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Aloe vera, sometimes referred as a "miraculous" or "wonder" plant, has been used by mankind for centuries for the treatment of different disorders due to the inner gel of its succulent leaves. Medical usage and applications of the main species, namely Aloe vera (L.) Burm. f. are mainly attributed to immunomodulatory or antioxidant activities. Our work on A. vera has begun with the separation of anthraquinones and continued with the purification and characterization of the lectins. In another study, hypoglycemic effect of A. vera leaf extracts was assayed in vivo, followed by the effect of the extracts on several tissues in diabetic rats. A. vera has shown a significant prophylactic effect on Ehrlich ascites tumour cells when given before tumour inoculation in mice. This effect was also seen with the purified lectin and attributed to the immunomodulatory effect of the plant. Assuming that its benefit could also be attributed to the antioxidant activity, the antioxidant potential of the leaves aqueous extract was evaluated. The leaf skin extract showed good antioxidant capacity in all tests while the inner gel did not exhibit any activity. Our work on A. vera continues on the research of the potential use of the plant leaves as anticancer and enzyme inhibitory agent.
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İstanbul Ecz. Fak. Derg. / J. Fac. Pharm. Istanbul

Aloe vera

4


2

3
4
 Aloe vera

            
     Aloe vera       

A. vera   
          
A. verain vivo
A. vera
Ehrlich ascites



  


A. vera

  Aloe vera   



Twenty years of research on Aloe vera

Aloe vera

         
  
Aloe


       
Aloe        

Aloe A. vera
A. barbadensisA. chinensisA. vulgaris
A. elongataA. officinalis
 A. arborescensnatalensis A. perryi
A. feroxA. africanaA. saponaria

Aloe
Aloe

AloeAloe
  
Aloe         
A. vera

   Aloe      
          




  
Aloe


Nuriye AKEV, Ayşe CAN, Nurhayat SÜTLÜPINAR, Eda ÇANDÖKEN, Nurten ÖZSOY,
Tuğba Yılmaz ÖZDEN, Refiye YANARDAĞ, Erdal ÜZEN
Aloe

 Aloe
 Aloe      
.
  Aloe
   Aloe
 
A. perryi
 
 Aloe
 Aloes  
.
 Aloe

 Aloe

 Aloe, 
 A. vera

 Aloe,  

 Aloe     
Aloe
 Aloe 
as 
 Aloe vera
 A. vera
 A. barbadensis  
Aloe vera 
 A. vera
.
 Aloe

 A. barbadensisA. vera
 A. vera
       A. vera       

 Aloe 
 Aloe
 A.vera 

Twenty years of research on Aloe vera

A. vera
        
 

A. vera
          

 
   A. vera       
         

   

         




  A.vera
 

             



 A.vera 
      
    
        





Aloe

Nuriye AKEV, Ayşe CAN, Nurhayat SÜTLÜPINAR, Eda ÇANDÖKEN, Nurten ÖZSOY,
Tuğba Yılmaz ÖZDEN, Refiye YANARDAĞ, Erdal ÜZEN
 Aloe vera   Aloe vera 
   

A. vera         





A. vera

Twenty years of research on Aloe vera
 Aloe vera

 Aloe vera

Nuriye AKEV, Ayşe CAN, Nurhayat SÜTLÜPINAR, Eda ÇANDÖKEN, Nurten ÖZSOY,
Tuğba Yılmaz ÖZDEN, Refiye YANARDAĞ, Erdal ÜZEN
Aloe
  
 




 





 








  

 


 



 







 



  
 

 



A. vera
   A. vera       
 
A. vera
Twenty years of research on Aloe vera

        

          

       
  


  
 
   

       


             
          
          
          
 A. vera

           
        A. vera 
     in vivo     in
vitro



  
        
in vitro



Nuriye AKEV, Ayşe CAN, Nurhayat SÜTLÜPINAR, Eda ÇANDÖKEN, Nurten ÖZSOY,
Tuğba Yılmaz ÖZDEN, Refiye YANARDAĞ, Erdal ÜZEN
 A. vera
 A. vera 
 

   




A. vera
laboratory
 A. vera      


  






A. vera
A. vera


Twenty years of research on Aloe vera200
Aloe vera

Aloe vera

A. vera
  


A. vera
 
    
            

Nuriye AKEV, Ayşe CAN, Nurhayat SÜTLÜPINAR, Eda ÇANDÖKEN, Nurten ÖZSOY,
Tuğba Yılmaz ÖZDEN, Refiye YANARDAĞ, Erdal ÜZEN
A. arborescensA. vera
  
         


 




         

          
Ehrlich ascites           
            
   
     

A.vera


A. vera
   A. vera

         
        
A. vera

 A. vera

A. vera
           
   
Twenty years of research on Aloe vera202

A. vera 

 


          
A. vera


       A.
vera   


A. vera    


  
 A. vera
         
A. arborescens
A. vera
         A. vera


A. vera 


A. vera


 


203
Nuriye AKEV, Ayşe CAN, Nurhayat SÜTLÜPINAR, Eda ÇANDÖKEN, Nurten ÖZSOY,
Tuğba Yılmaz ÖZDEN, Refiye YANARDAĞ, Erdal ÜZEN
          Ehrlich
ascites

A. veraEhrlich ascites
A. vera 
 A. vera
A. vera
A. vera

     


A. verain vitro



A. vera
A. vera
       



A. vera
  
A. vera

Aloe


        
A. vera
A. vera
       
Twenty years of research on Aloe vera204

 



A. vera

A. vera   
in vivo
A. vera
     
A. vera
       

A. vera
A. vera




         
         
 
        


Aloe
     A. vera       


205
Nuriye AKEV, Ayşe CAN, Nurhayat SÜTLÜPINAR, Eda ÇANDÖKEN, Nurten ÖZSOY,
Tuğba Yılmaz ÖZDEN, Refiye YANARDAĞ, Erdal ÜZEN
Aloe



          
A. vera


  A. vera   Aloe  



A. vera



Aloe




        
         
         
        

Twenty years of research on Aloe vera206
Aloe vera


Aloe vera

        
A. vera in
vivoin vitro



       



      
Aloe
Aloe
Aloe


   A.vera      
       
A. vera
A. vera




Aloe vera
          
       
   

207
Nuriye AKEV, Ayşe CAN, Nurhayat SÜTLÜPINAR, Eda ÇANDÖKEN, Nurten ÖZSOY,
Tuğba Yılmaz ÖZDEN, Refiye YANARDAĞ, Erdal ÜZEN

Aloe vera
J. Appl. Sci. Res.
 
aloe veraAfr. J. Biotechnol.
, Angiology
  
J. Food Sci. Technol. 525-533.
            
J. Ethnopharmacol., 
 Aloe vera
   Eur. J. Cell
Biol. 3.
Aloe vera
Phytother. Res.
    Aloe vera
   
   

 Aloe vera
 İstanbul Ecz. Fak. Mec., 

Aloe veraEhrlich ascitesEur. J. Cancer Prev.


Aloe veraEhrlich ascites
Phytother. Res.
Aloe vera
J. Anim. Vet. Adv.
          
AloePhytother.
Res.

Aloe veraIndian J. Pharmacol.
322-327.
   
Aloe veraAloe barbadensisToxicon
Twenty years of research on Aloe vera
            
Plant Food. Hum. Nutr.

 Aloe arborescens  
J. Ethnopharmacol 37-45.

Aloe arborescensnatalensisPhytother. Res., 

 Aloe vera  
Egypt. J. Biol.

Aloe vera     
Indian J. Exp. Biol.

Ann. Pharmacother
   
 Aloe vera 
      Türkiye Klinikleri J. Nephrol-
Special Topics
       
 Aloe vera .  
Phytomedicine, 
Aloe
vera Biol. Pharm.
Bull
 Aloe vera  





Aloe vera 

 FEBS J., 

Phytother. Res

Cell. Mol. Life Sci.

Nuriye AKEV, Ayşe CAN, Nurhayat SÜTLÜPINAR, Eda ÇANDÖKEN, Nurten ÖZSOY,
Tuğba Yılmaz ÖZDEN, Refiye YANARDAĞ, Erdal ÜZEN

J. Ethnopharmacol
Aloe vera
Semin. Integr. Med. 53-62.

             Aloe
barbadensis Process Biochem., 
Aloe barbadensis
The Internet Journal of Microbiology   

Aloe
veraAm. J. Roentgenol.

Aloe vera Int. J. Tissue React.,  
     Aloe vera       
Phytother. Res

 Aloe
veraCurr. Med.
Chem.
Aloe vera
Crit. Rev. Food Sci. 
          
Aloe barbadensisp
Plant Physiol. Biochem
   Aloe
veraContact Dermatitis
 
  ,
Hormone Res
 Vopr. Onkol.,
 
 Aloe vera 
Phytother. Res

     Aloe
veraMethods
Twenty years of research on Aloe vera
Aloe veraMolecules


Aloe
Phytother. Res.,  455-457.

Aloe veraArch.
Pharm. Res
        Aloe arborescens   
Phytother. Res.,  S20-S22.

        
Experientia
Aloe vera  
   Aloe vera       

Aloe vera
     


      Ehrlich
ascitesJ. Nutr. Sci.Vitaminol 540-546.
In vitro
Aloe veraLipids
Health Dis.,   


Aloe veraJ. Pharm. Res.


Aloe arborescens natalensisJ. Biochem., 

Aloe veraPhytother. Res., 
464.

Aloe
Appl. Biochem. Biotechnol.
              

Nuriye AKEV, Ayşe CAN, Nurhayat SÜTLÜPINAR, Eda ÇANDÖKEN, Nurten ÖZSOY,
Tuğba Yılmaz ÖZDEN, Refiye YANARDAĞ, Erdal ÜZEN
Aloe veraJ. Med. Plants
Res.

 
Cancer Lett. 55-63.
            

J. Urol. 343-347.
Aloe vera


Pharmacology, 
  
Aloe arborescens
natalensisFood Chem. Toxicol.

In vitroAloe vera
Journal de la Société Chimique de Tunisie
Aloe arborescens
           
Afr. J. Biotechnol
Aloe vera
Int. Res. J. Plant Sci.

     Aloe vera    
Asian J. Pharm. Clin. Res.

Aloe barberae
J. Ethnopharmacol.
Aloe
veraOrg. Med. Chem. Lett.

Aloe veraCurr. Sci.

Aloe barbadensis
Biokemistri
Aloe vera
Twenty years of research on Aloe vera
Phytother. Res.

Aloe vera
           
 

          
        
Aloe veraOxid. Med. Cell. Longev.
Aloe vera
., 
Aloe vera versus
           
Asian J. Chem.
 Aloe vera
İstanbul Ecz. Fak.
Mec., 
           
Aloe vera Escherichia coli
J. Ethnopharmacol
Aloe barbadensis
Appl. Biochem. Biotechnol.

   In vitro     Aloe vera    
  International Journal of Advanced
Biotechnology and Research

Aloe veraWorld J. Gastroenterol 303-304.
Aloe
veraClin. Exp.
Pharmacol. P. 232-237.
Aloe
veraJ. Appl. Sci. Res.

Aloe
veraJ. Plant Sci. 


Nuriye AKEV, Ayşe CAN, Nurhayat SÜTLÜPINAR, Eda ÇANDÖKEN, Nurten ÖZSOY,
Tuğba Yılmaz ÖZDEN, Refiye YANARDAĞ, Erdal ÜZEN
   Aloe vera
Fitoterapia
Aloe vera
Enzyme Protein
 
Aloe veraEnzyme Protein
In vitroAloe vera 
    International Journal of Community
Nutrition           

  Aloe arborescens  
Phytother. Res., 
            

The Egyptian Journal of Histology
           
Phytother. Res.
      
         Aloe vera
J. Toxicol., 
.
Science,

 Aloe veraAdv. Environ. Biol.

Aloe vera
 World J. Pharm.
Res. 
   Aloe vera
    
Phytomedicine 
       Aloe barbadensis     
Artemia franciscanaPhytother. Res.,  360-364.
Aloe vera
J. Clin. Den. Res. Edu.


Twenty years of research on Aloe vera
 
AloePharm. Biol
Aloe veraIndian J. Dermatol.


Aloe arborescensJ. Biochem
      


 


Aloe arborescens natalensis 
Phytother. Res. S43-S47.

Aloe vera
Journal of Herbal Pharmacotherapy
Aloe veraAloe vera
Aloe vera Aloe vera
.

Aloe veraJ. Ethnopharmacol
 Aloe vera 
Brit. J. Gen. Pract.

in vitroEcon. Bot. 


Aloe verachinensisLife Sci 622-630.
              
Experientia
            

Aloe veraPlanta Med
              
J Korean Med. Sci.

Nuriye AKEV, Ayşe CAN, Nurhayat SÜTLÜPINAR, Eda ÇANDÖKEN, Nurten ÖZSOY,
Tuğba Yılmaz ÖZDEN, Refiye YANARDAĞ, Erdal ÜZEN

Aloe vera ,Mec.,  65-75.
   Aloe vera      

       
Aloe vera  
, Phytomedicine, 
... Aloe vera L. is an important member of Liliaceae family and genus Aloe (Nie et al., 2018;Cock, 2015;Hasanuzzaman et al., 2008) widely cultivated in many countries due to its importance as an all-purpose herbal or medicinal plant. Due to this, the plant is sometimes referred as a "miraculous plant", 'the wonder plant', 'plant of immortality' and 'nature powder' (Lanka, 2018;Akev et al., 2015). It leaves of this plant contain fat compounds, carbohydrates, proteins, lipids, and 18 essential amino acids, vitamins (e.g., A, C, E, vitamin B12, folic acid), minerals, glycoprotein, C-glucosylchromone, anthraquinones, emodin, salicylic acid and various kinds of enzymes (Lanka, 2018;Hamman, 2008;Surjushe et al., 2008). ...
... A. vera is familiar for using as functional food supplement and preservative of foods for the presence of antioxidant molecules, high amount of carbohydrates, and vitamins as its constituents (Gupta et al., 2020a). The plant has wide use in cosmetology and medicine (Lanka, 2018;Cock, 2015;Akev et al., 2015;Eshun and He, 2004;Hamman, 2008). A. vera extract can also be used for the perturbation of enzymatic and nonenzymatic antioxidative indices levels in rats (Gupta et al. 2019(Gupta et al. , 2020b. ...
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Aloe vera L. is widely cultivated in many countries due to its importance as an all-purpose herbal or medicinal plant. The growth and yield of this plant can be enhanced by application of fertilizer. It is expected that a higher and balanced nutrient supply will result in higher crop production maintaining soil health, which is possible when the applied fertilizers are done in way that is efficient. So, there is a need to understand the amount of applied and type of fertilizer that will give the best output for farmers and to formulate economical market products. This study was conducted to investigate the effect of N fertilizer on leaf yield, its uptake and requirement, critical concentration, use efficiency and economics of Aloe vera L. Plants were grown at six levels of N: 0, 40, 80, 100, 150 and 200 kg ha −1 from urea and diammonium phosphate (DAP) following completely randomized design with three replicates under field condition. The highest values of yield and yield attributes and profit based on benefit cost ratio (3.81 for urea and 2.91 for DAP) were obtained with 150 kg N ha −1 (urea) and 100 kg N ha −1 (DAP). Leaf biomass yield increased by 18-128 % in urea-N and 30-139 % in DAP-N fertilized plant over control while DAP > urea by 7.59 %. Sucker production (mean number) was urea-N (4.95 Plant −1) > DAP-N (2.28 Plant −1). Both gel and leaf N concentration and uptake was highest at 200 kg ha −1 for both sources. For 80 % leaf biomass yield, minimum requirement of N was ca 74.90 (urea) and 89.60 kg ha −1 (DAP). Growth and yield parameters to N application exhibited significant and positive correlations. Critical leaf N concentration was ca 0.88% (DAP) and 0.90% (urea) while mean and maximum NUE was 34% and 64 % (urea) and 43% and 69% (DAP), respectively. Farmers can be advised to apply N at the rate of 150 kg ha −1 from urea for producing economically higher yield and better-quality A. vera leaves.
... Ae improved the quality of roselle plants by increasing the anthocyanin and nutrient content of potassium, and KSi also reduced the pH of the extract. Ae significantly enhanced the activity of proline to help plants deal with salt stress, which may be due to the naturally-occurring antioxidant components found in the aqueous extract of aloe leaves (e.g., total phenols, flavonoids, ascorbic acid, β-carotene, and αtocopherol) [112]. A. saponaria also contains phenols and flavonoids which could contribute toward plant tolerance of deficit irrigation. ...
Article
Full-text available
Two successive field trials were carried out at the experimental farm of the Agriculture Department of Fayoum University, Fayoum, Egypt, to investigate the sole or dual interaction effect of applying a foliar spray of Aloe saponaria extract (Ae) or potassium silicate (KSi) on reducing the stressful salinity impacts on the development, yield, and features of roselle (Hibiscus sabdariffa L.) plants. Both Ae or KSi were used at three rates: 0% (0 cm3 L−1), 0.5% (5 cm3 L−1), and 1% (10 cm3 L−1) and 0, 30, and 60 g L−1, respectively. Three rates of salinity, measured by the electrical conductivity of a saturated soil extract (ECe), were also used: normal soil (ECe < 4 dS/m) (S1); moderately-saline soil (ECe: 4–8 dS/m) (S2); and highly-saline soil (ECe: 8–16 dS/m) (S3). The lowest level of salinity yielded the highest levels of all traits except for pH, chloride, and sodium. Ae at 0.5% increased the values of total soluble sugars, total free amino acids, potassium, anthocyanin, a single-photon avalanche diode, stem diameter, fruit number, and fresh weight, whereas 1% of Ae resulted in the highest plant height, chlorophyll fluorescence (Fv/Fm), performance index, relative water content, membrane stability index, proline, total soluble sugars, and acidity. KSi either at 30 or 60 g L−1 greatly increased these abovementioned attributes. Fruit number and fruit fresh weight per plant also increased significantly with the combination of Ae at 1% and KSi at 30 g L−1 under normal soil conditions.
... vera) is actually Aloe barbadensis Miller. Nomenclature of Aloe is derived from two words; "alloeh" (in Arabic) or "allal" (in Hebrew) or "alsos" (in Greek) which translates to "bitter" and "vera" meaning, "true" [19]. A. vera is rich with numerous phytochemicals including coumarins, chromones, anthraquinones, flavonoids, enzymes, vitamins [20], anthrones, phenols, alkaloids, carbohydrates and proteins [21]. ...
Article
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Aims: Organ toxicity results from the accumulation of toxic substances in the organs which ultimately culminates in failure of the organ. Allopathic medications are not very effective in organ protection. Hence, it is imperative that a natural and safer organoprotective agent should be found. Study Design: To assess the organoprotective effect of Aloe vera gel against STZ for renal, hepato and pancreatic toxicity in albino Wistar rats. Place and Duration of Study: Whole work had been completed at the Microbiology and Molecular biology labs of IMBB, The University of Lahore during 2019-2020. Methodology: Organoprotective ability of different doses of ethanolic extracts of Aloe vera (A. vera) gel was evaluated against intraperitoneal induction of 55mg/kg Streptozotocin (STZ)-induced
... Ae improved the quality of roselle plants by increasing the anthocyanin and nutrient content of potassium, and KSi also reduced the pH of the extract. Ae significantly enhanced the activity of proline to help plants deal with salt stress, which may be due to the naturally-occurring antioxidant components found in the aqueous extract of aloe leaves (e.g., total phenols, flavonoids, ascorbic acid, β-carotene, and α-tocopherol) [112]. A. saponaria also contains phenols and flavonoids which could contribute toward plant tolerance of deficit irrigation. ...
Article
Full-text available
Abstract: Two successive field trials were carried out at the experimental farm of the Agriculture Department of Fayoum University, Fayoum, Egypt, to investigate the sole or dual interaction effect of applying a foliar spray of Aloe saponaria extract (Ae) or potassium silicate (KSi) on reducing the stressful salinity impacts on the development, yield, and features of roselle (Hibiscus sabdariffa L.) plants. Both Ae or KSi were used at three rates: 0% (0 cm3 L−1), 0.5% (5 cm3 L−1), and 1% (10 cm3 L−1) and 0, 30, and 60 g L−1, respectively. Three rates of salinity, measured by the electrical conductivity of a saturated soil extract (ECe), were also used: normal soil (ECe < 4 dS/cm2) (S1); moderately-saline soil (ECe: 4–8 dS/cm2) (S2); and highly-saline soil (ECe: 8–16 dS/cm2) (S3). The lowest level of salinity yielded the highest levels of all traits except for pH, chloride, and sodium. Ae at 0.5% increased the values of total soluble sugars, total free amino acids, potassium, anthocyanin, a single-photon avalanche diode, stem diameter, fruit number, and fresh weight, whereas 1% of Ae resulted in the highest plant height, chlorophyll fluorescence (Fv/Fm), performance index, relative water content, membrane stability index, proline, total soluble sugars, and acidity. KSi either at 30 or 60 g L−1 greatly increased these abovementioned attributes. Fruit number and fruit fresh weight per plant also increased significantly with the combination of Ae at 1% and KSi at 30 g L−1 under normal soil conditions.
... Ae improved the quality of roselle plants by increasing the anthocyanin and nutrient content of potassium, and KSi also reduced the pH of the extract. Ae significantly enhanced the activity of proline to help plants deal with salt stress, which may be due to the naturally-occurring antioxidant components found in the aqueous extract of aloe leaves (e.g., total phenols, flavonoids, ascorbic acid, β-carotene, and α-tocopherol) [112]. A. saponaria also contains phenols and flavonoids which could contribute toward plant tolerance of deficit irrigation. ...
Article
Full-text available
Two successive field trials were carried out at the experimental farm of the Agriculture Department of Fayoum University, Fayoum, Egypt, to investigate the sole or dual interaction effect of applying a foliar spray of Aloe saponaria extract (Ae) or potassium silicate (KSi) on reducing the stressful salinity impacts on the development, yield, and features of roselle (Hibiscus sabdariffa L.) plants. Both Ae or KSi were used at three rates: 0% (0 cm3 L−1), 0.5% (5 cm3 L−1), and 1% (10 cm3 L−1) and 0, 30, and 60 g L−1, respectively. Three rates of salinity, measured by the electrical conductivity of a saturated soil extract (ECe), were also used: normal soil (ECe < 4 dS/cm2) (S1); moderately-saline soil (ECe: 4–8 dS/cm2) (S2); and highly-saline soil (ECe: 8–16 dS/cm2) (S3). The lowest level of salinity yielded the highest levels of all traits except for pH, chloride, and sodium. Ae at 0.5% increased the values of total soluble sugars, total free amino acids, potassium, anthocyanin, a single-photon avalanche diode, stem diameter, fruit number, and fresh weight, whereas 1% of Ae resulted in the highest plant height, chlorophyll fluorescence (Fv/Fm), performance index, relative water content, membrane stability index, proline, total soluble sugars, and acidity. KSi either at 30 or 60 g L−1 greatly increased these abovementioned attributes. Fruit number and fruit fresh weight per plant also increased significantly with the combination of Ae at 1% and KSi at 30 g L−1 under normal soil conditions.
... The resulting zinc oxide nanoparticles have been majorly employed in different areas of medicine. Thus, the specific objectives of this study are: (1) develop and synthesise nano lubricant using the aloe vera plant; (2) evaluate the performance of the developed nano lubricant; (3) carry out performance evaluation in a domestic refrigerator; and (4) validate results by comparing them to the performance evaluation of a control (mineral oil) [5]. Aloe vera resembles a cactus because it is fleshy, has thorns all along periphery of its leaf tissue, is wax-coated, and holds a huge amount of water. ...
Article
Full-text available
Power consumption is a significant issue in developing countries, and the refrigerator is one of the largest consumers of electricity. Nanoparticles functioning as additives to refrigerants or lubricating oils help reduce compressor work and reduce the power consumption of refrigerators. In this study, zinc oxide nanoparticles were developed using Aloe Vera leaves and dispersed in mineral oil to reduce the compressor work and increase the performance of a domestic vapour compression refrigeration system. After the successful synthesis of the nanoparticles, spectroscopical investigations using EDS revealed the nanoparticles to have 73.31% zinc, 20.19% oxygen and 6.40% carbon indicating a significant phase of zinc oxide. Microstructural studies on the nanoparticles revealed an average nanoparticle size of 4.68 nm within the nanometric range. The nanoparticles were dispersed in mineral oil in concentrations of 0.5 g/250 ml, 0.75 g/250 ml, 1 g/250 ml, 1.25 g/250 ml and 1.5 g/250 ml of the oil and fed into the compressor to check the effect of each concentration on the performance of the refrigerator. The control sample contained pure mineral oil. The system was monitored for 225 minutes per sample, and coefficient of performance was determined. The results indicate an increase in COP by 14-15% from 0.4 wt% and 0.6 wt% respectively.
... [1] Africa, the Arabian Peninsula, Madagascar, and the islands of the Indian Ocean are the homelands of Aloe. [2] Aloe vera has triangular, plump leaves as well as serrated edges. It has plentiful seeds within its fruits and flowers. ...
Article
Oral lichen planus Oral submucous fibrosis Recurrent aphthous stomatitis A B S T R A C T Background and aim: Aloe vera is also called Aloe barbadensis Miller. Aloe vera has been utilized for its numerous salutary properties. It has been utilized for fast wound healing and pain alleviation. There are few clinical studies recorded where Aloe vera is utilized in the treatment of oral mucosal diseases. The rationale for this review is to study clinical trials to assess the adequacy of Aloe vera in the treatment of oral mucosal diseases. Materials and methods: PubMed (Central), Wiley online library, Elsevier, Google scholar, and Hinary were used from the electronic databases using keywords until December 2020 to perform systematic literature. The quest was based on the terms of Mesh. Randomized or quasi-randomized clinical trials, cross-sectional and case-control studies included in this review. Literatures in English were only considered for this review. Review articles, experimental studies, and in-vitro studies were excluded in this review. Results: A total of 20 articles met the inclusion criteria. These articles were clinical trials for assessing the efficiency of Aloe vera in oral mucosal diseases that showed the efficacy of Aloe vera in oral submucous fibrosis, oral lichen planus, burning mouth syndrome, recurrent aphthous stomatitis, and chemotherapy-induced stomatitis. It showed fewer beneficial effects on radiation-induced mucositis. Conclusion: In the future, Aloe vera can play a promising role in various oral diseases. More studies should be performed in the future to determine the appropriate dose and effects on oral mucosal diseases. Evaluating possible side effects and long-term application of Aloe vera is also recommended.
... On the other hand, some nutritional immunostimulants had an influential role in Penaeidin4 gene expression. An increase in Penaeidin4 gene expression due to the dietary addition of A. vera [63,76] was detected. ...
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This study was aimed to evaluate the efficiency of Sargassumpolycystum and nucleotides- supplemented diets to improve immune response and cold-tolerance of juvenile Litopenaeus vannamei. Four treatments were evaluated: T1, the control, shrimp received only a basal diet; T2, a basal diet with 500 ppm nucleotides; T3, a basal diet with 500 ppm S.polycystum powdered; T4, a basal diet with 500 ppm nucleotides and 500 ppm S.polycystum powdered. Shrimp were fed experimental diets for 56 days. Results revealed shrimp fed T4 diet exhibited the best significant improvement in water quality, survival, growth, and feed utilization indices followed by T2, and T3, while T1 showed the worst values. Additionally, nonspecific immune responses (phagocytosis (%), lysozyme, phenoloxidase, super oxide dismutase (SOD) activity, total nitric oxide) were improved with 1.7–3.2-fold in T4 higher than T1. Histomorphology of hepatopancreas in T4 showed the most increased activation of the hepatic glandular duct system compared with the other treatments. Moreover, nucleotides/seaweed-supplemented diets upregulated relative expression of cMnSOD, Penaeidin4, and heat shock protein70 (HSP70) genes, while translationally controlled tumor protein (TCTP) was downregulated. In conclusion, the synergistic effects of both S. polycystum and nucleotides have many advantages as a growth promoter, immunostimulant, antimicrobial, and cold-tolerant stimulant to L. vannamei.
... Antitumour and cytotoxic potential of A. vera extracts continues to be the interest of scientific research until recent years [6,13,28]. The success of A. vera in the treatment of multiple diseases has been attributed to the presence of several compounds [3,8,13,34]. The inner gel or pulp has been shown to contain compounds with immunomodulatory activity [16], nevertheless some researchers claim that the synergistic activity of all chemicals contained in the whole leaf extracts could be responsible for the healing properties of the "wonder plant" [15]. ...
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The comparative antimicrobial activities of the gel and leaf of Aloe vera were tested against Staphylococcus aureus, Pseudomonas aeruginosa, Trichophyton mentagraphytes, T. schoeleinii, Microsporium canis and Candida albicans. Ethanol was used for the extraction of the leaf after obtaining the gel from it. Antimicrobial effect was measured by the appearance of zones of inhibition. Antimicrobial susceptibility test showed that both the gel and the leaf inhibited the growth of S. aureus (18.0 and 4.0 mm, respectively). Only the gel inhibited the growth of T. mentagrophytes (20.0 mm), while the leaf possesses inhibitory effects on both P. aeruginosa and C. albicans. The results of this study tend to give credence to the popular use of both Aloe vera gel and leaf.
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A new and rapid affinity chromatography method based on cyanogen bromide (CNBr)-activated Sepharose 4B bound-ovalbumin is presented for the purification of the main lectin present in Aloe vera (L.) Burm. fil. The lectin was purified 60 fold to apparent homogeneity in native polyacrylamide disc gel electrophoresis (PAGE) showing an apparent molecular weight of 45000 kDa. The fact that sodium dodecyl sulfate (SDS)-PAGE gave a subunit molecular weight of 14 400 kDa tends to propose that the lectin is composed of three subunits and thus is in agreement with Aloctin I previously partially purified and characterized by us. The lectin did not exhibit antioxidant effect as assessed by the DPPḢ radical-scavenging assay.
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The partial purification of β-glucosidase from the pulp of Aloe vera L. Burm. fil. (sarisabir) leaves and some of its kinetic properties is presented. The fresh leaves of A. vera were used; the gel portion was separated and the remaining leaf pulps were cut into small pieces. The crude extract was prepared by homogenization of the leaf pulps in phosphate buffered saline (PBS), pH 7.4 and subsequent centrifugation. β-Glucosidase active fraction was precipitated by 30%-65% ammonium sulphate from the crude extract. Hydroxylapatite column chromatography resulted in a single peak showing β-glucosidase activity eluted with 200 mM phosphate buffer. The partially purified enzyme showed two protein and a single activity band in polyacrylamide gel electrophoresis. It was found that the enzyme exhibited maximum activity at 50°C and at pH 4.4. Km and Vmax values for 4-nitrophenyl-β-D- glucopyranoside were 6.8x10-4 M and 4,58x10-3 U, respectively. When β-glucosidase activity was investigated throughout the year, it was found that the activity increased in winter and decreased in summer.
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Background: The increasing prevalence of diabetes mellitus in the world is of great concern. As synthetic drugs have undesirable side effects or contraindications, traditional medicinal plants are being used for treatments of diabetes. Aim of the work: This study aimed to determine the protective effect of aloe vera (AV) on β cells of diabetic rats. Material and methods: Forty adult male rats were utilized and divided equally into four groups. The first served as the control group; the second was the streptozotocin (STZ) group (single intraperitoneal dose of 65 mg/kg body weight); the third was the preventive AV group, which was given a daily oral dose of AV (300 mg/kg body weight/day) for 14 days along with a single intraperitoneal injection of STZ given after 7 days from the start of AV; the fourth group was the curative AV group, which was given a single intraperitoneal injection of STZ and after 7 days were given a daily oral dose of AV for 14 days. Pancreatic tail samples were taken 14 days after the treatment with AV. Paraffin sections were prepared for histological and immunohistochemical studies. Results: The results revealed that a single dose of STZ induced marked cytoplasmic vacuolations and pyknotic nuclei in many islet cells. The AV preventive group showed normal-appearing islet cells. The AV curative group showed cytoplasmic vacuolations and pyknotic nuclei in many islet cells. Statistical analysis revealed a significant decrease (P<0.05) in anti-insulin antibody reaction and bcl2 expression in the diabetic group and the AV curative group compared with the control group, whereas there was an insignificant increase in the preventive group. Conclusion: The present study suggests that AV when used as a preventive agent can protect against STZ-induced diabetes in rats. Therefore, AV should be given to prediabetic patients and to individuals at high risk for diabetes.
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An attempt was made to study the beneficial effects of Aloe vera (L.) Burm. fil. in streptozotocin-induced diabetic rats. In diabetic induced rats fed with A. vera (300 mg/kg body wt), the fasting plasma glucose levels were reduced to normal and body weight was found to be increased. In the pancreatic sections of diabetic rats fed with A. vera, the islets were comparable to normal rats. In liver, the changes caused after induction of diabetes are granular cytoplasm, dilated sinusoids, shrunken nuclei and inflammation, which was re duced after feeding with A. vera. Excess proliferation of epithelium in the small intestine was observed in diabetic rats, which was reduced after A. vera feeding. In diabetic rats and diabetic rats fed with A. vera, no change was noticed in the kidney and stomach.
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New Perspectives on Aloe will cover research studies of aloe by the CAP (Creation Aloe Pharmaceuticals) team, which studied various aspects of aloe over a period of more than 10 years. The team was organized into two groups: the isolation and analysis group, which purified many components in terms of low molecular weight compounds, carbohydrates, proteins present in aloe, and the assay group, which determined the efficacy of those components. This type of target-oriented, organized research provides a model of how to conduct multidisciplinary research. The contents include a brief introduction of aloe, isolation, purification, and structural analysis of components, and various physiological effects of those components for possible use as health foods or drugs. Various functions identified were wound healing, angiogenesis, anti-allergy, skin whitening, stimulation of cell proliferation such as liver or kidney, protection against nephrotoxicity, and immune modulation. Moreover, we suggest standardization and quality control procedures for manufacturing raw aloe, and how to develop related products for successful application of aloe. This is important in Korea because last year the Korean government listed aloe as a health food for which the government establishes regulatory laws. Therefore, many scientists in Korea who are interested in studying health foods would be interested in this kind of text. Other major fields related to this kind of research will be medicine, biology, pharmaceutics, natural products and analytics.
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Many secondary plant metabolites have been reported to possess lipid-lowering properties. Aloe vera which has been extensively used for medical and cosmetic purposes contains multiple constituents with potential biological activities. This study was undertaken to investigate the beneficial effects of Aloe vera extracts in comparison to glibenclamide on serum lipid parameters, liver glycogen and on heart and skin lipid peroxidation. Type II diabetes was induced by 100 mg/kg, streptozotocin injection to neonatal rats (n0-STZ). The diabetic rats were separated into four groups and each group was given the following samples by gavage, daily for 15 d: I. Diabetic (Control): 6 mL/kg phosphate buffered saline (PBS),; II. Diabetic + Aloe gel: 10 mL = 63 mg/kg Aloe vera leaf gel extract; III. Diabetic + Aloe pulp: 500 mg/kg Aloe pulp extract; IV. Diabetic + Glibenclamide: Glibenclamide (I mg/kg). On day 15, blood and liver, skin and heart tissues were taken from each rat. In diabetic group given A. vera extracts, serum total cholesterol, LDL-cholesterol, atherogenic index (AI), total lipid, sialic acid, skin and heart tissues lipid peroxidation (LPO) levels decreased, whereas serum HDL-cholesterol, liver glycogen, serum total protein levels-increased, in comparison to diabetic controls. In the diabetic group given glibenclamide, AI and heart LPO which were diminished in Aloe given groups were rised, whereas HDL-cholesterol, liver glycogen which were increased in Aloe groups were reduced. These results reveal that diabetes mellitus increased oxidative damage in skin and heart tissue and that Aloe vera has an ameliorating effect better than glibenclamide on the oxidative stress via its antioxidant property. The administration of A. vera extracts may be also able to reduce hyperlipidemia which is one of the complications related to the risk of diabetes.
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This study was conducted to determine the antimicrobial activity of the Aloe vera juice against Gram-positive bacteria (Mycobacterium smegmatis, Staphylococcus aureus, Enterococcus faecalis, Micrococcus luteus and Bacillus sphericus), Gram-negative bacteria (Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli and Salmonella typhimurium) and Candida albicans as in vitro. The disc diffusion method was used to test the antimicrobial activity. The study showed that Aloe vera juice has antimicrobial activity against M. smegmatis, K. pneumoniae, E. faecalis, M. luteus, C. albicans and B. sphericus, but has no inhibitory effect against the other bacterial strains. The least inhibitory effect was found against M. luteus, while C. albicans was detected to be the most sensitive strain As a result; the antibacterial activity of the tested plant juice was found effective mainly against the Gram-positive bacteria. This is important to use of Aloe vera for medication, cosmetic and food purposes.