Methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI) contact dermatitis is a severe problem. The high concentrations of these substances and other isothiazolinones such as benzisothiazolinone (BIT) and octylisothiazolinone (OIT) contained in cleaning products may cause allergic contact dermatitisin sensitized patients.
To evaluate the exposure to isothiazolinones contained in cleaning products on the market and from sensitized patients, and verify the accuracy of labelling.
A total of 34 cleaning products were collected (17 supplied by sensitized patients and 17 bought randomly). Analysis was made of the concentrations of MI, MCI, BIT and OIT using liquid chromatography tandem mass spectrometry (LC-MS/MS).
MI and BIT were the components most frequently detected. Of all the products analyzed, 76.5% contained at least one isothiazolinone. Twelve products had a MI concentration above the permitted level for rinse-off cosmetics. Most of them were coming into direct contact with the skin in daily use. Mislabelling occurred in 8 products.
Some cleaning products with high concentrations of isothiazolinones may cause cutaneous symptoms in sensitized patients, especially in spray form. The labelling should be correct, also regarding the use of each article. This article is protected by copyright. All rights reserved.