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TOWARDS RANDOM WALKS UNDERLYING NEURONAL SPIKES
Arturo Tozzi
Center for Nonlinear Science, University of North Texas
1155 Union Circle, #311427, Denton, TX 76203-5017, USA, and
tozziarturo@libero.it
Arturo.Tozzi@unt.edu
Alexander Yurkin
Russian Academy of Sciences
Moscow, Puschino, Russia
alvl1yurkin@rambler.ru
James F. Peters
Department of Electrical and Computer Engineering, University of Manitoba
75A Chancellor’s Circle, Winnipeg, MB R3T 5V6, Canada and
Mathematics Department, Adiyaman University, Adiyaman, Turkey
james.peters3@umanitoba.ca
The brain, rather than being homogeneous, displays an almost infinite topological genus, because is punctured with a
very high number of topological vortexes, i.e., .e., nesting, non-concentric brain signal cycles resulting from inhibitory
neurons devoid of excitatory oscillations. Starting from this observation, we show that the occurrence of topological
vortexes is constrained by random walks taking place during self-organized brain activity. We introduce a visual
model, based on the Pascal’s triangle and linear and nonlinear arithmetic octahedrons, that describes three-dimensional
random walks of excitatory spike activity propagating throughout the brain tissue. In case of nonlinear 3D paths, the
trajectories in brains crossed by spiking oscillations can be depicted as the operation of filling the numbers of the
octahedrons in the form of “islands of numbers”: this leads to excitatory neuronal assemblies, spaced out by empty area
of inhibitory neuronal assemblies. These procedures allow us to describe the topology of a brain of infinite genus, to
assess inhibitory neurons in terms of Betti numbers, and to highlight how non-linear random walks cause spike
diffusion in neural tissues when tiny groups of excitatory neurons start to fire.
Keywords: arithmetic figures; Pascal’s triangle; geometrization of brain; central nervous system; nonlinear.
In this paper, we will tackle the issue of a scarcely observed topological property of the brain. The most successful
accounts implicitly assume that the brain is a Riemannian manifold with genus zero (Friston and Ao, 2012; Telley et al.,
2019). Genus is a particular topological invariant, generally used for classification of 2D manifolds, linked to the Euler
characteristic, which generalizes to higher dimensions. However, the brain displays countless holes, i.e., the transient
neuronal “punctures” with inhibitory activity (Hodge et al, 2019). We will term these neurons devoid of excitatory
spikes “brain vortexes”. This means that the brain is equipped with a countless, or at least very high, number of holes
surrounding excitatory spiking neurons. Assuming that the brain is isotropic/homogeneous at very large scales and that
the excitatory/inhibitory ratio is constant, the tissue concentration of these holes might be regular. To make a trivial
example, we might think to the brain as a sponge equipped with countless, uniformly placed, holes. Therefore, we ask:
how are brain vortexes produced during nervous activity, within the geometric dynamics on a 3D manifold of infinite
genus? The answer lies in the conserved differentiation programs, together with later-occurring environment-dependent
signals, that act on sequential ground states (Telley et al., 2019; Velasco et al., 2019).
What are the topological features, peculiarities and predictable physical consequences of a brain described in terms of a
Riemannian manifold with very high, almost infinite, genus? To answer these questions, we introduce a deterministic
geometric model that permits visual constructions of linear (without any acceleration) and nonlinear (with the simplest
uniformly acceleration) random walks in three-dimensional spaces. Our model is derived from the Pascal’s triangle, an
array of the binomial coefficients widely used in numerous contexts. Its applications in mathematics extend to algebra,
calculus, trigonometry, plane and solid geometry. The two major areas where Pascal’s Triangle is used are algebra and
probability/combinatorics (Edwards 2013). It is a useful tool in finding, without tedious computations, the number of
subsets of r elements that can be formed from a set with n distinct elements (Brothers 2012). In the real world, this leads
into the complex topic of graph theory (turning mapping information into structures such as shortest paths, airplane
routes and airport control, Dijkstra’s algorithm, computer graphics, engineering, search algorithms and data
management). In a triangular portion of a grid, the number of shortest grid paths from a given node to the top node of
the triangle is the corresponding entry in Pascal’s triangle. The pattern produced by an elementary cellular automaton
using rule 60 is exactly the Pascal’s triangle of binomial coefficients reduced modulo 2. Further, to provide a last
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example, Proton Nuclear Magnetic Resonance displays an inherent geometry in which Pascal’s triangles has a
prominent role (Hore 1983).
In the following, we will show how Pascal’s triangle-derived models are able to describe the paths of random walks
leading to short- and long-range brain oscillations and to explain the formation of brain vortexes.
GEOMETRIC MODEL OF RANDOM WALKS
Simple and visual geometric models are needed to substantiate the consistency in describing complex phenomena
(Klein 1956; Sommerfeld 1973). Here we propose various recursive formulas for calculating the step-shaped Pascal’s
triangle at various initial conditions, to assess cosmic random walks processes.
Pascal’s arithmetic triangle, its analogues, generalizations and possible applications of visual geometric models have
been thoroughly carried out (Yurkin, 2013, 2016, 2018; Yurkin et al., 2018). Novel, stepwise form for Pascal’s triangle
(1D), two-sided (2D) and multidimensional generalizations can be achieved in linear models of random walks
(Kolmogorov et al., 1995). Yurkin (1995) proposed an optical laser scheme standing for a nonlinear 1D walk in a
system of rays; further, a real laser nonlinear 2D random walk in a system of rays was carried out. Nonlinear and non-
Markovian random walks were described by Fedotov and Korabel (2015). Sarkar an Maiti (2017) described a
symmetric random walk on a regular tetrahedron, an octahedron and a cube. In the 1D case (along a straight line), a
random walk (linear and nonlinear) can occur along two mutually perpendicular directions (right, left) inside an
arithmetic triangle (the triangle has two corners on his base and one on his top) (Kolmogorov et al., 1995). In the 2D
case, a random walk (linear and nonlinear) can be carried out in four different directions (forward, back, right, left)
inside an arithmetic square (the square has four corners) (Yurkin 2019).
In this paper, we aim to assess visual linear and nonlinear 3D models in form of arithmetic octahedrons to describe
linear and nonlinear 3D random walks. In the 3D case of a Pascal’s triangle, a random walk (linear and nonlinear) can
be carried out in six different directions (forward, backward, right, left, up, down) inside an octahedron equipped with
six vertices.
Linear random 3D walk in the octahedron. A 3D linear random walk or a walk in a volume can be described using a
3D model in the form of an arithmetic regular octahedron. We achieve the linear binomial coefficients in the computed
cell of the octahedron by summing the numbers from the six cells adjacent to the computed cell.
Figures 1-4 show sequentially, for the first four iterations, images of linear arithmetic octahedrons composed of small
cubes. The parts of the Figures 1-4 termed with (a) show images of the arithmetic octahedrons themselves, while (b)
show images of layers of octahedrons composed of small cubes containing numbers. These numbers correspond to the
number of walks from the initial cell (initial cube) to the final cell (final cube).
Figure 1. The zero linear arithmetic octahedron (zero iteration 0) consists of 1 cube.
Figure 2. The first linear arithmetic octahedron (the first iteration 1) consists of 6 cubes.
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The sequence of numbers of octahedrons in the example is denoted by: . The total sum of numbers in
octahedrons is . The numbers characterizing the octahedron (which describe the location of the cubes composing the
octahedron) are denoted , and :
: (1)
Denote a number located in the – octahedron as
, then specify the number of the zero octahedron (), or, in
other words, the initial conditions:
for and
(2)
for the other values and .
The numbers in the linear arithmetic octahedron are linear binomial coefficients
. They can be can be calculated
using the recursive 3D linear expression:
(3)
Example 1: .
,
as
.
In Figures 3 and 4, these numbers are circled in red circle, except for the number
, which goes beyond the
square in Figure 3 in accordance with the expression (13); for this number: .
Figures 2-4 show that the octahedrons are densely filled with green cubes (branching cells). Neighboring empty cells
inside octahedrons (white cubes or gaps) will be filled with green cubes at the next iteration. We can say that numbers
densely (without spaces) fill the linear arithmetic octahedrons.
Nonlinear random 3D walk in the octahedron. To describe a nonlinear 3D random walk, we calculate nonlinear
coefficients using the recursion formula given below and check it in the Figures. A 3D nonlinear random walk or a
walk in a volume can also be described, like a linear one, using a 3D model in the form of a nonlinear arithmetic regular
octahedron. Nonlinear binomial coefficients in the computed cell of the octahedron are obtained by summing the
numbers of six cells adjacent to the computed cell; nonlinear binomial coefficients in the cell of the octahedron
we get by summing the numbers of six cells located one through the calculated cell; nonlinear binomial coefficients in
the cell of the octahedron we get by summing the numbers of six cells located two through the calculated cell;
etc.
Figures 5-8 show sequentially (for the first four iterations) images of the nonlinear arithmetic octahedrons composed
of small cubes. Figures 5-8 termed with (a) show images of the arithmetic octahedrons themselves, while (b) show
images of layers of octahedrons composed of cubes containing numbers. These numbers correspond to the number of
walks from the initial cell (initial cube) to the final cell (final cube).
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Figure 5. The zero nonlinear arithmetic octahedron (zero iteration 0) consists of 1 cube.
Figure 6. The first nonlinear arithmetic octahedron (the first iteration 1) consists of 6 cubes.
Figure 7. The second nonlinear arithmetic octahedron (the second iteration 2) consists of 36 cubes. The Figures
clearly show the formation of separate structures of numbers (“islands of numbers”).
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Figure 8. The third nonlinear arithmetic octahedron (the third iteration 3) consists of 175 cubes. The Figures
clearly show the formation of separate structures of numbers (“islands of numbers”). The image
of the corresponding octahedron is not dispalyed.
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The sequence of numbers of octahedrons (rows of numbers in the octahedron) for the 3D case in this example is
denoted by : . The total sum of numbers in octahedron is .
The numbers characterizing the nonlinear octahedron (the numbers illustrating the position of the cubes of which the
octahedron is composed) are denoted by, and :
; (4)
Denote a number located in the - octahedron as
then specifies the number of the zero octahedron (), or in
other words, the initial conditions:
for and
(5)
for the other values of and .
The numbers in the nonlinear arithmetic octahedron are nonlinear binomial coefficients
ℎℎcan be found
using the recursive 3D nonlinear expression:
(6)
Example 2: .
,
as
.
In Figures 7-8, these numbers are circled in blue.
Figures 6-8 illustrate that the octahedrons are not tightly filled with yellow cubes (branching cells). Some empty cells
inside the octahedrons (white cubes or gaps) will be filled with yellow cubes at the next iteration, and some empty cells
will be filled after several iterations, and some empty cells will be filled after many iterations, and so on. Our numerical
calculations show that for big numbers the relative quantity of the empty cells or gaps (relative to the general quantity
of cells in nonlinear octahedron) decreases with increasing.
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BRAIN RANDOM WALKS COME INTO PLAY
The results achieved in the previous paragraphs allow the classification of different types of random walks in the form
of the following table:
Linear random walk (one unit steps, perpendicular
each others)
Nonlinear random walk (first one unit steps, second
two units steps, third three unit steps, ets.,
perpendicular each others)
3D
case
• Steps of constant length along six perpendicular
directions in octahedron.
• Gaps and “islands of numbers” are absent in a
linear arithmetic octahedron.
• Steps of increasing length along six perpendicular
directions in octahedron.
• Gaps and “islands of numbers” appear and disappear
in different areas in a nonlinear arithmetic octahedron
after several or many iterations. The relative quantity
of the empty cells or gaps decreases with increasing.
Self-organizing brain oscillations. The above-described Pascal’s triangle-framed geometric linear/nonlinear
constructions and recursive formulas may find application to understand the activity of neuronal oscillations starting
from 3D random walks. Indeed, the brain is a complex, non-linear system operating at the edge of chaos, where inter-
dependent modules display spontaneous, self-organized emergent properties (Tognoli and Kelso, 2013; Fraiman and
Chialvo, 2012; Xu and Wang, 2014; Tozzi et al., 2016). The brain manifold is equipped with phase spaces where
particle movements take place, with trajectories displaying different paths (Wang et al., 2017). The occurrence of
spontaneous, genetic-driven oscillations during human brain development has been widely studied, also in syntetic
models. For example, it is well-known that spontaneous cortical electric fluctuations are already present by the 34th
week of gestation (Krueger et. al., 2014) and are more frequently observed in immature synapses (Kavalali et al. 2011).
Further, the vertebrate spinal cord and brainstem are equipped with central pattern generator circuits able to generate
meaningful functional output also in absence of sensory inputs. Neocortical circuits can be regarded as plastic types of
such pattern generator circuits: indeed, they not just display rich spontaneous dynamics engaged by sensory inputs, but
are also able to generate output independent of external stimuli (Yuste et.al., 2005). Trujillo et al. (2019) highlighted
how structural and transcriptional changes in network activity spontaneously follow fixed genetic programming in
human neocortical organoid models. These organoids exhibited phase-amplitude coupling during network-
synchronous events that are similar to human preterm neonatal EEG features; furthermore, they exhibited spontaneous
increases in electrical activity dependent on glutamatergic and GABAergic signaling, over the span of several months
during maturation. The transcriptional or epigenetic heterogeneity related to early biases in cell fate choices can be
externally induced or stochastic in nature (Soldatov et al., 2019). In terms of the Pascal’s triangle model, the filled cells
stand for single excitatory neurons which number is progressively expanding in the brain, while the empty cells
progressively produced inside the octahedrons stand for inhibitory neurons, which number progressively increases
(Figure 9). At the next iterations, the empty cells will be progressively filled with yellow cubes: this means that areas
of inhibition and excitation continuosly appear and disappear, when further iterations take place during the expansion of
the spike oscillation.
Bifurcations and excitability in brain. In touch with the framework theorized by Pascal’s triangle iterations, the steps
progression of nervous spikes has been already described in the brain. To provide an example, in touch with our
Pascal’s triangle framework, it is well-known that neural crest cells differentiate through a series of stereotypical
lineage-restriction binary decisions that involve coexpression/competition of genes driving alternative fate programs
(Soldatov et al., 2019). Multipotent neural crest cells decide among the multiple downstream available competing fates
and step through a progression of fate bifurcations during migration that can be formalized as a series of sequential
binary decisions. Wang et al. (2019) investigated the effects of spontaneous electromagnetic induction on organization
processes of self-organized neuronal networks. They found that spontaneous electromagnetic induction slows down
self-organization processes by decreasing neuronal excitability, resulting in a more homogeneous directed-weighted
network structure with lower causal relationship and less modularity. Furthermore, spontaneous electromagnetic
induction is able to reconfigure synaptic connections to optimize economical connectivity patterns (Wang et al., 2019).
These data highlight the critical role of spontaneous electromagnetic induction in the formation of an economical self-
organized neuronal network. Velasco et al. (2019) demonstrated in organoid models of the dorsal forebrain that
reproducible and highly constrained development of the cellular diversity of the central nervous system does not require
the embryonal growing environment. Whereas acquisition of ground states by daughter neurons is largely environment-
independent, epigenetically regulated cell-extrinsic processes come into play at later stages to sculpt final identity, as
demonstrated by the progressive emergence of input-dependent transcriptional programs (Telley et al., 2019).
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Figure 9. Oscillation expansion and excitatory/inhibitory occurrence in terms of random walks taking place inside a
3D lattice. In our octahedron model, inhibitory neurons look like gaps.
Vortex cycles in brain spikes. A punctured manifold is analogous to a physical/biological space with holes. This
means that we need to work on a manifold that is Riemannian. Briefly, a manifold is a topological space that is locally
Euclidean (i.e., around every point, there is a neighborhood that is topologically the same as the open unit ball in Rn). A
Riemann surface is a surface-like configuration that covers the complex plane with several, and in general infinitely
many, “sheets”. A sample Riemannian surface is shown in Figure 10. It is easy to notice that the center of the surface
is punctured with a hole, which stands, in our framework, for a rupture of neuronal excitability due to inhibitory
components. Inhibitory neurons can be modelled as vortex cycles (Peters, 2018; Peters, 2020) with induced order
proximity of spiraling hole vortexes (Ahmad and Peters, 2019). The rim of this brain vortex cycle represents the edge
of an inhibitory neuronal assembly. The inner cycles for a vortex reaching inward represent excitatory brain pull.
Therefore, the brain can be depited as nesting, non-concentric vortex cycles embedded in a punctured Riemann surface
(Weyl, 1955).
In this context, a novel formulation of the Borsuk Ulam theorem (BUT) might be of great help: the Vortex-BUT, which
works on a manifold with holes. There are three forms of vortexBUT:
physical geometry vortex BUT (pevBUT): each pair of antipodal vortex hypersphere surface points Sn-1(Rn)
maps to the Euclidean space Rn.
region-based vortex BUT (revBUT): each pair of antipodal vortex hypersphere surface regions in
1
2n
S
(
2n
R
)
region points map to the Euclidean space
2n
R
(Peters, 2016).
descriptive vortex BUT (phivBUT): each pair of anitipodal vortex surface points OR regions maps to Rk, k >=
1.
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Each glial structure is an example of a massive vortex cycle. A punctured physical surface is a surface populated by
vortices: this allows us to start viewing punctured brain surfaces using vortexBUT. The one very different thing about
the new form of BUT is that we replace the Borsuk-Ulam use of Sn with Vn, a vortex in n-dimensional space. Then the
simplest form of vortexBUT is defined by a continuous function
f: Vn → Rn
so that f(x) = f(-x) for antipodal points x,-x on Vn.
Several variants of BUT have been provided in the very last years to assess brain functions (Tozzi et al., 2017). Why
do we need another BUT variant? The answer is straightforward, if we consider that single neurons may have an impact
on surround firing statistics and even on simple behaviors. Exploiting the advantages of a simple cortex, Hemberger et
al. (2019) examined the influence of single pyramidal neurons on their surrounding cortical circuits. Brief activation of
single neurons triggered reliable sequences of firing in tens of other excitatory/inhibitory cortical neurons, reflecting
cascading activity through local networks. The evoked pyramidal patterns extended over hundreds of micrometers from
their source over up to 200 ms. In touch with a vortexBUT account of the brain, simultaneous activation of pyramidal
cell “pairs” (i.e., neuronal activities with matching description as dicatated by BUT) stand for balanced control of
population activity, preventing paroxysmal amplification. Single cortical pyramidal neurons can generate rapidly
evolving and non-random firing sequences, in touch once again with our Pascal triangle’s model (Hemberger et al.,
2019).
Figure 10. A Riemannian surface with the center of the surface punctured with a hole.
CONCLUSIONS
Our account of deterministic models and visual constructions of linear and nonlinear 3D random walks through
arithmetic figures display various interesting geometric properties. In 3D spaces encompassing linear random walks,
the achieved arithmetic octahedron is densely filled with numbers (Figures 2–4). In 3D spaces encompassing nonlinear
random walks, the achieved arithmetic octahedron is not completely filled with numbers, i.e., it contains gaps. Indeed,
some neighboring regions inside the nonlinear octahedron remain empty until either the very next iteration, or during
several or many iterations. Gaps and “islands of numbers” or separate structures of numbers consistently appear and
disappear after several or many iterations in the nonlinear 3D case (Figures 6–8). For high numbers, the relative
quantity of the empty cells or gaps (relative to the general quantity of cells in nonlinear octahedron) decreases with
increasing. In sum, for nonlinear 3D cases, we can speak of filling the numbers of the arithmetic octahedron in the
form of “islands of numbers” or separate structures of numbers: this leads us into the realm of a nonlinear brain
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punctured with inhibitory components that break the topological order of the neuronal tissue and propagating
oscillations. The fact that physical constraints, such as the ones described by Pascal’s triangle permutations, limit the
range of brain activity has been largely recognized in brain growth too. In an intriguing paper, Tripathy et al. (2018)
reported that Mast1, espressed just in postmitotic neuronal dendritic and axonal compartments, is associated with the
microtubule cytoskeleton in a MAP-dependent manner. Mice with Mast1 microdeletions display peculiar macroscopic
features, such as enlarged corpus callosum and smaller cerebellum, in absence of megalencephaly. These opposite
findings (abnormal increase vs abnormal reduction) let us to hypothesize that the macroscopic growth of the brain tissue
is regulated by physical constraints: keeping invariant the brain size (i.e., in absence of megaloencephaly), the central
nervous tissue of animals harboring Mast1 microdeletions undergoes a general rearrangement. In physical/mathematical
terms, a three-dimensional lattice (standing for the whole brain mass) harbors vectors and tensors which product
(including excitatory and inhibitory neurons) must be held constant. When lattice perturbations occurs(as in the case of
cytoskeleton’s genetic Mast1 alterations), one of the tensors modifies. In order to keep invariant the tensor product,
another tensor need to vary: in simpler words, the fact that more axons cross the midline in Mast1 Leu278 del mice
means that the size of other structures (in this case, the cerebellum) must decrease. In touch with this observation,
Tripathy et al. (2018) report that, in animals harboring Mast1 microdeletions, the PI3K/AKT3/mTOR pathway is
unperturbed, whereas Mast2 and Mast3 levels are diminished, indicative of a dominant-negative mode of action.
In our framework, the combinatorial properties of the Pascal’s triangle are correlated with the mathermatical operations
that lead to brain spikes, through iterated random walk patterns. The occurrence of inhibitory cells in terms of
“hollows” in the very structure of the brain tissue permits us to consider the topological features of a high-genus
manifold, compared with genus-zero manifolds. What does the occurrence of a neural manifold of very high genus
physically mean? There are, actually, many ways to generalize the notion of genus to higher dimensions, e.g.,
Heegaard genus in algebraic topology, arithmetic and geometric genus in algebraic geometry (Almgren and Thurston,
1977). Feldman et al. (1996) tackled the issue of the topological properties of infinite genus Riemann surfaces. They
introduced a class of infinite genus Riemann surfaces, specified by means of a number of geometric axioms, to which
the classical theory of compact Riemann surfaces up to and, including the Torelli Theorem, extends. The axioms are
flexible enough to encompass many interesting examples, such as the heat curve and a connection to the periodic
Kadomcev-Petviashvilli equation. Apart from the mentioned accounts, our results suggest the feasibility of another
intriguing operational approach, which allows us to generalize the notion of genus to higher dimensions through another
powerful weapon: the Betti number. The brain might stand for a manifold equipped with a Betti number corresponding
to the number of inhibitory neurons. Betti numbers are topological objects proved to be invariants by Poincaré, and
used to extend the polyhedral formula to higher dimensional spaces. Informally, the kth Betti number refers to the
number of path-connected edges (Kaczynski et al., 2004) embedded in surface holes. For a brain tissue with n vortex
cycles and k edges attached between each of the cycles, the Betti number = n + k (Manschot et al., 2012). The brain is a
dynamical system where the genus changes continuously, because inhibitory cells’ activity may vary. If the brain
displays a very high genus, the population of excitatory neurons cannot incresase beyond a given threshold, because, in
topological terms, the potential squeezing leaves always holes that cannot be reduced to a single point. The occurrence
of high genus might help to elucidate experimental data. Our numerical calculations show that, for big numbers, the
relative quantity of the empty cells or gaps (relative to the general quantity of cells in nonlinear octahedron) decreases
with increasing, until a threshold is reached. Our model provides another way to generate inhibitory activity: the
progressive iterations of random walks in an expanding excitatory neural brain lead to the production of hollows,
standing for places which can be filled by inhibitory neurons. Therefore, inhibitory structures might appear when
starting from nonlinear excitatory random walks occurring in the nervous structures.
Experimental data achieved from available neurotechniques suggest that our brain oscillations are strongly isotropic
and homogeneous at macroscales of observation, because a constant excitatory/inhibitory (E/I) ratio between the total
amount of excitatory and inhibitory stimulation occurs both in vitro and in vivo (Haider, 2006; de Arcangelis 2010). Is
it feasible to correlate our mathematical Pascal’s triangle approach with the detected isotropy and homogeneity of E7I
ratio? Here the concept of hyperuniformity comes into play, i.e., the anomalous suppression of density
fluctuations on large length scales occurring in amorphous cellular structures of ordered and disordered materials (Klatt
et al., 2019). The evolution of a given set of initial points takes place when, through Lloyd iterations, each point is
replaced by the centre mass of its Voronoi cell. This corresponds to a gradient descent algorithm which allows
a progressive, general convergence to a random minimum in the potential energy surface. Klatt et al. (2019)
report that systems equipped with different initial configurations (such as, e.g., either hyperfluctuating, or
anisotropic, or relatively homogeneous pointsets), converge towards the same high degree of uniformity after a
relatively small number of Lloyd iterations (about 105). This means that, in the brain’s adult stadium,
independent of the initial conditions, cell volumes become uniform and the dimensionless total energy
converges towards values comparable to the optimal deep local energy minima of the lattice. Therefore, we are
allowed to describe brain oscillation expansion in terms of Lloyd iterations, where the initial seeds stand for initial point
sets (one or few excited neurons), progressively converted to point sets with a centroidal Voronoi diagram. In
other words, the tiny perturbations in the brain oscillations which seed the later formation of excitatory macro-
structures might stand for the starting points of the subsequent processes described by Klatt et al. (2019) in terms of
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Voronoi cells and described by us in terms of Pascal’s triangle models. This would permit us observers to achieve,
starting from countless different possible conformations of the brain spikes, the currenlty detected isotropic and
homogeneous macrostructure of the E/I ratio in the brain. Indeed, after just 105 iterations, every possible initial system
must converge towards an hyperuniform state, in which observers perceive the degree of uniformity as very high.
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