Virtual reality and video games are increasingly considered as potentially effective tools for the assessment of several cognitive abilities, including executive functions. However, thus far, only non-commercial contents have been tested and virtual reality contents and video games have been investigated separately. Within this context, this study aimed to explore the effectiveness in the assessment of executive functions using a new type of interactive content - commercial virtual reality games - which combines the advantages of virtual reality with that of commercial video games. Thirty-eight participants completed the Trial Making Test as traditional commonly used assessments of executive functions and then played the virtual reality game Audioshield using an HTC Vive systems. Scores on the Trial Making Test (i.e., time to complete part A and B) were compared to scores obtained on Audioshield (i.e., number of orbs hit by the players and technical score). The results showed that: (a) performance on the Trial Making Test correlated significantly with performance on the virtual reality video game; (b) scores on Audioshield can be used as a reliable estimator of the results of Trial Making Test.