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Khandare et al Journal of Drug Delivery & Therapeutics. 2019; 9(4-s):595-597
ISSN: 2250-1177 [595] CODEN (USA): JDDTAO
Available online on 15.08.2019 at http://jddtonline.info
Journal of Drug Delivery and Therapeutics
Open Access to Pharmaceutical and Medical Research
© 2011-18, publisher and licensee JDDT, This is an Open Access article which permits unrestricted
non-commercial use, provided the original work is properly cited
Open Access Case Report
In-vitro Gastric acid percent neutralizing potential of household remedies
verses marketed antacid preparation: A case report
Balu S. Khandare*, Sandip S. Kshirsagar and Nikhil S. Bhujbal
Kasturi Shikshan Sanstha College of Pharmacy Shikrapur Pune, Maharashtra, India-412208
ABSTRACT
Gastric acidity is a very common condition among the peoples of developing and developed countries. Increased gastric pH is associated with
gastric ulceration, Bleeding ulcers, GERD, heartburn, discomfort, nausea and vomiting. The instant and quick relief from acidity can be obtained
by oral administration of antacids. Current study was carried out to determine the acid neutralizing effect of household remedies like cold milk,
Baking soda, Baking soda + citric acid in water verses marked preparations like Effervescent granules (ENO, Digene) and liquid antacid Gelusil
(5ml and 10ml). Gastric simulation fluid of pH1.2 was prepared and pH was recorded before and after addition of marketed antacid/ household
remedies. Observations were recorded in multiple of three for 0 min to 60 min. percent acid neutralization were calculated for each marketed/
household preparation. Results advocate that baking soda in water and Gelusil 10ml shows significant percent acid neutralization 444.35% and
428.57% respectively. The effect of acid neutralization of baking soda in water was instant and remained same whereas Gelusil 10ml showed
progressive acid neutralization over a period of time. Effervescent granules ENO and Digene showed 322.58303.14% acid neutralization
respectively. Milk 259.67% Gelusil188.28% and Baking soda + citric acidin Water421.25% showed acid neutralization. From results it can be
concluded that household remedies are also significantly effective to control the acidity.
Keywords: Antacid, Effervescent granules, Milk, Baking soda. % acid neutralization.
Article Info: Received 19 June 2019; Review Complet ed 23 July 2019; Accepted 29 July 2019; Available online 15 August 2019
Cite this article as:
Khandare BS, Kshirsagar SS, Bhujbal NS, In-vitro Gastric acid percent neutralizing potential of household remedies vers es
marketed antacid preparation: A case report, Journal of Drug Delivery and Therapeutics. 2019; 9(4-s):595-597
http://dx.doi.org/10.22270/jddt.v9i4-s.3271
*Address for Correspondence:
Balu S. Khandare, Kasturi Shikshan Sanstha College of Pharmacy Shikrapur Pune, Maharashtra,India-412208
INTRODUCTION:
Increase gastric pH is very common condition among the
children’s, Younger’s, adults and old age persons. Many
causative reasons contributes to increase the acidity like
Modern life style, Drugs, Smoking, alcohol addiction, spicy
food, stressful conditions, inadequate sleep, chewing tobacco,
beverages etc. acidity can be controlled by minimizing above
causative factors. In certain unavoidable conditions like
stressful work, work in night shift or daily dose of
medication acidity must be controlled by drug treatment.
Continuous increase in gastric pH and lack of treatment leads
to severe complications like heart burn, gastric and duodenal
ulcer, GI bleeding and GERD. Instant and quick relieve can be
given by oral administration of acid neutralizing agents and
prophylaxis treatment with ulcer healing drugs.
Antacids are alkaline that are used as acid-neutralizing
agents for protection against stomach acidity related
disorders. It is an inexpensive and safe over-the-counter
(OTC) medication that is available in tablet, effervescent
granules or suspension form. It can neutralize the gastric
acid fairly rapidly and is often used for immediate
symptomatic relief. Certainly the carbonate antacids (sodium
bicarbonate and calcium carbonate) can cause excessive
belching, nausea, abdominal distention, and flatulence. These
antacids when used in high doses or in patient with kidney
failure may result in metabolic alkalosis. Magnesium and
aluminum salts due to the opposite effects in may have
increase bowel movement. Whereas aluminum salts may
result in constipation, magnesium can lead to diarrhea.
Various home remedies are available to overcome the effect
of antacid and successfully control the acidity. Among them
cold milk and spoon of baking soda are very common.
Current study was conducted to screen the acid neutralizing
effect of home remedies against marketed acid neutralizing
preparations.
Objective:
Objective of current studies are:
1. To screen the In vitro acid neutralizing potential of
household remedies verses marketed antacid preparation.
Khandare et al Journal of Drug Delivery & Therapeutics. 2019; 9(4-s):595-597
ISSN: 2250-1177 [596] CODEN (USA): JDDTAO
2. To screen the percentage acid neutralization and duration
of action.
EXPERIMENTAL METHOD:
Preparation of Gastric simulation fluid:
Gastric simulation fluid is prepared by adding 2gm of NaCl+
7Ml HCl+ 3.2gm of purified pepsin and volume is making up
to 1000Ml of deionized water. PH of GSF is 1.2.
Screening of acid neutralizing effect:
1. For Marketed preparation:
a. Effervescent Granules:
Two common marketed preparations of Effervescent
Granules (ENO and Gasofast) were added in 200 ml of
drinking water. Prepared antacid solution was added in 200
ml GSF. pH was recorded before and after addition of antacid
solution. Change in pH was recorded after every 10 min for
next 1 hour.
b. Antacid suspension:
Antacid suspension (Gelosile) 5 ml and 10ml was added in
200 ml GSF. pH was recorded before and after addition of
antacid solution. Change in pH was recorded after every 10
min for next 1 hour.
2. For Household remedies:
a. Cold Milk:
Cold milk 200m was added in 200 Ml GSF. pH was recorded
before and after addition of antacid solution. Change in pH
was recorded after every 10 min for next 1 hour.
b. Baking Soda:
2gm of baking soda with and without citric acid was added in
200 ml drinking water. Prepared solutions were added 200
ml GSF. pH was recorded before and after addition of antacid
solution. Change in pH was recorded after every 10 min for
next 1 hour.
Percentage inhibition was calculated by change in pH before
and after addition of respective antacid.
RESULT AND DISCUSSION:
Percent Acid neutralizing effect of Marketed preparation verses Home remedies
Marketed
Preparation
Initial pH
of GSF
GSF pH
after
Addition
After 10
Min
After 20
Min
After 30
Min
After 40
Min
After 50
Min
After 60
Min
ENO( ENO sachet of 6gm added in 200ml water + GSF)
Mean
1.24
5.18
5.20
5.23
5.23
5.24
5.24
5.24
% Acid
neutralization
-------
317.74
319.35
321.77
321.77
322.58
322.58
322.58
Digene( Digene sachet of 6gm added in 200ml water + GSF)
Mean
1.27
5.01
5.05
5.07
5.07
5.04
5.06
5.12
% Acid
neutralization
-------
294.48
397.63
299.21
299.21
296.85
298.42
303.14
Gelusill 5mL( Gelusil 5ml Added in 200ml water + GSF)
Mean
1.28
1.34
2.30
2.73
3.06
3.27
3.40
3.69
% Acid
neutralization
-------
34
79.68
113.28
139.06
155.46
165.62
188.28
Gelusill 10Ml( Gelusil10ml Added in 200ml water + GSF)
Mean
1.26
6.15
6.23
6.43
6.48
6.58
6.63
6.66
%
neutralization
-------
388.09
394.44
410.31
414.28
422.22
426.19
428.57
Cold Milk( 200ml cold milk + 200 ml GSF)
Mean
1.24
4.41
4.29
4.35
4.40
4.64
4.78
4.46
% Acid
neutralization
-------
255.64
245.96
250.80
254.83
274.19
285.48
259.67
Baking soda in Water( 2gm baking soda added in 200ml water + 200ml GSF)
Mean
1.24
6.69
6.66
6.67
6.68
6.69
6.72
6.75
% Acid
neutralization
-------
439.51
437.09
437.90
438.70
461.29
441.93
444.35
Baking soda + citric acid in Water ( 2gm baking soda + 2ml citric acid added in 200ml water + 200ml GSF)
Mean
1.27
6.49
6.55
6.58
6.59
6.60
6.61
6.62
% Acid
neutralization
-------
411.02
415.74
418.11
418.89
419.68
426.47
421.25
CONCLUSION:
From current study it can be concluded that household
remedies like cold milk, baking soda in water and baking
soda + citric acid in water have significant potential to
control and neutralize acidity. In certain liver and kidney
disease effervescent granules are contra-indicated where
household remedies will be able to implement. Also
household remedies are cheap and cost effective as
compared to marketed antacid preparations.
Khandare et al Journal of Drug Delivery & Therapeutics. 2019; 9(4-s):595-597
ISSN: 2250-1177 [597] CODEN (USA): JDDTAO
REFERENCES
1. In Vivo and in Vitro Evaluation of Liquid Antacids John S.
Fordtran, M.D., Stephen G. Morawski, B.A., and Charles T.
Richardson, M.D. N Engl J Med 1973; 288:923-928May 3, 1973.
2. Assessment of in vitro Antacid Activity of Different Root Extracts
of Tephrosiapurpurea (L) Pers by Modified Artificial Stomach
Model Sandhya S, VenkataRamana K, Vinod K R,
ChaitanyaRsnakk.Asian Pacific Journal of Tropical Biomedicine
(2012)S1487-S1492.
3.Functional gastroduodenal disorders. Talley, N.J., Stanghellini, V.,
Heading, R.C., Koch, K.L., Malagelada, J.R. and Tytgat, G.N.J.,
1999, Gut, 45(suppl 2), pp.II37-II42.
4.Recent advances in proton pump inhibitors and management of
acid-peptic disorders,Jain, K.S., Shah, A.K., Bariwal, J., Shelke,
S.M., Kale, A.P., Jagtap, J.R. and Bhosale, A.V., Bioorganic &
medicinal chemistry, 2007. 15(3), pp.1181-1205.
5. Coping with common gastrointestinal symptoms in the
community: a global perspective on heartburn, constipation,
bloating, and abdominal pain/discomfort ,Hunt, R., Quigley, E.,
Abbas, Z., Eliakim, A., Emmanuel, A., Goh, K.L., Guarner, F.,
Katelaris, P., Smout, A., Umar, M. and Whorwell, P., 2014. Journal
of clinical gastroenterology, May 2013. 48(7), pp.567-578.
6. Novel therapeutic strategies in acid-related disorders,Tonini, M.,
De Giorgio, R. and De Ponti, F., 2003. Expert Opinion on
Therapeutic Patents, 13(5), pp.639-649.
7. Gastroesophageal reflux disease,Anderson, K., 2010. Radiologic
technology, 81(3), pp.251-268.
8. The Doctor's Guide to Gastrointestinal Health: Preventing and
Treating Acid Reflux, Ulcers, Irritable Bowel Syndrome,
Diverticulitis, Celiac Disease, Colon Cancer, Pancreatitis, Cirrhosis,
Hernias and More.Miskovitz, P. and Betancourt, M., 2010. John
Wiley & Sons.
9. Gastrointestinal tract. Pediatric sonography,Siegel, M.J., 2002., 4,
pp.339-83.
10. The stomach and duodenum. First principles of gastroenterology:
the basis of disease and an approach to management,Salena, B.J.,
Hunt, R.H., Sagar, M., Padol, I., Armstrong, D., Moayyedi, P., Yuan,
C. and Marshall, J., 1994.
