The role of green coffee extract on weight loss, glucose and lipid metabolism

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The purpose of this paper was to perform a review about the role of green coffee extract on weight loss, glucose and lipid metabolism. It has been shown that overweight and obesity are important problems for health and the financial and psychological aspects have been imposed many damages to governments and health care providers. The management of overweight and obesity is related to lifestyle, physical activity, and diet. In the past decade, the studies have been published about the effects of green coffee extract on hypoglycemic, weight losing and hypotensive have been increasing. there are limited number of human studies in this area. However, the majority of interventional and epidemiological studies have been shown the beneficial effects of green coffee extract on weight and blood glucose management and metabolism of lipids. Green coffee extract reduces the fat reserves in adipocytes and regulate blood glucose by several mechanisms. Accordingly, green coffee extract supplementation may be effective in weight management, glucose and lipid metabolism.

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... In addition, GLUT4 overexpression in muscle promotes glucose absorption and lowers insulin resistance. In addition, RBP4 and interleukin-6 (IL-6) are inflammatory cytokines produced by adipose tissue linked to a decrease in GLUT4 expression [56]. This explains the negative correlation between the RBP4 and GLUT4 in this investigation. ...
... Serine phosphorylation prevents GLUT4 translocation, which diminishes insulin sensitivity. GCBE reduced JNK activation and increased GLUT4 translocation to counteract insulin resistance caused by a high-fat diet [56]. ...
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Obesity is a serious public health issue worldwide. Finding safe and efficacious products to reverse obesity has proven to be a difficult challenge. This study showed the effects of Coffea arabica or green coffee bean extract (GCBE) on obesity disorders and the improvement of obesity-induced insulin resistance, dyslipidemia, and inflammation. The active constituents of GCBE were identified via high-performance liquid chromatography. Twenty-four male albino Wistar rats were divided into two groups. The first group (Group I) was fed a control diet, whereas the second group was fed a high-fat diet (HFD) for eight weeks till obesity induction. The second group was equally subdivided into Group II, which received HFD, and Group III, which received HFD + GCBE for another eight weeks. The body and organ weights of the animals were measured, and blood and adipose tissue samples were collected for analysis. The results indicated that the administration of GCBE significantly decreased the body and organ weights. Furthermore, it had an ameliorative effect on serum biochemical parameters. It dramatically reduced total cholesterol, triacylglycerol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, glucose, and insulin levels. In addition, an improvement in homeostasis model assessment-insulin resistance and an enhancement of high-density lipoprotein cholesterol levels were observed compared with the HFD group. In addition, the group treated with GCBE exhibited a marked increase in serum levels of adiponectin (an anti-inflammatory adipokine). In addition, a considerable reduction in adipocyte hypertrophy was found following GCBE treatment. Remarkably, the administration of GCBE resulted in a remarkable decrease in the expression of RBP4 (a pro-inflammatory cytokine), whereas an increase in GLLUT4 expression was observed in the adipose tissue. This improved insulin resistance in GCBE-administered HFD rats compared with other HFD rats. Our study showed that GCBE exhibits anti-obesity activity and may be used as a natural supplement to prevent and treat obesity and its associated disorders.
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