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Does extending controlled ovarian hyperstimulation during a GnRH antagonist protocol in vitro fertilization cycle affect oocyte quality?

Authors:
Sydney Chang
Sydney Chang
Sydney Chang
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T.G. Nazem at Icahn School of Medicine at Mount Sinai
T.G. Nazem
Carlos Alberto Hernández Nieto at Icahn School of Medicine at Mount Sinai
Carlos Alberto Hernández Nieto
Dmitry Gounko at University at Albany, State University of New York
Dmitry Gounko
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... Full efficacy and safety outcomes were presented previously. 1 Logistic regression was performed to separately identify relationships between each factor (per visit, as appropriate) and the cumulative live birth rate. Interaction effects of the factors with the treatment group (HP-hMG, rFSH) were investigated. ...
... Full efficacy and safety outcomes were presented previously. 1 RESULTS: There was no evidence of a difference between fresh and frozen transfer live birth rates for first trial transfer, even after normalization based on karyotype. ...
... The potential benefits of this strategy must be weighed against potential negative impacts, including hyperstimulation syndrome and impaired oocyte quality. Prior work has shown that delayed administration of OMT does not negatively impact the oocyte maturation rate, fertilization rate, and euploid rate [1]. Studies to date have not yet evaluated associated clinical pregnancy outcomes. ...
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