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Abstract P2071: β-1,3/1,6-d-glucan Of Indonesian Ganoderma Lucidum Mycelium Extract Reduces Systolic Blood Pressure & Inflammation In Hypertensive Patients

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Abstract

Background: Extract of Ganoderma lucidum Mycelium containing β-1,3/1,6-D-Glucan has shown to possess beneficial effects on cardiovascular diseases. Objective: To examine the effectiveness of β-1,3/1,6-D-Glucan (GLME) consumption to reduced blood pressure (BP) & inflammation in patients with hypertension. Material and Methods: A randomized, double-blind, placebo-controlled clinical trial was conducted in 50 hypertensive adults (JNC VII, age 50-70 years). The patients were divided into 6 groups. Group A: received GLME 540mg/day + CCB, Group B: GLME + ACEI/ARB, Group C: placebo + ACEI, Group D: placebo + CCB, Group E: GLME only & Group F: placebo only. We used the Morisky score to evaluate treatment’s adherence & excludes patients with Morisky < 6. A standardized method was used to measure BP at baseline and thereafter every 30 days until day 90. Further, heart rate (HR), LVEF, LVMI, hsCRP, MDA, TNF-α, IL-1, & IL-6 were measured at baseline & at 90-days. Results: At day 90, GLME lowered systolic BP (SBP) compared to placebo (–22.82±11.4 vs. –10±16.0 mmHg; p= 0.007), DBP was lowered without significant difference between GLME & placebo groups. The change in mean arterial pressure was significance compared with placebo p= 0.028. Group B have the most reducing SBP effect compared with others, p=0.000. The reducing effect of mean arterial pressure was significance in group A compared with others, p= 0.008. In Group B, we found that there was a significance decreasing in hsCRP compared with p=0.01. The reducing effect LVMI, TNF-α, plasma IL- 6 and IL-1 concentration was significantly lower in group B compared with other group (p= 0.043, p= 0.001, p= 0.0008, p= 0.0005, respectively). Conclusion: GLME may significantly reduce SBP systolic & LVMI & may have an anti-inflammatory effect shown through the reduction of IL-6, IL-1β, and TNF-α.

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... Therefore, orally administered b-glucans show many biological activities including antitumor, immunomodulating, bone injury healing, anti-diabetic, cholesterol-lowering, and antigenotoxic activities [10]. b-Glucans have been reported to have antihypertensive efficacy in hypertensive and hyperlipidemic persons, patients with type 2 diabetes, hypertensive patients, and obese persons [11]. However, most of the previous research did not elucidate the antihypertensive mechanism of b-glucans. ...
... Some mushroom b-glucans have been reported to have antihypertensive activities. The b-glucan of G. lucidum reduced systolic pressure in hypertensive patients [11]. Mushroom powders from Lentinus edodes and Grifola frondosa decreased blood pressure in spontaneously hypertensive rats [17]. ...
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BACKGROUND: There are growing interests in the use of medicinal mushrooms in controlling overweight and obesity. OBJECTIVE: The aim of the present study was to assess the effect of Lingzhi on anthropometric indices, fasting blood sugar, lipid profile and blood pressure of overweight individuals METHODS: This randomized double-blind clinical trial was performed on seventy-two overweight individuals (Body Mass Index (BMI) = 25–29.9 kg/m2) received 3 capsule Ganoderma Lucidum (each capsule containing 220 mg of whole powder and 30 mg of pure aqueous extract) daily or matching placebo for 6 weeks. Anthropometric indices, metabolic tests (fasting blood sugar (FBS) and serum lipid profile) and blood pressure were measured before and after treatment. RESULTS: Data analyses indicated that body weight and BMI were decreased after 6-week intervention (P < 0.05). The beneficial effect of supplementation was evident on some anthropometric indices. Changes in LDL-cholesterol were significantly different between two treatment and placebo groups (P < 0.05). FBS, other components of lipid profile and blood pressure did not significantly change by Lingzi treatment. CONCLUSIONS: Results showed that Ganoderma Lucidum might have some potential benefits on anthropometric indices and mild effects on lipid profile, but and there is no claim for weight lose function. Hence, further long-term studies are recommended.
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