This paper discusses micromanufacturing process quality proxies called "process fingerprints" in micro-injection moulding for establishing in-line quality assurance and machine learning models for Industry 4.0 applications. Process fingerprints that we present in this study are purely physical proxies of the product quality and need tangible rationale regarding their selection criteria such as sensitivity, cost-effectiveness, and robustness. Proposed methods and selection reasons for process fingerprints are also justified by analysing the temporally collected data with respect to the microreplication efficiency. Extracted process fingerprints were also used in a multiple linear regression scenario where they bring actionable insights for creating traceable and cost-effective supervised machine learning models in challenging micro-injection moulding environments. Multiple linear regression model demonstrated %84 accuracy in predicting the quality of the process, which is significant as far as the extreme process conditions and product features are concerned.
High-throughput manufacturing of transdermal microneedle arrays poses a significant challenge due to the high precision and number of features that need to be produced and the requirement of multi-step processing methods for achieving challenging micro-features. To address this challenge, we report a flexible and cost-effective process chain for transdermal microneedle array manufacture that includes mould production using laser machining and replication of thermoplastic microneedles via micro-injection moulding (micromoulding). The process chain also incorporates an in-line manufacturing data monitoring capability where the variability in the quality of microneedle arrays can be determined in a production run using captured data. Optical imaging and machine vision technologies are also implemented to create a quality inspection system that allows rapid evaluation of key quality indicators. The work presents the capability of laser machining as a cost-effective method for making microneedle moulds and micro-injection moulding of thermoplastic microneedle arrays as a highly-suitable manufacturing technique for large-scale production with low marginal cost.
Micro-injection moulding (μIM) is a replication-based process enabling the cost-effective production of complex and net-shaped miniaturized plastic components. The micro-scaled size of such parts poses great challenges in assessing their dimensional quality and often leads to time-consuming and unprofitable off-line measurement procedures. In this work, the authors proposed a novel method to verify the quality of a three-dimensional micro moulded component (nominal volume equal to 0.07 mm3) based on the combination of optical micro metrology and injection moulding process monitoring. The most significant dimensional features of the micro part were measured using a focus variation microscope. Their dependency on the variation of µIM process parameters was studied with a Design of Experiments (DoE) statistical approach. A correlation study allowed the identification of the product fingerprint, i.e., the dimensional characteristic that was most linked to the overall part quality and critical for product functionality. Injection pressure and velocity curves were recorded during each moulding cycle to identify the process fingerprint, i.e., the most sensitive and quality-related process indicator. The results of the study showed that the dimensional quality of the micro component could be effectively controlled in-line by combining the two fingerprints, thus opening the door for future µIM in-line process optimization and quality assessment.
The increasing demand for micro-products and components can be met only partly by the lithography-based micro-electromechanical systems fabrication processes that originated from the silicon-based microelectronics revolution of the late twentieth century. In particular, such processes have limitations when applied to new micro-devices which require the use of a variety of materials and complex 3D microstructures with high aspect ratios. In this context, the paper presents technologies complementary to
lithography-based processes for the manufacture of devices or components incorporating micro- and nano-scale features. More specifically, special attention is given to the main findings obtained over the last 5years from the authors’ research programme on a range of micro- and nano-manufacturing technologies, namely, micro-electrodischarge machining, laser ablation, micro-milling, focussed-ion beam machining, micro-injection moulding, nano-imprint lithography, hot embossing and electroforming.