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Review on Aloe Vera

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Review on Aloe Vera
Arup Jyoti Pegu
1
, Mrs. Ankita Sharma
2
1
Pharmacy Graduate,
2
Assistant Professor and Researcher,
1,2
Faculty of Pharmaceutical Science, Mewar University, Chittorgarh, Rajasthan, India
How to cite this paper: Arup Jyoti Pegu
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ABSTRACT
The Aloe Vera plant has been known and utilized for centuries for its wellbeing,
magnificence, therapeutic and skin care properties. There are over300 species of
aloe, which develops basically within the dry districts of Africa, Asia, Europe and
America. Aloe Vera could be a characteristic item that's presently a day regularly
utilized within the field of cosmetology. In spite of the fact that there are
different signs for its utilize, controlled trials are required to decide its genuine
viability. The aloe Vera plant, its properties, component of activity and clinical
employments are briefly looked into in this article. The Aloe plant is utilized as a
dietary supplement in an assortment of nourishments and as an fixing in
restorative items. The far reaching human introduction and its potential harmful
and carcinogenic exercises raise security concerns. Chemical examination
uncovers that the Aloe plant contains different polysaccharides and phenolic
chemicals, outstandingly anthraquinones. Ingestion of Aloe arrangements is
related with the runs, hypokalemia, pseudomelanosis coli, kidney
disappointment. Aloe Vera can be utilized in different conditions like Gentle to
direct burns, Erythema, Genital herpes, Seborrheic dermatitis, Psoriasis vulgaris,
Skin moisturizer, Sort 2 diabetes, Verbal lichen planus diseases, Angina pectoris,
Ulcerative colitis, UV-induced erythema, Kidney stones and Alveolar osteitis. In
common, topical application of aloe Vera arrangements has been respected as
secure as evaluated by the Corrective Fixing Audit Master Board. Be that as it
may, a few case reports of the advancement of touchiness responses and contact
dermatitis in reaction to topically connected aloe gel arrangements have been
distributed.
Keywords: Aloe Vera, health, ethno-botany, commercial uses, bioactive chemicals
INTRODUCTION
Aloe Vera may be an exceptionally compelling and
imperative home grown plant in numerous other plants, it
gives so numerous restorative exercises and
pharmacological impacts for human creatures and creature.
Aloe Vera also is utilized for restorative application
completely different framework of our societies. [1]. Aloe
Vera could be a tough, lasting, tropical, drought-resistant,
juicy plant .The aloe Vera has delivered the gigantic
conventional part in endemic framework of rules of
pharmaceutical such as the Siddha, Unani, Ayurveda and
Homeopathy. [2] Aloe Vera may be a standard, dry spell
debate, sticky plant. The aloe title is starts from the Arabic
"Alloeh" or Hebrew "Halal" implies heightening Sparkly
master. It has conveyed a considerable routine portion in
inborn course of action of pharmaceutical system like
Ayurveda, Siddha, Unani and Homoeopathy.[3] Aloe
barbadensis process administrator could be a semi tropical
plant is one of the 250 sorts of Aloe Vera. Aloe Vera
(/ˈæloʊiː/ or /ˈæloʊ/) could be a juicy plant species of the
class Aloe. An evergreen lasting, it begins from the Middle
Eastern Promontory but develops wild in tropical climates
around the world and is developed for rural and therapeutic
employments. The species is additionally utilized for
enriching purposes and develops effectively inside as a
pruned plant.[4] Directly, the utilize of aloe Vera has picked
up notoriety since of home grown development started by
naturopaths, yoggurus, elective medication promoters and
all encompassing healers. The industry estimate for aloe
crude fabric is assessed to be about $125 million dollars. The
volume of the industry for wrapped up items containing aloe
Vera is affirmed to be around $110 billion dollars [5]. 2000 a
long time prior, the Greek researchers respected Aloe Vera
as the all inclusive nostrum. The Egyptians called Aloe “the
plant of immortality.” Nowadays, the Aloe Vera plant has
been utilized for different purposes in dermatology.
.[6],[7],[8],[9],[10] Numerous reports of Aloe Vera gel
features a profitable activity on the harm recovering in both
normal and diabetic rats. The most common wide utilize of
Aloe Vera as a cure to upgrade the action of wound
recuperating and other restorative activities. Its instrument
in recuperating of wounds has not been examined in detail.
The Aloe vera is most vital and valuable plant within the
home grown drugs fabricating and other detailing its gives
valuable and profitable compounds.
Description
Aloe Vera could be a stem less or exceptionally short-
stemmed plant developing to 60–100 cm (24–39 in) tall,
spreading by offsets. The clears out are thick and plump,
green to grey-green, with a few assortments appearing white
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bits on their upper and lower stem surfaces.[11] The edge of
the leaf is serrated and has little white teeth. The blooms are
delivered in summer on a spike up to 90 cm (35 in) tall, each
bloom being pendulous, with a yellow tubular corolla 2–3 cm
(0.8–1.2 in) long.[11][12] Like other Aloe species, Aloe Vera
shapes arbuscular mycorrhiza, a beneficial interaction that
permits the plant way better get to to mineral supplements
in soil.[13].
Botany of Aloe Vera
The cactus-like juicy aloe Vera has a place to the sort of the
liliaceous plants. The plant is either stem-less or
exceptionally short-stemmed (stem up to 25 cm long) with
an normal approximately 20 takes off in a straight, thick
rosette. The clears out develop to up to 40 – 50 cm long and
6 – 7 cm wide. The takes off are or maybe thick, beefy, water
holding; concave on the beat side, grey-green frequently
ruddy and youthful plants are frequently dotted. The
underside of the leaf is curved with a pale pink edge that's
dressed with 2 mm long prickly teeth dispersed at each 10 –
20 mm. One leaf can weigh as much as 1.5 to 2 kg. The juicy
leaf of the aloe is an adjustment to the exceptionally dry
conditions of its living space. The roots of the aloe are
generally brief and lay flat implanted within the earth. [14]
Plants
The botanical title of Aloe Vera is Aloe barbadensis mill
operator. It has a place to Asphodelaceae (Liliaceae) family,
and may be a shrubby or arborescent, perpetual, xerophytic,
juicy, pea- green colour plant. It develops primarily within
the dry locales of Africa, Asia, Europe and America. In India,
it is found in Rajasthan, Andhra Pradesh, Gujarat,
Maharashtra and Tamil Nadu.
Leaves
Aloe Vera takes off are lance-shaped with serrated edges.
The clears out are:
1. Beefy thick.
2. Green or grey-greenish.
3. Waxy coated on the surface.
4. Value juicy, meaning they can keep their shape due to
the moist.
The clears out contain water (the gel) and are float on the
beat side, and adjusted at the foot side. In youthful clears out
of Aloe Vera spots are pale green to white. When the Aloe
Vera develops up, the spots vanish. Be that as it may, a few
species will not free their spots, which is due to hereditary
factors. [22]
Taxonomy
Kingdom- Plantae
Order- Asparagales
Division- Spermatophyte
Subdivision- Angiospermae
Class- Monocotyledoneae
Genus- Aloe
Species- Barbadensis Mill [15]
The species was to begin with depicted by Carl Linnaeus in
1753 as Aloe perfoliata var. Vera, [16] and was portrayed
once more in 1768 by Nicolas Laurens Burman as Aloe Vera
in Greenery Indicia on 6 April and by Philip Mill operator as
Aloe barbadensis a few ten days after Burman within the
Gardener's Dictionary.[17]
Synonyms
Aloe, Musabbar, Kumari
Biological source
Aloe is the dried latex of leaves of various species of Aloes,
namely:
Aloe barbadensis Miller (or Curacao Aloe);
Aloe ferox Miller (or Cape Aloe);
Aloe perryi Baker (or Socotrine Aloe);
Aloe Africana Miller and Aloe spicata Baker (or Cape Aloe)
All these species belong to the family Liliaceae. [18]
Aloe Vera is Comprising of the new juice collected by entry
point, from the bases of the clears out of distinctive species
of aloe. Aloe perryi, or Aloe Barbadensis Mil and Aloe ferox.
[19]
Family
It’s belonging to the Liliaceae family
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Aloe perryi Bread cook is found in Socotra and Zanzibar
islands and in there neighbouring ranges and so the aloes get
from this species is known as Socortrine or Zanzibar aloe.
Aloe Vera Linn is something else called Aloe vulgarise
Lamarek, or Aloe barbadensis Mil. Aloe officinalis Forskal.
Geographical Source
Aloe vera are innate to East and South Africa, however have
been brought into the West Indies and into topical countries,
and will indeed flourish within the countries skirting on the
Mediterranena. In India, it is found in Rajasthan, Andhra
Pradesh, Gujarat, Maharashtra, UK, Himachal Pradesh, and
Tamil Nadu, It is financially created in Aruba, Bonaire, Haiti,
India, South Africa, the Joined together of America and
Venezula .[20]
Morphology
Taste : - Bitter
Odour : - None
Size & Shape : - Plant growing to 60-100cm in lance-
shaped with elongated.
Strands Colour : - Leaves are green to grey- green flower.
Flower : - Yellow tubular in 25-35cm in a slender
loose staments.
Root : - Root fibbers that can reach 30-40 cm in
length. [21]
Active components with its properties
Aloe Vera contains 75 potentially active constituents:
vitamins, enzymes, minerals, sugars, lignin, saponins,
salicylic acids and amino acids.[23–24]
Vitamins: It contains vitamins A (beta-carotene), C and E,
which are cancer prevention agents. It moreover contains
vitamin B12, folic corrosive, and choline. Antioxidant
neutralizes free radicals.
Enzymes: It contains 8 chemicals: aliiase, antacid
phosphatase, amylase, bradykinase, carboxypeptidase,
catalase, cellulase, lipase, and peroxidase. Bradykinase
makes a difference to diminish over the top irritation when
connected to the skin topically, whereas others offer
assistance within the breakdown of sugars and fats.
Minerals: It gives calcium, chromium, copper, selenium,
magnesium, manganese, potassium, sodium and zinc. They
are fundamental for the correct functioning of different
chemical frameworks in numerous metabolic pathways and
few are antioxidants.
Sugars: It gives monosaccharide’s (glucose and fructose)
and polysaccharides: (glucomannans/polymannose). These
are determined from the mucilage layer of the plant and are
known as mucopolysaccharides. The foremost conspicuous
monosaccharide is mannose-6-phosphate, and the foremost
common polysaccharides are called glucomannans [beta-
(1,4)-acetylated mannan]. Acemannan, a unmistakable
glucomannan has too been found. As of late, a glycoprotein
with antiallergic properties, called alprogen and novel anti-
inflammatory compound, C-glucosyl chromone, has been
confined from Aloe Vera gel. [25, 26]
Mechanism of actions
Mending properties: Glucomannan, a mannose-rich
polysaccharide, and gibberellin, a development hormone,
interatomic with development figure receptors on the
fibroblast, subsequently fortifying its action and
multiplication, which in turn essentially increments collagen
amalgamation after topical and verbal Aloe Vera.[27] Aloe
gel not as it were expanded collagen substance of the wound
but moreover changed collagen composition (more sort III)
and expanded the degree of collagen cross connecting. Due
to this, it quickened wound withdrawal and expanded the
breaking quality of coming about scar tissue.[28] An
expanded blend of hyaluronic corrosive and dermatan
sulfate within the granulation tissue of a mending wound
taking after verbal or topical treatment has been
reported.[29]
Anti-Diabetic: The five Phytosterols of Aloe Vera, lophenol,
24-methyl-lophenol, 24-ethyl-lophenol, cycloartanol and 24-
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methy-lenecycloartanol illustrated unfriendly to diabetic
impacts in sort 2 diabetic mice. Aloe Vera contains
polysaccharides which grow the affront level and appear
hypoglycaemia Properties. [30]
Effects on the Immune system: Alprogen smothered
calcium drenching into shaft cells, in this way covering the
antigen-antiboby-interceded entry of histamine tamine and
leukotriene from shaft cells. In a ponder on mice that had
previously been inserted with murine sarcoma cells
acemannan enlivens the mix and entry of interleukin-1 (IL-
1) and tumour rotting variable from macrophages in mice,
which thus started a safe strike that accomplished
debasement and backslide of the harming cells.[31]
Antiseptic effect: Aloe Vera contains 6 sterile specialists:
Lupeol, salicylic corrosive, urea nitrogen, cinnamonic
corrosive, phenols and sulfur. They all have inhibitory
activity on organisms, microbes and viruses. [32]
Anti-Cancer Properties: The Aloe Vera created an critical
part in cancer-causing nature has not been evaluated well.
The consistent abuse of anthranoid-containing intestinal
solutions has been hypothesized to accept a portion in
colorectal tumour, be that because it may, no causal social
between anthranoid diuretic abuse and colorectal danger
has been displayed and have Aloe Vera juice empowers the
body to recuperate itself from besides the fiendishness
brought on by radio and chemotherapy that devastate solid
sound secure resistant cells essential for the recovery. [33]
Chemical Constituents
The foremost basic energetic boss constituents of Aloe Vera
are the three isomeric of Alones, Barboloin and Isobarbaloin,
which constitute the purported crystalline Aalin, show
within the pharmaceutical at from 10 to 30% constituent are
unclear Aaloin, sap, emodin and Aloe-emodin. The vital
bunch, complex sugars (among which acemannan rises) are
interior the takes off gel and have an insusceptible
empowering action. Following are the anthraquinoes,
contained within the fringe part of the skin, with a strong
laxative action. in conclusion are a couple of substances with
a wide cluster of exercises, for case, minerals, vitamins, vital ,
unnecessary and semi-vital amino acids, normal acids,
phospholipids, proteins, lignin and saponins.[34]
Pharmacological Activity of Aloe Vera
A number of investigations have attempted to relate the
chemical constituents in the gel to specific biological effects.
Wound-healing effects: Different mechanisms have been
proposed for the wound-healing effects of aloe gel, which
include keeping the wound moist, increase epithelial cell
migration, more rapid maturation of collagen and reduction
in inflammation.[35]
Anti-Tumour Activity: Different glycoproteins are available
in Aloe Vera. in this manner keeping the arrangement of
possibly disease starting benzopyrene-DNA adducts In the
provoking of glutathione s-transferase and an impediment of
the tumor-promating effects of phorbol myristic acidic
corrosive deduction has in like manner been represented
which propos possible favorable circumstances of using aloe
gel as a piece of cancer’[36]
Aloe gel: The gel or mucilage gotten from the tissue of the
leaf is 99% water at pH 4.5. The constituent polysaccharide
glucomannan is an successful human skin moisturizer, which
accounts for its utilize in numerous cosmetics.[37]
Aloe Vera is best known for its relieving and mending
impacts on burn and other wounds. Aloe Vera when
connected to a wound increments both the rate of wound
closure and the malleable quality of the wound by means of
the expansion of cells [38]. It does so by quickening the
stream of blood towards the injured region. Aloe is the
leading wound dressing ever discovered.[39]
Cultivation and Collection
There are more than 250 species of aloe develop around the
over in world. Be that because it may, fair two species are
created nowadays mechanically, with Aloe barbadensis Mill
operator and Aloe aborescens being the foremost prevalent.
The Aloe Vera plant is developed in warm tropical domains
and cannot survive setting temperatures. It is an evergreen
never-ending creating to 0.8 m by 1 m at a moderate rate.
The plants slant toward light (sandy) and medium (loamy)
soil requires all around drained soil can create in healthfully
destitute soil. The plant slants toward destructive,
nonpartisan and fundamental (fundamental) soil. It can't
create in shade. It requires dry or clammy soil and can
persevere dry spell. They are xerophytic plant. It can be
multiplied by seed. Youthful equalization are planted within
the soil after the whirling season in lines organized at a
separation of 60m.In the moment year takes off are gathered
by nearby individuals by ensuring their hands in light of the
prickly strategy for takes off. The clears out are cut near to
the base, kept inside light fuel tins and taken them to a
central spot for the course of action of aloe. Juice of aloe is
accessible in parenchymatous cells of pericycle that are
cement cell. In a single section point cement cells apply. [40]
USES
Aloe Vera is anthelmintic, cathartic, carminative, deobstuent,
depurative, diuretic, stomachic, and emmenagoge. Juice is
utilized as a portion of sound skin medicine, dyspepsia,
amenorrhea, smolders, colic, hyperdenosis, hepatopathy,
splenopathy, hindrance, run, menorrhea, stomach, tumors,
dropsy carbunles, sciatica, lumbago and tooting. Aloe Vera
gel is exceptionally valuable in ulcerative colitis and weight
ulcers. [41]
Mild to moderate burns.
Erythema.
Genital herpes.
Seborrheic dermatitis.
Psoriasis vulgaris.
Skin moisturizer.
Type 2 diabetes.
Oral lichen planus infections.
Angina pectoris.
Ulcerative colitis.
Fig: Aloe Vera Leaves.
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Conclusion
I was examined approximately the as well much data of
home grown plant i.e Aloe Vera. It could be a particular
plant, it appear different sorts of exercises in therapeutic
time .so it play an imperative part in pharmaceutical field.
Aloe Vera and its arrangement have been broadly utilized as
a pharmaceutical since old times. Different investigates have
been conducted to demonstrate the viability of aloe Vera in
different wellbeing issues. The dynamic fixing covered up in
its juicy clears out have the control to alleviate human life
and wellbeing in a heap ways. Aloe Vera as the ponder plant
is different from being an clean, ant-inflammatory operator,
makes a difference in soothing like cancer and diabetes, and
being a restorative field.
Reference
[1] Himes S, Sharma S, Mishra K, Singhai A.K and Chaubey
N; Qualitative & Quantitative profile of alone isolated
from Aloe Vera. International Research Journal of
Pharmacy, 2011; 2(9):121-122.
[2] Baby J, Justin SR. Pharmacognostic and phytochemical
properties of Aloe Vera linn –an overview.
International journal of pharmaceutical sciences
review and research 2010; 4:106.
[3] Benefits of Aloe Vera Plant, Aloe Vera Juice & Aloe Vera
Products. Knowledge Base Script.2009; 1-7. Available
from: www.knowledgepublisher.com. Das N,
Chattopadhay RN. Commercial cultivation of Aloe.
Natural product radiance 2004; 3:85-87.
[4] Perkins, Cyndi. "Is Aloe a Tropical Plant?". SFgate.com.
Retrieved 13 February 2016.
[5] Anonymous (2006) For Aloe Vera as semi finish
products like gel, powder and finish products like aloe
Vera drink or fizzy tablets. Technology transfer and
project management network, Enzyme consulting of
biotechnology. http://www.ensymm.com/pdf/
ensymmProjectstudyAloeVeraproduction.pdf. Accessed
on 5 October 2010.
[6] Davis RH, Kabbani JM, Maro NP. Aloe Vera and wound
healing. J Am Podiatric Med Assoc1987; 77:165-9.
[7] Visuthikosol V, Chowchuen B, Sukwanarat Y,
Sriurairatana S, Boonpucknavig V. Effect of Aloe Vera
gel to healing of burn wound- a clinical and histologic
study. J Med Assoc Thai 1995; 78:403-9.
[8] Miller MB, Koltai PJ. Treatment of experimental
frostbite with pentoxifylline and aloe Vera cream. Arch
Otolaryngology Head Neck Surge 1995; 121:678-80.
[9] Heggers JP, Pelley RP, Robson MC. Beneficial effects of
Aloe in wound healing. Phytotherapy Res 1993; 7:S48-
52.
[10] Unani Pharmacopeia of India .Part-1 vol. 1. New Delhi:
Department of Ayush; 2007 p.82-83.
[11] Yates A. (2002) Yates Garden Guide. Harper Collins
Australia
[12] Random House Australia Botanica's Pocket Gardening
Encyclopedia for Australian Gardeners Random House
Publishers, Australia
[13] Gong M, Wang F, Chen Y (2002). "[Study on application
of arbuscular-mycorrhizas in growing seedings of Aloe
Vera]". Zhong Yao CAI (in Chinese). 25 (1): 1–3. PMID
12583231
[14] https://www.aloe-medical-group.com/en/aloe-
vera/botany.html
[15] Nadkarni KM. Indian plants and Drugs. New Delhi;
srishti book Distributors, 2004 p.28-
29PMid:15129907.
[16] Linnaeus, C. (1753). Species plantarum, exhibentes
plants rite cognitas, ad genera relatas, cum differentiis
specificis, nominibus trivialibus, synonymies selectees,
loci’s natalibus, secundum systema sexual digests Vol.
2 pp. [i], 561–1200, [1–30, index], [i, err.]. Holmiae
[Stockholm]: Impensis Laurentii Salvii.
[17] Newton LE (1979). "In defense of the name Aloe Vera".
The Cactus and Succulent Journal of Great Britain. 41:
29–30
[18] www.epharmacognosy.com/2012/03/aloes.html
[19] 6.Davis, R. H., Donato, J. J., Hartman, G. M., and Haas, R.
C. Anti-inflammatory and wound healing activity of a
growth substance in Aloe Vera. J Am Podiatr.Med Assoc
1994; 84(2):77-81.
[20] Pecere, T., Sarinella, F., Salata, C., Gatto, B., Bet, A., Della,
Vecchia F., Diaspro, A., Carli, M., Palumbo, M., and Palu,
G. Involvement of p53 in specific anti-neuroectodermal
tumor activity of aloe-emodin. Int J Cancer 10-10-2003;
106(6):836-847.
[21] Singh, R. P., Dhanalakshmi, S., and Rao, A. R. Chemo
modulatory action of Aloe Vera on the profiles of
enzymes associated with carcinogen metabolism and
antioxidant status regulation in mice. Phytomedicine
2000; 7(3):209-219.
[22] 22.970212541aloevera.blogspot.com/2017/01/plant-
anatomy-and-morphology.html.
[23] Atherton P. Aloe Vera revisited. Br J Phytother. 1998;
4:76–83. [Google Scholar]
[24] Atherton P. The essential Aloe Vera: The actions and
the evidence. 2nd ed 1997. [Google Scholar]
[25] Ro JY, Lee B, Kim JY, Chung Y, Chung MH, Lee SK, et al.
Inhibitory mechanism of aloe single component
(Alprogen) on mediator release in guinea pig lung mast
cells activated with specific antigen-antibody reactions.
J Pharmacol Exp There. 2000; 292:114–21. [PubMed]
[Google Scholar]
[26] Hunter JA, Salmon M, Stavinoha WB, Satsangi N,
Williams RF, Streeper RT, et al. Anti-inflammatory C-
glucosyl chromone from Aloe barbadensis. J Nat Prod.
1996; 59:541–3. [PubMed] [Google Scholar]
[27] Chithra R Sajithlal GB, Chandrakasan G. Influence of
aloe Vera on collagen characteristics in healing dermal
wounds in rats. Mol Cell Biochem. 1998; 181:71–6.
[PubMed] [Google Scholar]
[28] Heggers J, Kucukcelebi A, Listengarten D, Stabenau J,
Ko F, Broemeling LD, et al. Beneficial effect of aloe on
wound healing in an excisional wound model. J Altern
Complement Med. 1996; 2:271–7. [PubMed] [Google
Scholar]
[29] Chithra P, Sajithlal G, Chandrakasan G. Influence of aloe
Vera on the glycosaminoglycan’s in the matrix of
International Journal of Trend in Scientific Research and Development (IJTSRD) @ www.ijtsrd.com eISSN: 2456-6470
@ IJTSRD | Unique Paper ID - IJTSRD23541 | Volume – 3 | Issue – 4 | May-Jun 2019 Page: 40
healing dermal wounds in rats. J Ethnopharmacol.
1998; 59:179–86. [PubMed] [Google Scholar]
[30] S.Ito R. Teradaira, H.Beppu, M. Obata, T. Negates and K.
Fujita,. Properties and pharmacological activity of
carboxpeptidase in aloe arborescens Mill.var. Natalen-
sis Berger, Phytotherapy Research, vol 7, No.7 1993pp
S26-S29. http:// dx.doi.org/10.1002/ptr.2650070710.
[31] L. Langmead, R.M. Feakins and S. Goldthorpe,
Randomized, Doubled, Placebo-controlled Trail of oral
aloe Vera gel for active Ulcerative Colitis , Alimentary
Pharmacology & Therapeutic, vol,19 No, 7. 2004
pp.739-747.
[32] West DP, Zhu YF. Evaluation of aloe Vera gel gloves in
the treatment of dry skin associated with occupational
exposure. Is J Infect Control? 2003; 31:40–2.
[33] Sai Krishna Borra, Radha Krishna Lagisetty and
Gownrinath Reddy Mallela. 2011. African Journal of
Pharmacy and Pharmacology vol.5.pp.1867-1871.
[34] 34. Wang, Z. W., Huang, Z. S., Yang, A. P., Li, C. Y., Huang,
H., Lin, X., Liu, Z. C., and Zhu, X F. [Radio protective
effect of aloe polysaccharides on three non-tumor cell
47. lines]. Ai. Zheng. 2005; 24(4):438-442.
[35] Reynolds T, Dweck AC. Aloe Vera leaf gel: A review
update. J Ethnopharmacol. 1999; 68:3–37. [PubMed]
[Google Scholar]
[36] S. Y. Peng, J.Norman, G Curtin D. Corrier, H. R.McDaniel
and D.Busbee, Decreased Mortality of Norman Murine
Sarcoma in Mice Treated with the Immuno-modulator,
Acemannaon , Molecular Biotherapy, vol.3, 1991,pp.79-
87.
[37] Wang ZW Huang ZS Yang AP Li CY Huang H Lin X Liu
ZC and Zhu XF Radioprotective effect of aloe
polysaccharides on three non tumor cell 47 lines Ai
Zheng 2005 24 4 438 442
[38] West, Dennis P, Ya Fen Zhu, Evaluation of Aloe Vera gel
gloves in dry skin associated with occupational
exposure, American Journal of Infection Control, 31(1),
2003, 40-42.
[39] Kumar KPS, Bhowmik D, Chiranjib and Biswajit, Aloe
Vera: A Potential Herb and its Medicinal Importance,
Journal of Chemistry and Pharmaceutical Research,
2(1), 2010, 21-29.
[40] R.H Thomson, Naturally occurring Quinines, 2
nd
edition, Academy Press, London, 1971.
[41] Yagi, A., Kabash, A., Mizuno, K., Moustafa, S. M., Khalifa,
T. I., and Tsuji, H. Radical Scavenging Glycoprotein
Inhibiting Cyclooxygenase-2 and Thromboxane A2
Synthase from Aloe Vera Gel. Planta Med. 2003;
69(3):269-271.
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Since ancient times, Aloe vera L. (AV) has attracted scientific interest because of its multiple cosmetic and medicinal properties, attributable to compounds present in leaves and other parts of the plant. The collected literature data show that AV and its products have a beneficial influence on human health, both by topical and oral use, as juice or an extract. Several scientific studies demonstrated the numerous biological activities of AV, including, for instance, antiviral, antimicrobial, antitumor, and antifungal. Moreover, its important antidepressant activity in relation to several diseases, including skin disorders (psoriasis, acne, and so on) and prediabetes, is a growing field of research. This comprehensive review intends to present the most significant and recent studies regarding the plethora of AV’s biological activities and an in-depth analysis exploring the component/s responsible for them. Moreover, its morphology and chemical composition are described, along with some studies regarding the single components of AV available in commerce. Finally, valorization studies and a discussion about the metabolism and toxicological aspects of this “Wonder Plant” are reported.
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Unrestricted interest in Aloe species has grown rapidly, and a lot of research is currently being done to learn more about the properties of the various Aloe constituents. Organic compounds containing amine as functional group are present in a vivid variety of compounds, namely, amino acids, hormones, neurotransmitters, DNA, alkaloids, dyes, etc. These compounds have amine functional groups that have various biological activities, which make them responsible for medicinal potential in the form of pharmaceutical, nutraceutical, and cosmeceutical applications. Consequently, the present review work provides an indication of the amines investigated in Aloe species and their therapeutic uses. Various amine compounds of the Aloe species have effective biological properties to treat diseases. Generally, the genus Aloe has various active amine-containing compounds to combat diseases when humans use them in various forms.
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Chapter
Aloe vera (synonym Aloe barbadensis Mill) commonly known as Barbados or Curaçao Aloe, is a plant that has been used in traditional and folk medicine for hundreds of years to heal a wide range of illnesses. It is a shrubby or arborescent, perennial, succulent xerophytic, pea-green plant that is a member of the family Liliaceae or Asphodelaceae. Aloe vera is commonly known because of its wide range therapeutic benefits. It is the most frequent natural sources of health for people.The plant’s chemical composition reveals that there are several physiologically active compounds. Numerous biological traits of the Aloe species are influenced by the inner gel of the leaves. Most research has concentrated on the biological characteristics of various Aloe species, like the antibacterial and antimicrobial activities of the nonvolatile leaf gel components. Aloe species are found practically everywhere in the world and are particularly common in Eastern Europe and Africa. The physicochemical, and histological analyses of Aloe species are presented in this chapter.
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Aloe vera (L.) Burm. f. is an important medicinal plant with long time tradition of use by variety of cultures. This plant is suffered with various fungal diseases caused by variety of fungal pathogens in different seasons which affects its morphological characters and diminishes the quality, quantity and production of gel. The present study was aimed to study the alteration in the morphological characteristics of Aloe vera artificially infested with Colletotrichum gloeosporioides and Fusarium proliferatum; the leaf spot disease causing fungi in this plant. Artificially infested leaves were examined in terms of plant height, leaf characteristics, colour and consistency of gel. Results of artificial infestation revealed that both the fungal pathogens have the ability to alter the morphological properties of A. vera plants. Therefore, control of the fungal diseases by applying appropriate management strategies is essential to protect this medicinal plant of massive commercial value.
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This study evaluated in vitro effect of different concentrations of Aloe vera (A. vera) ethanol extract and honey against Acanthamoeba spp. cysts in comparison with chlorhexidine (the drug of choice for treatment of Acan-thamoeba infection) at different incubation periods. Four different concentrations of the tested agents were used, 100, 200, 400, and 600 lg/ml for A. vera ethanol extract and 25, 50, 100, and 200 lg/ml for honey. Isolated Acan-thamoeba spp. cysts from keratitis patients were incubated with different concentrations of the tested agents as well as chlorhexidine 0.02% (drug control) for different incubation periods (24, 48, 72 h). After each incubation period, the effect of A. vera extract and honey against Acanthamoeba cysts was assessed by counting the number of viable cysts, determining the inhibitory percentage and detecting the morphological alternations of treated cysts compared to non-treated and drug controls. Both A. vera ethanol extract and honey showed a concentration and time-dependent effect on the viability of Acanthamoeba cysts. In comparison with chlorhexidine (the drug control), A. vera ethanol extract possessed a potent cysticidal activity at all tested concentrations throughout different incubation periods, except for concentration 100 lg/ml which recorded the lower inhibitory effect. With increasing the dose of A. vera ethanol extract to 200, 400, 600 lg/ml, the recorded inhi-bitory percentages of Acanthamoeba cysts viability were 82.3%, 92.9% and 97.9% respectively, after 72 h compared to 76.3% of chlorhexidine. Similarly, honey at concentrations of 50-100 lg/ml gave higher inhibitory effect of 59% and 76.7%, respectively compared to chlorhexidine which showed an inhibitory percentage of 55.7% after 24 h. Meanwhile, the lowest tested concentration of honey (25 lg/ml) gave an inhibitory effect by 47.7-67% which was less than that of chlorhexidine throughout different incubation periods. With increasing the dose of honey to 200 lg/ml, the inhibitory effect was 98.9% after 72 h higher than that of chlorhexidine (76.9%). Using a scanning electron microscope, Acanthamoeba cysts treated by A. vera ethanol extract showed alternations in their shapes with flattening, collapsing, and laceration of their walls. Also, treated cysts by honey were highly distorted and difficult to identify because most of them were shrinkage and collapsed to a tiny size. On the other hand, chlorhex-idine showed less structural and morphological changes of Acanthamoeba cysts. A. vera ethanol extract and honey had considerable cysticidal effects on Acanthamoeba cysts. They may give promising results for treatment of Acan-thamoeba keratitis.
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Aloe vera (L.) Burm. f. is an important medicinal plant with long time tradition of use by variety of cultures. This plant is suffered with various fungal diseases caused by variety of fungal pathogens in different seasons which affects its morphological characters and diminishes the quality, quantity and production of gel. The present study was aimed to study the alteration in the morphological characteristics of Aloe vera artificially infested with Colletotrichum gloeosporioides and Fusarium proliferatum; the leaf spot disease causing fungi in this plant. Artificially infested leaves were examined in terms of plant height, leaf characteristics, colour and consistency of gel. Results of artificial infestation revealed that both the fungal pathogens have the ability to alter the morphological properties of A. vera plants. Therefore, control of the fungal diseases by applying appropriate management strategies is essential to protect this medicinal plant of massive commercial value.
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__________________________________________________________________ Abstract Aloe vera contains numerous vitamins and minerals, enzymes, amino acids, natural sugars and agents which may be anti-inflammatory and anti-microbial. The combination and balance of the plant's ingredients are what purportedly gives it its healing properties. The part of the Aloe vera which is used are the leaves. The Aloe is an Emollient, Purgative and Vulnerary. It is also used for its antibacterial, anesthetic and antiseptic properties, and is good to use as a tool for restoration of tissue. It is most commonly used on burns and minor cuts, especially good for sunburns, although it is being used for the treatment of skin cancer. Aloe is very useful on rashes caused by Poison Ivy, and it may help to draw out infection. It may help with Vaginal Yeast Infections, although this is not solid at this time. Aloe be made into a warm tea, made from the juice as a wash for eyes. The washing of eyes with Aloe may protect the eyes from ultraviolet rays from the sun. It can be used as a purgative. Aloe is also an extremely powerful laxative, and it is not recommended that it is taken internally. It is recommended that the fresh juice from the plant is used, and not the store bought juice within other products or on its own. The reason for this is that the medicinal use of the plant diminishes with time, and there is much questioning about whether or not you can receive benefits from the store bought aloe, even if the product has been filled with preservatives. It gives a healthy and supple look to the skin by reducing wrinkles, curing acne, rejuvenating and giving it a youthful glow.
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In a study of twenty-seven patients with partial thickness burn wound, they were treated with aloe vera gel compared with vaseline gauze. It revealed the aloe vera gel treated lesion healed faster than the vaseline gauze area. The average time of healing in the aloe gel area was 11.89 days and 18.19 days for the vaseline gauze treated wound. Statistical analysis by using t-test and the value of P < 0.002 was statistically significant. In histologic study, it showed early epithelialization in the treated aloe vera gel area. Only some minor adverse effects, such as discomfort and pain were encountered in the 27 cases. This study showed the effectiveness of aloe vera gel on a partial thickness burn wound, and it might be beneficial to do further trials on burn wounds.
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Ficus carica grows in tropical and subtropical regions of India, it is used in indigenious system of medicine like ayurveda, siddha, unani and homoeopathy. Different biologically active compounds were isolated form this plant. The barks, leaves,fruits are considered to be very effective in various treatments, such as diabetes, skin diseases, ulcers, dysentry, diarrohoea, stomachache, piles . Latex is widely used for warts, skin ulcers and sores, and taken as a purgative and vermifuge. The present review is therefore, an effort to give a detailed survey of the literature on its Pharamacognosy, phytochemistry, and traditional properties.
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The therapeutic effects of Aloe vera have been examined in preventing progressive dermal ischaemia caused by burns, frostbite, electrical injury, distal dying flap and intra-arterial drug abuse. In vivo analysis of these injuries showed that the mediator of progressive tissue damage was thromboxane A2 (TxA2). Experimentally Aloe was compared to a variety of antithromboxane agents to include U38450, a lodoxamide, a lazaroid and Carrington wound gel. In the burn injury Aloe was comparable to the lodoxamide and lazaroid with an 82% to 85% tissue survival when compared with the control and the Carrington wound gel (p=0.05). Tissue survival in the experimental frostbite injury was 28.2% when compared with the control (p=0.05). Similar results were obtained for the electrical injury, and intra-arterial drug abuse. Clinically burn patients treated with Aloe healed without tissue loss as did those with frostbite (p=0.001). In the intra-arterial drug abuse patients Aloe reversed the tissue necrosis. This therapeutic approach was used to prevent progressive tissue loss in each injury by actively inhibiting the localized production of TxA2. Aloe not only acts as a TxA2 inhibitor but maintains a homeostasis within the vascular endothelium as well as the surrounding tissue.
Article
An extract from the parenchyma of Aloe barbadensis Miller shown to contain long chain polydispersed beta (1,4)-linked mannan polymers with random O-acetyl groups (acemannan, Carrisyn) was found to initiate the phagocyte production of monokines that supported antibody dependent cellular cytotoxicity and stimulated blastogenesis in thymocytes. Acemannan, in both enriched and highly purified forms, was administered intraperitoneally to female CFW mice into which murine sarcoma cells had been subcutaneously implanted. The rapidly growing, highly malignant and invasive sarcoma grew in 100% of implanted control animals, resulting in mortality in 20 to 46 days, dependent on the number of cells implanted. Approximately 40% of animals treated with acemannan at the time of tumor cell implantation (1.5 x 10(6) cells) survived. Tumors in acemannan-treated animals exhibited vascular congestion, edema, polymorphonuclear leukocyte infiltration, and central necrosing foci with hemorrhage and peripheral fibrosis. The data indicate that in vivo treatment of peritoneal macrophages stimulates the macrophage production of monokines, including interleukin-1 and tumor necrosis factor. The data further indicate that sarcomas in animals treated i.p. with acemannan at the time of tumor cell implantation were infiltrated by immune system cells, became necrotic, and regressed. The combined data suggest that acemannan-stimulated synthesis of monokines resulted in the initiation of immune attack, necrosis, and regression of implanted sarcomas in mice.
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To compare the therapeutic effects of systemic pentoxifylline and topical aloe vera cream in the treatment of frostbite. The frostbitten ears of 10 New Zealand white rabbits were assigned to one of four treatment groups: untreated controls, those treated with aloe vera cream, those treated with pentoxifylline, and those treated with aloe vera cream and pentoxifylline. Tissue survival was calculated as the percent of total frostbite area that remained after 2 weeks. The control group had a 6% tissue survival. Tissue survival was notably improved with pentoxifylline (20%), better with aloe vera cream (24%), and the best with the combination therapy (30%). Pentoxifylline is as effective as aloe vera cream in improving tissue survival after frostbite injury.
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Aloe vera improves wound healing and inhibits inflammation. Since mannose-6-phosphate is the major sugar in the Aloe gel, the authors examined the possibility of its being an active growth substance. Mice receiving 300 mg/kg of mannose-6-phosphate had improved wound healing over saline controls. This dose also had anti-inflammatory activity. The function of mannose-6-phosphate in A. vera is discussed.