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Pulsed Magnetic Field Treatment of Anxiety, Panic and Post-Traumatic Stress Disorders

Authors:
Anxiety Disorders Include:
• Separationanxiety
• Selectivemutism
• Specicphobia
• Socialanxiety(socialphobia)
• Panicdisorder
• Agoraphobia
• GeneralizedAnxietyDisorder(GAD)
• Substance/medication-inducedanxiety
• Anxietyduetoanothermedicalcondition
 Anxietycanbeverydisablingandalthoughtheavailablemethods
oftreatmentaresafeandeffective(thatis,medications,psychother-
apyandcognitive behavioral therapy), about25%of people do not
respond[1].Manymedicationscarrytheriskofaddictionorlifetime
dependencewithproblematicwithdrawalreactions.Withadvancesin
*Corresponding author: William Pawluk, PEMF Training Academy, Towson,
Maryland, USA, Tel: +1 8664557688; E-mail: DrPawluk@drpawluk.com
Citation: Pawluk W (2019) Pulsed Magnetic Field Treatment of Anxiety, Panic
and Post-Traumatic Stress Disorders. J Altern Complement Integr Med 5: 075.
Received: September 15, 2019; Accepted: September 23, 2019; Published:
September 30, 2019
Copyright: © 2019 Pawluk W. This is an open-access article distributed under
the terms of the Creative Commons Attribution License, which permits unrestrict-
ed use, distribution, and reproduction in any medium, provided the original author
and source are credited.
theunderstandingoftheneurobiologyinvolvedinanxietydisorders,
newtreatmentsare being considered, including PulsedElectromag-
neticFields(PEMFs).
Many people with anxiety disorders experience physical symp-
tomsrelatedtoanxietyandsubsequentlyvisittheirprimarycarepro-
viders.Despite the highprevalence rates oftheseanxiety disorders,
theyoftenareunder-recognizedandunder-treatedclinicalproblems.
What Happens in the Brain that Relates to Anxiety?
 Somebelievethatthereisanimbalancebetweenthehemispheres
ofthe brainand/oradecitof limbicandbrain cortexcontrol. This
couldmeanthatanxiety,considereda“withdrawingfromasituation”
related emotion, is located in the right hemisphere, whereas emo-
tionsrelatedto being able to“approach”,suchas joy or happiness,
arebasedinthelefthemisphere.Thereappearstobeincreasedright
hemisphereactivityinanxietydisorders.
Panic Disorder (PD) is considered to be a more severe form of
anxiety.PDisseen withrecurrentandunexpectedattacksofsudden
onset and short duration (10 - 15 minutes).A panic attack may be
followedfor upto onemonth bypersistentworryregardinganother
panicattack.Itmayconsistofsymptomssuchasfeelingsofshortness
ofbreath,hyperventilation,palpitations,chestpain,sweating, chills,
nausea,trembling,fearofdyingor losing control, numbness and a
feelingofdetachmentorunreality.Brainneuroimagingstudies have
veriedspecicabnormalitiesinvolvedinpanicdisorder.
In Generalized Anxiety Disorder (GAD) brain scanning shows
thatlimbicorfrontalbrain regions were activated in people with a
high degree of hesitation in reacting to stressful stimuli. The same
areaswerefoundtobenotactivatedinlessanxiousindividualswhen
exposed to anxiety provoking situations. Repetitive Transcranial
MagneticStimulation (rTMS) giventoGAD patients overtheright
upperforeheadfor15minutes(900pulses/day)signicantlyreduces
anxiety.
Quantitative EEG (QEEG) gives a glimpse into the underlying
electrical patterns of the brain. The electrical activity of the brain
causesvariousneurochemicalchangesorcanbethe resultofneuro-
chemicalprocessesinthebrain.Thediagnosticandtherapeuticclini-
caldisciplineofneurofeedbackreliesonQEEGmeasurements.Neu-
rofeedback uses the latest developments in neuroscience. Through
neurofeedback, changes in EEG patterns result in improvement of
cognitive, psychological and emotional symptoms and conditions.
There is a large body of neuroscience research to support this ap-
proachtomanagingbehavioralhealthconditions[2].
Conventional Treatments for Anxiety
Psychological interventions are still the keystone to non-med-
ication management of anxiety disorders. There are a few studies
comparing the value of psychological interventions versus medical
therapies.Thelong-termeffectivenessofCognitiveBehavioralTher-
apy(CBT)comparedtomedicationsinpanicdisorderwasevaluated.
HSOA Journal of
Alternative, Complementary & Integrative Medicine
Review Article
William Pawluk*
PEMF Training Academy, Towson, Maryland, USA
Pulsed Magnetic Field Treatment
of Anxiety, Panic and Post-
Traumatic Stress Disorders
Abstract
Anxiety is a normal adaptive response to stress that allows cop-
ing with adverse situations. However when anxiety becomes exces-
sive or disproportional in relation to the situation that evokes it or
when there is no special reason for it, such as irrational dread of
routine stimuli, it becomes a disabling disorder and is considered to
be pathological. Anxiety disorders comprise the most frequent psy-
chiatric disorders and can range from relatively benign feelings of
nervousness to extreme expressions of terror and fear.
Anxiety disorders are the most common type of psychiatric disor-
ders. In the United States the lifetime presence of anxiety disorders
is about 29%.
Pawluk W, J Altern Complement Integr Med 2019, 5: 075
DOI: 10.24966/ACIM-7562/100075
Citation: Pawluk W (2019) Pulsed Magnetic Field Treatment of Anxiety, Panic and Post-Traumatic Stress Disorders. J Altern Complement Integr Med 5: 075.
• Page 2 of 8 •
J Altern Complement Integr Med ISSN: 2470-7562, Open Access Journal
DOI: 10.24966/ACIM-7562/100075
Volume 5 Issue 3 • 100075
AreviewoftheresearchdoneusingCBTshowedamodestprotective
effectofCBT in panic disorder patients. CBT plusmedicationhad
a70%benet butCBTalone only hadbenetfrom 14 to28%[3].
Effectiveness of different types of psychological interventions are:
IndividualCBT-notvery effective, group CBT 8%, exposure and
socialskills14%,self-helpwithsupport14%,self-helpwithoutsup-
port25%andpsychodynamicpsychotherapy38%.IndividualCBT
comparedwithpsychological placebohada44%benet.SSRIsand
SNRIscomparedwith pill placebo were 56% effective[4].Oneof
thebiggestchallengeswithpsychologicalinterventions,isthatmany
peopleareresistanttodoingthem,preferringtheanonymityandthe
assumedeffectiveness(withoutconsideringtherisk)ofmedications.
 Useofcomplementaryandalternativemedicineingeneralhasin-
creasedoverthepastdecade.Avarietyofstudieshavesuggestedthat
thisuseisgreaterinpersonswithsymptomsordiagnosesofanxiety
anddepression.Datasupporttheeffectivenessofsomepopularherbal
remediesanddietarysupplements;insomeoftheseproducts,particu-
larlykava,thepotentialforbenetmaybegreaterthanthatforharm
withshort-termuseinpatientswithmildtomoderateanxiety[5].
 Themostcommonmedicalapproachtomanaginganxietyiswith
theuseof medications.MedicationtreatmentsforGADcurrentlyli-
censedin the UnitedKingdomwere ranked: duloxetinewasranked
rstforresponse(thirdacrossalltreatments,3%effectiveness);escit-
alopramwasrankedrstforremission(secondacrossalltreatments,
27%)and pregabalinwas rankedrstfortolerability(secondacross
alltreatments,8%).A3%responserateis clearly notthateffective
[6].Therefore,medication treatmentof anxietyisnotapanaceaand
isassociatedwithsignicantlong-termrisks,nottheleastofwhichis
drugdependencyanddementia[7].
Few economic evaluations of pharmacological treatments for
GADhave beenpublishedto date.However,theevidenceindicates
thatforone drug in particularitwouldcost over $20,000 USDper
extraQualityAdjustedLifeYear(QALY)gained.AQALYofzeroin-
dicatesthatthereisanequalbenettocost.AnegativeQALYwould
indicatethatthere’smorebenetthancost.TherearefewQALYstud-
iesforanyhealthcareintervention,nevermindthemedicalmanage-
mentofanxiety.Nevertheless,thisstudyindicatesthatforatleastone
drug,which appearsto beone ofthemosteffectivemedicationsfor
anxiety,itisextraordinarilyexpensiveforitsvalueinimprovingqual-
ityoflife[8].Thisevidenceclearlyindicatestheneedforalternative
approachestothemanagementofanxiety.
Withadvancesintheunderstandingoftheneurobiology involvedin
anxiety disorders, new treatments are being considered, including
PEMFs.
Neuroscience and Anxiety
 QEEGresearchhasfound fairly typical patterns in thecomplex
disorder of anxiety.Anxiety has been found to have at least six or
sevenpatterns.QEEGpatternsseeninanxietyinclude:imbalancein
thefrontal lobes inalphafrequencies, excessivebetafrequencies in
manypartsofthe brain, and possibly high alpha frequencies>11.5
Hz.Basedonthesendings,neurofeedbackpractitionersrecommend
treatingeitherbothfrontallobeswithloweralphaoralphaatthesides
ofthehead.Somecallthisalphatraining[2].
 Whileneurofeedbackistypicallyappliedinapractitioner’sofce,
itisaverydifferentapproachtoPEMFstimulation.Thereisevidence
thatPEMF stimulationcauseschanges tothe underlyingbrainEEG
patterns.Thisiscalledentrainment.Manyotherformsofentrainment
havebeen testedand used,particularlycranialelectricalstimulation
(CES)andAudiovisualStimulation(AVS).ThevalueofPEMFsover
theseotherformsofentrainmentis that PEMFs could do the same
kind of entrainment stimulation but penetrate deeper into the brain
andhavetheopportunitytobeabletohealtheunderlyingcausesofa
probleminthebrain.
Can PEMFs Can Entrain to the Alpha Level Fre-
quencies?
Oscillatory brain wave activity within the EEGalphab and has
many brain function aspects, including memory processing and at-
tention.Braincellsresponsibleforperception,cognition,andaction
havedistinctvibrationpatterns.Increaseinrestingstatealphaactivity
inthebackofthebraindenotesastateofrelaxedwakefulness[9].
Magnetic eld strength is measured in Tesla (T) or Gauss (G).
OneTequals10,000G.OnemilliT(mT)isabout10G.TheEarth’s
magneticeldintensityaveragesabout0.5G(50microT).Evenvery
weak0.01G(1microT)PEMFat<1Hz(Hzisfrequencyatcycles/
second)appliedacrossbothsidesoftheheadcausetheEEGfrequen-
cychangepresentinthebraintochangetotheapplied PEMF fre-
quency - called entrainment. Even very weak PEMFs in the micro
Trangecancauseentrainmentor“synchronization”oftheEEGfre-
quencies[10].Oneofthemoreobviousresultsofapplyingextremely
lowfrequency(ELF)PEMFstimulationtothebrainismoreEEGal-
pha(8-13Hz)activity[11].
Wherever there is electrical activity there are magnetic elds.
Thebrainproduces itsownveryweakmagneticelds.Alphawaves
havebeenmeasuredinhumansbyMagnetoencephalography(MEG).
Thenaturalmagneticeldsofthebrainwillinteractwithexternally
appliedmagnetic elds likePEMFs.The electromagneticforcethat
isgeneratedinthebrainduringrhythmicTMS can cause local en-
trainment of natural brain oscillations. TMS tuned to the alpha (α)
frequency (called α-TMS), entrains alpha-oscillations in the brain
areastimulated, increasing progressivelywiththe durationofexpo-
sure.Thegreater theunderlyingamountofalpha inthebrainbefore
startingstimulation,thefasterandthegreatertheentrainment.These
frequenciescanlookverysimilar tothetypesofbrain rhythmsseen
naturallyduring mental tasks.Theend resultisthat TMSactionon
brainactivitycanresultinbehavioralchangesthatarefrequency-spe-
cic[12].
 Inaddition,researchinGermanyfoundthat10Hz(alpha)entrain-
mentstabilizedcircadianrhythms[13].Useofthisfrequencycanre-
storejetlag and othersleepdisturbances.Circadian rhythm control
thehormoneorchestra of the body andwhentheyare out of align-
mentornotinproperphase,manyproblemsbegintoshowupinthe
bodyrelated topoorhormone function.Stressand anxietyareclear
examples of how they can cause circadian rhythms and brainwave
frequencypatternstobecomedisrupted.So,10Hzstimulationcan
beveryusefulforreducingmoneyofthephysicaleffectsofstressby
balancingcircadiandisruption.
 Intensemagneticeldbrainstimulationhasalsobeenreportedto
affectmonoamineneurotransmitterfunction.Dailyexposureto10Hz
eldsat1.8–3.8milliT(18-38G)increasedsynthesisofdopamineand
5- Hydroxytryptamine (5-HTP) in the frontal cortex of rats. So, in
Citation: Pawluk W (2019) Pulsed Magnetic Field Treatment of Anxiety, Panic and Post-Traumatic Stress Disorders. J Altern Complement Integr Med 5: 075.
• Page 3 of 8 •
J Altern Complement Integr Med ISSN: 2470-7562, Open Access Journal
DOI: 10.24966/ACIM-7562/100075
Volume 5 Issue 3 • 100075
addition to entrainment, alpha frequencies also increase signicant
amountsofneurotransmitterproduction[14].
What is the Evidence those PEMFs can Improve
Anxiety?
 Theevidencecomesfromanimalstudiesandhumanstudiesusing
bothhighintensity(TMS)andlowerintensityPEMFstimulation.
Animal Studies
 Aspecic pulsed low-frequencymagneticeld of 100 microT
peak intensity was studied in a mouse experiment of anxiety.The
micehadareductionof“anxiety-like”behaviors,seenintherst10-
15minutesofexposure.Whencomparedtoarelativelylowdoseofa
classicalanxietymedication,benzodiazepine,behaviorwassimilarly
improvedbythemagnetic eld [15,16]. Rats havealsobeenfound
to have similar results in reducing anxiety levels [17]. PEMF at a
modulationfrequencyof4and 6 Hz in rats signicantly decreased
theemotionally negativereactions ofanxiety andfear by370%and
450%,respectively.Bycontrast,environmentalEMFwithamodula-
tionfrequencyof20Hzsignicantlyincreasedemotionallynegative
reactionsofanxietyandfearby200%[18].
 rTMSonratsselectivelybred for High (HAB) and Low (LAB)
anxiety-related behavior found that rTMS of frontal brain regions
inducesprofoundreductions in acute stress reactionsandhormonal
systemreactions tostress.This onlyhappenedin HABratsand not
in LAB rats. The HAB results were similar to antidepressant drug
treatment[19].
 WhiledataevaluatingforpossibleoriginsofGADandpanicdis-
orderhave beenobtainedusing imagingstudies,tissue studieshave
foundresultstoo.LowintensityPEMFspositivelyaffectsbrain5-Hy-
droxytryptamine(5HT)receptorsat 0.1-2 mT (1-20 G), withabout
50% of the effect at 0.5 mT [20].This means that PEMFs lead to
physiologicalchangesinthecentralnervoussystem,helpfulformood
disorders,wherethe5HTsystemplaysamajorrole.Thismayexplain
thebenets seenwith higherintensityPEMFstimulationintreating
depression.
Human Studies - Low Intensity
 Mostalphabrainstimulationresearchisconductedbystimulating
thebraindirectly.However,stimulatingotherpartsofthebody may
haveanindirectactiononthebrainaswell.AlphaEEGbrainactivity
inhealthyindividuals with PEMFappliedseparately to therightor
lefthandwasincreasedin77%.ThesmallestEEGchangeswereseen
inthosewho were self-reliantandshowed little indicationofstrain
andanxiety.Thegreatestchangeshappenedinthoseshowinganxiety,
constraining activity,and less addictiveness. Other PEMF research
also reveals that healthy cells, tissues or individuals show little re-
sponsetoPEMFs[21].
 Ontheotherhand,verylowintensityPEMFinhealthywomen
appliedsimultaneouslyto2brainareasatthetop ofthe sidesofthe
head for only 9 minutes at 10 Hz (mid-alpha),14 Hz (high alpha)
and18Hz(lowbeta)causedEEGchanges.The10Hzstimulationalso
signicantlysimultaneouslydecreasesbeta(15-25Hz), sensormotor
rhythm(13-15Hz)andtheta(4-8Hz)by12-27%afterexposure.This
studyshowsthatPEMFtothetopoftheheadat10Hzalphaalsode-
creaseshigher anxiety-associated frequencies,adding to theanxiety
treatmentbenet[22].
 Peoplewithothermedicalconditionscanexperiencesignicant
anxiety.A62yroldmalewithParkinson’sdiseaseatage51hadtyp-
icalsymptomsofParkinson’s.Healsoexperiencedsleepdisturbanc-
esand continuousanxiety.He wastreatedwith avery lowintensity
PEMFfor6minutes(2minutesovereachtempleareaand2minutes
overthetop ofhishead). ImmediatelyfollowingPEMF,hereported
decreasedanxiety,completedisappearanceofmuscle aches,marked
elevationsinmoodandlevelofenergy,increasedappetite,andgen-
eralizedfeelingof well-being.Healsohadmarkedimprovementsin
abilitytomovehismuscles.Theeffectsofthissingletreatmentlasted
about3days.Becauseofthistreatmentsuccesshebegansimilarmag-
neticeldtreatmentsathomenightlyusingaportabledevice[23].
 WhilePEMFsmaybehelpful inthemanagementofanxietydis-
orders,whether appliedlocallyor tothewhole body,someofthese
effects may be due to coincidental stimulation of the acupuncture
pointsunderthemagneticapplicator.Asearlyas1990,PEMFshave
been used in the local treatment of so-called biologically active
points (BAP; acupuncture points or “acupoints”). They called this
“Magnetic Puncture” (MP). In addition to coincidental stimulation
of acupuncture points, small and focused magnetic applicators can
beapplied directly toverysmall acupuncturepoints.This approach
wasused inmen withduodenalulcers,well-knownto becaused by
signicantlevels ofanxietyandstress.BAPs forgeneral adaptation
wereexposedfor1minute.Painand dyspepsiawerecontrolledin3
daysandulcerhealingin18days,9daysfasterthanamedicationonly
group.CombiningMP and medicationtherapyactuallytook longer
tocontrolpainanddyspepsia(9daysandsixdays,respectively)and
healingtimewasthesame. MP therapy,like needle or electro-acu-
puncture,effectively controlledanxiety.The authorsstatedthatcor-
rectionofanxiety-relatedautonomicnervoussystemdysfunctionwas
thephysiologicalmechanismofthetherapeuticeffectofMP[24].
 LowEnergyEmission Therapy(LEET)isa way of givingther-
apeuticlow levelsof electromagneticenergy.Electricaldeviceslike
theLEETdeliverbothanelectricalandamagneticeld.Itisimpossi-
bletosegregatewhichcomponentisproducingtheresults.Therefore,
itiscommonlybelievedthatelectrostimulationsystemsproducevery
similarresultsbiologicallytoPEMFsystems,throughacoupleofdif-
ferentmutuallyhelpfulmechanisms.SowhathappenswiththeLEET
isalsolikelytohappenwithPEMFs.
 TheLEETisabattery-powereddeviceemittingacarrierfrequen-
cyof27.12MHz,modulatedatspecicfrequenciesbetween0.5and
300Hz.LEETisapplied inthemouthbyanelectricallyconducting
mouthpiece.The backofthe palate isveryclose tothespinal cord.
This where the ReticularActivating System (RAS) is located. The
RAScontrolssleepdepth.
 Healthyvolunteersreceived 15-minutes of either activeofinac-
tiveLEET.EEGsduringthe15-minperiodfollowingLEETtreatment
showedadecreasedtimetofallasleepanddeepersleepthanplacebo
andimproved feelings ofrelaxation.LEET wasalsotested onindi-
viduals with chronic anxiety.They received a 15-minute treatment
inthe morning anda30-minute treatment intheevening everyday
for six weeks.Anxiety measured with the Hamilton Anxiety Scale
(HAM-A)improvedbymorethan50%in 61%of theindividualsat
theendoftherstweekandin90%bytheendofthethirdweek[25].
Unfortunately,whileLEETiseffectiveforsleepandanxiety,itisnot
commerciallyavailable.
Citation: Pawluk W (2019) Pulsed Magnetic Field Treatment of Anxiety, Panic and Post-Traumatic Stress Disorders. J Altern Complement Integr Med 5: 075.
• Page 4 of 8 •
J Altern Complement Integr Med ISSN: 2470-7562, Open Access Journal
DOI: 10.24966/ACIM-7562/100075
Volume 5 Issue 3 • 100075
 LikeLEET,CranialElectroStimulation(CES)maybeconsidered
a form of PEMF stimulation. CES has been used as an alternative
therapy for the treatment of insomnia, anxiety,and depression and
avariety of other conditions and symptoms worldwide. One group
conductedareviewofrandomized,controlledstudiestoevaluatethe
efcacyof CESfor selectedpsychological andphysiologicalcondi-
tions. Eight studies were for CES to treat anxiety,2 to treat brain
dysfunction,2totreatheadaches,and2totreatinsomnia.Analysisfor
treatinganxiety showedCES tobesignicantlymoreeffectivethan
shamtreatment[26].
 CESwas alsotestedfor itsabilityto relieveanxietyin morese-
verely affected psychiatric inpatients. They received either active
CESor placebostimulation. Stimulationwasat100Hz for30 min-
utesforvesessionsonconsecutivedays.They wereretestedsixto
ninedaysfollowingthelasttreatment.TheactiveCESgroupshowed
signicantlygreateranxietyreductionthanthecontrolgroup[27].
 Amore complicatedgroupof individuals withanxietyare those
who are chemically dependent. The more severe need treatment in
a hospital setting. Chemically dependent hospital in patients was
evaluatedfortheeffectivenessofCESinadouble-blindstudy.About
60%werealcoholabusersand40%weresingleorpoly-drugabusers.
CESwasat100Hzappliedthroughelectrodesplacedjustbehindthe
earlobe. Fifteen 30-minute treatment/sham treatment sessions were
giventoeach person, once a day for3weeksexcluding weekends.
Sham-treatedpeoplehad minimal improvement.Those treated with
CEShadsignicantlyreducedanxietylevelscomparedtotheirinitial
levelon everyanxietymeasure. So,even thischallengingtreatment
group,commonlyresistanttomostforms oftherapy,benetedfrom
thisformofelectromagnetictherapy[28].
Human Studies - High Intensity
 SomestudiesshowbenetusingrTMSinthetreatmentofGAD.
rTMSappliedtotherightforeheadareaatlowfrequencywasfound
tobeeffectiveinrelievingdepressionandpanicsymptoms,andaddi-
tionallyitreducedthecorticalexcitabilityassociatedwithanxiety.On
theotherhand,treatmentwith lowfrequencyrTMS(<10Hz)ofthe
rightupperforeheadinpanicdisorderpatientsunderSSRImedication
hasbeennotsignicant[29].
Anxiety can occur in people with other psychiatric disorders.
Reducingtheiranxietycan often have an impactontheunderlying
condition as well.A study in which 1-Hz, 1-T rTMS was given to
schizophrenicandmajordepressionpatientsfor10daysreportedthat
thedepressedpatientsappearedtoshowimprovementsinmoodand
theschizophrenicpatients showed somedecreasein their degreeof
anxietyandrestlessness[30].
 Inindividuals withmajor depression,taken offtheir usualmedi-
cations,singlesessionrTMSmadethemfeelmorerelaxedorcalmer
aftertreatment,butthiseffectdisappearedbynextmorning[31].
 High-frequency20 Hz (HFrTMS),as anadd-onanti-depressive
treatment,was usedin individualswith medication-resistantdepres-
sionandanxiety.They continued their regular medication. Patients
weredividedinto2groupstoreceiveHFrTMSorplacebotreatment
for two weeks with two weeks of follow-up in a randomized dou-
ble-blinddesign. Next,rTMS wasoffered fortwo weeksto patients
whofailedtoimproveor who were in the placebo group. Eachre-
ceived 10 sessions of HF rTMS treatment on consecutive days.
TheywereallassessedbytheHamiltonAnxietyRatingScale(HARS)
at baseline and after weeks 1, 2, and 4. Real HF rTMS decreased
HARSscoressignicantlymoreinHARSscoresinbothgroupsafter
therst week.This amountedto a34fold, 18fold, and10foldim-
provementbetweenthescores,byweek,respectively[32].
 Apregnantwomanwithclinicaldepressionwassuccessfullytreat-
edwithrTMSduringweek19ofherpregnancy.Shereportedexperi-
encinganacutepanicattackwithbeinginopenspaces(agoraphobia)
while recovering from bronchitis. Her symptoms rapidly worsened
over the course of several days to include depressed and anxious
mood,severerestlessnessand insomnia, constant anxiety about the
healthofherbaby,obsessivefeelingsaboutherlackofappetite,and
fearaboutbeinghospitalizedforherbronchitis.Atthetimeofevalu-
ation,shewasunabletositstill,wasconstantlypacingandclenching
hersts,haddifcultymaintainingfocus,andcouldmaintainacon-
versationonlywithdifculty.An extensive medical and obstetrical
workupruled outanymedicalcausefor hersymptoms.She refused
antidepressant medications because of their unknown effect on her
fetusanddecidedtotry1sessionperweekofactivecounseling.She
hadonlyminimalimprovementafter2weeks, anddecided toenroll
inanrTMSstudy.
 Atweek22ofpregnancy,shereceivedactivelowfrequencyrTMS
onceadayfor5daysovera9-day period at 5-Hz, for 20 minutes
eachtime.rTMSproducednochangesinherbloodpressure,oxygen
saturation, or heart rate.After the 2nd week treatment session, she
wastaperedoffrTMSoverthecourseof5sessions(totalof14days
oftreatment over3 weeks).She toleratedthe treatmentwell andre-
peatedlyexperiencedacalmingeffectaround12minutesintotherst
treatmentsessionand reported being “relaxed andtired”.Onday 6
ofstimulation,thisrelaxedeffectoccurredaround3minutesintothe
session.Anxietyreturnedto normal. Shealsoshowed improvement
inheragoraphobia. For example,onher rst weekendoftreatment
shewent shoppingwitha friendandattended anengagementparty.
After 9 days of treatment, she attended a job meeting out of town
andhasnot experienced anyrecurrenceofher anxieties. Hermood
becamebright,conversationmoreelaborate,andshewasminimally
preoccupiedwithherbody.Periodicfollow-upevaluationsindicated
thatsheremainedinremission.Shedeliveredahealthy(3.4-kg)baby
boyat term.rTMS maybe consideredin circumstancessuch asthis
becauseitinvolvesnofetalexposuretoanesthesia,usedwithECT,or
tomedications[33].
Post-Traumatic Stress Disorder (PTSD)
 PTSDisoftenconsideredatypeofanxietydisorder.Inthestrictest
senseit is consideredtobe the psychologicalandemotional effects
following experiencing or observing trauma. In the broadest sense
PTSDresultsfrom symptomsarisingfrom anynegativepsychologi-
caleventorevents.Itischaracterizedbysymptomsthatappearsud-
denly,cause psychological withdrawal and hyper arousal that may
resultinsignicantsocialoroccupationaldysfunction.Itisestimated
that 8% of the United States population experience PTSD in their
lifetimeanditisestimatedthatitcausesimpairedabilitytoworkthat
costs in excess of $3 billion per year in lost productivity.There is
nodenitive medicaltreatment forcorePTSDsymptoms.Although
medications and psychotherapy have been shown to help reduce
symptomsandtreatcomorbidanxietyanddepressivesymptoms,in
onethirdofindividualsthereisnoimprovementinsymptoms.
Citation: Pawluk W (2019) Pulsed Magnetic Field Treatment of Anxiety, Panic and Post-Traumatic Stress Disorders. J Altern Complement Integr Med 5: 075.
• Page 5 of 8 •
J Altern Complement Integr Med ISSN: 2470-7562, Open Access Journal
DOI: 10.24966/ACIM-7562/100075
Volume 5 Issue 3 • 100075
In PTSD, EEG studies have shown alpha decreases in the right
hemisphere compared to control groups while they are exposed to
trauma-related pictures. These ndings have been corroborated by
SPECTstudies thathaveshown brainblood ow tothe righthemi-
sphereis increasedinPTSD whentheyhear trauma-relatedsounds.
Trauma-related stimuli during visual memory tests in combat vet-
eranswithoutPTSDandcombatveterans with PTSD are different.
Thereisgreateractivationintherightfrontalbraincomparedtothe
control group in PTSD. PTSD patients may require more effort to
ignoreemotionallydistractingstimuli[34].Thesendingsmeanthat
peoplewithPTSDcouldbenetfromPEMFtreatment.
Relatively few studies have investigated the effects of TMS on
anxietydisorders,andevenfewerinPTSD.InPTSDpatients,one
sessionof single-pulseTMSappliedover thetop ofthe headfor 15
minutesproducedasignicantimprovementthatlasted24hrs.How-
ever, the symptoms returned to baseline by 7 days after treatment.
PTSDanddepressionshowdifferentbrainchangesonimagingstud-
ies[35].
 OnestudydescribedIndividualswithaccidents,combatreactions
andassault,experiencingtheirtraumaaboutsixyearsearlieronaver-
age.Amajoritywerebeingtreatedwithmedications.Inaddition,they
receivedasingleTMStreatmentwith30stimuli,maximumoutputof
25,000gauss(2.5T)overthetopofthehead.Resultswereassessed
at2hoursbeforetreatment(baseline),24hours,1week,and28days
aftertreatment.Allindividualsshowedsignicant improvements in
symptoms during the rst 24 hours after TMS which gradually re-
turnedtobaselinelevels.Psychologicalwithdrawalsymptoms,which
arecorePTSDsymptoms,weresignicantlydecreasedforupto7
daysafterTMS.Anxietyandphysicalpreoccupationweresignicant-
lydecreasedafter24hoursandthedecreaseinthephysicalpreoccu-
pationpersisted for28days.So,even witha singleTMS treatment,
PTSDsymptoms improvedmarkedly.Multiplecourses oftreatment
would be expected to produce more enduring results [36]. Similar
higherintensityPEMFdevicesarenowavailableforhomeusefor
bothinitialtreatmentandmaintenance.
 Anotherpaperdescribed2peoplewithPTSDinwhomrTMSap-
peared to normalize the hyper metabolic areas around their limbic
system. One was a 29-yr woman with a 12-year history stemming
fromtraumaticevents when she wasbetween8and 12. Her symp-
tomsincludeddepressed mood,cognitivedysfunctionwith poorat-
tentionskills, irritability,chronic fatigue,decreasedappetite, abnor-
malsleeppatterns, frequent senseofnot feeling herself,unpleasant
memoriesthat would intrudeonother thoughts,andoccasional sui-
cidalthoughts.Theotherwasa42-yearoldwomanwithPTSDfor2.5
years, associated with a shooting incident. Her symptoms included
ashbacks, sleep disturbances, exaggerated startle responses, pan-
icattacks, depression andirritability.Bothwomenhad beentreated
withavarietyofmedicationswithonlyminimalimprovement.1-Hz
rTMSwasfor20minutes/day,seventeentreatments3timesperweek
fortherst2weeks,thenincreasedto5timesweekly.Improvement
in symptoms was more pronounced during the second half of the
4-weektreatmentperiod.FrequencyofPTSDsymptomswassigni-
cantly decreased and personal sense of cognitive clarity improved.
ThebenetsofrTMSslowlyreducedandPTSDsymptomsgradually
returnedtobaseline1monthafterthelastrTMSsession.The42-year-
oldwomanwastreatedwith30sessions ofright frontal1-HzrTMS
given20minutesdaily,3-4times/weekfor3weeksthenincreasedto
4-5times/weekfor another 3 weeks. Duringtreatmentshehad sig-
nicant symptomatic improvement. She felt greatest improvement
in symptoms when treatments were more given more frequently.
Her symptoms returned to baseline 1 month after rTMS ended. In
both women, regional brain metabolic rates were measured before
andwithin24hrafterthenalrTMStreatmentbyPETscans.rTMS
causedoverall decreases in hyper-excitedbrainmetabolism toward
normal.Themostprominentdecreaseswereseenovertherighthemi-
sphere[37].
Low-frequency TMS (1 Hz) is inhibitory, and high frequency
TMS(frequency above10 Hz)isrelativelyexcitatoryto underlying
braintissue.Areviewpaperofverandomizedclinicaltrialsstudying
118individualsfoundthat activeTMSwas signicantlysuperiorto
shamTMSfortreatmentofcorePTSDsymptoms[34].
Caution: EMFs Can Make Anxiety Worse
 Sofar,emphasis hasbeen on the therapeutic actions of PEMFs
onanxiety.It appearsthatindividualsliving near power lines, who
aresufferingfromsignicantanxietydisorders,needtobeevaluated
forthepossibilityofEMFexposureintheirresidences,asapotential
contributingfactorfor their anxiety.Over the range of 50-Hzmag-
neticuxdensitiesencounteredinhomes(>1-100mG),longermag-
netic-eldexposure maybeassociated withpoorer healthandmore
“chronicanxiety”symptoms,consistentwithadirecteffectofchronic
50-Hzmagneticeldexposureonthenervoussystem[38].
From clinical experience, some individuals, regardless of how
muchtheytrytoreducetheiranxietywithanyparticulartherapeutic
approach,justdo not respond.Manytimes this canactuallybe due
tothebackgroundEMFsin theirenvironment[39].Asnotedabove,
EMFsinthehomeenvironment,thatwouldenterthebedroominpar-
ticular, can be potent irritants to the nervous system, especially in
electrosensitive individuals[40].Unless theseEMFsare dealtwith
andreducedoreliminated,itbecomesverychallengingforanytreat-
menttowork.
Conclusion
 Thetreatment of anxiety,panicdisordersand PTSD leavemuch
tobedesired.Alternative therapiesareneededandavailable. Brain
stimulation using Electromagnetic Fields (PEMFs) have numerous
physiologicactionswhichcontributetoabenettohelpingwiththese
conditions.Theyalsoappeartosatisfyanimportantconditionofsafe-
tyandlowrisk, along with effectiveness.PEMFs,includinghigher
andlowerintensityPEMFs,havebeenfoundtobeveryhelpfulinthe
treatmentofanxietydisorders,includingPTSD.ThevalueofPEMFs
isthatthereis a great potential for ongoingPEMFtherapiesinthe
homesettingtoprovideenduringandlong-lastingbenetswithcon-
tinuedtreatment.Thiscanbedonewithshort-termhometreatments
orpotentiallywithlongertimesofusewithportablePEMFsystems
applyingprimarily alphabrainwave stimulation.These home-based,
longer-term PEMF approaches would appear to produce the most
benet.Nevertheless,sinceanxietydisordersarecomplex,combina-
tionapproaches,includingcognitivebehavioraltherapyandmedica-
tions,maywellbenecessarytoproducethebestresultsandlong-term
use may be necessary.Another benet of commercially available,
portable,battery-operatedPEMFdevicesofaround200-700Gaussis
theabilitytodotreatmentathomethroughoutthenighttotheheador
underthepillowtoenhancesleepandanxietydisorders.Whilethese
Citation: Pawluk W (2019) Pulsed Magnetic Field Treatment of Anxiety, Panic and Post-Traumatic Stress Disorders. J Altern Complement Integr Med 5: 075.
• Page 6 of 8 •
J Altern Complement Integr Med ISSN: 2470-7562, Open Access Journal
DOI: 10.24966/ACIM-7562/100075
Volume 5 Issue 3 • 100075
arenotaspowerfulasthehighintensityTMSdevices,theyaremore
affordableandpersonallycommerciallyaccessible.
Conict of Interest Statement
Dr.William Pawluk owns a website www.drpawluk.com which
hascommerciallyavailable PEMFdeviceswithcharacteristicssimi-
lartosomeofthemagneticeldsmentionedinthisreview.
References
1. MachadoS, Paes F,VelasquesB, TeixeiraS, PiedadeR,et al.(2012)Is
rTMSaneffectivetherapeutic strategy that can be used to treatanxiety
disorders?Neuropharmacology62:125-134.
2. BudzynskiT,BudzynskiH, EvansJ,AbarbanelA(2009)Introductionto
quantitative EEG and neurofeedback: advanced theory and applications
(2ndedn).Elsevier,Amsterdam,Netherlands.
3. NadigaDN,HensleyPL,Uhlenhuth EH(2003) Reviewofthelong-term
effectivenessofcognitivebehavioral therapycomparedtomedicationsin
panicdisorder.DepressAnxiety17:58-64.
4. Mayo-WilsonE,DiasS,MavranezouliI,KewK,ClarkDM,etal.(2014)
Psychological and pharmacological interventions for social anxiety dis-
order in adults: a systematic review and network meta-analysis. Lancet
Psychiatry1:368-376.
5. Saeed SA, Bloch RM,Antonacci DJ (2007) Herbal and dietary supple-
mentsfortreatmentofanxietydisorders.AmFamPhysician76:549-556.
6. BaldwinD,WoodsR,LawsonR,TaylorD(2011)Efcacyofdrug treat-
mentsforgeneralised anxietydisorder:systematic reviewandmeta-anal-
ysis.BMJ342:1199.
7. RoblesBayónA,GudeSampedro F (2014) Inappropriatetreatmentsfor
patientswithcognitivedecline.Neurologia29:523-532.
8. MavranezouliI,MeaderN,CapeJ,Kendall T(2013)The costeffective-
nessofpharmacologicaltreatmentsforgeneralizedanxietydisorder.Phar-
macoeconomics31:317-333.
9. NiedermeyerE(1999)TheNormalEEGoftheWakingAdult.Lippincott
WilliamsandWilkins,Baltimore,Philadelphia,Pennsylvania,USA.
10.Persinger MA, Hoang V, Baker-Price L (2009) Entrainment of stage 2
sleepspindlesby weak,transcerebralmagnetic stimulationinan “epilep-
tic”woman.ElectromagnBiolMed.28:374-382.
11.BellGB,MarinoAA,ChessonAL,StruveFA(1991)Humansensitivityto
weakmagneticelds.Lancet338:1521-1522.
12.ThutG,VenieroD,RomeiV,MiniussiC,SchynsP,etal.(2011)Rhythmic
TMScauseslocalentrainment ofnaturaloscillatorysignatures.CurrBiol
21:1176-1185.
13.WeverRA (1985) The Electromagnetic Environment and the Circadian
Rhythmsof HumanSubjects. In:GrandolfoM.,MichaelsonS.M., Rindi
A.(eds)BiologicalEffectsandDosimetryofStaticandELFElectromag-
neticFields.EttoreMajoranaInternationalScienceSeries.Springer,Bos-
ton,MA,USA.
14.SierońA,LabusŁ,NowakP,CieślarG,BrusH,etal.(2004)Alternating
extremelylowfrequency magnetic eld increasesturnoverof dopamine
andserotonininratfrontalcortex.Bioelectromagnetics25:426-430.
15.CholerisE,ThomasAW,Prato FS(1999)Acomparisonoftheeffectsof
a100ut specic pulsed magneticeld and diazepam onanxiety-related
behaviors in male CF1 mice. Bioelectromagnetics Society,21st Annual
Meeting,20-24June,LongBeach,CA,AbstractNo.91:129-130.
16.CholerisE,ThomasAW,OssenkoppK,Kavaliers M, ValsecchiP,etal.
Sexdifferencesinconditionedtasteaversionandintheeffectsofexposure
toaspecicpulsed magneticeldindeermicePeromyscusManiculatus.
PhysiolBehav71:237-249.
17.KalkanMT,Korpinar MA,Seker S,BirmanH, HacibekirogluM (1998)
The effect of the 50 Hz frequency sinusoidal magnetic eld on the
stress-relatedbehaviorofrats.Proceedings ofthe 19982ndInternational
ConferenceBiomedicalEngineeringDays,Istanbul,Turkey78-81.
18.SemenovaTP,MedvinskaiaNI,BliskovkaGI,AkoevIG(2000)Inuence
ofelectromagneticeldsontheemotionalbehaviourofrats.RadiatsBiol
Radioecol40:693-695.
19.KeckME, WeltT,PostA,Müller MB,ToschiN, etal. (2001)Neuroen-
docrineandbehavioraleffectsofrepetitivetranscranialmagneticstimula-
tionina psychopathological animalmodelare suggestive ofantidepres-
sant-likeeffects.Neuropsychopharmacology24:337-349.
20.MassotO,GrimaldiB,BaillyJM,KochanekM,DeschampsF,etal.(2000)
Magneticeld desensitizes5-HT(1B) receptorin brain:pharmacological
andfunctionalstudies.BrainRes858:143-150.
21.SelitskiiGV, KarlovVA, Sorokina ND(1996)Mechanisms of magnetic
eldreceptioninthehumanbrain.FiziolCheloveka22:66-72.
22.AmirifalahZ,FiroozabadiSM,ShaeiSA(2013)Localexposureofbrain
centralareasto a pulsed ELF magneticeldfor a purposeful change in
EEG.ClinEEGNeurosci44:44-52.
23.Sandyk R, TsagasN, Anninos PA, Derpapas K (1992) Magneticelds
mimicthe behavioral effectsof REM sleepdeprivation in humans.Int J
Neurosci65:61-68.
24.KravtsovaTIu,RybolovlevEV,KochurovAP(1994)Theuseofmagnet-
icpuncturein patientswithduodenalpepticulcer.VoprKurortolFizioter
LechFizKult22-24.
25.PascheB(2000)Lowenergyemissiontherapy(leet) forthetreatmentof
insomniaandanxiety.BioelectromagneticsSociety,22ndAnnualMeeting,
11-16June,Munich,Germany,AbstractNo.P-151,p.240-241.
26.Klawansky S,YeungA, Berkey C, Shah N, Phan H,, et al. (1995) Me-
ta-analysis of randomized controlled trials of cranial electrostimulation.
Efcacyintreatingselectedpsychologicalandphysiologicalconditions.J
NervMentDis183:478-484.
27.Ryan JJ, Souheaver GT (1976) Effects of transcerebral electrotherapy
(electrosleep)onstateanxietyaccordingtosuggestibilitylevels.BiolPsy-
chiatry11:233-237.
28.SchmittR,CapoT,BoydE(1986)Cranialelectrotherapystimulationasa
treatmentforanxiety inchemicallydependent persons.AlcoholClinExp
Res10:158-160.
29.DurmazO,AtesD(2013)AReviewofRepetitiveTranscranialMagnetic
StimulationUseinPsychiatry.DisMolMed1:77-86.
30.WassermannEM, Lisanby SH (2001) Therapeutic application of repeti-
tivetranscranial magnetic stimulation:areview.ClinNeurophysiol 112:
1367-1377.
31.SzubaMP,O’ReardonJP,RaiAS,Snyder-KastenbergJ,AmsterdamJD,et
al.(2001)Acutemoodandthyroidstimulatinghormoneeffectsoftranscra-
nialmagneticstimulationinmajordepression.BiolPsychiatry50:22-27.
32.Garcia-ToroM,MayolA,ArnillasH,CapllonchI,IbarraO,etal.(2001)
Modestadjunctivebenetwithtranscranialmagneticstimulationinmedi-
cation-resistantdepression.JAffectDisord64:271-275.
33.Nahas Z, Bohning DE, Molloy MA, Oustz JA, Risch SC, et al. (1999)
Safetyandfeasibilityofrepetitivetranscranialmagneticstimulationinthe
treatmentof anxious depressionin pregnancy: acase report. JClin Psy-
chiatry60:50-52.
34.TrevizolAP,Barros MD, Silva PO, Osuch E, Cordeiro Q, et al. (2016)
Transcranialmagneticstimulationforposttraumaticstressdisorder:anup-
datedsystematicreviewandmeta-analysis.TrendsPsychiatryPsychother
38:50-55.
35.LisanbySH,Kinnunen LH, CrupainMJ(2002)Applicationsof TMS to
therapyinpsychiatry.JClinNeurophysiol19:344-360.
Citation: Pawluk W (2019) Pulsed Magnetic Field Treatment of Anxiety, Panic and Post-Traumatic Stress Disorders. J Altern Complement Integr Med 5: 075.
• Page 7 of 8 •
J Altern Complement Integr Med ISSN: 2470-7562, Open Access Journal
DOI: 10.24966/ACIM-7562/100075
Volume 5 Issue 3 • 100075
36.GrisaruN,AmirM,CohenH,KaplanZ(1998)Effectoftranscranialmag-
neticstimulationinposttraumaticstressdisorder:apreliminarystudy.Biol
Psychiatry44:52-55.
37.McCann UD, Kimbrell TA, Morgan CM (1998) Repetitive transcranial
magneticstimulation forposttraumatic stressdisorder.ArchGen Psychi-
atry55:276-279.
38.BealeIL,PearceNE,ConroyDM,HenningMA,MurrellKA(1995)Psy-
chologicaleffectsofchronicexposureto50Hzmagneticeldsinhumans
livingnearextra-high-voltagetransmissionlines.Bioelectromagnetics18:
584-594.
39.HussA,KüchenhoffJ,BircherA,HellerP,KusterH,etal.(2004)Symp-
tomsattributedtotheenvironment--asystematic,interdisciplinaryassess-
ment.IntJHygEnvironHealth207:245-254.
40.BaliatsasC,Van KampI,LebretE,Rubin GJ(2012) Idiopathicenviron-
mentalintolerance attributedtoelectromagnetic elds(IEI-EMF): asys-
tematicreviewofidentifyingcriteria.BMCPublicHealth12:643.
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... It has been indicated that long-term exposure of either ELF-MF or low-frequency pulsed EMF improved depression-like behaviors in rodents [Ansari et al., 2016;Yang et al., 2019]. Besides, pulsed EMF exposure has been shown to reduce anxiety-like behaviors in animals and humans [Pawluk, 2019]. Moreover, radiofrequency exposure in pregnant dams had an anxiolytic effect on the offspring [Aldad et al., 2012]. ...
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Prenatal exposure to stress predisposes offspring to mental health problems in adulthood. However, the underlying mechanisms remain obscure. The prefrontal cortex's (PFC) role is vital in regulating sleep and mood. Cryptochrome type 2 (CRY2), as a magnetoreceptor and an important part of the circadian system, has been linked to depression and anxiety. We aimed to determine CRY2 role in prenatal stress and extremely low-frequency electromagnetic fields (ELF-EMF) on the PFC of rat offspring and its relationship with behavior. Female Wistar rats were exposed to chronic mild stress (CMS) or electromagnetic field (EMF) (50 Hz, 100 μT, 4 h/day) for 21 days before and during pregnancy. Behavioral tests, including the elevated plus maze, open field, and forced swimming test, were conducted on the male offspring at postnatal day (PND) 80, 81, 90. The expressionof CRY2 in the PFC and levels of serum corticosterone (CORT) were also measured. The results showed that maternal stress exposure caused anxiety- and depression-like behaviors in the male offspring, accompanied by decreased prefrontal CRY2 protein expression and increased serum CORT levels. In addition, maternal EMF had no significant effect on CRY2 expression in the male offspring. However, parallel ELF-EMF and stress exposure significantly attenuated anxiety and depression-like behaviors and decreased serum CORT levels.
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Introduction Transcranial magnetic stimulation (TMS) is a promising non-pharmacological intervention for posttraumatic stress disorder (PTSD). However, randomized controlled trials (RCTs) and meta-analyses have reported mixed results. Objective To review articles that assess the efficacy of TMS in PTSD treatment. Methods A systematic review using MEDLINE and other databases to identify studies from the first RCT available up to September 2015. The primary outcome was based on PTSD scores (continuous variable). The main outcome was Hedges' g. We used a random-effects model using the statistical packages for meta-analysis available in Stata 13 for Mac OSX. Heterogeneity was evaluated with I² (> 35% for heterogeneity) and the χ² test (p < 0.10 for heterogeneity). Publication bias was evaluated using a funnel plot. Meta-regression was performed using the random-effects model. Results Five RCTs (n = 118) were included. Active TMS was significantly superior to sham TMS for PTSD symptoms (Hedges' g = 0.74; 95% confidence interval = 0.06-1.42). Heterogeneity was significant in our analysis (I² = 71.4% and p = 0.01 for the χ² test). The funnel plot shows that studies were evenly distributed, with just one study located marginally at the edge of the funnel and one study located out of the funnel. We found that exclusion of either study did not have a significant impact on the results. Meta-regression found no particular influence of any variable on the results. Conclusion Active TMS was superior to sham stimulation for amelioration of PTSD symptoms. Further RCTs with larger sample sizes are fundamental to clarify the precise impact of TMS in PTSD.
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Background Social anxiety disorder—a chronic and naturally unremitting disease that causes substantial impairment—can be treated with pharmacological, psychological, and self-help interventions. We aimed to compare these interventions and to identify which are most effective for the acute treatment of social anxiety disorder in adults. Methods We did a systematic review and network meta-analysis of interventions for adults with social anxiety disorder, identified from published and unpublished sources between 1988 and Sept 13, 2013. We analysed interventions by class and individually. Outcomes were validated measures of social anxiety, reported as standardised mean differences (SMDs) compared with a waitlist reference. This study is registered with PROSPERO, number CRD42012003146. Findings We included 101 trials (13 164 participants) of 41 interventions or control conditions (17 classes) in the analyses. Classes of pharmacological interventions that had greater effects on outcomes compared with waitlist were monoamine oxidase inhibitors (SMD −1·01, 95% credible interval [CrI] −1·56 to −0·45), benzodiazepines (−0·96, −1·56 to −0·36), selective serotonin-reuptake inhibitors and serotonin–norepinephrine reuptake inhibitors (SSRIs and SNRIs; −0·91, −1·23 to −0·60), and anticonvulsants (−0·81, −1·36 to −0·28). Compared with waitlist, efficacious classes of psychological interventions were individual cognitive–behavioural therapy (CBT; SMD −1·19, 95% CrI −1·56 to −0·81), group CBT (−0·92, −1·33 to −0·51), exposure and social skills (−0·86, −1·42 to −0·29), self-help with support (−0·86, −1·36 to −0·36), self-help without support (−0·75, −1·25 to −0·26), and psychodynamic psychotherapy (−0·62, −0·93 to −0·31). Individual CBT compared with psychological placebo (SMD −0·56, 95% CrI −1·00 to −0·11), and SSRIs and SNRIs compared with pill placebo (−0·44, −0·67 to −0·22) were the only classes of interventions that had greater effects on outcomes than appropriate placebo. Individual CBT also had a greater effect than psychodynamic psychotherapy (SMD −0·56, 95% CrI −1·03 to −0·11) and interpersonal psychotherapy, mindfulness, and supportive therapy (−0·82, −1·41 to −0·24). Interpretation Individual CBT (which other studies have shown to have a lower risk of side-effects than pharmacotherapy) is associated with large effect sizes. Thus, it should be regarded as the best intervention for the initial treatment of social anxiety disorder. For individuals who decline psychological intervention, SSRIs show the most consistent evidence of benefit. Funding National Institute for Health and Care Excellence.
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Introduction: Some treatments are inappropriate for patients with cognitive decline. We analyse their use in 500 patients and present a literature review. Development: Benzodiazepines produce dependence, and reduce attention, memory, and motor ability. They can cause disinhibition or aggressive behaviour, facilitate the appearance of delirium, and increase accident and mortality rates in people older than 60. In subjects over 65, low systolic blood pressure is associated with cognitive decline. Maintaining this figure between 130 and 140 mm Hg (145 in patients older than 80) is recommended. Hypocholesterolaemia < 160 mg/dl is associated with increased morbidity and mortality, aggressiveness, and suicide; HDL-cholesterol<40 mg/dl is associated with memory loss and increased vascular and mortality risks. Old age is a predisposing factor for developing cognitive disorders or delirium when taking opioids. The risks of prescribing anticholinesterases and memantine to patients with non-Alzheimer dementia that is not associated with Parkinson disease, mild cognitive impairment, or psychiatric disorders probably outweigh the benefits. Anticholinergic drugs acting preferentially on the peripheral system can also induce cognitive side effects. Practitioners should be aware of steroid-induced dementia and steroid-induced psychosis, and know that risk of delirium increases with polypharmacy. Of 500 patients with cognitive impairment, 70.4% were on multiple medications and 42% were taking benzodiazepines. Both conditions were present in 74.3% of all suspected iatrogenic cases. Conclusions: Polypharmacy should be avoided, if it is not essential, especially in elderly patients and those with cognitive impairment. Benzodiazepines, opioids and anticholinergics often elicit cognitive and behavioural disorders. Moreover, systolic blood pressure must be kept above 130 mm Hg, total cholesterol levels over 160 mg/dl, and HDL-cholesterol over 40 mg/dl in this population.
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Background Idiopathic environmental intolerance attributed to electromagnetic fields (IEI-EMF) remains a complex and unclear phenomenon, often characterized by the report of various, non-specific physical symptoms (NSPS) when an EMF source is present or perceived by the individual. The lack of validated criteria for defining and assessing IEI-EMF affects the quality of the relevant research, hindering not only the comparison or integration of study findings, but also the identification and management of patients by health care providers. The objective of this review was to evaluate and summarize the criteria that previous studies employed to identify IEI-EMF participants. Methods An extensive literature search was performed for studies published up to June 2011. We searched EMBASE, Medline, Psychinfo, Scopus and Web of Science. Additionally, citation analyses were performed for key papers, reference sections of relevant papers were searched, conference proceedings were examined and a literature database held by the Mobile Phones Research Unit of King’s College London was reviewed. Results Sixty-three studies were included. “Hypersensitivity to EMF” was the most frequently used descriptive term. Despite heterogeneity, the criteria predominantly used to identify IEI-EMF individuals were: 1. Self-report of being (hyper)sensitive to EMF. 2. Attribution of NSPS to at least one EMF source. 3. Absence of medical or psychiatric/psychological disorder capable of accounting for these symptoms 4. Symptoms should occur soon (up to 24 hours) after the individual perceives an exposure source or exposed area. (Hyper)sensitivity to EMF was either generalized (attribution to various EMF sources) or source-specific. Experimental studies used a larger number of criteria than those of observational design and performed more frequently a medical examination or interview as prerequisite for inclusion. Conclusions Considerable heterogeneity exists in the criteria used by the researchers to identify IEI-EMF, due to explicit differences in their conceptual frameworks. Further work is required to produce consensus criteria not only for research purposes but also for use in clinical practice. This could be achieved by the development of an international protocol enabling a clearly defined case definition for IEI-EMF and a validated screening tool, with active involvement of medical practitioners.
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Although conditioned taste aversion (CTA) has been investigated and described in laboratory rodents and domestic animals, less is known regarding wild rodents. Here, we describe CTA in males and females of a “wild” species of rodent, the deer mouse (Peromyscus maniculatus). In addition, as CTA has often been induced by exposure to intense electromagnetic, X or γ, radiation, in a second study, we also investigated the effects of a specifically designed, pulsed extremely low-frequency and low-intensity magnetic field on the flavor preferences of male and female deer mice. The results of these investigations showed that: (i) deer mice quickly developed a marked CTA for a novel flavor after a single pairing with LiCl; (ii) although the intensity of the CTA was the same in males and females, there was a sex difference in the duration of the flavor aversion, with males displaying it for a longer period (4 days) than females (3 days); (iii) both males and females showed a rapid and complete extinction of the aversion, in contrast to what has been reported for laboratory rodents; (iv) there was no recovery of CTA on re-test 10 days after extinction; (v) neither male or female deer mice developed a taste aversion as a consequence of exposure to a weak electromagnetic field; and (vi) there was a sex difference in response to the magnetic field, with exposure to the magnetic field significantly enhancing novel taste preference in male but not in female deer mice. Overall, our results show that there are several sex differences in the behavior of deer mice, both in the characteristics of the CTA and in the response to magnetic field exposure. The sex differences are discussed in terms of a sexually dimorphic sensitivity to experimental manipulation and the induction of stress and/or anxiety.
Article
Background Generalized anxiety disorder (GAD) is one of the most prevalent anxiety disorders, with important implications for patients and healthcare resources. However, few economic evaluations of pharmacological treatments for GAD have been published to date, and those available have assessed only a limited number of drugs. Objective To assess the cost effectiveness of pharmacological interventions for patients with GAD in the UK. Methods A decision-analytic model in the form of a decision tree was constructed to compare the costs and QALYs of six drugs used as first-line pharmacological treatments in people with GAD (duloxetine, escitalopram, paroxetine, pregabalin, sertraline and venlafaxine extended release [XL]) and ‘no pharmacological treatment’. The analysis adopted the perspective of the NHS and Personal Social Services (PSS) in the UK. Efficacy data were derived from a systematic literature review of double-blind, randomized controlled trials and were synthesized using network meta-analytic techniques. Two network meta-analyses were undertaken to assess the comparative efficacy (expressed by response rates) and tolerability (expressed by rates of discontinuation due to intolerable side effects) of the six drugs and no treatment in the study population. Cost data were derived from published literature and national sources, supplemented by expert opinion. The price year was 2011. Probabilistic sensitivity analysis was conducted to evaluate the underlying uncertainty of the model input parameters. Results Sertraline was the best drug in limiting discontinuation due to side effects and the second best drug in achieving response in patients not discontinuing treatment due to side effects. It also resulted in the lowest costs and highest number of QALYs among all treatment options assessed. Its probability of being the most cost-effective drug reached 75 % at a willingness-to-pay threshold of £20,000 per extra QALY gained. Conclusion Sertraline appears to be the most cost-effective drug in the treatment of patients with GAD. However, this finding is based on limited evidence for sertraline (two published trials). Sertraline is not licensed for the treatment of GAD in the UK, but is commonly used by primary care practitioners for the treatment of depression and mixed depression and anxiety.
Article
This study examines the simultaneous exposure of 2 brain areas in the location of central electrodes (C3 and C4) to a weak and pulsed extremely low-frequency magnetic field (ELF-MF) on the electroencephalogram (EEG). The intent is to change the EEG for a therapeutic application, such as neurofeedback, by inducing the "resonance effect." A total of 10 healthy women received 9 minutes of ELF-MF (intensity 200 μT) and sham in a counterbalanced design. ELF-MF exposure frequencies were 10, 14, and 18 Hz. The paired t test revealed that local pulsed ELF-MF significantly decreases beta (15-25 Hz), sensorimotor rhythm (13-15 Hz), and theta (4-8 Hz) powers at a frequency of 10 Hz in C3 and C4 regions (12.0%-26.6%) after exposure, in comparison with that achieved during the exposure (P < .05). Variations during the exposure were transient and different from those after. The resonance effect was observed nowhere around the regions. The study suggests that this technique may be applied in the treatment of anxiety; however, further investigation is needed.