A physical plasma-based portrayal of living bio-cells

Abstract

This brief article presents an amalgamated fusion of “physical plasma” and “biological plasma”, which are, hitherto, remaining as two distinct autonomous natural entities. It is emphasized that this bio-physical coupling procedure is operable to see living bio-cells and evolutionary dynamics exactly from a new interdisciplinary perspective of atypical plasma-wall interface phenomenology alongside an aboveboard indication to nontrivial scope.

Full text

atitl
Magazine
of
School
of
Sciences, Tezpur University, 2020
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.,
. . .

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...
AL
pLASMA-BASED
PORTRAYA
L
OF
A
PHYSIC
LIVIN
G
BI
O
-CELLS
Dr.
Pralay
Kumar
Karmakar
Associate
Prof.
Department
of
Physics
Tezpur
Un
i
versity
Abstract: This brief article presents
an
amalga
" d "b' I · I I "
mated
fus
·
"physical
plasma
an
10
og1ca
p
asma
,
which
are,
hithe
1on
0
1
t I t·t·
rto,
rerna-
.
as
two distinct autonomous
na
ura
en
1
1es.
It
is
emphasiz
d h ,
1n1~
. d . e
ereinti.
..
this bio-physical coupling proce ure
ts
usable
to
see
living
b'
"!Gt
• • • 1
0-cells
evolutionary dynamics exactly from a new
mterd1sciplinaryp
a~
.
erspecr
of
atypical plasma-wall
interface
phenomenology
along
.
Ne
. . . f
With
a
straightforward
ind1cat1on
to uture
scope.
It
is
widely well-known
that
all
organisms
are
made
u f
biological
cells,
th~
s~ruc~ural
and functional
aut~n~mous
self-repli~ti~
units
of
life,
originating
from
the
pre-ex1st1ng
cells.
The
cells
compositionally consist
of
large concentrations of
bio-ions,
such
as
sodium
(Na+),
potassium
(K+),
chloride
(Cl-),
variable
concent
rationsof
calcium
(Ca
2
+),
and
much lower concentrations
oforganicacids
andbase
s
of
many
types. Their anatomical interstice
contains
a
nucleus,
cytoplasm
surrounded
by
membrane or boundary wall. A
fundamentalas
pect
,thus
,
of understanding the
"truth
of
life" directly
lies
in
exploring
the
cells,
cellular dynamics
and
diverse. involved low-frequency
wave-
activ
ities
from a realistic reliable viewpoint.
In
this direction, about decades before
[1-3],
a
few
authorsjoi~tly
carried
out
an
interdisciplinary study to
understand
the
role
of
physical
plasma,
the unique state
of
matter
rich
in
collective
dynamics,
inthhe
h . h m
zon
as
P
ys,cal
phenomena
of
the
biological cells.
Among
t e '
in
analytically derived the criteria
for
the existence of
the
plasma
st
1
ate
of
h
Id
va
ues
the cytoplasmic fluids on the basis
of
the
estimated
thres
O • 2
~ ,
the static dielectric constant
[l].
Then,
Uehara
and
Sakanedi~ffusive
f
lectro·
1
pro~~s~d
an
ele~e~tary
theoretical
m~del O
_e
_
lasma
[2]
,
Th~
equihbnum
of
the tonic species
of
the
considered
bto
P
the
cell
d rt
across
ed
mo
el
was
applicable to understand the ionic
transpo
. 5
ourc
b .
chan1sm,
~em
ranes,
and,
electrical double layer formation
me
I
sm
and
the
via
the existing voltage between the cell's internal
cyt~~:
elernentalY
external bio-plasma
[2
-5).
As
a fruitful outcome,
applyi
1
0
gth
rte~
concepts
of
the plasma state physics the
plasma
oebye
~icrornetre
mic '
("'
few"'
hese
rometre), the thickness
of
the cell membrane •
t·ied
,
Fort
f
and
sig
'fl . d
nd
oss1
·0
no
.
ni
cant transport properties were
stud1e
a . d'
stribUtl
est1mati
h .
ulat1on
I
sonie
th
ans,
t
ey
considered the Maxwellian
pop
'd
plasfll
3•
10
e ionic concentration within the bio-cell
containing
liqui
rgufllents
other auth .
phical
a
ors [4) have offered many phtloso

bio-cell containing liquid plasma. Some
other
authors
141
have
offered many
philosophical
ar~uments
to
mpathize
the
role
of
plasma,
as
a
unique
source
sy
h . . f l"f d .
mechanism, in t e origin o I e an its
evolution.
It
has
been
indicated
that
the
plasma may be realized
mainly
in
three distinct ways: (a) plasma plays a crucial
intra-organismal
role,
(b)
it
participates
in
the
origination
of
life
and
in
i~ter-generational
transmission
of
life, and, finally,
(c)
It acts
as
a receptor-
like
medium interacting
with
environmental
agents.
A
fundamental
question
in
our
mind
arose,
as,
whether the static
equilibrium
approximation
(1-5]
could
really lead
to
a bounded
solution
of
the
closing
electrostatic Poisson
equation,
to
exist in reality?
By
the
term "bounded
solution"
,
we
mean
the
existence
of a maximum value
of
the
electric
field
associated
with the non-neutral space charge layer
defining
and
specifying
the
cell
boundary.
We
did
not
find
any
bounded solution
for
the
space charge
electric
field
under the Maxwellian
behaviour
of
the
constituent
ionic species.
This,
simply,
implicates
that
the
conventional static
picture
of
the
heuristic
electro-
diffusive
equilibrium
among
the
heterogeneous
cellular species is
not
a
suitable
and
justifiable
theoretical
model
to
describe
the
realistic physical
phenomena and electrical state
of
the
biological cells.
In
this analytical comprehensive
formalism,
instead,
we
consider a hy~ro-dynamical
model
of
bio-plasma
equilibrium
with
the
full
inertial
dynamics
of
the
ionic
and
other
constituent
spec
ies
under
spherical
geometry approximation. Despite
the
elusive fact
that
the
cells
have a
wide
variety
of
shape [5]; a typical
cell,
spherical in structure, is
only
accounted
for
the
inv
estigation
to
procee,q
_.
All
other
nano sized bio-
macromolecules are considered
as
inertial
fluids
with
the viscoelastic
eff~cts
taken
into
account
. We
interestingly find
that
a
bounded
solution
does exist
in
the presence
of
differential
inertial
motions
of
the
i
onic
species
.
In
this projected investigation, we
would
li
ke
to explore quantitative descriptive analysis
of
the
Physical
size
and electrical state
of
the
biological cell
~nd
compa
re
with
the
experimental
values available
in
the abreast literature [1-9] . We assign a
distinct
and
unique nomenclatur
e,
like Bio-Plasma Sheath iBPS),
for the non-neutral space charge layer coupled
with
the
biological c
11
b d .
e oun ary, thus
forming
electrical
double
layer
structure.
Finally,
albeit
underlying
related
th
· ·
eonzation and experimentation
we
hope
that
such
int
d"
· 1· '
. . er
1scIp
inary studies may excite more
s~1ent1sts and
s~u_dent~
-
of
plasma physics and
of
biology communities conjoint
to
further
dig
into
the
role
of
plasma physics
to
yield high socio-economic
values in
the
aimed realistic
BPS
framework
under
plasma-wall interaction processes.
References:
[1]
J.
R. Zone, "The living cell
as
plasma physical
system", Physiological Chemistry and Physics, vol. 12,
pp. 357-364, 1980.
[2] M. Uehara,
K. K.
Sakane,
H.
S.
Maciel and
W.
I.
Urruchi, "Physics and Biology: Bio-plasma physics",
American Journal
of
Physics, vol. 68 (5), pp. 450-455,
2000.
[3]
J.
Gimmel,
A.
Sriram,
S.
Gershman and
A.
Post-
Zwicker, "Bio-plasma physics: Measuring ion transport
across cell
membranes
with
plasmas",
American
Physical
Society,
Ohio
Section
Fall
Meeting
in
conjunction
with,
abstract #lP.017,
http://adsabs.harvard.
edu/abs/
2002APS
..
OSF.1P017G.
[4]
J.
Zone, "Bioplasma and physical plasma in living
systems: A study in science and philosophy",
http://
www.kul.pl/files/57/pracownicy/zon/bioplazma/
Jozef _Zon_Bioplazma _summary . .
[SJ
D.
Andelman,
"Electrostatic
properties
of
membranes
: The
Poisson
--
8:oltzmann
theory",
Chapter-12,
in
Structure and Dynamics
of
Membranes,
edited by
R.
Liposky and
E.
Sackmann,
vol.18,
pp. 603-
642 (Elsevier, New York, 1995).
[6] R. Kupferman
et
al., "Analytical
calculation
of
intracellular calcium wave characteristics", Biophysical
Journal, vol. 72, pp. 2430-2444, 1997.
[7]
M.
Leonetti and
E.
Dubois-Violette, "An electro-
osmotic
instability
in biological c_ells", Europhysics
Letters, vol. 37(3), pp. 231-235, 1997. ·.
[8] K. E.
Kasza
et
al., "The cell
as
a material", Current
Opinion in Cell Biology, vol. 19, pp. 101-107, 2007.
[9] P.
Kollmannsberger
and B Fabry,
"Linear
and
nonlinear rheology
of
living cells", Annual Review
of
Material
Research, vol. 41, pp. 75-97, 2011.