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Topic: Complications after HSCT, excluding GVHD Abstract No: 8465
Evaluation of the association of CMV immunoglobulins (cytomegalovirus) with
transplantation time in patients with bone marrow transplantation in Kermanshah
Sakineh Ghorbani1 ; Mehrdad Payandeh*2 ; Azam Elahi3 ; Roya Chagneh Lorestani3
1Medical bone marrow research center ,Kermanshah university of medical sciences,
Kermanshah, Iran / Medical bone marrow research center ,Kermanshah university of
medical sciences, Kermanshah, Iran / Iran, Islamic Rep. of, 2Department of
hematology and medical oncology ,Kermanshah university of medical
sciences,Kermanshah,/ Department of hematology and medical oncology
,Kermanshah university of medical sciences,Kermanshah,/ Iran, Islamic Rep. of,
3Department of Microbiology, Kermanshah University of Medical Sciences,
Kermanshah, Iran/ Department of Microbiology, Kermanshah University of Medical
Sciences, Kermanshah, Iran/ Iran, Islamic Rep. of
Abstract Content
Evaluation of the association of CMV immunoglobulins (cytomegalovirus) with
transplantation time in patients with bone marrow transplantation in Kermanshah
Dr. Mehrdad Payandeh1, Sakineh Ghorbani1, Roya Chagneh Lorestani2, Azam Elahi2
1- Department of Hematology and Oncology, Kermanshah University of Medical
Sciences, Kermanshah,Iran 2- Department of Microbiology, Kermanshah University
of Medical Sciences, Kermanshah, Iran
Introduction: Cytomegalovirus (CMV) infection is one of the most important factors
in the incidence and mortality of bone marrow transplantation. The incidence of
CMV infection is seen in a period of time (less than 100 days) after transplantation
and can involve several organs, including the lung, intestine, gastrointestinal tract,
eyes, central nervous system, etc. Common tests for the detection of CMV infection
in these patients include the anti-CMV test and the CMV DNA polymerase (PCR)
assay. The purpose of this study was to measure the relationship between CMV
presence and transplantation time.
Method: IgM-Anti CMV and IgG-Anti CMV tests were performed for transplant
patients and transplant recipients, as well as CMV-PCR for all patients. Patients with
chemotherapy leukemia who referred to Imam Reza Hospital who needed bone
marrow transplantation were examined.
Statistical analysis was performed using SPSS software (version 21) and P-value less
than 0.005 was considered as signi=cant level.
Results: Sixty-six patients underwent transplantation of bone marrow stem cells, 48
patients (77.4%) had autologous transplantation and 14 patients (22.6%) had
allogeneic transplantation. The mean transplantation time was 9.4 ± 1.89 days and
2 patients (22.2%) died. One patient (61.1%) was IgM-Anti CMV positive and 35
patients (56.4%) were IgG-Anti CMV positive. The prevalence of IgM-Anti CMV and
IgG-Anti CMV in transplant recipients (allogeneic) was 0% and 71.4%, respectively.
The incidence of CMVPCR was 4.8%. There was no signi=cant relationship between
the presence of CMV with the timing of transplantation (P> 0.005). The association
between IgM-Anti CMV and IgG-Anti CMV in patients and patients was signi=cant (p
<0.001).
Conclusion: Although the results of this study showed that there is no signi=cant
relationship between prolongation of transplantation and CMV infection, But its early
diagnosis is important in preventing progression of the disease Because most CMV
infections are initially asymptomatic and in case of neglect,
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most cases of activated infection of the virus (due to the weakening of the immune
system of these patients) can not be controlled.
Keywords: bone marrow transplantation, cytomegalovirus, transplantation time