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An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Author Correction: TGF-βinduces miR-100 and
miR-125b but blocks let-7a through LIN28B
controlling PDAC progression
Silvia Ottaviani 1, Justin Stebbing1, Adam E. Frampton 2,3, Sladjana Zagorac1, Jonathan Krell3,
Alexander de Giorgio1, Sara M. Trabulo4,5, Van T.M. Nguyen1, Luca Magnani 1, Hugang Feng6,
Elisa Giovannetti7,8, Niccola Funel8, Thomas M. Gress9, Long R. Jiao2, Ylenia Lombardo1, Nicholas R. Lemoine10,
Christopher Heeschen4,5 & Leandro Castellano 1,11
Correction to: Nature Communications https://doi.org/10.1038/s41467-018-03962-x, published online 10 May 2018
The original version of this Article omitted a declaration from the competing interests statement, which should have included the
following: One of the authors, Y.L., is an editor on the staff of Nature Communications, but was not in any way involved in the journal
review process. The other authors declare no competing interests. This has now been corrected in both the PDF and HTML versions of
the Article.
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© The Author(s) 2019
https://doi.org/10.1038/s41467-019-11752-2 OPEN
1Department of Surgery and Cancer, Division of Cancer, Imperial College London, Imperial Centre for Translational and Experimental Medicine (ICTEM),
London W12 0NN, UK. 2Department of Surgery and Cancer, HPB Surgical Unit, Imperial College, Hammersmith Hospital Campus, London W12 0HS, UK.
3Department of Surgery and Cancer, Division of Cancer, Imperial College London, Institute of Reproductive and Developmental Biology (IRDB), London W12
0NN, UK. 4Stem Cells & Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid 28028, Spain. 5Stem Cells in Cancer & Ageing, Barts
Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK. 6Epigenetics and Genome Stability Team, The Institute of Cancer Research, 237
Fulham Road, London SW3 6JB, UK. 7Department of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam 1081 HV, The
Netherlands. 8Cancer Pharmacology Lab, AIRC Start-Up Unit, University of Pisa, Pisa 56126, Italy. 9Clinic for Gastroenterology, Endocrinology, Metabolism
and Infectiology, Philipps-University Marburg, Marburg 35037, Germany. 10 Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of
London, London EC1M 6BQ, UK. 11University of Sussex, School of life Sciences, John Maynard Smith Building, Falmer, Brighton BN1 9QG, UK. These authors
contributed equally: Silvia Ottaviani, Justin Stebbing. Correspondence and requests for materials should be addressed to L.C. (email: l.castellano@sussex.ac.uk)
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... During quality control of the mapped data, RNAs with less than 10 readcounts across all samples were excluded and -Strathmann et al., 2014;Lardenoije et al., 2015;Lu et al., 2017;Salta and De Strooper, 2017b;Elliott et al., 2018;Jin et al., 2018;Ottaviani et al., 2019 miR-129-1 −0.7 miR-129-2 −0.9 Strickland et al., 2011miR-132 −2.5 Majer et al., 2012Freischmidt et al., 2013;Bicker et al., 2014;Essandoh et al., 2016;Tasaki et technical replicates were collapsed after heatmap inspection (Supplementary Figure S1). Transcripts with less than 10 reads across all remaining samples were discarded. ...
... It has been found to be associated with other neurodegenerative diseases as well (Lardenoije et al., 2015;Salta and De Strooper, 2017b). TGF-β induced miR-100 and miR-125b (Ottaviani et al., 2019). MiR-100 and miR-125b coordinately suppress Wnt/b-catenin negative regulators, thereby increasing Wnt signaling (Lu et al., 2017). ...
... Eight miRs were exclusively altered in the hippocampus between 3 and 8 month-old in WT mice. TGF-β induced an lncRNA with its encoded miRs, miR-100 and miR-125b Ottaviani et al., 2019). MiR-100 and miR-125b coordinately suppressed Wnt/β-catenin negative regulators thereby increased Wnt signaling (Lu et al., 2017). ...
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