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Daily Consumption of the Collagen Supplement Pure Gold Collagen® Reduces Visible Signs of Aging [Corrigendum]



Borumand M, Sibilla S. Clin Interv Aging. 2014;9:174 7– 1758. The authors noticed a mistake in their paper which was overlooked during the revision process of the paper. On page 1749, 3rd line of paragraph 15 of the introduction, the sentence “. . . hydrolyzed collagen type I obtained from the cartilage of fish . . .” should read “. . . hydrolyzed collagen type I obtained from fish skin . . .”.Read the original article
Daily Consumption of the Collagen Supplement Pure Gold Collagen
Reduces Visible Signs of Aging [Corrigendum]
Borumand M, Sibilla S. Clin Interv Aging. 2014;9:174
The authors noticed a mistake in their paper which was
overlooked during the revision process of the paper.
On page 1749, 3
line of paragraph 15 of the introduction,
the sentence . . . hydrolyzed collagen type I obtained from
the cartilage of sh . . .should read . . . hydrolyzed col-
lagen type I obtained from sh skin . . ..
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... At the skin level, vitamin D has been correlated with reduced expression of collagen I and III, and other collagen isoforms [23]. A visible reduction in signs of aging has been observed following regular consumption of collagen [24], this is directly correlated with a high level of vitamin D [25], and deficiency of vitamin D receptor in keratinocytes augments dermal fibrosis and inflammation [26]. Articular cartilage erosions are correlated with low levels of vitamin D; thus it can be concluded that collagen formation is vitamin D dose-dependent. ...
... Vitamin D is involved in collagen synthesis [24,25,33] and its deficiency is correlated with profibrotic factors by inducing an antifibrotic phenotype in multipotent mesenchymal cells. Studies have been conducted to test vitamin D supplementation as a preventive or early treatment strategy for cardiovascular diseases and associated fibrotic disorders [23,26] and concluded that vitamin D decreases fibrosis. ...
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Background/Aim: Rapid onset of facial ptosis can impact physical appearance and compromise the outcomes of facelift procedures. The level of vitamin D has a potential correlation with collagen formation and its deficiency with inflammatory processes that affect the breakdown of hyaluronic acid. This study aims to investigate the potential relationship between accentuated facial ptosis in women and low levels of vitamin D. Furthermore, it aims to explore preventive measures or strategies to slow down facial ptosis and enhance the longevity of facelift results. Materials and Methods: The study was focused on monitoring the vitamin D levels in women and men with advanced facial ptosis and comparing them with a control group. Results: Notably, a direct association between gender and serum vitamin D levels was observed, indicating less sustainable outcomes in women. Conclusions: Women face additional challenges in the aging process due to hormonal shifts after menopause or premenopausal, which are associated with osteoporosis and lower vitamin D levels.
... As such, strategies aiming at reinforcing skin barrier function may be effective and our data suggest that nutritional intervention with pHF-W may be a viable alternative for strengthening the skin barrier by reducing TEWL. Further support for beneficial cutaneous effects by oral supplementation with hydrolysed protein can be found in the skincare field [61][62][63]. Several clinical trials have shown that oral supplementations with peptides from collagen were able to improve skin quality and hydration in adults based on biophysical measurement methods, including corneometry (skin conductance), elasticity, and TEWL, among others [61,62]. ...
... Further support for beneficial cutaneous effects by oral supplementation with hydrolysed protein can be found in the skincare field [61][62][63]. Several clinical trials have shown that oral supplementations with peptides from collagen were able to improve skin quality and hydration in adults based on biophysical measurement methods, including corneometry (skin conductance), elasticity, and TEWL, among others [61,62]. The in vivo improvement in the quality and quantity of collagen and improved skin hydration was underscored by a direct effect of collagen peptides on the glycosaminoglycan levels and collagen content in human skin explants [61]. ...
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Specific partially hydrolysed whey-based infant formulas (pHF-W) have been shown to decrease the risk of atopic dermatitis (AD) in infants. Historically, AD has been associated primarily with milk allergy; however, defective skin barrier function can be a primary cause of AD. We aimed to ascertain whether oral supplementation with pHF-W can improve skin barrier function. The effect of pHF-W was assessed on transepidermal water loss (TEWL) and antibody productions in mice epicutaneously exposed to Aspergillus fumigatus. Human primary keratinocytes were stimulated in vitro, and the expression of genes related to skin barrier function was measured. Supplementation with pHF-W in neonatal mice led to a significant decrease in TEWL and total IgE, but not in allergen-specific antibody levels. The whey hydrolysate was sufficient to decrease both TEWL and total IgE. Aquaporin-3 gene expression, linked with skin hydration, was modulated in the skin of mice and human primary keratinocytes following protein hydrolysate exposure. Skin barrier improvement may be an additional mechanism by which pHF-W may potentially reduce the risk of AD development in infants. Further human studies are warranted to confirm the clinical efficacy of these observations.
... They looked, in particular, at the proliferation and development of collagen. Collagen concentrations of 48-97 μg/mL were found to result in optimal proliferation (191%) [55]. ...
One of the most abundant proteins formed in the human body is collagen. It is responsible for the strength of body tissues in all cellular systems by establishing support networks. Collagen fibers are generally opaque and white, due to this reason they are easily recognized in the tissues. Collagen fibers, which are viscoelastic, have low extensibility and high tensile strength. The isoelectric point is around pH 5.8. Collagen is widely used as it helps blood coagulate, remodeling tissue. Although there are no known side effects, there is some concern about its role in inflammation, group-to-group variability, and possible disease transfection, given that animal-derived (natural) collagen is used in many clinical applications. Not every protein is of equal value, so not every collagen is of equal value. Thanks to its low molecular weight, hydrolyzed collagen is quickly digested by our body and enters our blood circulation. According to study, the most suitable type of collagen is the one in powder or liquid form for collagen peptides that can be easily absorbed and used by our body. It is necessary to rely on the most appropriate analysis technique to evaluate the quality feature. Techniques such as SEC, MS, HPLC and NMR are used to characterize complex peptide mixtures. Classical fibril-forming collagen includes collagen types I, II, III, V, and XI. These collagenes are characterized by their ability to aggregate into highly oriented supramolecular aggregates, forming fibrillar arrays with diameters between 25 and 400 nm. Being a natural protein and its technical characteristics, it is expected that development and consumption of collagen hydrolyzate will increase in the coming years. In this review, physical and chemical properties of collagen, types, pharmacology properties, quantity determination methods are briefly described.
... We also observed that supplementation with hydrolyzed fish cartilage promoted a significant decrease in dermis echogenicity in the nasolabial region of the face. This result revealed an increase in dermis density, greater formation of collagen fibrils, and repair of current damage, helping to reduce the chronological aging and photoaging process and improving the skin density [8,27]. An increase in dermis thickness was also observed and was correlated with hydration of deeper skin layers and with the maintenance of skin homeostasis, thus helping to reduce the damage caused by chronological aging and other factors [6][7][8]. ...
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Collagen and its peptides are natural ingredients used in food supplements and nutricosmetics with the claim of providing benefits for skin health and beauty. In this context, the aim of the present study was to evaluate the clinical efficacy of oral supplementation with hydrolyzed fish cartilage for the improvement of chronological and photoaging-induced skin changes. A total of 46 healthy females aged 45 to 59 years were enrolled and divided into two groups: G1—placebo and G2—oral treatment with hydrolyzed fish cartilage. Measurements of skin wrinkles, dermis echogenicity and thickness, and morphological and structural characteristics of the skin were performed in the nasolabial region of the face before and after a 90-day period of treatment using high-resolution imaging, ultrasound, and reflectance confocal microscopy image analyses. A significant reduction in wrinkles and an increase of dermis echogenicity were observed after a 90-day period of treatment with hydrolyzed fish cartilage compared to the placebo and baseline values. In addition, reflectance confocal microscopy (RCM) image analysis showed improved collagen morphology and reduced elastosis after treatment with hydrolyzed fish cartilage. The present study showed the clinical benefits for the skin obtained with oral supplementation with a low dose of collagen peptides from hydrolyzed fish cartilage.
... Borumand and Sibilla conducted research oriented to investigating the effect of a supplement composed of collagen hydrolysates from tilapia and pangasius fish, hyaluronic acid, vitamins, and minerals on skin properties [126]. The study was carried out in 294 volunteers aged 18-74 years old recruited by 40 dermatologists across five different countries. ...
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Antioxidants are molecules that delay or inhibit the oxidation of other molecules. Its use significantly increased in recent years in the diet of people. Natural antioxidants are replacing the use of synthetic antioxidant ingredients due to their safety, nutritional, and therapeutic values. Hydrolyzed collagen (HC) is a popular ingredient considered to be an antioxidant. This low molecular weight protein has been widely utilized due to its excellent biocompatibility, easy biodegradability, and weak antigenicity. It is a safe cosmetic biomaterial with good moisturizing properties on the skin. The antioxidant properties of HC are conditioned to the size of the molecule: the lower the molecular weight of peptides, the greater the ability to donate an electron or hydrogen to stabilize radicals. The antioxidant capacity of HC is mostly due to the presence of hydrophobic amino acids in the peptide. The exact mechanism of peptides acting as antioxidants is not clearly known but some aromatic amino acids and histidine are reported to play an important role in the antioxidant activity. Oral ingestion of HC increases the levels of collagen-derived peptides in the blood torrent and improves the skin properties such as elasticity, skin moisture, and transepidermal water loss. Additionally, daily intakes of HC protect the skin against UV melasma, enhances the fibroblast production and extracellular matrix of the skin. HC has been identified as a safe cosmetic ingredient for topical formulations with good moisturizing properties at the stratum corneum layer of the skin. It reduces the effects of skin aging (dryness, laxity, and wrinkles). The use of HC as a principal ingredient in safe formulations for skin protection was reviewed and compared when it is used by topical and/or oral administration.
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Skin is a complex and dynamic organ that provides a protective interface between theexternal environment and the body; changes in skin appearance are often the first visible signs ofaging. It is well established that nutrients and other bioactive substances have important roles in thestructure and functions of human skin; however, the effects of dietary supplementation of suchbioactives are much less investigated. The objective of this randomised, double‐blind placebocontrolledstudy was to investigate the effects of liquid food supplement, characterised by acombination of water‐soluble coenzyme Q10 (Q10Vital®) and collagen, on dermal density and otherskin parameters in comparison to placebo. The trial was performed on 34 healthy women aged 40–65 that received either the test product (n = 17) or the placebo (n = 17) for twelve weeks.Measurements and assessments of skin parameters were performed at baseline and after 12 weeksof intervention. We observed improved dermis density, reduced periorbital wrinkle area and thetotal wrinkle score, and improved skin smoothness was observed. On the other hand, changes inskin hydration, dermis thickness, transepidermal water loss (TEWL) and viscoelasticity were notsignificant.
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