Urban arterials and intersections account for a large proportion of high severity crashes in Australia and New Zealand, particularly involving vulnerable road users. Safety gains appear to be slower in these ‘mixed use’ environments than in other areas. Austroads commissioned research to help identify solutions that might be applied on mixed use arterial roads to improve safety through the provision of Safe System infrastructure. The project involved assessment of six case studies around Australia and New Zealand. Concept designs were developed for each of the routes based on analysis of safety issues and the likely safety benefits were assessed. This paper presents information on the safety solutions identified, as well as the broader issues that need to be considered when addressing safety on mixed use urban arterial roads.