucociliary pulmonary clearance effects, protect the lungs
and trachea against harmful irritants and enhance lung
protection during pulmonary aspiration. NS was also
reported to protect against lung injury in many disease
conditions e.g. hyperoxia-induced lung injury, improve
asthma symptoms and wheezing frequency together with
improving pulmonary function tests in asthmatic patients
and exert antihistaminic effects in the airways of asthma
patients [15].
NS was also reported to improve the respiratory
symptoms and lung function tests in human war victims
[16], improve all the parameters of respiration in
asthmatic patients [17], potentiate immunotherapy in
patients with allergic rhinitis [18] and decrease allergic
serum parameters e.g. IgE and eosinophilic count. NS was
also reported to improve the subjective feeling in patients
with allergic diseases [18].
6. Promising Antiviral Effects of Nigella
Sativa
NS was reported to exert potent antiviral effects with
raising the endogenous human antiviral immunity (serum
interferon) in patients having viral hepatitis C [20]. NS
was reported to decrease corona virus replication and
decrease the virus load of corona viruses in virus cultures
by more than 95% [1]. NS was also reported to maintain
seronegative condition in an AIDS patient [21].
7. NS is a Safe Effective Treatment in
Many Diseases In Human Patients
NS was reported to be safe, effective, and tolerable for
use in human patients having diabetes mellitus,
hypertension and hyperlipidemia [22].
NS was used in many reported and published
human studies in many countries to treat different diseases
e.g. uncontrolled diabetes mellitus with uncontrolled
hyperlipidemia [23], insulin resistance syndrome [24],
cardiac dysfunction [25], hypertension [26], rheumatoid
arthritis [27], allergic rhinitis [28], helicobacter pylori
infection [29], psoriasis [30]. NS was reported to exert
many prophylactic benefits against a lot of diseases e.g.
asthma [31,32]. Moreover, NS was reported to enhance
memory, attention and cognition in healthy human
volunteers [33].
8. Natural Honey and Its Therapeutic
Benefits
Natural honey has anti-oxidant, anti-bacterial and anti-
inflammatory properties. Natural honey is a confirmed
remedy in prophetic medicine. It can be used as a wound
dressing to promote rapid and improved healing. These
effects are due to honey's anti-bacterial action, secondary
to its high acidity, osmotic effect, anti-oxidant content and
hydrogen peroxide content. The use of honey leads to
improved wound healing in acute cases, pain relief in burn
patients and decreased inflammatory response in such
patients [34].
9. Antiviral Effects of Natural Honey
Honybee products are promising as antiviral medicinal
treatments and nutrition. A recent meta-analysis reported
an evidence from many trials that propolis is the best of all
natural products in the treatment of herpetic skin lesions,
especially those related to HSV-1 [35]. Al-Waili et al.
reported the use of honey in adult patients with recurrent
attacks of herpetic lesions (labial and genital) [36].
Topical treatment with honey was compared with
acyclovir treatment. Honey showed better results with no
side effects, over patients using acyclovir who reported
itchiness [36]. The trial showed that topical honey
application was effective in the management of pain and
other signs and symptoms of recurrent lesions from
genital and labial herpes [36]. Manuka honey efficiently
inhibited influenza virus replication and exerted virucidal
effects [37]. Honey was also reported to help in herpes
simplex gingivostomatitis in children [38].
10. Anthemis Hyalina and Citrus Sinensis
Inhibit Corona Viruses Replication
Anthemis hyaline was reported to suppress the
replication of coronaviruses by 100% while citrus sinensis
(sweet orange) was reported to suppress the replication of
coronaviruses by less than 90% [1].
11. TaibUVID Treatment for COVID-19
Herein, we introduce TaibUVID treatment as a
potential curative medicinal nutritional therapy for
COVID-19 contacts and patients.
A single TaibUVID dose includes: 1 large spoonful of
nigella sativa oil (or 2 gram Nigella sativa seeds) mixed
with 1 gram of grinded anthemis hyaline and 1 large
spoonful of natural honey. This mixture is to be chewed in
the mouth and swallowed orally (Figure 1Figure 3).
American Journal of Public Health Research 57
Figure 1. Decoction of nigella sativa for nebulized local vapour administration to treat pneumonia
Figure 2. Anthemis hyalina (chamomile) and citrus sinensis (sweet orange) inhibit corona viruses replication
58 American Journal of Public Health Research
Figure 3. A single TaibUVID dose includes: 1 large spoonful of nigella sativa oil (or 2 gram Nigella sativa seeds) mixed with 1 gram of grinded
anthemis hyaline (chamomile) and 1 large spoonful of natural honey. This mixture is to be chewed orally
12. COVID-19 Treatment Objectives
Using TaibUVID
Table 1. Targeted and suggested evidence-based TaibUVID
treatment for COVID-19 infections
Effective COVID-19 therapies should achieve the following:
-enhance antiviral immunity.
-inhibit virus replication.
-exert tissue-protective effects.
Unfortunately, current COVID-19 treatments are not as needed.
Components of the evidence-based TaibUVID treatment (natural
products) for COVID-19:
A single TaibUVID dose includes:
1 large spoonful of nigella sativa oil (or 2 gram Nigella sativa seeds)
mixed with 1 gram of grinded anthemis hyaline and 1 large spoonful of
natural honey. This mixture is to be chewed orally.
1. Nigella sativa:
-Inhibits corona virus replication (>90%).
-Potentiates immunity.
-Protects tissues
-exerts potent anti-inflammatory effects.
2. Oral honey:
-exerts potent Anti-inflammatory effects
- exerts tissue-protective effects
-exerts potent general anti-viral effects.
3.Anthemis hyaline:
-Inhibits corona virus replication (100%).
N.B. Citrus sinensis juice should be provided with all meals.
Citrus sinensis inhibits corona virus replication (<90%).
To save human lives and minimize mortality.
To make use of therapeutic benefits of NS/honey in
COVID-19 patients.
To make use of the antioxidant effects of NS/honey
in COVID-19 patients.
To make use of the immune potentiating effects of
NS/honey in COVID-19 patients.
13. Treatment Protocol Using TaibUVID
N.B. Serum and blood samples are taken before
treatment and every day (or every other day) till cure God
willing (in shaa Allah).
-2 ml serum from every patient (before treatment, every
2 days and after finishing treatment) should be kept in
eppendorf tubes in -30C for future laboratory analysis.
14. Treatment Guidelines for COVID-19
Patients and Contacts
***Level I measures: (For prophylaxis and contacts):
One TaibUVID dose (once or twice daily till end of
COVID-19 pandemic).
-Add sweet oranges to regular diets.
*** Level II measures: For confirmed patients (mild to
moderate cases):
One TaibUVID dose (2-4 times daily for a week).
-Add sweet oranges to regular diets.
*** Level III measures: For severe cases (with
American Journal of Public Health Research 59
pneumonia), comatosed patients and ventilated patients:
-Add sweet oranges (or fresh orange juice) to regular
diets in all the three stages of level III measures.
IIIA- If patient can swallow: One TaibUVID dose
(5-6 times daily for 1-2 weeks).
IIIB: If patient cannot swallow, drowsy or
comatosed: dissolve one TaibUVID dose in 20 ml water.
Give orally using a nasogastric tube 5-6 times daily for
1-2 weeks).
IIIC. For patients having pneumonia: Give treatment
as IIIA or IIIB (one TaibUVID dose (in 20 ml water if
patient cannot chew). Give orally using a nasogastric tube
5-6 times daily for 1-2 weeks).)+ nebulized nigella sativa
decoction vapor.
How to prepare nebulized nigella sativa decoction
vapor?
*4-6 grams are boiled in water and the resultant hot
water (200-300 ml) is cooled up. Then, NS decoction
water is filtered in a complete aseptic medical
environment to remove the seeds. The NS water is
nebulized via a nebulizer and the vapour is administered
to patients through a face mask (to improve the lungs
condition and the respiratory functions) (Figure 1).
- 1 cup of natural orange Juice containing 1 gram of
anthemis hyalina 4 times daily (orally or through
nasogastric tube).
N.B. If nebulized nigella sativa decoction cannot be
prepared, nigella sativa oil can be used for nebulization.
15. Patients follow-up:
N.B. Patients evaluation should be done twice weekly.
1. Clinical evaluation: on daily basis (to assess the
clinical improvement of symptoms, especially respiratory
condition and the response to treatment)
2. Laboratory evaluation:
1) Determining virus count (load) and activity:
RT-PCR for determining virus load in serum and
respiratory (nasal or pharyngeal swabs).
Repeating nasal swab for detecting PCR seroconversion.
2) Evaluating organ functions and extent of tissue
damage or repair:
Respiratory function tests and chest X-ray and chest
CT or MRI.
Kidney function tests
Liver function test.
3) Evaluating COVID-19 cytokines storm and
inflammatory activity:
Serum CRP, serum Il-1, Il-2, Il-6, TNF-α and TGF-β
4) Evaluating immunity against COVID-19:
Serum interferon-gamma
Immunity markers (complete blood count for
counting WBCs, lymphocytes and neutrophils)
CD4 lymphocytes (T-helper cells) and CD8
lymphocytes (T-cytotoxic cells).
5) Evaluating antioxidant tissue protection vs
COVID-19-induced tissue damage:
Oxidative stress and tissue-damage markers
(e.g. serum malondialdehyde and H2O2).
Antioxidant tissue protection e.g. serum glutathione
peroxidase, catalase and total antioxidant capacity).
Expected results:
TaibUVID treatment results in:
Rapid seroconversion from positive to negative in
COVID-19 cases
Decreased morbidity and mortality.
Tissue protection and rapid recovery
Increased immune potentiation (raised WBCs, CD4
lymphocytes, CD8 lymphocytes and Interferon-
gamma).
Decreased anemia and physiological leucocytosis
Decreased oxidative stress and tissue-damage
markers (decreased malondialdehyde, increased
glutathione peroxidase, increased catalase and
increased total antioxidant capacity).
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