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Use of white noise-emitting devices in infants and small children as assessed by their parents

Authors:

Abstract

Introduction: Crying and anxiety in an infant are not only a defence reaction informing of a health problem, but also a signal of hunger, fatigue or difficulties falling asleep. There are many methods of reducing a child’s adaptation problems. Various positions, breastfeeding, rocking and contact with the mother’s skin are used. Currently, white noise-emitting devices are increasingly popular. White noise consists of monotonous sounds without volume changes, similar to the sounds of nature (rain, the sea), heard by the child during foetal life (the hum of large maternal blood vessels), which has a calming effect and masks the sounds of external environment. Aim of the study: The aim of the study was to assess the motives, efficacy and correctness of the use of white noise-emitting devices. Material and methods: A survey was conducted among 580 parents who used white noise-emitting devices (Szumiś, Whisbear, applications on personal electronic devices). The survey collected data on the parent population, the prevalence of the method, the reasons for choosing this method to relieve the child’s problems, the device’s efficacy and manner of use and users’ awareness of potential hazards associated with incorrect use of such devices. Results: The results indicate a widespread use of white noise-emitting devices for helping children fall asleep and reducing their anxiety or colic pain, particularly in infants. Parents made a frequent use of these devices and left them switched on for a long time in close proximity to their children. They did not notice any negative effects of their use and would recommend them to other parents. Conclusions: White noise-emitting devices may be helpful in taking care of a restless child. However, they may be recommended by medical professionals provided that they comply with appropriate technical criteria and the rules for their use have been established considering the unknown long-term impact of such devices on the child’s development.
291
Use of white noise-emitting devices in infants and small children
as assessed by their parents
Stosowanie urządzeń wytwarzających biały szum u niemowląt i małych dzieci
w ocenie ich rodziców
Department of Paediatrics in Bytom, School of Health Sciences in Katowice, Medical University of Silesia, Bytom, Poland
Correspondence: Jolanta Pietrzak, Department of Paediatrics in Bytom, Batorego 15, 41-902 Bytom, Poland, tel.: +48 32 786 14 98, e-mail: jpietrzak@sum.edu.pl
Introduction: Crying and anxiety in an infant are not only a defence reaction informing of a health problem, but also a signal
of hunger, fatigue or difficulties falling asleep. There are many methods of reducing a child’s adaptation problems. Various
positions, breastfeeding, rocking and contact with the mother’s skin are used. Currently, white noise-emitting devices are
increasingly popular. White noise consists of monotonous sounds without volume changes, similar to the sounds of nature (rain,
the sea), heard by the child during foetal life (the hum of large maternal blood vessels), which has a calming effect and masks
the sounds of external environment. Aim of the study: The aim of the study was to assess the motives, efficacy and correctness
of the use of white noise-emitting devices. Material and methods: A survey was conducted among 580 parents who used white
noise-emitting devices (Szumiś, Whisbear, applications on personal electronic devices). The survey collected data on the parent
population, the prevalence of the method, the reasons for choosing this method to relieve the child’s problems, the devices
efficacy and manner of use and users’ awareness of potential hazards associated with incorrect use of such devices. Results:
The results indicate a widespread use of white noise-emitting devices for helping children fall asleep and reducing their anxiety
or colic pain, particularly in infants. Parents made a frequent use of these devices and left them switched on for a long time in
close proximity to their children. They did not notice any negative effects of their use and would recommend them to other
parents. Conclusions: White noise-emitting devices may be helpful in taking care of a restless child. However, they may be
recommended by medical professionals provided that they comply with appropriate technical criteria and the rules for their use
have been established considering the unknown long-term impact of such devices on the child’s development.
Keywords: white noise, Szumiś, infants, children, crying, falling asleep
Wstęp: Płacz i niepokój u niemowlęcia nie tylko stanowią reakcję obronną informującą o zagrożeniu zdrowotnym, ale są też
sygnałem głodu, zmęczenia czy trudności w zasypianiu. Istnieje wiele metod redukujących problemy adaptacyjne dziecka.
Wykorzystuje się różnego typu pozycje ułożeniowe, karmienie piersią, kołysanie czy kontakt ze skórą matki. Coraz
popularniejsze są obecnie urządzenia wytwarzające biały szum, czyli monotonne dźwięki bez zmian głośności, podobne do
odgłosów natury (deszcz, szum morza), słyszane przez dziecko w życiu płodowym (szum wielkich naczyń krwionośnych
matki), mające działanie uspokajające i maskujące odgłosy środowiska zewnętrznego. Cel: Celem pracy była ocena motywów,
skuteczności i prawidłowości używania urządzeń wytwarzających biały szum. Materiał i metody: Ankietowe badanie
przeprowadzono wśród 580 rodziców używających urządzeń wytwarzających biały szum (Szumiś, Whisbear, aplikacje
w personalnych urządzeniach elektronicznych). Miało ono na celu ocenę populacji rodziców, ocenę rozpowszechnienia tej
metody, ocenę powodów, dla których opiekunowie wybrali ten sposób łagodzenia dolegliwości dziecka, oraz ocenę
skuteczności, sposobu stosowania i świadomości potencjalnych zagrożeń wynikających z niewłaściwego używania takich
urządzeń. Wyniki: Wyniki wskazują na powszechne stosowanie tego typu urządzeń w celu ułatwienia dzieciom zasypiania,
łagodzenia niepokoju czy bólu kolkowego, zwłaszcza u niemowląt. Rodzice korzystali z tych urządzeń często, włączając je na
długi czas i umieszczając blisko dzieci. Nie zauważyli negatywnych skutków ich używania i poleciliby je innym rodzicom.
Wnioski: Urządzenia emitujące biały szum mogą być przydatne w opiece nad dzieckiem niespokojnym. Warunkiem ich
rekomendowania przez personel medyczny musi być jednak spełnienie odpowiednich kryteriów technicznych i ustalenie
zasad ich stosowania, ze względu na nieznany długofalowy wpływ używania tych urządzeń na rozwój dziecka.
Słowa kluczowe: biały szum, Szumiś, niemowlęta, dzieci, płacz, zasypianie
Abstract
Streszczenie
Jolanta Pietrzak, Paulina Kurdyś, Łukasz Surówka, Anna Obuchowicz
© Pediatr Med Rodz 2019, 15(3), p. 291–296
© Medica l Commun ications Sp. z o.o. This isa n open-acc ess article distributed under the terms ofthe Creative Commons Attribut ion-NonCommercial-NoDerivatives License
(CC BY-NC-ND). Reproduct ion ispermitte d for personal, edu cational, non-c ommercial use , provided that t he origina l article isin w hole, unmodi fied, andprope rly cited.
DOI: 10.15557/PiMR.2019.0049
Received: 16.12.2018
Accepted:
05.03.2019
Published:
29.11.2019
Jolanta Pietrzak, Paulina Kurdyś, Łukasz Surówka, Anna Obuchowicz
292
PEDIATR MED RODZ Vol. 15 No. 3, p. 291–296DOI: 10.15557/PiMR.2019.0049
INTRODUCTION
During the neonatal and infant period, the child
adapts to the surrounding environment. Crying,
which is common in this period, is a defence re-
action. Crying is indicative of a health problem and is a re-
action to pain (intestinal colic, vaccinations), fatigue, hun-
ger or discomfort(1). It always worries parents and is oen
the reason for premature discontinuation of breastfeeding.
Apart from the need to identify medical causes of crying,
methods of comforting the child are sought in order to re-
duce its and the parents’ stress. Various positions, cuddling,
rocking, kangaroo care and breastfeeding are used or sweet
drinks are administered to relieve the baby’s symptoms(2–13).
Acoustic stimuli such as maternal voice, calm music(14,15)
and white noise are also utilised(1,2,16–19).
White noise is a type of monotonous sound in the form of
acoustic resonance whose spectrum is balanced across the
majority of audible frequency range, without rapid chang-
es in volume. White noise is similar to the sounds of na-
ture such as rain, snowstorm or the sea. It can also be com-
pared to the sound emitted by a quietly working dryer or
vacuum cleaner. It is believed that the child experiences
such a monotonous acoustic phenomenon already in the
mother’s womb (her heartbeat, blood ow in large blood
vessels)(13,20). These sounds are the white noise of foetal
life(13,20). Similar sounds heard during the neonatal and in-
fant period may have a soothing and calming eect; in ad-
dition, they may mask other sounds and external environ-
mental noise(13,20).
There are plush mascots available which contain white
noise-emitting devices inside such as Szumiś or Whisbear
(Figs. 1, 2). Applications for a mobile phone, tablet or lap-
top have also been developed.
From the parents’ point of view, the use of this method
seems promising; however, there are a number of medical
doubts about it. is is because there is an insucient num-
ber of studies conrming the safety of white-noise emitting
devices (concerning their impact on hearing and psycho-
logical development of the recipient, among other prob-
lems). Should the paediatrician recommend or discourage
from the use of such devices?
AIM OF THE STUDY
e aim of the study is to investigate whether and in what
situations parents use white noise-emitting devices, what
their ecacy rating is and whether they are used correctly.
MATERIAL AND METHODS
An anonymous survey was conducted using electronic means.
The survey was directed at parents who used white noise-emit-
ting devices. The subjects were selected at random. The sur-
vey was conducted from 01.01.2018 to 31.03.2018 via so-
cial media and forums and topical groups for young parents.
The survey was developed by the present authors and includ-
ed single and multiple choice questions and comprised three
parts. The questions concerned demographical data, indica-
tions and efcacy rating of white noise-emitting devices, con-
ditions of their use and their impact on the child’s behaviour.
Due to the fact that the white noise-emitting devices used by
the respondents did not have a sound intensity scale, the re-
spondents were asked to rate the volume on a scale of 1–5
(1 indicated very quiet and 5 very loud sound emission).
In total, 580 individuals took part in the study. The respondents
came from all Polish provinces. The majority of answers were
received from the Mazowieckie province (168 surveys) and
Śląskie province (107 surveys). Women accounted for 99.3%
Fig. 1. Szumiś
Fig. 2. Whisbear the Humming Bear
Use of white noise-emitting devices in infants and small children as assessed by their parents
293
PEDIATR MED RODZ Vol. 15 No. 3, p. 291–296 DOI: 10.15557/PiMR.2019.0049
of the respondents. The mean age of the subjects was 29.3
years. The largest group were individuals aged 25–30 years
(39.1%). Parents aged 31–35 years accounted for 32.1% of the
respondents. There were 19% of individuals aged 18–25 years
and 9.8% aged over 35. 64% of the subjects had one child,
30% had two children and 6% had three or more children.
The numbers of boys and girls were comparable (302 vs. 278,
respectively). The children were aged from 1 to 24 months.
49.1% of the respondents lived in a city of more than 100,000
inhabitants and others lived in smaller towns and in rural ar-
eas. There were 68.9% of respondents with higher education,
27.4% with secondary-level education and the remaining ones
had vocational education.
Based on routine screening tests, 97.6% of children had
a normal hearing. In 2.4% of neonates the result was ab-
normal, no test had been performed or risk factors for hear-
ing damage had been found. 96.2% of parents declared that
their children were vaccinated in accordance with the of-
cial vaccination schedule.
Statistical analysis was performed using Statistica version
12 software; descriptive statistics methods and Spearman’s
test were utilised.
RESULTS
The most frequently used white noise-emitting devices
were Szumiś (40.3%), Whisbear (32.8%) and recordings of
sounds imitating electrical appliances (30.9%).
e primary aim of using white noise-emitting devices was
to put the child to sleep (86.9%). In addition, parents used
these devices when the child was restless (24.3%) or during
an attack of intestinal colic (14.1%).
50% of the respondents chose white noise-emitting devic-
es, since traditional methods of comforting the child turned
out to be ineective. 58.6% of parents learnt about white
noise-emitting devices from the Internet and one third from
friends. Among the subjects, 27.0% bought this type of de-
vice based on a fashion for using them and 20% received it as
a present. 80.3% of parents had previously used other acous-
tic methods of putting the child to sleep or comforting it such
as lullabies or classical music. Other parents (19.7%) decided
to use white noise-emitting devices in the rst place.
Data regarding the manner of use of white noise-emitting
devices by the respondents are presented in Tab.1.
e devices were most oen used over the rst six months
of the child’s life (31.2%). In the rst month, the devices
were used by 10.9% of parents. In 17.6% of cases the devic-
es were used over the rst 3 months of life. 17.0% of the re-
spondents used the devices for one year, while 23.3% of par-
ents used them for longer.
Among the surveyed parents, 24.7% used the devices 3 and
more times daily, 24.1% used them 2 times a day and 23.1%
switched them on sporadically. Other respondents used
such devices once a day or a few times a week. e time of
a single sound session was up to one hour (29.5% of the re-
spondents), up to 30 minutes (24.5%) or shorter (35.9%).
Others (10.1%) switched on the device for more than one
hour at a time.
More than half of parents (48.1%) placed white noise-emit-
ting devices in the child’s cot; 39.8% of devices were put on
a night table next to the cot.
The subjects set the volume of the devices to low (35.9%)
and medium (31.6%). Based on Spearman’s test, no rela-
tionship was demonstrated between the placement of the
device and the volume set (rs=0.009).
Assessed parameter Number of parents
n = 580 %
Period of use
Over the first month of life 63 10.9
Over the first 3 months of life 102 17.6
Over the first 6 months of life 181 31.2
For a year 99 17.0
For longer 135 23.3
Frequency of use
Once a day 95 16.4
Twice a day 140 24.1
3 or more times a day 143 24.7
A few times a week 68 11.7
Sporadically 134 23.1
Time of single session
Up to 5 minutes 65 11.2
Up to 15 minutes 143 24.7
Up to 30 minutes 142 24.5
Up to an hour 171 29.5
More than one hour 59 10.1
Device placement
In the cot 279 48.1
On the night table 231 39.8
>2 m from the cot 70 12.1
Volume level set
1 104 17.9
2 208 35.9
3 183 31.6
4 62 10.7
5 23 3.9
Tab. 1. Data regarding the use of white noise-emitting devices
by the respondents
No Yes
0% Does the child
fall asleep
quicker?
Does the child
calm down?
Does the child
stop crying?
Does the child
start crying?
Is the child
restless?
Is the child less
responsive
to acoustic
stimuli?
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
Fig. 3. Childrens behaviour during the use of white noise-emit-
ting devices
Jolanta Pietrzak, Paulina Kurdyś, Łukasz Surówka, Anna Obuchowicz
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PEDIATR MED RODZ Vol. 15 No. 3, p. 291–296DOI: 10.15557/PiMR.2019.0049
In the third part of the survey, parents were asked about
their child’s behaviour during the use of white noise-emit-
ting devices (Fig.3).
When asked a yes/no answer about a positive inuence of
white noise-emitting devices (falling asleep quicker, calm-
ing down, stopping crying), the majority of the respondents
(over 80%) chose the afrmative answer.
The majority of parents did not notice any negative effects
of using white noise-emitting devices. Almost all of them
(94.0%) chose the “no” answer to questions regarding signs
of fear and anxiety, crying or parents’ subjective impression
of hearing deterioration in the children.
Among the surveyed parents, 82% would recommend this
method of soothing children to other young parents.
DISCUSSION
Crying and anxiety in a child, even aer all potential somat-
ic causes have been excluded (gastrological, allergic, cardi-
ac, neurological and other) always raise negative emotions
in parents. Even though it is believed that approximately
20% of infants cry frequently for no apparent reason over
the rst 4 months of life, parents of a crying child may feel
anxiety, depression, helplessness and even anger and frus-
tration(1–5). Parents may be afraid that they are hurting their
own child by not being able to help it and experience a feel-
ing of guilt and shame(5). is may have a negative impact
on parental bonds and parental perception of the child(5).
e caregivers are oen not able to cope with the problem
on their own and need the help of qualied healthcare pro-
fessionals(4,5).
Since time immemorial, ways of comforting an anxious or
crying child have been sought. Intuitive methods used for
centuries (e.g. taking the child for a walk in a pram or giv-
ing it a warm bath) have found scientic explanation and
are still recommended in caring for a restless child(1).
Rhythmical rocking of an infant induces the secretion of
endorphins by stimulating the vestibular system, which re-
duces the duration of anxiety and crying and relieves pain
caused by infantile colic, for example(17,21).
Research results emphasise the benecial eects of breast-
feeding on soothing a child and on pain reduction dur-
ing procedures such as injections (e.g. vaccinations), n-
gerstick or heel lance for diagnostic blood collection(7,12,22).
e mechanism involved is of multifactorial nature. It in-
cludes the sucking reex, skin-to-skin contact, warmth,
rocking, the sound of the mother’s voice, maternal scent
and the eects of endogenous opioids contained in breast
milk(7,12). In addition, it has been found that olfactory stim-
ulation by the smell of the mother’s milk also has a soothing
eect(23). A similar and in some studies even stronger anal-
gesic eect is observed when sugar solutions are adminis-
tered to the child via the oral route(8–11).
Appropriate positioning of the infant has also resulted in
reducing the child’s anxiety and crying. In a method called
THB (The Happiest Baby) conditions of foetal life are
reproduced: the child is placed on the side with its head
downwards and it is wrapped tightly with a diaper cloth
(but loosely enough to allow movement in the hips and
avoid overheating). Monotonous sounds are played and the
child is rocked in a rhythmical fashion(2,24).
Skin-to-skin care (SSC), also called kangaroo mother care
(KMC), is a method that has been used for a few decades
at neonatal wards and has been recommended for everyday
infant care: for soothing anxiety and crying and helping the
child fall asleep(6,8,9,13,25).
Chirico et al. conducted an interesting study investigating
the sensation of pain during blood drawing in preterm in-
fants who were listening to their mother’s recorded voice.
e child’s behaviour, heart rate, blood pressure, O2 satu-
ration and adverse reactions such as apnoea or vomiting
were assessed. e study results showed this method to be
eective(26).
A positive eect of listening to music was also demonstrat-
ed (a melody hummed by parents or calm classical music)
in similar situations for soothing pain and crying in pre-
term infants and relieving infantile colic(13–15,20,21).
White noise is an acoustic phenomenon whose spectrum
is balanced across the majority of audible frequency range,
without rapid changes in intensity, monotonous, repeti-
tive and usually similar to the sounds of nature such as the
sound of the sea, stream or rain. e child is subjected to
white noise already in the womb: it can hear its mother’s
rhythmical heartbeat, ow of blood in large vessels and the
sounds of uterine and gastrointestinal tract movements(17,20).
is results in the child becoming accustomed to these phe-
nomena(27). erefore, such noise comforts the neonate/in-
fant, reduces the duration of crying, relieves pain, includ-
ing iatrogenic pain, helps the child fall sleep and prolongs
sleep duration(17,19,20,27,28). e use of white noise masks other
sounds and noises of the external environment(13,19).
e inuence of white noise on children falling asleep start-
ed to be investigated in the nineties of the previous century.
Spencer et al. demonstrated positive eects of white noise in
80% of infants(18). e impact of such sounds on shortening
the period of adaptation of a neonate to the external world
during the postpartum period has been investigated multi-
ple times. is includes, for example, early breast sucking,
which translates into a longer duration of natural feeding.
Very promising results were achieved(20,28). In a multicen-
tre, randomised, controlled clinical trial, Sezici and Yigit
checked whether using white noise-emitting devices reduc-
es the time of crying and increases sleep duration in chil-
dren suering from colics. eir assumptions concerning
the eects of white noise compared to other methods such
as rocking, for example, were conrmed. e study revealed
that white noise caused a statistically signicant reduction
in crying and the time it took the children to fall asleep,
particularly when the method was used for many days(17).
Karakoç et al. found that white noise is an eective, non-
pharmacological method of pain relief, crying time reduc-
tion and improvement in vital signs of hospitalised neonates
Use of white noise-emitting devices in infants and small children as assessed by their parents
295
PEDIATR MED RODZ Vol. 15 No. 3, p. 291–296 DOI: 10.15557/PiMR.2019.0049
subjected to blood drawing and vaccinations(16). Simi-
lar results were observed in a group of preterm infants(13).
e present study shows that white noise-emitting devices
are oen used by parents with higher education in partic-
ular in everyday care of children of various ages. Such de-
vices are mainly used to help the child fall asleep (86.9%)
or calm it down (24.3%). It is surprising that only14.1% of
parents use white noise-emitting devices to relieve pain in
intestinal colic.
In the context of informed care over a child, the statement
of more than half of the respondents that they chose such
a device when other methods of soothing the child’s anxi-
ety proved ineective is a positive nding. What is charac-
teristic for the contemporary times is acting upon informa-
tion found on the internet and following trends, such as the
one for having white noise-emitting devices, which is con-
rmed by the results of the survey.
e knowledge of the right manner of use of white noise-
emitting devices is a very important issue. Canadian authors
demonstrated that too high intensity, long duration of sin-
gle exposure or too close placement of the device may have
a negative impact on the child’s hearing (hearing damage,
impaired development of the hearing system and speech)
(19). ey suggest that this type of devices should be placed
as far away from the child as possible, the lowest sound in-
tensity should be applied and time of use should be as short
as possible. ese conclusions were based on objective study
of volume (in decibels) and the distance between the de-
vice and the child (in centimetres). Unfortunately, the de-
vices used by the respondents from the present study (both
Szumiś and online applications) do not have volume lev-
els expressed in decibels provided. Therefore, the pres-
ent authors had to use a scale of 1–5 to investigate this as-
pect of white noise inuence on the child. e majority of
the subjects prefer using quiet or moderately loud sounds.
Unfortunately, half of the respondents put the device near
the child, usually in the cot. e duration of a single session
is 15–60 minutes with a trend to prolong this time to as much
as a few hours. ere is also the worrying fact of using such
devices at least twice a day by nearly half of the respondents.
82% of the respondents, who believe that the device is use-
ful in taking care of their child, would recommend this
method of soothing children to other parents. In the era
of long working hours, in situations where grandparents
do not participate in childcare and considering the wide-
spread use of new equipment and technologies, improving
the comfort of parents’ and childrens lives with white noise-
emitting devices seems to be justied. However, these de-
vices need to be medically safe (limited volume level and
operation time, preferably with an automatic switch).
Parents should be informed of the correct manner of use of
the devices by instruction manuals and medical profession-
als. e problem is all the more important since more than
half of the respondents learnt about white noise-emitting
devices from the Internet, while in one third of cases it was
friends who recommended this method to the respondents
without making them aware of the potential risks of us-
ing such devices. us, a new task has emerged for general
practitioners taking care of children as part of health pre-
vention education.
e Canadian study mentioned above includes recommen-
dations for parents regarding the use of white noise-emit-
ting devices(19). Such recommendations, developed by pae-
diatricians, neonatologists and paediatric ENT specialists,
should be provided to all users of the devices.
CONCLUSIONS
1. White noise-emitting devices may be useful as one of
the methods for calming down infants and helping them
to sleep.
2. Medical professionals may recommend white noise-
emitting devices on condition that they are compliant
with appropriate technical criteria (standardised volume,
operation time meter) and the rules for their use have
been established.
3. e long-term eects of using white noise-emitting de-
vices placed too close to a child are unknown; therefore,
a safe distance should be kept and the time of operation
should be limited. Users should be made aware of this
aspect of the use of the device in particular.
Conict of interest
e authors do not report any nancial or personal aliations to per-
sons or organisations that could adversely aect the content of or claim
to have rights to this publication.
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... Bayi baru lahir terkena suara white noise di dalam rahim sehingga dapat mendengar detak jantung ibunya, aliran darah di pembuluh darah besar, dan suara gerakan rahim dan /saluran pencernaan. White noise lebih efektif dalam mengurangi tanda-tanda nyeri dibandingkan musik biasa (Pietrzak et al., 2019). Penelitian lainnya menunjukkan white noise tidak hanya efektif dalam mengurangi tanda-tanda nyeri pada bayi, namun memiliki efek positif lainnya seperti memberikan tandatanda vital yang stabil, menurunkan episode apnea dan bradikardia, meningkatkan berat badan, mengurangi episode intoleransi makanan, dan memfasilitasi transisi lebih awal ke nutrisi enteral,, dan keluar dari perawatan intensif lebih awal (Döra & Büyük, 2021). ...
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Bayi baru lahir (neonatus) yang mengalami kondisi yang mengancam nyawa salah satunya asfiksia ditempatkan di ruang perawatan intensif yaitu Neonatal Intensive Care Unit (NICU) untuk mendapatkan intervensi khusus untuk memperbaiki kondisinya. Comfort care berdasarkan model kenyamanan Kolcaba merupakan salah satu intervensi spesifik yang biasa dilakukan perawat untuk mendukung penatalaksanaan terapeutik pada neonatus. Tujuan penelitian ini adalah untuk mengetahui pengaruh comfort care (White noise, light reduction, dan nesting) terhadap peningkatan parameter fisiologis dan tingkat kenyamanan neonatus dengan asfiksia sedang di NICU. Penelitian ini menggunakan metode case report yang melibatkan pasien neonatal dengan asfiksia sedang. Pengukuran dilakukan sebelum dan sesudah intervensi dengan menggunakan instrumen yang terdiri dari tanda-tanda vital (denyut jantung, laju pernapasan, dan SpO2) dan Comfort neo scale. Hasil penelitian menunjukkan bahwa dengan intervensi comfort care selama 3 hari terjadi peningkatan parameter fisiologis. Denyut jantung hari ke-1 sebelum intervensi 148 x/menit hingga 131 x/menit, SpO2 dari 86% menjadi 96%, laju pernapasan dari 35x/menit menjadi 27 x/menit, kenyamanan dari 20 menjadi 8. Denyut jantung hari ke-2 sebelum intervensi 158 x /menit hingga 134 x/menit, SpO2 dari 88% menjadi 98%, laju pernapasan dari 46 x/menit menjadi 25 x/menit, kenyamanan dari 19 menjadi 8. Denyut jantung hari ke-3 sebelum intervensi 180 x/menit hingga 138 x/menit , Spo2 dari 89% menjadi 97%, laju pernapasan dari 25 x/menit menjadi 21 x/menit, kenyamanan dari 16 menjadi 7. White noise, light reduction, dan nesting dapat meningkatkan parameter fisiologis dan kenyamanan pada bayi dengan asfiksia sedang di NICU.
... Hieronta on myös todettu tehokkaaksi menetelmäksi, jolla voidaan vähentää vauvojen levottomuutta ja itkuisuutta (Çetinkaya & Başbakkal, 2012;Sheidaei ym., 2016). Hiustenkuivaajan ääntä muistuttavaa white noise -kohinaa voidaan käyttää parantamaan vauvan unta (Pietrzak, Kurdyś, Surówka, & Obuchowicz, 2019;Sezici & Yigit, 2018). Lisäksi ääni on tehokas lääkkeetön kivunlievitysmenetelmä, se voi vähentää itkuaikaa ja saattaa jopa parantaa vauvan elintoimintoja (Karakoç & Türker, 2014). ...
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A link to the book (in Finnish): https://trepo.tuni.fi/handle/10024/123755 The main purpose of this study was to evaluate the effectiveness and feasibility of The Happiest Baby infant calming intervention. The study included four phases. Phase I explored the consequences of having an excessively crying infant in the family using an integrative literature review. Phase II described mothers’ self-efficacy, parenting satisfaction and the mother and infant related factors associated with the above parenting aspects in the first days postpartum using a descriptive cross-sectional design. Phase III evaluated the effectiveness of The Happiest Baby intervention on mothers’ self-efficacy and parenting satisfaction during the postpartum period using a randomized controlled study design. Phase IV described mothers’ experiences of the feasibility of The Happiest Baby intervention. The overall aim was to produce evidence of the effectiveness and feasibility of the intervention in calming a crying infant and reducing excessive crying in infants. The hypothesis was that The Happiest Baby infant calming intervention increases mothers’ self-efficacy and parenting satisfaction. The literature review search was conducted in databases: MEDLINE, CINAHL, PsycINFO, Medic and Journals@Ovid and consisted of empirical research literature published between January 2008 and April 2018. Quality appraisal was performed using CASP tools and JBI checklists. The extracted data were analyzed using thematic analysis. Thirty-one articles were included in the integrative literature review. Ten themes were identified: The consequences of having an excessively crying infant in the family creates desperation; it ruins everyday life; impairs breastfeeding; isolates and casts parents into loneliness; strains and breaks family relationships; brings feelings of failure as a parent; brings a struggle that can lead to physical and mental exhaustion; the infant may have problems later in childhood; parents are actively trying to solve the problem and adjust; time allows survival with traces of negative symptoms, feelings and memories. The empirical data were collected during March 1st to May 20th, 2019 from three postpartum units in one university level hospital in Finland. A total of 250 Finnish speaking mothers of healthy infants agreed to participate, of which 120 were randomly allocated to the intervention and 130 to the control group. All mothers xii completed a baseline questionnaire after randomization. Mothers in the intervention group were taught The Happiest Baby infant calming technique in the postpartum units. The control group mothers received standard care. Follow-up data were collected six to eight weeks postpartum. Parenting self-efficacy and satisfaction were measured using validated instruments. The primary outcome measure was to compare the change in parenting self-efficacy and parenting satisfaction over the followup period between the intervention and control groups. Mothers’ self-reported parenting self-efficacy and parenting satisfaction were high during the first days postpartum. Age, marital status, education and type of birth were not associated with parenting self-efficacy nor satisfaction. Mothers who were unemployed or working only part-time reported statistically significantly higher scores across all categories of parenting self-efficacy, compared to full time employed mothers. A higher number of children (≥ 3) were positively associated with both parenting self-efficacy and satisfaction. Mothers who reported poor breastfeeding initiation success also reported statistically significantly lower scores in parenting self-efficacy and parenting satisfaction across all categories. Parenting self-efficacy showed significant differences in median improvements between the groups. The intervention group showed significantly larger improvements in their scores. There were no statistically significant differences in median improvements in parenting satisfaction between groups. Almost all mothers, who used The Happiest Baby technique, experienced it feasible; all infants calmed completely or somewhat, and all mothers recommended the method to other families. This study concludes that having an excessively crying infant in the family causes many problems. The Happiest Baby infant calming intervention can strengthen mothers’ parenting self-efficacy. The mothers experienced the intervention feasible, when calming their infants. Further research is needed, especially by means of implementation research. Keywords: infant, mothers, parents, crying, excessive crying, postpartum period, parenting self-efficacy, parenting satisfaction, infant calming method, behavioral methods, intervention, randomized controlled trial
Article
Background: Preterm babies are exposed to many repetitive painful interventions in NICU. Aims: This study aimed to comparatively determine the effect of white noise and lullabies on pain perception and vital signs of premature babies during painful interventions. Design: Randomised controlled trialParticipants/Subjects; A sample group of 66 premature babies with a gestational age of 3237 weeks and a weight more than 1000 g were included in this study conducted between May and August 2019 in the NICU of a university hospital. Methods: The babies were randomly divided into three groups: lullaby, white noise, and control. The behavioral responses of the babies were recorded with a camera during the whole procedure. Before, during, and after the procedure, the heart rate, respiratory rate, and oxygen saturation level were measured and recorded, and the pain was evaluated using the premature infant pain profile (PIPP) after the procedure. The mean PIPP score, heart rate during and after the procedure, mean respiratory rate, and oxygen saturation were significantly lower in the white noise and lullaby groups compared with the control group (P < 0.001). Results: The premature babies in the white noise group were found to have the lowest mean PIPP score, mean heart rate, and respiratory rate, and the highest mean oxygen saturation rate (p < 0.001). Conclusions: The white noise and lullabies played to premature babies during the blood collection process were effective in pain reduction, and the pain score was lower in the white noise group than in the lullaby group.
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Aims and objective This study aimed to compare the effects of swinging and playing of white noise on the crying and sleeping durations of colicky babies. Background Infantile colic (IC) is one of the most common reasons for doctor visits among babies younger than 3 months. One of five babies older than 3 months also experiences IC. IC, unlike gastrointestinal problems, is regarded as an individual differentiation and maturation of the central nervous system. Providing a warm bath, breastfeeding, swinging and playing of white noise are nonpharmacological methods. The efficiency of these methods has been proven by various studies independently of one another. Design The study is a prospective, multicentre, paired randomised controlled trial. Methods The study was conducted between April–December 2016. The study sample consisted of 40 1‐month‐old babies with gas pains who passed a hearing screening and their mothers. The total daily crying and sleeping durations of the babies were determined without any intervention on the first week. On the second week, 20 randomly selected babies (first group) were swung each time they cried, and on the third week, they were made to listen to white noise. The other 20 babies (second group) were made to listen to white noise on the second week and were swung on the third week. Swinging and playing of white noise were performed until the babies stopped crying. After every intervention, the total crying and sleeping durations of the babies were evaluated using a “Colicky Baby's Diary.” Results Playing of white noise significantly decreased the daily crying durations (p < .05) and increased the sleeping durations of the colicky babies (p < .05) compared to swinging in both groups. Conclusion Playing of white noise was found to be a more effective nonpharmacological method on crying and sleeping durations of colicky babies than swinging. Relevance to clinical practice Playing of white noise may be helpful for parents and healthcare personnel in reducing the gas pains of babies.
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Introduction Infantile colic is a painful condition in the first months of infancy. This study was carried out with the aim of testing the hypothesis that massage treatment has a clinically relevant effect on this condition. Materials and Methods This randomized clinical trial was conducted among 100 infants of < 12 weeks of age with infantile colic. They were randomly assigned to either infant massage (n = 50) or rocking groups (n = 50). In the massage group, trained individuals taught the parents of the infants the massage technique and gave them a brochure. Rocking group parents was recommended to rock their infants three times a day for 1 week. Parents recorded the pattern of crying (numbers, length, and severity of crying). After 1 week of intervention, data were analysed using t-test, Chi square test, and repeated measurement analysis of variance (P < 0.05). Results Significant differences were not observed in infant and mother demographic information. Before intervention, the mean of total number, length, and severity of crying were 6.12 (1.76) time/day, 4.97 (1.37) hour/day, and 6.60 (1.54) in the massage group and 6.96 (2.9) time/day, 3 (1.31) hour/day, and 5.98 (2.22) in the rocking group, respectively. After 1 week of intervention, the mean difference of total number, length, and severity of crying were 4.08 (1.83) time/day, 2.81 (1.77) hour/day, and 2.9 (2.37) in the massage group and 0.56 (2.28) time/day, 0.27 (1.09) hour/day, and 0.02 (1.64) in the rocking group, respectively. Conclusions This trial of massage treatment for infantile colic showed statistically significant or clinically relevant effect in comparison with the rocking group.
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Background: Two studies have demonstrated an analgesic effect of maternal milk odor in preterm neonates, without specifying the method of olfactory stimulation. Research aim: This study aimed to assess the analgesic effect of maternal milk odor in preterm neonates by using a standardized method of olfactory stimulation. Methods: This trial was prospective, randomized, controlled, double blinded, and centrally administered. The inclusion criteria for breastfed infants included being born between 30 and 36 weeks + 6 days gestational age and being less than 10 days postnatal age. There were two groups: (a) A maternal milk odor group underwent a venipuncture with a diffuser emitting their own mother's milk odor and (2) a control group underwent a venipuncture with an odorless diffuser. The primary outcome was the Premature Infant Pain Profile (PIPP) score, with secondary outcomes being the French scale of neonatal pain-Douleur Aigu? du Nouveau-n? (DAN) scale-and crying duration. All neonates were given a dummy. Results: Our study included 16 neonates in the maternal milk odor group and 17 in the control group. Neonates exposed to their own mother's milk odor had a significantly lower median PIPP score during venipuncture compared with the control group (6.3 [interquartile range (IQR) = 5-10] versus 12.0 [IQR = 7-13], p = .03). There was no significant difference between the DAN scores in the two groups ( p = .06). Maternal milk odor significantly reduced crying duration after venipuncture (0 [IQR = 0-0] versus 0 [IQR = 0-18], p = .04). Conclusion: Maternal milk odor has an analgesic effect on preterm neonates.
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Background Preterm neonates undergo many painful procedures as part of their standard care in the neonatal intensive care unit. However, pain treatment is inadequate in many of these routine procedures. In the present study, we investigated the impact and mechanism of combined music and touch intervention (CMT) on the pain response in premature infants. Methods Sixty-two preterm neonates (gestational age of <37 weeks) were randomly assigned to either the experimental or control group. Infants in the experimental group underwent painful procedures with CMT, and those in the control group underwent painful procedures without CMT. Blood samples were collected from all infants at the beginning of hospitalization and 2 weeks later to assess the cortisol and β-endorphin concentrations. Differences in the levels of cortisol and β-endorphin between two groups were examined using analysis of covariance (ANCOVA). ResultsIn total, 3707 painful procedures were performed on 62 neonates during their hospitalization. The average number of painful procedures in the control group (n = 35.5) was higher than that in the experimental group (n = 29.0) during hospitalization, although no significant difference was reached (P > 0.05). After 2 weeks, the Premature Infant Pain Profile scores were significantly higher in the control group than experimental group (13.000 ± 0.461 vs 10.500 ± 0.850, respectively; P < 0.05). The cortisol concentration was not significantly different between the control and experimental groups either at the beginning of hospitalization (131.000 ± 18.190 vs 237.200 ± 43.860, respectively; P > 0.05) or 2 weeks later (162.400 ± 23.580 vs 184.600 ± 21.170, respectively; P > 0.05). However, the serum β-endorphin concentration was higher in the experimental group than in the control group both at the beginning of hospitalization (1.640 ± 0.390 vs 1.179 ± 0.090, respectively; P < 0.05) and 2 weeks later (2.290 ± 0.740 vs 1.390 ± 0.410, respectively; P < 0.05). ConclusionsCMT might decrease the pain response of preterm neonates by significantly improving the β-endorphin concentration, but not the blood cortisol concentration. Trial registrationCurrent Controlled Trials ISRCTN14131492. Registered on 01 Aug 2016.
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Objective: The aim of this randomized controlled experimental study was to evaluate the effect of breastfeeding on the pain of babies during vaccination. Materials and methods: The sample of the study consisted of 100 babies who complied with the sampling criteria between July and November 2012. The babies breastfed from their mothers 5 minutes before, during, and after the vaccine injections. The Neonatal Infant Pain Scale (NIPS), duration of crying, heart rate, and oxygen saturation were evaluated before, during, and after the vaccine injections. Data were evaluated by descriptive statistics, chi-square, Cronbach's alpha consistency coefficient, independent sample t-test, and Mann-Whitney U test. Results: The babies in the control group experienced severe pain and the babies in the breastfeeding group felt moderate pain during the vaccine injections (p < 0.05). The NIPS score of the babies in the breastfeeding group was lower than the control group during the vaccine injections. The breastfeeding group spent less time crying, and had lower heart rates and higher oxygen saturation values during vaccine injections Conclusion: Breastfeeding prevented increased heart rates, duration of crying, NIPS, falling oxygen saturation, and reduced pain during the invasive procedures in newborns more than control group.
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The purpose of this study was to evaluate the effect of white noise as a distraction method in relieving procedural pain caused by vaccination for premature infants. This experimental study was performed at a neonatal intensive care unit (NICU) of a university hospital in Turkey between July and September 2013. The study population was composed of 75 premature infants (35 in the study group and 40 in the control group) who met the inclusion criteria. Premature infants in the study group were exposed to white noise using MP3 players placed at the head of the infants’ open crib for 1 minute before vaccination. The white noise continued until 1 minute after vaccination. Premature infants in the control group were not exposed to white noise. The Premature Infant Information Form, Intervention Follow-up Form, and Premature Infant Pain Profile (PIPP) were used to collect study data. Descriptive statistics, chi-square test, and independent sample t-tests were used to evaluate the data. The pain level of the control group (PIPP = 14.35 ± 2.59) was significantly higher than the pain level of the study group (PIPP = 8.14 ± 3.14) (p < .05). The authors found that 67.6% of the infants in the study group had moderate pain during vaccination and only 2.9% had severe pain. Most of the infants in the control group (82.5%) had severe pain, whereas 17.5% had moderate pain (p < .05). White noise was found to be effective for this sample; however, there is a dire need for extensive research on white noise and its use with this vulnerable population.
Article
Background During the first 4 months of age, approximately 20% of infants cry a lot without an apparent reason. Most research has targeted the crying, but the impact of the crying on parents, and subsequent outcomes, need to receive equal attention. This study reports the findings from a prospective evaluation of a package of materials designed to support the well‐being and mental health of parents who judge their infant to be crying excessively. The resulting “Surviving Crying” package comprised a website, printed materials, and programme of Cognitive Behaviour Therapy‐based support sessions delivered to parents by a qualified practitioner. It was designed to be suitable for United Kingdom (UK) National Health Service (NHS) use. Methods Parents were referred to the study by 12 NHS Health Visitor/Community Public Health Nurse teams in one UK East Midlands NHS Trust. Fifty‐two of 57 parents of excessively crying babies received the support package and completed the Edinburgh Postnatal Depression Scale and Generalized Anxiety Disorder‐7 anxiety questionnaire, as well as other measures, before receiving the support package and afterwards. Results Significant reductions in depression and anxiety were found, with numbers of parents meeting clinical criteria for depression or anxiety halving between baseline and outcome. These improvements were not explained by reductions in infant crying. Reductions also occurred in the number of parents reporting the crying to be a large or severe problem (from 28 to 3 parents) or feeling very or extremely frustrated by the crying (from 31 to 1 parent). Other findings included increases in parents' confidence, knowledge of infant crying, and improvements in parents' sleep. Conclusions The findings suggest that the Surviving Crying package may be effective in supporting the well‐being and mental health of parents of excessively crying babies. Further, large‐scale controlled trials of the package in NHS settings are warranted.
Article
Aim: Alleviating pain in neonates should be the goal of all caregivers. We evaluated whether recorded maternal voices were safe and effective in limiting pain in preterm infants undergoing heel lance procedures in the neonatal intensive care unit of an Italian children's hospital. Methods: This prospective, controlled study took place from December 2013 to December 2015. We enrolled 40 preterm infants, born at a 26-34 weeks of gestation, at a corrected gestational age 29-36 weeks and randomised them to listen or not listen to a recording of their mother's voice during a painful, routine heel lance for blood collection. Changes in the infants' Premature Infant Pain Profile, heart rate, oxygen saturation and blood pressure during the procedure were compared by analysis of variance. Possible side effects, of apnoea, bradycardia, seizures and vomiting, were also recorded. Results: Both groups showed a marked increase in PIPP scores and decrease in oxygen saturation during the procedure, but infants in the treatment group had significantly lower PIPP scores (p=0.00002) and lower decreases in oxygen saturation (p=0.0283). No significant side effects were observed. Conclusion: Using recorded maternal voices to limit pain in preterm infants undergoing heel lance procedures appeared safe and effective. This article is protected by copyright. All rights reserved.
Article
Background: Administration of oral sucrose with and without non-nutritive sucking is the most frequently studied non-pharmacological intervention for procedural pain relief in neonates. Objectives: To determine the efficacy, effect of dose, method of administration and safety of sucrose for relieving procedural pain in neonates as assessed by validated composite pain scores, physiological pain indicators (heart rate, respiratory rate, saturation of peripheral oxygen in the blood, transcutaneous oxygen and carbon dioxide (gas exchange measured across the skin - TcpO2, TcpCO2), near infrared spectroscopy (NIRS), electroencephalogram (EEG), or behavioural pain indicators (cry duration, proportion of time crying, proportion of time facial actions (e.g. grimace) are present), or a combination of these and long-term neurodevelopmental outcomes. Search methods: We used the standard methods of the Cochrane Neonatal. We performed electronic and manual literature searches in February 2016 for published randomised controlled trials (RCTs) in the Cochrane Central Register of Controlled Trials (CENTRAL; The Cochrane Library, Issue 1, 2016), MEDLINE (1950 to 2016), EMBASE (1980 to 2016), and CINAHL (1982 to 2016). We did not impose language restrictions. Selection criteria: RCTs in which term or preterm neonates (postnatal age maximum of 28 days after reaching 40 weeks' postmenstrual age), or both, received sucrose for procedural pain. Control interventions included no treatment, water, glucose, breast milk, breastfeeding, local anaesthetic, pacifier, positioning/containing or acupuncture. Data collection and analysis: Our main outcome measures were composite pain scores (including a combination of behavioural, physiological and contextual indicators). Secondary outcomes included separate physiological and behavioural pain indicators. We reported a mean difference (MD) or weighted MD (WMD) with 95% confidence intervals (CI) using the fixed-effect model for continuous outcome measures. For categorical data we used risk ratio (RR) and risk difference. We assessed heterogeneity by the I(2) test. We assessed the risk of bias of included trials using the Cochrane 'Risk of bias' tool, and assessed the quality of the evidence using the GRADE system. Main results: Seventy-four studies enrolling 7049 infants were included. Results from only a few studies could be combined in meta-analyses and for most analyses the GRADE assessments indicated low- or moderate-quality evidence. There was high-quality evidence for the beneficial effect of sucrose (24%) with non-nutritive sucking (pacifier dipped in sucrose) or 0.5 mL of sucrose orally in preterm and term infants: Premature Infant Pain Profile (PIPP) 30 s after heel lance WMD -1.70 (95% CI -2.13 to -1.26; I(2) = 0% (no heterogeneity); 3 studies, n = 278); PIPP 60 s after heel lance WMD -2.14 (95% CI -3.34 to -0.94; I(2) = 0% (no heterogeneity; 2 studies, n = 164). There was high-quality evidence for the use of 2 mL 24% sucrose prior to venipuncture: PIPP during venipuncture WMD -2.79 (95% CI -3.76 to -1.83; I(2) = 0% (no heterogeneity; 2 groups in 1 study, n = 213); and intramuscular injections: PIPP during intramuscular injection WMD -1.05 (95% CI -1.98 to -0.12; I(2) = 0% (2 groups in 1 study, n = 232). Evidence from studies that could not be included in RevMan-analyses supported these findings. Reported adverse effects were minor and similar in the sucrose and control groups. Sucrose is not effective in reducing pain from circumcision. The effectiveness of sucrose for reducing pain/stress from other interventions such as arterial puncture, subcutaneous injection, insertion of nasogastric or orogastric tubes, bladder catherization, eye examinations and echocardiography examinations are inconclusive. Most trials indicated some benefit of sucrose use but that the evidence for other painful procedures is of lower quality as it is based on few studies of small sample sizes. The effects of sucrose on long-term neurodevelopmental outcomes are unknown. Authors' conclusions: Sucrose is effective for reducing procedural pain from single events such as heel lance, venipuncture and intramuscular injection in both preterm and term infants. No serious side effects or harms have been documented with this intervention. We could not identify an optimal dose due to inconsistency in effective sucrose dosage among studies. Further investigation of repeated administration of sucrose in neonates is needed. There is some moderate-quality evidence that sucrose in combination with other non-pharmacological interventions such as non-nutritive sucking is more effective than sucrose alone, but more research of this and sucrose in combination with pharmacological interventions is needed. Sucrose use in extremely preterm, unstable, ventilated (or a combination of these) neonates needs to be addressed. Additional research is needed to determine the minimally effective dose of sucrose during a single painful procedure and the effect of repeated sucrose administration on immediate (pain intensity) and long-term (neurodevelopmental) outcomes.
Article
Review question/objective: The objective of this review is to synthesize the best available evidence related to the effectiveness of music as pain relieving method among preterm infants during painful procedures in the neonatal intensive care unit.Review questions are: Among preterm infants in the neonatal intensive care unit, is music effective in reducing BACKGROUND: Preterm infants (i.e. babies born at or before 37 gestational weeks) compose a patient group of the most vulnerable to pain. Infants treated in a neonatal intensive care unit (NICU) are exposed to a variety of painful procedures (e.g. heel prick, iv cannula insertion, endotracheal suctioning) and to environmental stress (e.g. noise, light). Simons et al., for example, described an average 14 +/- 4 painful procedures during the first 2 weeks of life within a period of 24 hours among 151 neonates. Many studies have shown that repeated and sustained pain can have direct and long-term consequences on the neurological and behavior-oriented development of the neonates during the rapid development phase of the central nervous system. Pain can cause detectable physiological, behavioral and hormonal changes and contribute to the altered development of the pain system during later childhood and adolescence. Instead, live music such as singing is excellent type of music when it is steady, constant, quiet, soothing and directed to the infants. Graven emphasizes that recorded sound should not replace human voice exposure in the NICU; therefore, health care providers should provide ample opportunity for the infant to hear parent's voices live, such as singing or humming, in interactions between the parent and the infant at the bedside.The AmericanAcademy of Pediatrics Committee on Environmental Health has recommended safe levels of sound, and these recommendations have been updated by an expert team of practitioners. Recommendations specify that continuous sound should not exceed an hourly equivalent sound level of 50 A-weighted decibels (dBA), and music as an auditory stimulus not exceed 75 dB in NICU. If earphones or other devices are used, sound sources should be kept at reasonable distances from the infant's ear, played for brief periods and at levels below 55 dB.Music listening can be initiated with or without the involvement of a music therapist. In this review, music can be implemented for premature infants by a music therapist or any health care providers and it will include both recorded and live music. Outcomes: Regardless of the type of music, several studies have investigated the short term effects of music on preterm infants, including the improvement in physiological outcomes (e.g. oxygen saturation, heart rate, respiratory rate, and blood pressure), as well as in behavioural state (e.g. crying, facial expression, body movements) and pain scores. For example, Chou et al. showed that premature infants receiving recorded music, that was the combination of womb sounds and the mother singing, with endotracheal suctioning had significantly higher oxygen saturation than when they did not receive music. Butt & Kisilewsky compared recorded music involving both the vocal and instrumental version of Brahms lullaby versus no music, and found that infants older than 31 weeks demonstrated significant reduction in heart rate, behavioral state and pain.In the study of Arnon et al. the infants receiving live music, compared with infants receiving recorded music or no music, had significantly reduced heart rate and behavioral scores during the post-intervention period. Live music comprised of a lullaby sang by the female voice with frame drum and an accompanying harp. The same music was played by a tape recorder. Live music showed significant benefits, whereas no statistically significant changes were found for the recorded music and control groups. Teckenberg-Jansson et al. indicated that music therapy combined with kangaroo care decreased the pulse, slowed down the respiration and increased the transcutaneous oxygen saturation in preterm infants. The musical instruments used were a lyre and a female human voice, which hummed or sang.There is evidence that music has also positive consequences on long-term outcomes, including length of hospitalization, weight gain, and non-nutritive sucking. For example, in the study of Caine the preterm infants received music stimulation which consisted of recorded vocal music (including lullabies and children's music) and routine auditory stimulation. Exposure to the music stimulation had many positive effects on preterm infants, such as it increased daily average weight, formula and caloric intake, and significantly reduced total hospital stays and stress behaviors for the experimental group. In addition, according to Lubetzky et al. exposure to music by Mozart significantly lowered energy expenditure among healthy preterm infants.Hartling et al. have published a systematic review on the efficacy of music for medical indicators in term and preterm neonates. Nine randomized trials (1989-2006) were included. According to the results of this review music may have positive effects on physiological parameters and behavioral states, and may reduce pain and improve oral feeding rates among the premature infants. The effects of music were evaluated during medical procedures (circumcision, heel prick) and for other indicators. In addition, Cignacco et al. conducted a systematic literature review on the efficacy of non-pharmacological interventions in the management of procedural pain in preterm and term neonates during the period from 1984 to 2004. According to this review there was no clear evidence that the method of music could have a pain-alleviating effect on neonates. In the Cochrane Library, one systematic review is also available up to year of 2011 concerning non-pharmacological management of infants and young children (preterm, neonate, older up to three years) during procedural pain, but this review did not consider music as an intervention.To date, there is also one meta-analysis published by Standley concerning the efficacy of music therapy for premature infants during the period from 1950 to 1999. It concluded that music was beneficial for many outcomes among the preterm infants in the NICU. However, the results of this review were limited by the poor methodological quality of the included studies, and unclear reporting on the phases of review.In our systematic review, studies published in 2000 and after will be considered for inclusion in the review. The number of the RCT's concerning the effectiveness of music among the preterm infants in NICU is especially increased during the last few years, and these studies have not included in the previous systematic reviews and meta-analysis.