No full-text available
To read the full-text of this research,
you can request a copy directly from the authors.
. Clinical efficacy of Dinamallika (Cestrum diurnum) in Kitibha kustha (Psoriasis)
Abstract
A non-native ornamental plant "Cestrum diurnum" know as Din-ka-raja or Dinamallika has been in use among some of the traditional Ayurvedic Vaidyas who by trial and error found out that the leaves of the plant are useful in the treatment of Kitibha Kushta. Further review of literature based on the methodology of anuktadravya, the drug has been found suitable for therapeutic use in skin ailments such as Kitibha Kustha (Psoriasis). Keeping in view, the burning problem of Psoriasis in the present era and its associated devastating disease, it has been decided to do research on Kitibha Kustha (Psoriasis) by using the oil prepared with "Cestrum diurnum" externally. As the drug does not have direct reference in Ayurveda to prove its action scientifically, there is a need to conduct appropriate clinical trials to establish the same. Further, as the plant is very easy to cultivate and the useful part being the leaves it is an ideal choice for therapeutic usage. Hence in the present study the drug "Cestrum diurnum" was selected to prove its efficacy clinically in Kitibha Kustha (Psoriasis).
... The leaf paste of C. diurnum is used by Malayali tribe of Tamil Nadu to treat joint pain [10]. The plant demonstrated to possess a wide range of pharmacological activities including antioxidant [4], anticancer [4], hypolipidemic [11], antipsoriatic [12], thrombolytic [13], antidiabetic [5], larvicidal [6] and antimicrobial [14] properties. Previous phytochemical analysis of the crude extracts revealed the presence of phytochemicals including alkaloids [14,15], norlignans, glycosides [9], saponin glycosides [8,16], triterpenes (ursolic acid, β-amyrin) and steroids (β-sitosterol, vitamin D 3 , 1,25-(OH) 2 D 3 ) [8,17,18]. ...
... Previous phytochemical analysis of the crude extracts revealed the presence of phytochemicals including alkaloids [14,15], norlignans, glycosides [9], saponin glycosides [8,16], triterpenes (ursolic acid, β-amyrin) and steroids (β-sitosterol, vitamin D 3 , 1,25-(OH) 2 D 3 ) [8,17,18]. Leaves of C. diurnum was found to be rich in β-carotene, lutein, xanthine, calcium, vitamin D 3 [19], calcitriol-a naturally occurring active form of vitamin D 3 [12] and the calcinogenic glycoside-1,25-dihydroxycholocalciferol which leads to vitamin D toxicity [6]. C. diurnum also contains different fatty acids including myristic, palmitic, stearic, oleic and linoleic acid [18]. ...
... C. diurnum has been well documented in medicinal plant repositories and herbal compendia, and used as herbal raw material for the management of pain and inflammatory disorders in complementary and alternative medicine throughout the globe. The plant extract was found to be safe and well tolerated in several clinical trials [2,7,12]. Nevertheless, adequate evidence is not available to support its therapeutic value in the treatment of pain and inflammation with underlying mechanism. ...
Abstract Background Cestrum diurnum L. (Solanaceae), locally known as buno-Hasnahena, is widely used in different traditional medicinal practices to treat pain, burn, swelling and related disorders. Adequate evidence is not available to support its medicinal properties for further use and drug development. Present study was designed to evaluate its traditional use in pain and inflammation with further characterisation of its chemical constituents through liquid chromatography-mass spectroscopic (LC-MS) analysis. Methods Antinociceptive and analgesic potential of methanol extract of the aerial parts of C. diurnum was carried out using carrageenan induced paw oedema and formalin induced paw licking test in mice at the oral doses of 150 and 300 mg/kg body weight. Inhibition of the inflammatory mediator nuclear factor kappa B (NF-κB) was evaluated by tumour necrosis factor α (TNF-α) induced NF-κB activation assay in macrophage cells at the concentration of 100 μg/ml. LC-MS analysis of the extract was performed to characterise the active component responsible for bioactivities. Results The extract significantly inhibited (p
... Together, these phytochemicals give its medicinal value and a host of health advantages. [25,26] Antipsoriatic - [63] * The (-) symbol denotes the lack of that activity in the plant. Table 2. ...
... Calcitriol 3 microg/g ointment has also been thoroughly tested for the treatment of chronic plaque-type psoriasis, and has been demonstrated to be efficacious, safe, and well-tolerated in a variety of short and long-term clinical trials. Topical calcitriol ointment yields low systemic absorption, according to pharmacokinetic investigations in psoriasis sufferers and healthy control volunteers 16 . ...
In Ayurveda all the Skin disorders are explained under Kustharogaadhikarand classified as 7 Mahakusthasand 11Kshudrakusthas .Kitibhakustha and Ekakustha are among the KshudraKusthas. Kitibhakusthais characterized by symptoms like Shyavam( blackish brown/ash colour lesions), kina Rauksham (hard and dry in nature), Kharasparsha(rough on touch), ugrakandu(excessive itching) and Ekakustha have symptoms like aswedanam(loss of sweating), mahavastu(covering of large surface areas ), matsyashakalopam(scaly lesions ) with predominance of vata and kaphadoshas in both.Due to similarities in symptoms it can be correlated to Plaque Psoriasis. It is chronic in nature and mainly caused due to autoimmune factor characterized by sharply defined erythematous squamous lesion, reddish scaly patches on the skin. AcharyaCharak has indicated repeated shodhanaand shaman chikitsa for kustha.Inbahyachikitsaapplication of various tailsand lepas are described. Thus the aim of the study is to review and discuss various external applications described in Psoriasis as per Ayurveda.Methodology- The classical texts of Ayurveda and modern medicine, Journals and Research articles were reviewed. Observations and Discussion- In the study following formulations like Dhatrayadhyolepa, Kutajasuryapakitaila, Karanjabeejataila showed significant result in reducing the symptoms of Psoriasis .Conclusion- Psoriasis(kustha)can be managed effectively by Lepachikitsathat is local application of various medicated herbs in form of lepa, and tails.
Cestrum diurnum L. (Solanaceae) is a fragrant ornamental tree cultivated in different parts around the world. In this study, the essential oil (EO) of the aerial parts was extracted by hydro-distillation (HD), steam distillation (SD) and microwave-assisted hydro-distillation (MAHD). GC/MS analysis of the three EOs revealed that phytol represents the major component in SD-EO and MAHD-EO (40.84 and 40.04%, respectively); while in HD-EO it only represented 15.36%. The SD-EO showed a strong antiviral activity against HCoV-229E with IC50 of 10.93 µg/mL, whereas, MAHD-EO and HD-EO showed a moderate activity with IC50 values of 119.9 and 148.2 µg/mL, respectively. The molecular docking of EO major components: phytol, octadecanol acetate and tricosane showed a strong binding to coronavirus 3-CL(pro). Moreover, the three EOs (50 μg/mL) decreased the levels of NO, IL-6 and TNF-α and suppressed IL-6 and TNF-α gene expression in LPS-induced inflammation model in RAW264.7 macrophage cell line.
Field survey was conducted in rural areas of Varanasi district of Uttar Pradesh including Ramnagar, Manduadih and surrounding areas to identify and collect information on undocumented medicinal plants (Anukta Dravya) by direct interaction with folklore people through field survey and indirect means by means of comprehensive survey of available literature. Local names of undocumented medicinal plants along with other relevant information were collected, after recording local names of medicinal plants, their botanical identification was done by comprehensive survey of literature, and the plants were identified according to Bentham & Hooker's system of classification using local floristic works. Expert opinion of plant taxonomists was also sought for cross checking and confirmation on identity. The freshly collected specimens were photographed for visual identification of the species. After identification, nomenclature of 10 Anukta Dravya was done as per the criteria of nomenclature mentioned in Nighantus.
- Vagbhata
Vagbhata. Ashtanga Hridaya, Vol. 2.
Srikanthamurthy KR, editor. 1 st ed. Varanasi:
Chaukhambha Orientalia; 1992. p.139.
- Vagbhata
Vagbhata. Ashtanga sangraha, Vol. 1.
Srikanthamurthy KR, editor. 3 rd ed. Varanasi:
Chaukhambha Orientalia; 2000. p.402.
Yadavji Trikamji Acharya, editor. Varanasi: Chaukambha Krishnadas Academy
- Sushrutha
Sushrutha. Sushrutha Samhita (Nibandha
Sangraha commentary by Dalhana). Yadavji
Trikamji
Acharya,
editor.
Varanasi:
Chaukambha Krishnadas Academy; 2002. p.
443, 824.
Saketh Ram T. Non-Native Drugs (Namataha Anukta Dravya) in Ayurveda
- Ala Vidyasagar
- Narayana
Vidyasagar, Ala Narayana, Saketh Ram T.
Non-Native Drugs (Namataha Anukta Dravya)
in Ayurveda. CCRAS IMR Project; 2005-06.
(Unpublished work)