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Validated UV Spectrophotometric Methods for the Estimation of Letrozole in Solid Dosage Forms
Abstract
The main intent of this research is to develop two new simple, novel, cost efficient and precise UV spectrophotometric methods for estimation of letrozole in pure and pharmaceutical dosage forms. For estimation of letrozole based on the measurement of UV light absorption, the spectras of letrozole were scanned efficiently and it exhibits maximum absorption wavelength (λmax) at 240nm for Method A and 245nm for Method B. The analysis was carried out against phosphate buffer pH 6.8 (Method A) and phosphate buffer pH 3.8 (Method B) respectively. The drug shows linear response commencing from 0.5-20 µg/mL for both methods A & B. The regression equation was found as Y= 0.099X + 0.079 (Method A) and Y= 0.1359x + 0.0048 (Method B), and correlation coefficient were 0.999 (Method A) and 0.9999 (Method B). The method validation was accomplished as per the regulation of ICH Q2R1 guidelines for linearity, accuracy, and precision studies. These reported methods have good reproducibility with percentage RSD less than one. These methods were extended towards the formulation and there was no interruption from excipients in the formulation. Hence, these proposed methods can be effectively employed for evaluation of letrozole in quality control as well as routine analysis work in pharmaceutical industries.
... Studies of the published literature show that only a small number of articles using bisoprolol fumarate in spectroscopy with aqueous solvents have been published up to this point. In light of this, efforts have been made to develop and validate a new analytical approach for the medication bisoprolol fumarate utilizing straightforward solvent systems [5][6][7], which has the potential to be cost-effective and is easily used for regular analysis. Investigations on the limits of detection and quantification are also carried out, as are the optical characteristics and method validation parameters. ...
... Investigations on the limits of detection and quantification are also carried out, as are the optical characteristics and method validation parameters. These studies ensure that the method in question is both sensitive and linear [4,6,7]. ...
The current investigation signifies, a simple, affordable, precise, and accurate UV spectrophotometric method to estimate and validate lumefantrine concentrations in bulk and pharmaceutical formulations. Shimadzu twin beam UV-VIS spectrophotometer operated by UV probe software was used in the study. The resulting absorbance at a maximum wavelength of 268 nm was observed using the solvent 0.1N HCL. Numerous validation metrics, including accuracy, precision, linearity, and optical characteristics, were used to optimise the established method. Within a concentration range of 10-60 µg/mL, the regression co-efficient (R2) value of 0.997 was incorporated to obtain the linearity Graph. Less than 2%, of the results for accuracy and precision studies were executed, which shows increasing accuracy and precision levels. Due to low %RSD values in the recovery exploration, no excipients were included in the formulation of the tablet dosage form. The proposed method's accuracy study was confirmed at (80%, 100%, 120%) three levels, and the outcomes were validated in accordance with ICHQ2R1 guidelines. These findings indicate that the procedure has practical value as a tool for quality control when analysing drugs in their tablet dosage forms in the pharmaceutical industry.
... LTZ was previously quantified using various analytical techniques, including chromatographic separation such as high-performance thin layer chromatography [26], reversed phase liquid chromatography [27,28], liquid chromatography coupled with tandem mass spectrometry [29,30], and capillary zone electrophoresis [31]. Furthermore, different spectrophotometric methods were reported for the determination of LTZ in various media [32][33][34][35][36]. However, very few articles were concerned with potentiometric determination of LTZ [37]. ...
The advanced and high-functional activities of magnesium oxide and copper oxide nanoparticles encourage the extensive use of these metal oxides as remarkable electroactive materials in electrochemical and sensing detections. The current study described a comparative sensing activity and selectivity of modified coated wire membrane sensors enriched with magnesium oxide and copper oxide nanoparticles for quantifying the breast cancer medication letrozole (LTZ) in its pharmaceutical form and human plasma. The fabricated sensors were based on the incorporation of LTZ with phosphomolybdic acid (PMA) to form the electroactive complex letrozole-phosphomolybate (LTZ-PM) in the presence of o-nitrophenyloctyl ether (o-NPOE) as a solvent mediator. Under optimum conditions, the modified sensors LTZ-PM-MgONPs and LTZ-PM-CuONPs demonstrated linear relationships of 1.0 × 10−8–1.0 × 10−2 and 1.0 × 10−10–1.0 × 10−2 mol L−1, respectively. Least square equations were calculated as EmV = (56.4 ± 0.7) log [LTZ] + 569.6 and EmV = (58.7 ± 0.3) log [LTZ] + 692.6 for LTZ-PM-MgONPs and LTZ-PM-CuONPs, respectively. The conventional type LTZ-PM showed a potential response EmV = (53.3 ± 0.5) log [LTZ] + 451.4 over concentration range of 1.0 × 10−6–1.0 × 10−2 mol L−1. The suggested sensors were successfully used to determine LTZ in pharmaceutical formulations and biosamples. Method validation ensured the suitability of the suggested potentiometric sensors.
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