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A review on bioactive potential of Benzoin Resin

Authors:
  • University of Chakwal

Abstract

Styrax benzoin (benzoin resin) is a perennial tree belonging to the family (Styracaceae). It has been cultivated in the different regions of the world for thousands of year for incense and pharmaceutical preparations. Styrax benzoin usually contains benzaldehyde, benzoic acid, benzyl benzoate cinnamic acid and vanillin. Its chemical composition is influenced by the place of its origin, geographical, and climatic conditions. Styrax benzoin has been used traditionally for the treatment of skin diseases, arthritis, wounds, muscle pain, anxiety, and nervous disorders. Benzoin oil is widely used in the food, drinks and alcoholic beverage to give flavor, and for varnishing woods. The methods of production of resins are much traditional so there is a growing need to develop the new methods to maximize the production of resins.
IJCBS, 10(2016):106-110
Sharif et al., 2016 106
A review on bioactive potential of Benzoin Resin
Atia Sharif1, Haq Nawaz1, Rafia Rehman1, Ayesha Mushtaq1*, Umer Rashid2
1Department of Chemistry, University of Agriculture, Faisalabad-38040-Pakistan and 2Institute of Advanced Technology,
Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
Abstract
Styrax benzoin (benzoin resin) is a perennial tree belonging to the family (Styracaceae). It has been cultivated in the different
regions of the world for thousands of year for incense and pharmaceutical preparations. Styrax benzoin usually contains
benzaldehyde, benzoic acid, benzyl benzoate cinnamic acid and vanillin. Its chemical composition is influenced by the place of its
origin, geographical, and climatic conditions. Styrax benzoin has been used traditionally for the treatment of skin diseases,
arthritis, wounds, muscle pain, anxiety, and nervous disorders. Benzoin oil is widely used in the food, drinks and alcoholic
beverage to give flavor, and for varnishing woods. The methods of production of resins are much traditional so there is a growing
need to develop the new methods to maximize the production of resins.
Key words: Benzoin resin, dermatology, cinnamic acid, diuretic
Full length article *Corresponding Author, e-mail: ayesha_mushtaq123@yahoo.com
1. Botany
1.1. Introduction
Styrax Benzoin (benzoin resins) are perennial trees
which belong to the family (Styracaceae). Styracaceae is
native to subtropical or tropical regions, for example
Mediterranean, North or South America and Asia. There are
approximately 150 species of Styrax present which are used
for the production of aromatic resin when they are burned.
The Styrax, genus is different from all the members of the
family Styracaceae due to the production of the resins which
excrete from the trunks and barks of the plants after injured
with sharps [1]. Styrax is self or cross pollinated and
variability is present in flowers, fruits shape and colours and
stem wood or chemical composition of resins due to cross
pollination [2].
Styrax Benzoin is known by different names
depending where you are in the world. The common names
of the Styrax Benzoin are benzoin resins, benzoin trees,
Sumatra benzoin. Styrax in Swedish is known as benzoin. In
German, it is called as benzoebaum. In Spanish, it is well
known as bálsamo de Benjuí and in French as arbre à
benjoin. In Chinese it is known as xi xiang. The species of
Styrax is divided into two groups ‘Siam Benzoin and
‘Sumatra Benzoin’. Styrax benzoin and Styrax
paralleloneurm are known as ‘Saim benzoin’ and ‘Styrax
tonkinensis is known as ‘Sumatara benzoin’[3]. The plant
can be shrub or tree with approximately 25m in length and
has diameter 30cm with smooth and simple hairy dark green
leaves and white flowers. The fragrance of the benzoin
resins is most familiar among the people since ancient times
and used in every culture of the world as medicine or
perfume.
The resin has great variability between the species
and cultivars and is thought to be related to growing
conditions, geographic origin, genetic factors, different
chemo-types and differences in the nutritional status of the
plants. In Indonesia, Styrax benzoin which is known as
Sumatra benzoin is tapped to get the resin, after collection it
is dried. This dried resin gave the fragrance when burned
and it was believed that it has magical properties. In north
Sumatra greater than 18,000 families are depending on the
production of benzene resins [4]. A benzoin resin have
vanilla like fragrance with reddish yellow to milky white
colour in ‘Siam benzoin’ due to presence of benzoic acid
while in ‘Sumatra benzoin ‘its colour is dull reddish to
greyish brown with storax like fragrance due to presence of
cinnamic acid.
Benzoin resins have variability between the species
and quality of benzoin resins depends on the practice of the
farmers. There are two main varieties of benzoin resins;
Sumatra benzoin and Saim benzoin which are present in the
market. These two varieties grow in different geographical
areas. Saim benzoin grows in Laos while Sumatra benzoin
grows in Indonesia [5]. Due to distinct growing region, their
chemical composition is also different. Sumatra benzoin is
reported to contain more cinnamic acid and cinnamates than
Siam benzoin [6]. It is not possible to give annual
consumption of benzoin resins due to sufficient accuracy
International Journal of Chemical and Biochemical Sciences
(ISSN 2226-9614)
Journal Home page: www.iscientific.org/Journal.html
© International Scientific Organization
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Sharif et al., 2016 107
worldwide. Sumatra benzoin mainly used in incense purpose
while Saim benzoin is mainly used in pharmaceutical
industries and its minor use in varnishes the town woods [7].
1.2 History/Origin
Styrax benzoin is native to the South-East or East
Asia from tropical region to warm temperate of Northern
Hemisphere. The name Styrax originates from the Greek
word sturax and benzoin is derived from Arabic word luban
jawi which means java incense. In Roman it was used
approximately 2000 years ago.
In 15th and 16th centuries, England imported
benzoin in powdered form with spices for perfume
preparation which was used by Queen Elizabeth Ӏ. Benzoin
was also used in religious ceremonies and drives away the
evil spirits in the culture of ancient Malayan. Styrax
Benzoin trees are most abundantly present in Indonesia
especially in Sumatra therefore it is also known as Sumatra
benzoin.
1.3 Demography/Location
Styrax benzoin grows in warm temperate to tropical
regions. Some are found also across the equator in South
America. Natural home of Styrax benzoin is Sumatra,
Indonesia but it is also available in the Western countries
from ancients. Styrax species other than Styrax benzoin
grow in many countries such as China, Laos, Malaysia,
Vietnam, Cambodia and Thailand. The plant grows in the
rain forests of tropical region of Sumatra.
Singapore imports 5330 tons of benzoin, Malaysia
133 tons, China 77 tons, United Arab Emarates, 22tons,
Kuwait 16 tons, India 70 tons, Pakistan 16 tons, Saudi
Arabia 10 tons, Japan 25 tons, respectively. Singapore is the
biggest importer of benzoin resins and then Europe imports
benzoin resins for pharmaceuticals and other direct
importers of Sumatra benzoin are Indian sub-continent,
Japan and other countries of Middle East.
1.4 Botany, Morphology, Ecology
Styrax benzoin is a perennial tree of tropical areas
which grow up to height of 15-25 meters. Styrax benzoin has
tap roots which disappear laterally and tree also has shallow
root system. Leaves are ovate and arranged alternately in the
form of crown around the stem with hairy underside and
smooth upper surface having length in the range of 6-10 cm
and 3-5 cm wide. Flowers are bisexual and white in colour
or bell shaped in the time of blooms in spring and has 5
petals which are arranged in the form of cluster along the
branches. Fruits are closed in the hard and flat shell having
the diameter approximately 2-3 cm. Seeds dormant after 6-7
months of fruit fall [8]. Resins of Styrax benzoin obtained
from tapping of the bark which is produced after 15-20
years. Styrax benzoin resins are yellow in colour when
obtained and later it becomes reddish-brown after hardening
and thickening.
Styrax benzoin originated in rainforest that has
medium to high altitude. Cultivation periods require 1300
millimetre rain per year or 3 to 6 dry months. Plants survive
in extremely low or high temperatures ranging from -4 to
45°C. Soil having low base saturation and high acid content
(pH below than 4.5) is required for best growth.
2. Chemistry
Styrax benzoin is acrid, impressively aromatic and
have strong vanilla like smell [9]. Main components of
Styrax benzoin are benzaldehyde, benzoic acid, benzyl
benzoate, cinnamic acid and vanillin [6]. Vanilla like
fragrance of plant is due to the presence of vanillin.
Cinnamates present in the Styrax benzoin are used as
flavouring agent and produce chocolate like flavor.
2.1. Chemical composition
Styrax benzoin contains cinnamyl cinnamate 8-14
%, methyl cinnamate 10-17 %, cinnamic acid 4-7 %, benzyl
cinnamate 2-4 % and little amount of vanillin, benzoic acid,
phenylpropylic alcohol. Before the use of Styrax benzoin, a
skin test must be taken as it causes allergy. Styrax benzoin is
composed of 18% of benzoic acid, a little amount of volatile
acids and 75 % of amorphous resins. Free benzoic and
cinnamic acid and their corresponding esters such as
coniferyl and p-coumaryl alcohol are present in different
amounts and also some other higher molecular weight
compounds like pinoresinol is also present [6].
2.2. Phyto-chemistry
Styrax benzoin has vanilla like odour due to the
presence of vanilline. Trans-coniferyl alcohol benzoate or
trans-p-cumaryl alcohol is obtained from the Styrax benzoin
[10]. Styrax benzoin contains the cinnamic acid, benzoic
acid, methyl cinnamate, coniferyl benzoate,cinnamayl
cinamate, cinamic acid, phenylethylene, and vanillin. Figure
1 shows structures of important phytochemicals of Styrax
benzoin. Due to difference in production region and varieties
of benzoin such as Siam benzoin and Sumatra benzoin, it
has significant differences in chemical composition [11].
Table.1. Compounds composition in the styrax species of
Styrax benzoin and Styrax paralleloneurm
Compounds
Styrax
benzoin
(%)
Styrax
paralleloneurm
(%)
Benzoic acid
46.9
26
Cinnamic acid
40.4
26
Cinnamyl benzoate
0.5
0
Benzyl cinnamate
0
1.6
Cinnamyl cinnamate
0
1.9
ρ-Coumaryl benzoate
0
9.2
Coniferyl cinnamate
0
1.4
Pinoresinol
6.1
8.2
Benzoic acid ester
0.6
3.3
Triterpene
2.3
1.9
Cinnamic acid ester
0
5.4
Benzoic acid
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Sharif et al., 2016 108
Cinnamic acid
Triterpene
Pinoresinol
Figure 1. Structures of some bioactive compounds found
in Styrax benzoin
4. Postharvest technology
Styrax benzoin resins are obtained by tapping of the
trees. In order to obtain the resins in the form of tears having
5-6 cm length and 8-10 cm wide notches are made on the
cambium of trunk and bark of tree is removed. The tapper
makes a notch of 8-10 cm wide and 5-6 cm long into the
cambium of the trunk and the bark is removed. Along the
trunk of tree a number of notches are made after the interval
of 20 to 30 cm and the first notch is made at a length of 30
cm above the ground level. After tapping exuded resins are
lifted on the trunk of tree after approximately 4 to 5 months
for hardening the resins. The process of tapping occurs
during the first cold day of the winter and benzoin tear is
obtained. In natural forests, first tapping of benzoin tree is
done in the age of 3-5 years while in the regenerated forests;
tapping is done in the age of 6 to 8 years. After the
collection of resins, sorting and hard cleaning is carried out
for the removal of bark pieces but extra care is required to
retain the whole tear as such.
5. Value addition
A few local industries of Central Java produced
cigarette known as Klembak menyan which is used to
reduce stress. The components of this cigarette are tobacco,
a large amount of benzoin resins and cloves [12]. According
to the papyrus records, benzoin resins are grinded in powder
form and mixed with cypress, galbanum, juniper and pine to
make a cone that the Egyptian dancers used to place on their
heads. Romans and Greeks used benzoin resins from
ancients for incense purpose and in their traditional dishes;
they use benzoin oil with black paper, juniper, berry, ginger,
lavender, sweet marjoram and rosemary. The native people
of Sumatra use Lubanja; a benzoin resins it is burnt with
coffee and gave vanilla like odour in their coffee ceremonies
as relaxant.
Benzoin oil is also used in the treatment of skin
diseases by mixing 10 ml of almond oil, 6 drops of benzoin
oil and 2 drops of wheat germ oil and by applying on the
affected area such as wounds, skin ulceration, burn and bad
sores. Benzoin oil is used for the treatment of psoriasis and
eczema with clay as taking 2 tbsp clay and by adding 3
drops of benzoin oil along with distilled water to make paste
apply on affected areas and leave it for 20 minutes and then
rinse off with water. Benzoin is useful with lemon juice for
the treatment of brown marks on the face by adding 2 drops
of lemon juice, 10 ml almond oil, 4 drops benzoin oil and 2
drops of wheat germ oil [13].
6. Uses Styrax bnzoin resin is widely used as an ingredient
in the incense and is believed that it helps to drive out the
evil spirits. Benzoin is also used as a preservative and
fragrance compound in the perfumes, soaps, cosmetics and
toiletries. Benzoin is also used as a flavouring agent in the
food, alcoholic beverage and soft drinks. Benzoin resins act
as powerful antioxidants and help to prevent the rancidity of
fats. Styrax benzoin is also used in the healing of wounds
[14].
6.1. General uses
Styrax benzoin is used as disinfectant and it is a
good herbal remedy for the throat infection and for
respiratory elements. Styrax benzoin tincture is used as a
mouthwash for the treatment of cold sores. After the tooth
extraction, dentists use benzoin resins tincture as an anti-
inflammatory agent. Benzoin resins are familiar in the
products which are used in the treatment of skin diseases
like irritated or dry skin, wounds and inflamed skin. Benzoin
resins are used as a herbal remedy for the muscle pain, poor
circulation, gout and arthritis. Benzoin resins are used in the
religious ceremonies in the many regions of the world. After
burning, it produces a sweet smell that uplifts the mood and
stimulates the nervous system. It stimulates the heart beat by
giving the warm feelings and improves the circulation of
blood [5]. Oil extracted from the aromatic plant is known as
essential oil [15-18] which has various pharmacological uses
[19-20] due to the presence of various bioactive
components. Benzoin oil is used as sedative and relaxant
and relieves the tension, stress, anxiety and nervousness. It
brings out the neurotic or nervous system to normal. GC-MS
analysis is generally used to find out bioactive components
present in essential oils [18-21-22]. Styrax benzoin contains
the compounds like benzoic acid, benzaldehyde and benzyl
benzoate which are most effective bactericidal, germicidal,
antiviral substances and fungicidal. If smoke of benzoin
resin is spread then smoky zone become free of germs.
Benzoin oil also has anti- flatulent and carminative
properties.
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Sharif et al., 2016 109
7. Pharmacological uses
7.1. Phytotherapy in dermatology
Phytotherapy in dermatology is the process of
reparation of medicines from plants and their uses in the
treatment of skin. Benzoin is used in conditioning of the
skin and also to toughen the skin [23]. Benzoin oils are also
used for beauty of skin, making the skin fresh and youthful.
It also has ability to heal the wounds and scars. Benzoin oil
has healing properties that owe to benzoic acid,
benzaldehyde and benzyl benzoate. Cinnamate present in
the benzoin is also used in toughening of the skin but it is
quite toxic and cause allergy [23].
7.2. Respiratory problems
There are a lot of respiratory problems such as
chest infection, pneumonia, asthma, noisy breathing,
obstructive sleep apnoea and aspiration [24]. Essential oil of
benzoin is used to treat congestion, coughing and other
respiratory problems. Benzoin is an excellent disinfectant
and has expectorant qualities which help free mucus and
ease breathing. As well as clearing up the respiratory
system, its sedative properties can help clear the way to a
good night’s sleep. Styrax benzoin used in the
pharmaceutical industries for the treatment of bronchitis,
cough laryngitis and as an antiseptic for prevent the
infections.
7.3. For digestion
In digestive issues like cramping and flatulence,
then benzoin essential oil might provide relief. This
wonderful essential oil has carminative properties as well as
being able to relieve gas and inflammation in the intestines.
It helps to relax the stomach muscles enabling excess wind
to pass naturally, relieves pain related to gas. Benzoin
essential oil also improves general digestion and helps
improve your appetite. One of the health benefits of benzoin
essential oil is preventing the acidity that occurs in the
stomach and avoid many diseases are caused by gastric
acidity. In cultivated region of Styrax benzoin people use it
for the ache of stomach.
7.4. Diuretic
Diuretic is the disease which commonly
characterized as the excess of extracellular fluid, the
nephritic syndrome, kidney diseases, heart failure and
cirrhosis [25]. Benzoin essential oil has natural diuretic
properties, which essentially means that it helps to boost
both urine production and frequency of urination. Diuretics
are used to efficiently cleanse and remove toxins from the
blood stream. These properties can have a positive effect on
blood pressure and can even help you to lose weight caused
by stubborn water retention [26]. Styrax benzoin has
diuretic properties as it promotes and facilitates the quantity
and frequency of urination and through urination it also
helps to remove the toxic substances from the blood. It also
helps to reduce weight, improving digestion and lowering of
the blood pressure.
References
[1] Q.-L. Li, B.-G. Li, H.-Y. Qi, X.-P. Gao, G.-L.
Zhang. (2005). Four new benzofurans from seeds
of Styrax perkinsiae. Planta medica. 71(09): 847-
851.
[2] M. Lobdell. Styrax in cultivation: evaluation of an
underrepresented ornamental genus. University of
Delaware, 2013.
[3] C.G. Fernández. (2004). Benzoin, a resin produced
by Styrax trees in North Sumatra Province,
Indonesia. Forest products, livelihoods and
conservation: case studies of non-timber forest
product systems. volume 1-Asia. 148.
[4] M. Van Wyk, B.D. Wingfield, P. Clegg, M.J.
Wingfield. (2009). Ceratocystis larium sp. nov., a
new species from Styrax benzoin wounds
associated with incense harvesting in Indonesia.
Persoonia. 22: 75.
[5] J. Coppen. (1999). Benzoin: production, uses and
international trade. Perfumer & flavorist. 24(3):
11-22.
[6] I. Pastorova, C. De Koster, J. Boon. (1997).
Analytical study of free and ester bound benzoic
and cinnamic acids of gum benzoin resins by GC
MS and HPLCfrit FABMS. Phytochemical
Analysis. 8(2): 63-73.
[7] J.-J. Filippi, C. Castel, X. Fernandez, M. Rouillard,
M. Gaysinski, S. Lavoine-Hanneguelle. (2009). An
unusual acenaphthylene-type sesquiterpene
hydrocarbon from Siam and Sumatra benzoin gum.
Phytochemistry Letters. 2(4): 216-219.
[8] R. Kiew. (1982). Germination and seedling
survival in kemenyan, Styrax benzoin. Malaysian
Forester. 45(1): 69-80.
[9] P. Burger, A. Casale, A. Kerdudo, T. Michel, R.
Laville, F. Chagnaud, X. Fernandez. (2016). New
insights in the chemical composition of benzoin
balsams. Food Chemistry. 210: 613-622.
[10] S. Popravko, I. Sokolov, I. Torgov. (1984).
Derivatives of unsaturated aromatic alcohols in
propolis and Styrax benzoin. Chemistry of Natural
Compounds. 20(2): 140-147.
[11] M. Hovaneissian, P. Archier, C. Mathe, G. Culioli,
C. Vieillescazes. (2008). Analytical investigation
of styrax and benzoin balsams by HPLC-PAD-
fluorimetry and GC-MS. Phytochemical Analysis.
19(4): 301-310.
[12] L.T. Tarmidi. (1996). Changing structure and
competition in the kretek cigarette industry.
Bulletin of Indonesian Economic Studies. 32(3):
85-107.
[13] J. Lawless. (2013). The Encyclopedia of essential
oils: the complete guide to the use of aromatic oils
in aromatherapy, herbalism, health, and well being.
Conari Press: pp.
[14] J. Du, H. Singh, T.-H. Yi. (2016). Antibacterial,
anti-biofilm and anticancer potentials of green
synthesized silver nanoparticles using benzoin gum
(Styrax benzoin) extract. Bioprocess and
biosystems engineering. 39(12): 1923-1931.
[15] H.A. Abdulmumeen, A.N. Risikat, A.R. Sururah.
(2012). Food: Its preservatives, additives and
applications. International Journal of Chemical and
Biochemical Sciences. 1(2012): 36-47.
IJCBS, 10(2016):106-110
Sharif et al., 2016 110
[16] A.Y. Al-Maskri, M.A. Hanif, M.Y. Al-Maskari,
A.S. Abraham, J.N. Al-sabahi, O. Al-Mantheri.
(2011). Essential oil from Ocimum basilicum
(Omani Basil): a desert crop. Natural product
communications. 6(10): 1934578X1100601020.
[17] Z. Arshad, M.A. Hanif, R.W.K. Qadri, M.M. Khan.
(2014). Role of essential oils in plant diseases
protection: a review. International Journal of
Chemical and Biochemical Sciences. 6: 11-17.
[18] M.A. Hanif, M.Y. Al-Maskari, A. Al-Maskari, A.
Al-Shukaili, A.Y. Al-Maskari, J.N. Al-Sabahi.
(2011). Essential oil composition, antimicrobial
and antioxidant activities of unexplored Omani
basil. Journal of Medicinal Plants Research. 5(5):
751-757.
[19] E.M. Abdallah, A.E. Khalid. (2012). A preliminary
evaluation of the antibacterial effects of
Commiphora molmol and Boswellia papyrifera
oleo-gum resins vapor. International Journal of
Chemical and Biochemical Sciences. 1: 1-15.
[20] A.A. Hamid, O.O. Aiyelaagbe. (2012).
Pharmacological investigation of Asystasia
calyciana for its antibacterial and antifungal
properties. International Journal of Chemical and
Biochemical Sciences. 1: 99-104.
[21] M.A. Hanif, A.Y. Al-Maskri, Z.M.H. Al-Mahruqi,
J.N. Al-Sabahi, A. Al-Azkawi, M.Y. Al-Maskari.
(2011). Analytical evaluation of three wild growing
Omani medicinal plants. Natural product
communications. 6(10): 1934578X1100601010.
[22] I. Shahzadi, R. Nadeem, M.A. Hanif, S. Mumtaz,
M.I. Jilani, S. Nisar. Chemistry and biosynthesis
pathways of plant oleoresins: Important drug
sources.
[23] A.M. Dattner. (2003). From medical herbalism to
phytotherapy in dermatology: back to the future.
Dermatologic therapy. 16(2): 106-113.
[24] P. Seddon, Y. Khan. (2003). Respiratory problems
in children with neurological impairment. Archives
of disease in childhood. 88(1): 75-78.
[25] D.A. Sica. (2012). Diuretic use in renal disease.
Nature Reviews Nephrology. 8(2): 100-109.
[26] J. Lawless. (1995). The illustrated encyclopedia of
essential oils: the complete guide to the use of oils
in aromatherapy and herbalism. Shaftesbury,
Dorset: Element Books Ltd. 256p. ISBN.
1852306610.
... Kemenyan dapat mengatasi nyeri otot, memperlancar sirkulasi darah, asam urat, dan radang sendi (Hidayat N., et al, 2019;Atia Sharif H.N., et al , 2016;Sohail A.M. dan Alam T., 2022). ...
... Gambar 1. Struktur kimia senyawa aktif resin kemenyan b. AntiinflamasiResin kemenyan banyak digunakan untuk mengatasi iritasi atau kulit kering dan peradangan pada kulit(Atia Sharif H.N., et al, 2016). Asam sinamat merupakan senyawa yang bertanggung jawab terhadap aktivitas antiinflamasinya yaitu dengan menghambat enzim siklooksigenase (COX) sehingga mengurangi produksi prostaglandin(Guo J., et al, 2011). ...
... Guo J., et al, 2011;Atia Sharif H.N., et al, 2016; Sohail A.M. dan Alam T., 2022).k. Antikonvulsan dan sedatifKemenyan juga memiliki aktivitas antikonvulsan dan sedative (Atia Sharif H.N., et al 2016; Sohail A.M. dan Alam T., 2022). ...
Article
Full-text available
Studies on drug discovery from natural ingredients are important to determine the pharmacological effects of the compound’s content so that it can be used to treat diseases. Kemenyan (Styrax benzoin) resin has been widely used by the local community for various purposes, including medicine. This review article aims to provide a comprehensive view of the potency of Kemenyan resin and its active compounds so that they could be used and developed to treat diseases in the future. The method used was based on searching for scientific literature in national and international journals. The results showed that the Kemenyan resin contains active compounds, including cinnamic acid, benzoic acid, benzaldehyde, benzyl benzoate, vanillin, styrene, styracin, coniferyl benzoate, benziresinol resin, resinotannol, sterols, phthalic acid, and sumaresorcinol. These compounds are known to have various pharmacological effects, including antibacterial, anesthetic, anti-inflammatory, antispasmodic, antimutagenic, fungicidal, herbicidal, tyrosinase inhibitory, and LDL synthesis inhibitory effects. Based on these studies, it can be concluded that the Kemenyan resin has great potential for the treatment of various diseases.
... Some think that Siam benzoin can provide a sweeter and vanilla-like odor, which makes Siam benzoin superior to Sumatra benzoin in the food industry, regardless of prices. In contrast, the Sumatran type is spicier and features a styrax-like odor, playing a role in the daily chemical industry and pharmaceutical preparations [11][12][13]. There are also other benzoin resins produced by Styrax, with benzoin in lesser field and quality, such as Bolivia benzoin produced by S. pearceivar bolivianum, Bogota Storaque by S. Aureum and Solid Storaque by S. officinale [14]. ...
... In the Compendium of Materia Medica, benzoin was apotropaic [34]. In Sumatra, people use benzoin burnt with coffee, obtaining a vanilla-like fragrance to relax [11]. Besides contributing its own fragrance, its tenacity and ability to prevent the loss of middle and top notes of more volatile compounds makes it popular in industries such as perfumes, cosmetics, soap and detergents [7]. ...
... Benzoin is mixed with tobacco in Klembak menyan, a kind of cigarette produced in central Java [36]. Romans and Greeks also put benzoin in their traditional dishes [11]. In the United States, benzoin was approved for food use in 1992. ...
Article
Full-text available
Benzoin is a pathologic exudation produced by plants of the family Styrax. It is secreted by traumatic resin ducts after injury, which are derived from parenchymal cells in secondary xylem by schizolysigeny. Some 63 chemical constituents have been isolated and identified from this resin, including balsamic acid esters, lignans and terpenoids. It has a long history of applications, including as incense along with olibanum, a flavor enhancer in the food industry, materials in the daily chemistry industry as well as therapeutic uses. Up to now, high-performance liquid chromatography (HPLC) and gas chromatography mass spectrometry (GC-MS) have been widely used in qualitative and quantitative analysis of benzoin. Other technologies, including near-infrared reflectance spectroscopy (NIR), proton transfer reaction time-of-flight mass spectrometry (PTR-ToF-MS) and Fourier-transform infrared spectroscopy (FT-IR), have also been used to distinguish different resins. Herein, this paper provides a comprehensive overview of the production process, phytochemistry, traditional uses and quality control of benzoin and looks to the future for promoting its further research and applications.
... Styrax benzoin, or called "kemenyan" in Bahasa Indonesia, is fragrance resin produced by Styrax trees, which is categorized under the Styracaceae family, consisting of over 150 species and indigenous to the subtropical and tropical regions (Sharif et al., 2016). Similar to frankincense, which is fragrance resin produced from Boswellia trees, Styrax benzoin, or benzoin, is produced by wounding the Styrax tree barks so as the saps flow from the wounds, left to dry for a few months, and then collected during harvest periods. ...
... Event Proceedings: LUT Scientific and Expertise Publications: Moreover, Styrax benzoin provides high economic value to the traditional communities as the benzoin gardens are passed down from generation to generation as main economic source for many families (Harada et al., 2022). In addition to the uses as incense, aromatherapy or perfume due to the pleasing fragrant, Styrax benzoin is a key ingredient to such consumer products as disinfectant, mouthwash, medicating skin diseases or wounds, remedy muscle pain or gout and arthritis, sedative as well as many pharmacological uses that include dermatology treatments, treat respiratory and digestive problems (Sharif et al., 2016). These wide range of uses are attributed to the main chemical ingredient of benzoate, that are naturally contained in Styrax benzoin (He et al., 2023). ...
Conference Paper
Aiming for a sustainable business model, circular economy is the main source for innovations. The main objective of this study is to investigate current practices of business model formulated and implemented for bio-based products in order to develop a conceptual framework for a high performing Styrax Benzoin business model. This study examines three cases, namely, the traditional Styrax model, small-business Patchouli model, and Patchouli Refinery Centre model, through in-depth interviews and thick descriptions. These cases were then compared and analysed using a proposed business model framework. Results showed that the first and second models are in dire need of renewal, while the third model exemplifies an integrated value chain model with numerous innovation opportunities. The proposed conceptual framework orchestrates circular business model innovations to create value sustainably.
... Main components of Styrax benzoin are benzaldehyde, benzoic acid, benzyl benzoate, cinnamic acid and vanillin [16]. Styrax benzoin contains compounds such as benzoic acid, benzaldehyde and benzyl benzoate which are bactericidal, germicidal, antiviral substances and fungicidal [17]. Thus, although the antibacterial property of carbon nanodots are not new, of course the fact that the carbon nanodots in the smoke also possess antibacterial activity is what has been disclosed in this study. ...
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Antimicrobial compounds have been gaining paramount importance in recent years since there has been a lot of concern over the increasing threats from microbial infections. Medicinal smoke has always been received with warmth and positivity and being an age-old traditional process, has been practiced down the generations. Nanomaterials have become highly promising when it comes to antimicrobial applications and carbon nanomaterials have also gained preeminence. In the following study, carbon nanodots were extracted and characterized from benzoin resin smoke and tested for its antibacterial, anti oral bacterial and anti-biofilm properties. With rising concerns over chemically synthesized nanomaterials, green extraction of carbon nanodots from benzoin smoke, will come handy for multiple biomedical applications.
... The Benzoin Resin or kemenyan resin is a very important commodity in the pharmaceuticals, cosmetics and perfume industries, this is due to the active compound content of Benzoin, one of the largest being cinnamic acid and benzoic acid (Sharif et al. 2016). The high demand for Benzoin resin is due to the many benefits of Benzoin sap, one of which is used as wound healing (Melinda Harahap 2019). ...
... The plants and its parts, which are used as its decoctions and infusions and their combinations could be done as a treatment benefit for COVID-19 patients and those with seasonal flu and health issues. This may also increase immunity of the patients and provide resistance and safety of them against the viral infection [83][84][85][86][87][88][89][90][91][92][93][94][95][96]. ...
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