An understanding of the principles underlying cellular growth, of the interplay of regulatory circuits with physiological factors, and of the myriad processes that involve gene expression, relies ultimately on a knowledge of chromosome structure. There is a wide variation in the complexity of prokaryotic genomes. Nevertheless, each genetic element consists, in the simplest terms, of a series of
... [Show full abstract] genes (with their associated control regions), perhaps interspersed with non-coding — ‘silent’ — stretches: and, at the chemical level, of a macromolecule of nucleic acid.