This study explores the co-evolutionary triangle of crisis, innovation, and change management in less-developed local business ecosystems. It takes as a case study the region of Eastern Macedonia and Thrace-one of the least developed regional socioeconomic business ecosystems in Greece and the EU-and tries to find out the correlation between the different aspects of this "global crisis-innovation-change management" triangle from the perspective of a sample of micro and small enterprises operating in this ecosystem. To this end, the authors conducted a qualitative, introductory, field research, finding that there is a significant gap between the predominant scientific view of regional underdevelopment and the perception of the people of everyday business practice. This article supports that this deficient perception is one of the determining factors of the delayed development for this regional entrepreneurial ecosystem.