ArticlePDF Available

Ayurvedic treatment outcome for Chronic Liver diseases

January 2020

Authors:

Ashok Kumar Panda

Central Council for Research in Ayurveda sciences

Kshirod Kumar Ratha

Central Council for Research in Ayurvedic Sciences

Currently available medical therapies for liver disorders have more systemic toxicity, cost effective and liver transplantation was advised to many cases. So many patients want to take ayurveda medication as last choice or as a choice due to poverty. We have documented more than 200 cases and found 40% cases are Non Alcoholic Fatty liver diseases followed by Cirrhosis of liver. There are more than three hundred herbo-mineral preparations in Ayurveda system of medicine for the treatment of jaundice and chronic liver diseases. More than 50% people of our country relay on Ayurveda and herbal medicine for liver diseases. Ayurveda medicine could represent a promising tool to postpone the need of liver transplantations, increase the QoL of patients with cirrhosis, and reduce overall treatment costs of Chronic liver diseases. Ayurveda also delivered sodhana ( Purificatory treatment) by means of Panchakarma treatment. Rasayana therapy is very helpful in CLD. Diet has a integral role in Outcome of a CLD patient. Evidences are coming for remission of hepatao-cellular carcinoma and reversal of fibrosis of liver with high life expectancy. So public participation as well as awareness for Ayurveda treatment in Chronic liver diseases are required. Proper training and modern skill development should be mandatory for of Ayurveda Physicians treating liver diseases . More evidences in terms of Ayurveda outcome studies are the need of the hour to create a hope for CLD Patients.

Content uploaded by Ashok Kumar Panda

Content may be subject to copyright.

REVIEW ARTICLE

Nov-Dec 2019

Journal of Ayurveda and Integrated Medical Sciences | Nov - Dec 2019 | Vol. 4 | Issue 6

Ayurvedic treatment outcome for Chronic Liver

diseases

Dr. Ashok Kumar Panda,

Dr. K. K. Rath

1,2

Research Officer (Ayurveda), Central Ayurveda Research Institute of Hepatobiliary disorders, Bharatpur, Near

Kaliga Studio, Bhubaneswar, Odisha, INDIA. A unit of CCRAS, M/O AYUSH, GOI.

NTRODUCTION

Chronic liver diseases are disease process of liver

which involves progressive destruction and

regeneration of liver parenchyma leading to

functional and structural changes in form of fibrosis

Address for correspondence:

Dr. Ashok Kumar Panda

Research Officer (Ayurveda), Central Ayurveda Research Institute

of Hepatobiliary disorders, Bharatpur, Near Kaliga Studio,

Bhubaneswar, Odisha, INDIA.

E-mail: akpanda_06@yahoo.co.in

Submission Date: 17/11/2019 Accepted Date: 22/12/2019

Access this article online

Quick Response Code

Website: www.jaims.in

Published by Maharshi Charaka

Ayurveda Organization, Vijayapur,

Karnataka (Regd) under the license CC-

by-NC-SA

and cirrhosis. Chronic liver disease refers to diseases

of the liver which lasts over a period of six months. It

consists of a wide range of liver pathologies which

includes inflammation ( chronic Hepatitis), reduction

of size (Liver cirrhosis), Polycystic liver disease, and

Hepato cellular carcinoma.

[1]

It leads to various

complications to end stage liver disease and hepatic

failure. Ayurveda is traditionally skill full and treating

liver diseases since centuries and the drug toxicity

appears to be less as compared to conventional

medicine. Yakrit is the root of Rakta vaha srotos and

pitta is the mala (by product) of Rakta dhatu. Excess

intake of Madya (Alcohol) said to be increase pitta

and vitiate rakta dhatu and alter the architecture

rakta vaha srotas.

[2]

Ayurveda literature found Yakrit

suska which may be compaired with Cirrhosis of liver.

Pandu, Kamala, Asmari, Yakrit vidradhi (Liver Abcess),

Yakrit granthi ( Liver cyst), Yakrit dalludara (Hepatitis

A B S T RA C T

Currently available medical therapies for liver disorders have more systemic toxicity

, cost

effective

and liver transplantation was advised to many cases. So many patients want to take ayurveda

medication as last choice or as a choice due to poverty. We have documented more than 200 cases

and found 40% cases are Non Alcoholic Fatty liver diseases followed by Cirrhosis of liver. There are

more than three hundred herbo-mineral preparations in Ayurveda system of medicine for the

treatment of jaundice and chronic liver diseases. More than 50% people of our country relay on

Ayurveda and herbal medicine for liver diseases. Ayurveda medicine could represent a promising tool

to postpone the need of liver transplantations, increase the QoL of patients with cirrhosis, and reduce

overall treatment costs of Chronic liver diseases. Ayurveda also delivered sodhana ( Purificatory

treatment) by means of Panchakarma treatment. Rasayana therapy is very helpful in CLD. Diet has a

integral role in Outcome of a CLD patient. Evidences are coming for remission of hepatao-cellular

carcinoma and reversal of fibrosis of liver with high life expectancy. So public participation as well as

awareness for Ayurveda treatment in Chronic liver diseases are required. Proper training and modern

skill development should be mandatory for of Ayurveda Physicians treating liver diseases . More

evidences in terms of Ayurveda outcome studies are the need of the hour to create a hope for CLD

Patients.

Key words: CLD, Cirrhosis, ALD, DILI, NAFLD, NASH, Kamala, Halimaka, Panaki, Yakrit Suska, Yakrit

Vidradhi

(Liver Abcess), Yakrit

Granthi

( Liver cyst), Yakrit

Dalludara

, Krimija

Yakruit Roga

Dr. Ashok Kumar Panda et al. Ayurvedic treatment outcome for Chronic Liver diseases

ISSN: 2456-3110 REVIEW ARTICLE

Nov-Dec 2019

Journal of Ayurveda and Integrated Medical Sciences | Nov - Dec 2019 | Vol. 4 | Issue 6

or hepato megaly), Jalodara, and Krimija yakruit roga

are the various diseases described in Ayurveda

literature. Kamala, Halimaka and Panaki are different

stages of liver diseases. Ayurveda Practitioners have

been practicing and claimed cure Chronic liver

diseases successfully.

[3]

Recent times Ayurveda

medication induced liver cirrhosis publications

[4]

are

also came to purview of many Ayurveda Practitioners.

It is interesting to note that Ayurveda Liver tonic

(Livomyn) also reported induce liver injury by the

same author.

[5]

The author may be published the data

without analyse the cause properly or to suprees the

poularity of Ayurveda in CLD.

Currently available medical therapies for liver

disorders have more systemic toxicity therefore

physicians hesitate to administrate modern medicine

for long term use.

[6]

Clinical and animal research in

this century has confirmed the efficacy of several

medicinal plants and herbo-mineral compounds

described in Ayurveda in the treatment of liver

disease, it may be cause for patients with chronic liver

disease seek primary or adjunctive herbal treatment

and it is a common occurrence observed all over the

globe. Chronic Liver diseases are the serious ailments

and the medical treatment scenario is worsened day

by day for lack of proven precise therapeutic

regimens. There are many plants and their extracts

that have been shown to possess hepato-protective

activities. There are more than three hundred herbo-

mineral preparations in Indian system of medicine for

the treatment of jaundice and chronic liver diseases.

More than 50% people of our country relay on

Ayurveda and herbal medicine for liver diseases.

Undoubtly Ayurveda herbs and products having

defined biochemical active component can protect

liver from oxidative stress, promote virus elimination,

block fibrogenesis, anti inflammatory, immune-

modulating, liver regenerating and inhibit tumour

growth in vitro and in vivo studies. Ayurveda also

delivered sodhana ( Purificatory treatment) By means

of Panchakarma treatment. Rasayana therapy is very

helpful in CLD.

Central Ayurveda Research Institute of Hepatobiliary

disorders, Bhubaneswar is premier Institute of

CCRAS, Ministry of AYUSH where various researches

of liver has been growing and Researchers are

working hard to generate evidences. We have

documented more than 200 cases and found 40%

cases are Non Alcoholic Fatty liver diseases followed

by Cirrhosis of liver. So many case study and case

series were reported regarding the efficacy of

Ayurveda drug in Chronic Liver Diseases. The

observation found that Fatty liver and NASH can be

corrected within six months to one year of treatment

along with lifestyle modification. Viral hepatitis is well

managed with Ayurvedic herbs and sometimes

patients are using antiviral therapy along with

Ayurveda medication. Ayurveda treatment for Auto

immune liver disease can block fibro genesis and

regenerate the hepatocyte of liver by immune

modulating herbs. Ayurveda treatment for

Thrombocytopenia has back through a new treatment

modality.

[7]

Ayurveda treatment could be a potentially

safe and effective complement in these cases of

Alcoholic liver cirrhosis. It can be presume that

Ayurveda treatment modalities block the fibro genesis

of liver and regenerate the hepatocytes. It needs

animal experiment. If replicated in clinical trial then

Ayurveda medicine could represent a promising tool

to postpone the need of liver transplantations,

increase the QoL of patients with cirrhosis, and reduce

overall treatment costs of ALD patient. Ayurveda can

well manage hyperbilirumia and hyponatrimia arised

due to Liver cirrhosis. Ayurveda treatment and

Lifestyle modification is a very successful treatment

strategy for NAFLD and NASH.

[8]

Evidences are

generated for Herbal treatment for Hepatis B

infection.

[9]

Many cases of advised liver transplant

can managed well by Ayurveda and survival outcome

is more than five years in our initial reports. Regading

Hapato cellular carcinoma( HCC), Complete remission

of HCC can be achieved by Ayurveda treatment and

strict dietary schedule. Evidences are coming for

better survival outcome with good quality of life in

HCC.

[10],[11]

Liver tumor markers like alpha feto protein

(AFP) and organ specific auto immune markers like-

antinuclear antibody (ANA)-HEp-2 are also reducing in

Ayurveda medication as per our primary observation.

Ayurveda has been using to treat several liver

Dr. Ashok Kumar Panda et al. Ayurvedic treatment outcome for Chronic Liver diseases

ISSN: 2456-3110 REVIEW ARTICLE

Nov-Dec 2019

Journal of Ayurveda and Integrated Medical Sciences | Nov - Dec 2019 | Vol. 4 | Issue 6

ailments, but its efficiency is poorly documented by

means of scientific studies. High number of Ayurveda

liver tonics has been prescribing for chronic liver

diseases and G.I. disorders by all systems of doctors.

Thirteen classical Ayurveda formulations and eight

medicinal plants mostly used by Ayurveda were

reviewed along with scientific studies. Arogyavardhini

vati is highest prescribing medicine in liver disorders.

Liv 52 has own place in CLD with high number of

publications. Haridra, Katuki, chireeta, punnanava,

kiratatikta, Bhumi amalaki are commonest single herb

used by the herbalist and Ayurveda physician in the

treatment of Jaundice and other liver disorders.

[2]

Lokanth rasa, Gomutra Haritaki, Tapyadi lauha, Sidhha

Makaradwja, Sarbeswar rasa, Bruhat sutasekhar,

kamadudha rasa, Potola katu rohinyadi kasaya,

punnavadi kasaya, are the common prescribed

medicines of Ayurveda for CLD. Diet plays an

important role in the outcome of CLD. Takra (home

made butter milk), Cow ghee (emulsified fat), milk,

Mamasa Rasa (mutton juice), Lajja, potala, snake

guard with moderate protein , low salt diet for six

times a day shows better result in our practice. Water

intake restricted to 800-1000ml depending on patient

and concomitant diseases conditions. Sodium

depletion, oesophageal bleeding, hypo albumin,

ascites, sacropenia, portal hypertension, peritonitis,

Infection and encephalopathy are most serious

complications observed in our practice of CLD.

Hyponatrimea can be manageable by rock salt mixed

with butter milk. Elderly Alcoholic cirrhosis patients

have worst outcome compared to other Cirrhosis

patients. Alcohol obstinate is the prime factor for ALD.

Knowledge of modern haematological and

radiological investigations, Fibroscan, Prognostic

scoring like Child–Pugh score, MELD score are very

essential for Ayurveda doctors. Ayurveda doctor

should manage the complications with help of

hepatologist and gastroentrologist. Primary

prevention, secondary and tertiary prevention should

undertake individually and properly. Yogic exercise

has significant role in Primary prevention, secondary

and tertiary prevention of CLD. Panchakarma and

Rasayana therapy has good outcome in RCT. The

ayurveda treatment outcome in CLD is better

compared to modern system of medicine. It needs

integration for better outcome. So public

participation and awareness for Ayurveda treatment

in Chronic liver diseases are required along with

proper training and skill development of Ayurveda

Physicians.

[12],[13]

More evidences will create a hope

for CLD Patients.

EFERENCES

1. Mukherjee PS, Vishnubhatla S, Amarapurkar DN, Das K,

Sood A, Chawla YK, et al. (2017) Etiology and mode of

presentation of chronic liver diseases in India: A multi

centric study. PLoS ONE 12(10): e0187033.

https://doi.org/10.1371/journal.pone.0187033

2. Panda AK, Bhuyan GC, Rao MM (2017) Ayurvedic

Intervention for Hepatobiliary Disorders: Current

Scenario and Future Prospect. J Tradit Med Clin Natur

6: 210.

3. Philips C A, Augustine P, Paramaguru R, et al. (February

22, 2019) Ayurveda Herbal Medicine-induced Liver

Cirrhosis. Cureus 11(2): e4122.

doi:10.7759/cureus.4122

4. Philips CA, Paramaguru R, Joy AK, Antony KL, Augustine

P. Clinical outcomes, histopathologic patterns and

chemical analysis of ayurveda and herbal medicine

associated with severe liver injury—a single center

experience from South India. Indian J Gastroenterol.

2018; 37: https://doi.org/10.1007/s12664-017-0815-8.

5. Luper S (1998) A review of plants used in the treatment

of liver disease: part 1.Alter Med Rev 36: 410-421.

6. Del Prete A, Scalera A, Iadevaia MD, Miranda A, Zulli C,

et al. (2012) Herbal Products: Benefits, Limits, and

Applications in Chronic Liver Disease. Evid Based Compl

Alter Med 2012

7. Panda, Ashok Kumar et al. Phyto Extracts of Carica

Papaya and Tinospora Cordifolia can correct

Thrombocytopenia In Alcoholic Decompensate Liver

Cirrhosis : Case Series. Journal of Ayurveda and

Integrated Medical Sciences (ISSN 2456-3110),

http://www.jaims.in/index.php/jaims/pages/view/Cita

tion, v. 3, n. 1, p. 99 - 101, apr. 2018. ISSN 2456-3110.

8. Ravirajsinh Jadeja, Ranjitsinh V. Devkar, and Srinivas

Nammi, “Herbal Medicines for the Treatment of

Nonalcoholic Steatohepatitis: Current Scenario and

Future Prospects,” Evidence-Based Complementary

Dr. Ashok Kumar Panda et al. Ayurvedic treatment outcome for Chronic Liver diseases

ISSN: 2456-3110 REVIEW ARTICLE

Nov-Dec 2019

Journal of Ayurveda and Integrated Medical Sciences | Nov - Dec 2019 | Vol. 4 | Issue 6

and Alternative Medicine, vol. 2014, Article ID 648308,

18 pages, 2014. https://doi.org/10.1155/2014/648308.

9. Panda AK, Das D, Dixit AK, Hazra J (2015) Rapid

clearance of HbsAg and liver transaminase in hepatitis

B infection with classical Ayurvedic formulation: case

study. Asian J Phytomed Clin Res 3: 1-5.

10. Panda AK, Rath KK, Barik LD (2016) Survival outcome in

the patients with advanced hepato-celluar carcinoma

treated with Ayurveda medication: Case series.

Proceeding of World Ayurveda congress.

11. Ashok Kumar Panda , Fiboscan evidence of Reversal of

Liver fibrosis by Ayurveda Medication: Case series,

Journal of Clinical and Experimental Hepatology,

Volume 8,

12. Poornima P, Efferth T (2016) Ayurveda for Cancer

Treatment. Med Aromat Plants (Los Angel) 5: e178.

doi: 10.4172/2167-0412.1000e178

13. Nishanta Shukla , Ayurvedic approach for management

of liver parenchymal disease: A case study,5th World

Congress on Hepatitis & Liver Diseases Proceeding ,

August 10-12, 2017 London, UK.

*******************************

How to cite this article:

Dr. Ashok Kumar Panda, Dr. K.

K. Rath. Ayurvedic treatment outcome for Chronic Liver

diseases. J Ayurveda Integr Med Sci 2019;6:1-4.

Source of Support: Nil, Conflict of Interest: None

declared.

article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0),

which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Ayurveda management in terminally sick patients of hepatocellular carcinoma: A case series

Experiment Findings

Full-text available

Dec 2024

Hepatocellular Carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide. The traditional system of medicines is gaining momentum with increasing acceptance in the management of various pathologies; HCC is also one among such ones. Still, there is no consensus on the Ayurveda treatment algorithm for hepatocellular cancer. This case series is intended to provide evidence of the efficacy of Ayurveda treatment protocol for patients diagnosed with HCC. The case series presents four diagnosed cases of HCC, who were evaluated through pretreatment and during treatment assessment through laboratory data, patient performance status, Child-Pugh Scale, and the Barcelona clinic's Liver cancer staging system. The survival outcome, i.e., the time from initiation of Ayurveda medication until death was noted for all the cases. An Ayurveda treatment regimen was prepared from conventional practices and administrated to four cases of advanced HCC. The Ayurveda intervention increased the survival time more than the predicted survival time irrespective of etiology, without the contemporary chemotherapy medications, and patient performance status in all four cases. However, hepatitis B virus-infected patients had less survival time than HCC manifested from alcoholic cirrhosis. These preliminary observations have brought an idea about the positive effects of Ayurveda interventions in terminal HCC patients. Further studies are recommended to prepare the Ayurveda treatment algorithm for hepatocellular cancer.

Discovering the Efficacy of Integrated Therapies on Chronic Liver Disease

Article

Full-text available

Jul 2024

Chronic liver disease (CLD) poses a significant global health challenge and has become a primary cause of mortality worldwide. The development of CLD can be attributed to various factors, such as alcohol abuse, obesity and metabolic disorders, autoimmune hepatitis, and viral hepatitis. This case series explores the clinical journey and combined Ayurvedic treatments used for patients with CLD, aiming to integrate various holistic approaches to enhance overall well-being and potentially achieve remission in CLD. Data were collected at Patanjali Wellness Center, Patanjali Yogpeeth II, Haridwar, from June 2023 to December 2023. In this period of 6 months, we had taken 4 cases of chronic liver disease from IPD. The cases that we found are in the age range of 40 to 60 years. The pre- and post-treatment data on the patient’s outcomes were studied over a period of 6 months, followed by a continuous 3-month follow-up. In this case series, a positive and effective outcome was observed through a holistic strategy. After undergoing treatment, the patient's symptoms showed a noteworthy alleviation of CLD-related symptoms. Simultaneously, the patient's quality of life improved. Their liver function test also showed balanced parameters. At present, they are leading a normal and fulfilling life. The collective impact of these alternative therapies played a significant role in the patient's notable recovery from CLD. Nevertheless, further investigation and exploration are necessary to facilitate larger-scale clinical trials in this area.

AYURVEDIC MANAGEMENT OF CHRONIC LIVER DISEASE (CLD) –AN ANALYTICAL REVIEW

Article

Full-text available

Jun 2021

Rita Kumari

Liver controls our whole body activities. Liver cirrhosis is a most common medical problem today. One and the chief cause of it is chronic alcoholic consumption. Excessive and prolonged use of alcohol affects every organ of the body. Although liver, heart and kidney are most affected due to heavy consumption, alcohol induced liver cirrhosis is a life threatening condition in maximum cases. More than 50% people of in India rely on Ayurveda and herbal medicine for liver diseases. More than three hundred herbo-mineral preparations are available in Ayurvedic system of medicine for the treatment of jaundice and chronic liver diseases. Ayurveda plays a master role in the fast and safe recovery of damaged liver. Liver cirrhosis can be correlated to Kumbhakamala in Ayurveda w.s.r. etiology, symptoms, complications and line of treatment. Ayurvedic drugs helps in rejuvenating the liver and minimizing the complications of cirrhosis such a liver cancer, fulminant hepatitis and prevents the chronicity of the disease. In the present article, analytical review of liver disorders and its management in Ayurveda has been evaluated.

USE OF CANNABIS IN INDIAN CLASSICAL FORMULATIONS

Chapter

Mar 2024

This book series invites all the Specialists, Professors, Doctors, Scientists, Academicians, Healthcare professionals, Nurses, Students, Researchers, Business Delegates, and Industrialists across the globe to publish their insights and convey recent developments in the field of Nursing, Pharmaceutical Research and Innovations in Pharma Industry. Book series on Pharmacy and Nursing covers research work in a set of clinical sciences and medicine.

Therapeutic uses of Cannabis in Indian Traditional medicine with attention on Gastrointestinal disorders

Article

Jan 2024

Ayurveda is the world's oldest and most complete spiritual teachings, as well as the "oldest medicinal system" known to man. Ayurvedic treatments along with natural substances do not have any usual side effects as contemporary drugs. The cannabis plant has been used as a medicine for thousands of years to treat various illnesses including gastrointestinal disorders. Tetrahydrocannabinol (THC) and cannabidiol (CBD) are the most well-known and researched phyto cannabinoids, with impressive therapeutic properties for a variety of neurological, gastrointestinal, ophthalmic, and skin problems. Cannabis and cannabinoids are beneficial in healing the sign and symptoms of several gastrointestinal diseases, according to research, in part because they interact with the digestive tracts endogenous cannabinoid receptors. This could help in relaxing pain and cramps, reducing discomfort, and improving motility. Many Indian classical formulations were found cannabis is used processing agent in pharmaceuticals. For the treatment of GI issues, there are some popular cannabis-based ayurveda or herbal formulations on the market. CBD levels are frequently higher in medical marijuana, while THC levels are lower. For certain people, the therapeutic CBD is desirable for medicinal purposes, but the psychoactive THC may be needless and undesired. There are numbers of traditional cannabis formulations on the market that lack standardised quality control parameters and methods of evaluation.So, there is a need to develop a standardization technique with special reference to CBD and THC content to include this system of medicine in the main stream of health science. Standardization of popular Ayurvedic or herbal formulations is essential in order to assess the quality, safety, efficacy of that.

Ayurveda Herbal Medicine-induced Liver Cirrhosis

Article

Full-text available

Feb 2019

We present the rare case of a young male with sinusoidal obstruction syndrome due to Ayurvedic herbal medicine which he took for management of bilateral leg swelling associated with protein-losing enteropathy due to intestinal lymphangiectasia. The patient developed progressive sinusoidal fibrosis leading to cirrhosis on long term follow-up. In a diagnosis that took three years to conclude, we showcase serial liver biopsies that reveal the rare disease progression. Complementary and alternative medicine use among apparently healthy population is a potentially modifiable risk factor for liver diseases, in the presence of adequate public health education from concerned authorities.

Ayurvedic Intervention for Hepatobiliary Disorders: Current Scenario and Future Prospect

Article

Full-text available

Jan 2017

Hepatobiliary diseases include a heterogeneous group of diseases of the liver and biliary system affecting more than 50% population ranging from Non-alcoholic fatty liver diseases, gall stone, hepatitis to hepato-cellular carcinoma. Ayurveda has been using to treat several liver ailments, but its efficiency is poorly documented by means of scientific studies. High number of Aurveda liver tonics has been prescribing for chronic liver diseases and G.I. disorders. Thirteen classical Ayurveda formulations and eight medicinal plants mostly used by Ayurveda were reviewed along with scientific studies. Arogyavardhini vati is highest prescribing medicine in liver disorders. Haridra, Katuki, chireeta, punnanava, kiratatikta, Bhumi amalaki are commonest single herb used by the herbalist and Ayurveda physician in the treatment of Jaundice and other liver disorders. Many grey areas of hepato billiary disorders can be addressed through scientific research in Ayurveda.

Etiology and mode of presentation of chronic liver diseases in India: A multi centric study

Article

Full-text available

Oct 2017
PLOS ONE

There is a paucity of health policy relevant data for chronic liver disease from India, impeding formulation of an interventional strategy to address the issue. A prospective, multicentric study to delineate the etiology and clinical profile of chronic liver disease in India is reported here. A centrally coordinated and monitored web-based data repository was developed (Feb, 2010 to Jan, 2013) and analyzed. Eleven hospitals from different parts of India participated. Data were uploaded into a web based proforma and monitored by a single centre according to a standardized protocol. 1.28% (n = 266621) of all patients (n = 20701383) attending the eleven participating hospitals of India had liver disease. 65807 (24·68%) were diagnosed for the first time (new cases). Of these, 13014 (19·77%, median age 43 years, 73% males) cases of chronic liver disease were finally analyzed. 33.9% presented with decompensated cirrhosis. Alcoholism (34·3% of 4413) was the commonest cause of cirrhosis while Hepatitis B (33·3%) was predominant cause of chronic liver disease in general and non-cirrhotic chronic liver disease (40·8% out of 8163). There was significant interregional differences (hepatitis C in North, hepatitis B in East and South, alcohol in North-east, Non-alcoholic Fatty Liver Disease in West) in the predominant cause of chronic liver disease. Hepatitis B (46·8% of 438 cases) was the commonest cause of hepatocellular Cancer.11·7% had diabetes. Observations of our study will help guide a contextually relevant liver care policy for India and could serve as a framework for similar endeavor in other developing countries as well.

Rapid Clearance of HBSAG and Liver Transaminase in Hepatitis B Infection with Classical Ayurvedic Formulation: Case Study

Article

Full-text available

Mar 2015

Phyto-medicines have been used traditionally by herbalists and indigenous healers worldwide for the prevention and treatment of liver diseases specially jaundice. More than sixty percent of jaundice patients of our country have the 1st choice to visit to traditional healers for their treatment. Classical text of Ayurveda vividly narrated about Kamala (Jaundice) and many classical formulations are in active practice along with anupana (adjuvents)). Hepatitis is one of the causes for Kamala (Jaundice). None of the classical Ayurveda formulation’s therapeutic outcome is studied meticulously in hepatitis infections. Therefore we plan to observe the outcome of hepatitis cases treated with conventional Ayurveda treatment. Here we presented one hepatitis B infection treated with two classical Ayurvedic formulations, Argyavardhinivati along with leaf juice of Bhumyamlaki (Phyllanthusfraternus G.B.Wbster.) and triphlachurna. The loss of HBsAg has taken place in 45days. SGOT and SGPT were normalised after 45days of treatment. It is very clear from this observational study that Argyavardhinivati along with leaf juice of Bhumyamlaki (Phyllanthusfratarnus L.) and Triphlachurna have significant role to clearance of HBs Ag rapidly and normalise Liver Transminase in Hepatitis B infection within 45days. RCT on large sample is recommended.

Herbal Medicines for the Treatment of Nonalcoholic Steatohepatitis: Current Scenario and Future Prospects

Article

Full-text available

Jun 2014
EVID-BASED COMPL ALT

Nonalcoholic steatohepatitis (NASH) is a multifactorial disease and has close correlations with other metabolic disorders. This makes its treatment difficult using a single pharmacological drug. Use of plant extract/decoction or polyherbal formulation to treat various liver diseases is very well mentioned in various traditional systems of medicine (Ayurveda, Japanese or traditional Chinese Medicine, and Kampo medicine). Medicinal herbs are known for their multifaceted implications and thus can form an effective treatment schedule against NASH. Till date, several plant extracts, polyherbal formulations, and phytochemicals have been evaluated for their possible therapeutic potential in preventing onset and progression of NASH in experimental models, but clinical studies using the same are sparse. Herbal extracts with antioxidants, antidiabetic, and antihyperlipidemic properties have been shown to ameliorate symptoms of NASH. This review article is a meticulous compilation of our current knowledge on the role of natural products in alleviating NASH and possible lacunae in research that needs to be addressed.

Phyto extracts of Carica papaya and Tinospora cordifolia can correct thrombocytopenia in alcoholic decompensate liver cirrhosis : Case Series

Article

Mar 2018

Ashok Kumar Panda

Thrombocytopenia (platelet count less than 150 × 109/L) is a frequent complication of decompensate cirrhosis and is considered as an indicator of advanced disease. Carica papaya leaf juice has beneficial effect in thrombocytopenia associated with dengue. Tinospora cordifolia has been shown to prevent the fibrous tissue deposition of liver by modulation of kupffer cell activation. An attempt was taken to observe the usefulness of extract Carica papaya and Tinospora cordifolia in alcoholic decompensate cirrhosis. A market available product Cariden is easily available to the patients which contains Phyto extracts of Carica papaya 1100mg and Tinospora cordifolia 500mg. Phyto extracts of Carica papaya and Tinospora cordifolia can enhance the platelet count within 15 days and it can normalise the platelet within 90 days of therapy in all three cases. Further randomised control trial is suggested.

Clinical outcomes, histopathological patterns, and chemical analysis of Ayurveda and herbal medicine associated with severe liver injury-A single-center experience from southern India

Article

Feb 2018

LINK TO ARTICLE FULL: http://rdcu.be/HIGe Introduction Ayurvedic and herbal medicines (AHM) are known to cause varying degrees of drug-induced liver injury (DILI). Clinical, biochemical, histological spectrum and outcomes of AHM linked to severe DILI are not well studied. Methods Out of 1440 liver disease patients, 94 were found to have a severe liver injury and associated AHM intake. Thirty-three patients were suspected to have AHM-DILI on Roussel Uclaf Causality Assessment Scoring Method. Forty-seven and 30 of retrieved AHM samples were analyzed for heavy metals and hepatotoxic volatile organic compounds (hVOCs), respectively. Eleven patients ingested AHM from unregistered traditional healers (UTH). Clinicopathological outcomes were analyzed in 27 patients (who underwent liver biopsy) and outcomes with respect to chemical analyses were studied in 33 patients. Results Males predominated (70.4%) with mean age 46.9±15.8 years. Mean follow up was 119.2±81.4 days. The median duration of drug intake was 28 days (10 – 84). Five patients died (18.5%). Hepatic encephalopathy, hypoalbuminemia, and hepatic necrosis were significantly associated with mortality (p < 0.005). Arsenic and mercury ingestion was significantly associated with death (p < 0.005). hVOCs were detected in more than 70% of samples. AHM intake from UTH was associated with higher mortality. Conclusion Adequate regulation and scrutiny regarding AHM use among the general population is an unmet need. Early liver biopsy after clinical identification of at-risk patients can expedite definitive treatment with a liver transplant.

A Review of Plants Used in the Treatment of Liver Disease: Part 1

Article

Jul 1999
ALTERN MED REV

SND Luper

Botanicals have been used traditionally by herbalists and indigenous healers worldwide for the prevention and treatment of liver disease. Clinical research in this century has confirmed the efficacy of several plants in the treatment of liver disease. Basic scientific research has uncovered the mechanisms by which some plants afford their therapeutic effects. Silybum marianum (milk thistle) has been shown to have clinical applications in the treatment of toxic hepatitis, fatty liver, cirrhosis, ischemic injury, radiation toxicity, and viral hepatitis via its antioxidative, anti-lipid peroxidative, antifibrotic, anti-inflammatory, immunomodulating, and liver regenerating effects. Picrorhiza kurroa, though less well researched than Silybum, appears to have similar applications and mechanisms of action. When compared with Silybum, the hepatoprotective effect of Picrorhiza was found to be similar, or in many cases, superior to the effect of Silybum.

Article ID 648308, 18 pages

Jan 2014

and Alternative Medicine, vol. 2014, Article ID 648308, 18 pages, 2014. https://doi.org/10.1155/2014/648308.

Survival outcome in the patients with advanced hepato-celluar carcinoma treated with Ayurveda medication: Case series

Jan 2016

A K Panda
K K Rath
L D Barik

Panda AK, Rath KK, Barik LD (2016) Survival outcome in the patients with advanced hepato-celluar carcinoma treated with Ayurveda medication: Case series. Proceeding of World Ayurveda congress.

Ayurvedic treatment outcome for Chronic Liver diseases

Abstract

Recommended publications

AYURVEDIC MANAGEMENT OF CHRONIC LIVER DISEASE (CLD) –AN ANALYTICAL REVIEW

Ayurveda Management of Liver Diseases (Yakrit Vikara)

Prevention and to stop the progression of fatty liver diseases: Evidence of ayurveda in hand

Hepatology practice in Ayurveda: Opportunities and Challenges