In this paper, first, we generated medical images cut as frame still image from laparoscopic video acquired by endoscopy. Using these images, we processed to encode and decode by H.265/HEVC in certain image regions, and we generated evaluation images. Next, we evaluated objectively seeing from the coded image quality by using PSNR (Peak Signal to Noise Ratio), considering the automatic detection of coded defect region information. Furthermore, we analyzed for color information by measuring both the luminance using S-CIELAB color space and the color difference using CIEDE2000. Finally, we try to classify effectively using Support Vector Machine (SVM), and we discussed including the automatic detection of coded defect region information whether it is possible for application of medical image diagnosis or not.