Background: Musa acuminata (Musaceae) is a perennial tree-like plant that is grown in many tropical and subtropical areas throughout the globe. Bananas, which may be consumed as a fruit or a vegetable, is one of the most significant crops in many nations owing to their nutrient-dense diet and diverse therapeutic properties. Introduction: Apigenin glycosides, myricetin glycoside, myricetin-3-O-rutinoside, delphinidin, pelargonidin, peonidin, malvidin, naringenin glycosides, kaempferol-3-O-rutinoside, dopamine, N-acetyl serotonin, rutin, polyphenols, flavonoids, total dietary fiber, insoluble dietary fiber, lignin, hemicellulose, cellulose, lipids, proteins, and minerals are found in bananas. Objective: The primary goal of this research is to confirm and emphasize the therapeutic and nutritional value of M. acuminata. Methods: Fever, cough, bronchitis, dysentery, allergy infections, sexually transmitted infections, and certain non-communicable illnesses have all been linked to M. acuminata, according to a literature review. Result: M. acuminata has been reported to have anti-oxidant, anti-diabetic, immunomodulatory, hypolipidemic, anti-cancer, and anti-microbial properties. Pharmacological studies back up the medicinal plant's traditional significance and suggest that indigenous peoples used M. acuminata to cure and heal a variety of illnesses and ailments. Individual bioactive constituent(s) from different sections of this plant, on the other hand, need to be studied further to validate various pharmacological claims and to investigate the potential of M. acuminata in drug development and usage in functional foods. Conclusion: A thorough examination of M. acuminata's biological activity is provided, as well as potential processes and phytochemicals involved, in order to develop effective disease prevention and management methods.