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Exploring the Viability of Exogenous Ketones as Weight Loss Supplements (P21-017-19)

Authors:
Angela Poff
Angela Poff
Angela Poff
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Koutnik Andrew at University of South Florida
Koutnik Andrew
Sara Moss
Sara Moss
Sara Moss
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Sahith Mandala
Sahith Mandala
Sahith Mandala
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Abstract

Objectives: 70.7% of Americans over 20 years of age are overweight or obese. Currently, the main strategy for weight loss is caloric restriction. Ketone bodies have been shown to facilitate voluntary caloric restriction through altering the appetite stimulating hormone ghrelin. However, these non-toxic ketone bodies have not been evaluated as weight loss supplements. C57BL6J mice were used to determine the weight loss efficacy of exogenous ketones by adding synthetic (R/S 1,3-Butanediol Acetoacetate Diester and 1,3-Butanediol) and natural (Beta-hydroxybutyrate and Beta-hydroxybutyrate + Medium Chain Triglycerides) ketogenic agents to standard rodent chow ab-libitum. Methods: Six groups (R/S 1,3-butanediol acetoacetate diester, 1,3-butanediol, beta-hydroxybutyrate, beta-hydroxybutyrate + medium chain triglycerides, caloric restriction, standard diet ad-libitum) were housed 2-5 animals per cage and monitored to ensure appropriate acclimation prior to intervention. Mice were treated for two weeks with ketogenic agents, adjusting % of agent daily to ensure 20% weight loss was achieved. Results: All ketogenic agents induced weight loss and voluntary caloric restriction. Weight loss for beta-hydroxybutyrate and beta-hydroxybutyrate + medium chain triglycerides was explained by caloric restriction alone. However, R/S 1,3-butanediol acetoacetate diester induced weight loss at lower dosages which could not be explained by caloric restriction alone. Conclusions: Taken together, all ketogenic agents may assist in weight loss. However, R/S 1,3-butanediol acetoacetate diester appears to be a more potent non-toxic ketogenic supplement that facilitates weight loss via both voluntary caloric restriction and caloric restriction-independent mechanisms. Future studies should explore caloric-restriction independent weight loss mechanisms of R/S 1,3-butanediol acetoacetate diester. Funding sources: Disruptive Nutrition.
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1850 Obesity
Exploring the Viability of Exogenous Ketones as Weight Loss
Supplements (P21-017-19)
Angela Po, Andrew Koutnik, Sara Moss, Sahith Mandala, and
Dominic D’Agostino
University of South Florida
Objectives: 70.7% of Americans over 20 years of age are overweight
or obese. Currently, the main strategy for weight loss is caloric re-
striction. Ketone bodies have been shown to facilitate voluntary caloric
restriction through altering the appetite stimulating hormone ghrelin.
However, these non-toxic ketone bodies have not been evaluated
as weight loss supplements. C57BL6J mice were used to determine
the weight loss ecacy of exogenous ketones by adding synthetic
(R/S 1,3-Butanediol Acetoacetate Diester and 1,3-Butanediol) and
natural (Beta-hydroxybutyrate and Beta-hydroxybutyrate +Medium
Chain Triglycerides) ketogenic agents to standard rodent chow
ab-libitum.
Methods: Six groups (R/S 1,3-butanediol acetoacetate diester, 1,3-
butanediol, beta-hydroxybutyrate, beta-hydroxybutyrate +medium
chain triglycerides, caloric restriction, standard diet ad-libitum) were
housed 2–5 animals per cage and monitored to ensure appropriate
acclimation prior to intervention. Mice were treated for two weeks with
ketogenic agents, adjusting % of agent daily to ensure 20% weight loss
was achieved.
Results: All ketogenic agents induced weight loss and voluntary
caloric restriction. Weight loss for beta-hydroxybutyrate and beta-
hydroxybutyrate +medium chain triglycerides was explained by caloric
restriction alone. However, R/S 1,3-butanediol acetoacetate diester
induced weight loss at lower dosages which could not be explained by
caloric restriction alone.
Conclusions: Taken together, all ketogenic agents may assist in
weight loss. However, R/S 1,3-butanediol acetoacetate diester appears
to be a more potent non-toxic ketogenic supplement that facilitates
weight loss via both voluntary caloric restriction and caloric restriction-
independent mechanisms. Future studies should explore caloric-
restriction independent weight loss mechanisms of R/S 1,3-butanediol
acetoacetate diester.
Funding Sources: Disruptive Nutrition.
CURRENT DEVELOPMENTS IN NUTRITION
... 19 BHB is a metabolic product synthesized by the body and known to provide energy under starvation conditions. 20 Due to high demands, BHB has been synthesized artificially in the laboratory and is commercially available in the market as a supplement for the management of obesity or weight loss. 19e21 BHB seems to improve brain and nerve function and is also known to provide energy to muscles and to increase the ability to perform physical activities. ...
Regulatory effects of ketogenic diet on the inflammatory response in obese Saudi women
Article
Full-text available
  • Mar 2023
Objective: In recent years, the use of a ketogenic diet (KD) against obesity has gained popularity in KSA. This study was designed to determine the impact of KD on anthropometric indices and on the abnormal regulation of inflammatory activities in obese Saudi women. Moreover, we investigated the potential of beta-hydroxybutyrate (BHB) supplementation on the inhibition of pro-inflammatory activities. Methods: We enrolled 31 Saudi women (aged, 35.3 ± 8.4 years) with an average BMI of 33.96 ± 4.44 kg/m2 underwent an 8-week KD (8KD) from January to March 2021. Changes in anthropometric measurements were collected at baseline and after 4-8 weeks of intervention. Compliance with the dietary regimen was monitored weekly by plasma BHB level. Results: Twenty-nine females commenced the diets and 23 completed the study (a 79% completion rate). In comparison to pre-intervention, the 8KD resulted in a significant increase in the levels of plasma BHB (P < 0.001) throughout the duration of the trial. This was accompanied by a significant reduction in weight loss (7.7 kg ± 11.3; P < 0.001), BMI, waist circumference (P < 0.001), and levels of the inflammatory cytokine IL-1β (P < 0.001). Conclusions: An 8-week KD was found to be useful in producing a positive impact on anthropometric indices, biochemical and inflammatory processes. This study indicated that the intake of a KD by obese Saudi women induced the release of BHB in the blood without stimulation of an overall starvation response. This may be useful to alleviate the severity of chronic inflammatory disorders associated with obesity.
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