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Dandelion Root and Chronic Myelomonocytic Leukemia
Abstract
Case 1
70 year old man presented with acute myelo-monocytic leukemia diagnosed in June 2009. He demonstrated no response to standard 7+3, nor high dose AraC. He remains in remission from his acute leukemia 4 years from his diagnosis, as long has he remains on the dandelion root tea, which was started immediately after chemotherapy. If he takes less than three cups / day of the DRT, his peripheral blood monocytes start to rise.1 Repeat testing demonstrates chronic myelomonocytic leukemia.
Case 2
Sixty year old female with acute myelomonoctyic leukemia possibly progressing from chronic myelomonocytic leukemia. She underwent induction chemotherapy with 7+3. Her day 28 marrow showed no evidence of remission. She then underwent re-induction with high dose Ara-C at 3 gm/ m2 x 6 doses. She did receive neupogen support, and on day 28, her peripheral blood white blood count was 60 x 109/L with monocytes of 3.0 x 109/L and blasts 1.2 x 109/L. Repeat bone marrow biopsy identified chronic myelomonocytic leukemia (CMML). She stopped the neupogen and started dandelion root tea, three cups per day. She is now 5 months from her initial diagnosis and remains in complete hematological response: WBC 4.2/ Hgb 127 / Platelet 182/ Neutophils 2.6 / Monocytes 0.8.
Other Cases
We have had other possible cases that may support the efficacy of this product in refractory hematological malignancies. In one case of CMML-2 a 76 year old man did receive azacytadine for the duration of his treatment, as well as DRT. He finally succumbed to his disease at 30 months after his diagnosis. We previously presented an elderly female that used only DRT to treat her CMML and experienced a hematological remission for 3 months prior to relapse. Her initial WBC was 130,000 x 109/L.3 Another case of acute myeloid leukemia, who, because of co-morbidities was not a candidate for more aggressive options, relapsed from her M2- acute myeloid leukemia in November 2010. She was treated with low dose AraC, and then dandelion root tea. Although she remained transfusion dependent, she only developed peripheral blasts when she was unable to find the DRT for one month. She continues on the DRT at 15 month from relapse of her acute leukemia.3
We have a phase 1 clinical trial open at our centre investigating a novel formulation of dandelion root extract in refractory hematological malignancies. We plan to study the molecular pathways previously described in CMML including TET2 , CBL , NRAS, KRAS, JAK2 and RUNX1. http://www.ontario.canadiancancertrials.ca/trial/Default.aspx?dsEndecaNav=Ro%3A0%2CNs%3AP_TrialStatus_sort_en%7C101%7C-1%7C%2CNrc%3Aid-30-dynrank-disabled%7Cid-130-dynrank-disabled%7Cid-131-dynrank-disabled%7Cid-132-dynrank-disabled%7Cid-619-dynrank-disabled%7Cid-620-dynrank-disabled%7Cid-621-dynrank-disabled%7Cid-622-dynrank-disabled%7Cid-4294965875-dynrank-disabled%2CN%3A4294952782&TrialId=OCT1226&lang=en
1 Caroline Hamm and Sindu M. Kanjeekal, Unusual Response of Acute Monocytic Leukemia to Dandelion Root Extract, Blood (ASH Annual Meeting Abstracts), Nov 2011; 118: 4288
2. Kohlmann A, Grossmann V, et al. Next Generation Sequencing of Technology Reveals a Characteristic Pattern of Molecular Mutations in 72.8% of Chronic Myelomonocytic Leukemia by Detecting Frequent alterations in TET2, CBL, RAS, and RUNX1. JCO (28) 2009.
3. Ng W, Hamm C. Can Dandelions Cure? Schulich School of Medicine Research Day, 2009
Disclosures
No relevant conflicts of interest to declare.
... Our hypothesis is that our patient's CMML disease course has been modified by NHPs and OTC supplements. In vitro data demonstrate anticancer activity with the use of PLE, DRE, and curcumin [1,[4][5][6]. It is unclear whether any of the other supplements have contributed to the stable disease course. ...
... Arber et al. demonstrated selective efficacy in induction of programmed cell death in aggressive and resistant CMML cell lines using DRE [3]. Hamm et al. described a case of a 70-year-old man with a history of primary refractory acute myelomonocytic leukemia who received DRE tea after failing induction chemotherapy [6]. What emerged was a diagnosis of CMML. ...
... e patient achieved a complete hematological remission with the ongoing use of DRE tea. When he drank less than three cups per day of the DRE tea, his peripheral blood monocyte count started to rise [6]. e same group reported an elderly female with CMML who only used DRE tea to treat her disease. ...
Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic disorder which shares clinical and morphological features of myelodysplastic syndrome and myeloproliferative neoplasms. Conventional therapeutic options include hydroxyurea, hypomethylating agents, and systemic chemotherapy, which are all palliative measures and are associated with potential side effects. Allogeneic hematopoietic cell transplantation is the only curative option. Natural health products such as papaya leaf extract and dandelion root extract have been shown to demonstrate anticancer activity in preclinical and clinical studies, respectively. We present a case study of a 76-year-old male with previously untreated CMML, whose hematological parameters remained stable and whose bone marrow blast counts vastly improved while taking papaya leaf extract and dandelion root extract.
Integrative and Functional Medicine Nutrition Therapy provides an evidence-based approach to oncology designed to enhance health-related quality of life and improve clinical outcomes through diet and nutrition, lifestyle interventions, detoxification, mind-body medicine, and alternative therapies. With conventional cancer treatment focused solely on the cancer, a strategy is needed to optimize outcomes that focus on the whole person. Toxicity, nutrient insufficiency and deficiency, poor diet, environmental exposures, emotional health, genetics-epigenetic potential, and low-grade inflammation are all factors affecting metabolism that contribute to both a cancer diagnosis and the outcome.
Tyrosine kinase inhibitor treatments for chronic myeloid leukaemia based on nilotinib (NIL), dasatinib (DAS) and imatinib (IMA) have improved patient quality of life and have turned chronic myeloid leukaemia from a fatal disease into a chronic disease. Dandelion is a rich source of phenolic compounds with strong biological properties, and the effects of using this plant in the treatment of different illnesses can be linked to the presence of various polyphenols found in the different parts of the plant. Thus, dandelion can potentially be used as a nutraceutical (dietary antioxidant) to prevent different disorders associated with oxidative stress, i.e., cardiovascular disorders, cancer and inflammatory processes. Mutual interference between a drug and a food constituent may result in altered pharmacokinetics of the drug and undesired or even dangerous clinical situations. In the present study, a bioanalytical Ultra performance liquid chromatography ‐ tandem mass spectrometer (UPLC‐MS/MS) method was developed and validated for the quantification of DAS, IMA, and NIL in rat plasma. Sample preparation was carried out using solid‐phase extraction (SPE) with C18 cartridges with a good extraction recovery of not less than 94.37% for the three drugs..The method was fully validated as per the FDA guidelines.
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