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Role of Rhizome Powder of Turmeric in the management of Madhumeha w.s.r. to Diabetes Mellitus -A Case Study

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Diabetes mellitus is a group of metabolic disorders characterized by chronic hyperglycemia associated with disturbances of carbohydrates, fat, protein metabolism due to absolute or relative deficiency in insulin secretion, that metabolic disorder is considered as the Madhumeha in Ayurveda based on their symptoms. It is one of the types of Vataja Prameha. It results from various etiological factors. Here objective was to evaluate the efficacy of Ayurveda treatment in management of Madhumeha. A 35years old male came to SDM College of Ayurveda Hospital Kayachikitsa special OPD with complaint of Prabhoothamutra, Karapada Daha, Avila Mutrata and Kshudaathi Pravrthi. Examination, investigations and history leads to diabetes mellitus. So patient was treated with Haridra Choorna, Pathya, Apathya and Yogasananas. Ayurveda treatment has effective results in the management of Madhumeha by single drug administration orally.
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ISSN: 2456-3110 CASE REPORT
Mar-Apr 2017
Journal of Ayurveda and Integrated Medical Sciences | Mar - Apr 2017 | Vol. 2 | Issue 2
242
Role of Rhizome Powder of Turmeric in the
management of Madhumeha w.s.r. to Diabetes
Mellitus - A Case Study
Vasavda Krup,
1
Hegde Prakash L,
2
Harini A.
3
1
Assistant Professor, Department of Agadtantra, J S Ayurveda College, Nadiad, Gujarat,
2
Professor,
3
Associate
Professor, Department of Dravyaguna, SDM College of Ayurveda and Hospital, Hassan, Karnataka, India.
I
NTRODUCTION
Diabetes mellitus is a major public health problem in
the developed as well as developing countries. It is
ranked seventh among the leading causes of death,
and third when all its fatal complications are taken
into account.
[1]
The disease Madhumeha, its
definition, etiology, clinical features and principles of
treatment appear to be similar with the disease
“Diabetes mellitus”, which is considered as “Ice Berg”
disease in the present era.
[2]
In conventional therapy,
Address for correspondence:
Dr. Krup Vasavda
Assistant Professor, Department of Agadtantra,
J S Ayurveda College, Nadiad, Gujarat, India.
E-mail: krup1881@gmail.com
Submission Date : 03/03/2017 Accepted Date: 04/04/2017
Access this article online
Quick Response Code
Website: www.jaims.in
DOI: 10.21760/jaims.v2i2.7737
Type I diabetes is treated with exogenous insulin and
Type 2 with oral hypoglycemic agents
(sulphonylureas, biguanides etc).
[3]
Though different
types of oral hypoglycemic agents are available along
with insulin for the treatment of diabetes, there is an
increased demand by patients to use natural products
with antidiabetic activity.
[4]
The main symptom which
was in the patient of diabetes which was mentioned
by Acharyas are Prabootha Mootratha (micturition
during day time), Avila Mootratha (turbidity of urine),
Kshudhaathi Pravrithi (increase of appetite),
Dhourbhalya (debility), Karapada Daha (burning
senstation inpalms and soles.
[5]
The present case
study, treatment with Haridra Choorna is conducted
to confirm its efficacy, as it is given as
Madhumehahara effect in many of the classical texts .
M
ATERIALS AND
M
ETHODS
Selection of patient
A newly diagnosed male patient aged about 35 years
visited SDM college of Ayurveda Hospital Kayachikitsa
special OPD with following presenting with complaints
A B S T R A C T
Diabetes mellitus is a group of metabolic disorders characterized by chronic hyperglycemia associated
with disturbances of carbohydrates, fat, protein metabolism due to absolute or relative deficiency in
insulin secretion, that metabolic disorder is considered as the Madhumeha in Ayurveda based on their
symptoms. It is one of the types of Vataja Prameha. It results from various etiological factors. Here
objective was to evaluate the efficacy of Ayurveda treatment in management of Madhumeha. A
35years old male came to SDM College of Ayurveda Hospital Kayachikitsa special OPD with complaint
of Prabhoothamutra, Karapada Daha, Avila Mutrata and Kshudaathi Pravrthi. Examination,
investigations and history leads to diabetes mellitus. So patient was treated with Haridra Choorna,
Pathya, Apathya and Yogasananas. Ayurveda treatment has effective results in the management of
Madhumeha by single drug administration orally.
Key words: Curcuma longa Linn, Diabetes mellitus, Haridra, Madhumeha.
Vasavda Krup et. al. Role of Rhizome Powder of Turmeric in the management of Madhumeha.
ISSN: 2456-3110 CASE REPORT
Mar-Apr 2017
Journal of Ayurveda and Integrated Medical Sciences | Mar - Apr 2017 | Vol. 2 | Issue 2
243
of Prabhutha Mutra day and night, Avilamutrata,
Karapada Daha, Kshudhadhikyata and Dourbalya.
This diagnosis was done as diabetes mellitus.
Symptoms
1. Prabhuthamutrata
2. Kshudhadhikyata
3. Avila mutratha
4. Pipasadhikyata
5. KarapadaDaha
6. Dourbalya
Investigation
1. FBS
2. FUS
3. PPBS
4. PPUS
Single drug which is having Madhumehahara action
Drug: Rhizome powder of Haridra
Dose: 3g. two times a day
Mode of administration: orally
Duration of treatment: 30 days
R
ESULTS
Table 1: Effect Of Rhizome Powder Of Curcuma
Longa Linn. for subjective parameters.
N
o
Subjective
parameter
Before
treatmen
t
(Scoring)
Review
after 2
weeks
(Scoring
)
Review
after 4
weeks
(Scoring
)
1 Prabhuta
Mootrata
2 1 0
2 Avila Mootrata 1 1 0
3 Pipasadhikyata 0 0 0
4 Kshudhadhikyat 1 0 0
a
5 Karapada Daha 2 1 0
6 Dourbalya 1 1 1
7 Angamarda 2 1 0
Table 2: Effect of Rhizome Powder of Curcuma Longa
Linn. for objective parameters.
No Objective
parameter
Before
treatment
(Scoring)
Review
after 2
weeks
(Scoring)
Review
after 4
weeks
(Scoring)
1 F.B.S 136.2 124.5 116.9
2 F.U.S Trace Absent Absent
3 P.P.B.S 176.1 170.1 152.6
4 P.P.U.S 1.0% 1.0% Trace
D
ISCUSSION
Effect of therapy on subjective parameters
Prabhutmootrata and Avilmootrata between day 1
and day 30 was significantly reduced. Other
subjective parameters like Kshudhadhikyata,
Karapada Daha and Angamarda was also significantly
reduced. Only in Dourbalya no change is seen.
Effect of therapy on objective parameters
FBS reduced significantly with the p value at 0.03 after
a period of two months. FUS reduced significantly
with the p value at 0.01 after a period of two months.
PPBS reduced significantly with the p value at 0.19
after a period of two months. PPUS reduced
significantly with the p value at 0.02 after a period of
two months.
Diabetes mellitus is a major public health problem in
the developed as well as developing countries. It is
ranked seventh among the leading causes of death
and third when all its fatal complications are taken
into account. In the present study, treatment with
Haridra Choorna produced significant hypoglycemia.
Vasavda Krup et. al. Role of Rhizome Powder of Turmeric in the management of Madhumeha.
ISSN: 2456-3110 CASE REPORT
Mar-Apr 2017
Journal of Ayurveda and Integrated Medical Sciences | Mar - Apr 2017 | Vol. 2 | Issue 2
244
Haridra possess Katu Tikta, Rasa, Laghu Rooksha
Guna, Usna Virya and Katu Vipaka.
[6]
It mainly acts as
Pitta-Kapha Shamaka, Meda, Kleda Upashoshana. It
has Usna Virya which is mainly acts as a Vatahara. It
is having opposite qualities to that of Kapha and
Medas. This Tridosha Shamaka property of the
drugs helps to correct the Dhatu Dushti and Sroto
Dushti leading to their normal functioning. Hence it
acts as Mehahara. Haridra Choorna has showed
significant improvement in the symptoms of
Madhumeha and blood sugar. Curcuma Longa Linn. is
known to contain curcuminoids, glycosides,
terpenoids and flavonoids.
[7]
Maximal inhibition of the
enzyme Human Pancreatic Amylase (HPA) was
obtained with Curcuma Longa isopropanol extract and
acetone extract. This inhibitory action on HPA causes
reduction in starch hydrolysis leading to lowered
glucose levels.
[8]
C
ONCLUSION
Madhumeha known as silent killer needs to be
treated as early as possible to stop onset of
complication. Single drug treatment like Haridra
Churna can prove to be boon to the wide population
suffering from Diabetes mellitus comprising of
Pathyakara Aahara Vihara followed with regular
practice of Yogasanas. This case study proves that
Haridra Choorna is an efficient as well as an ideal
drug for its potent Madhumehahara (Anti
hyperglycemic) effect.
R
EFERENCES
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2. Acharya Agnivesha; Charaka Samhita; redacted by
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********************************
How to cite this article:
Vasavda Krup,
Hegde Prakash
L, Harini A. Role of Rhizome Powder of Turmeric in the
management of Madhumeha w.s.r. to Diabetes
Mellitus - A Case Study. J Ayurveda Integr Med Sci
2017;2:242-244.
http://dx.doi.org/10.21760/jaims.v2i2.7737
Source of Support:
Nil,
Conf
l
ict of Interest:
None
ResearchGate has not been able to resolve any citations for this publication.
Article
Full-text available
Pancreatic α-amylase inhibitors offer an effective strategy to lower the levels of post prandial hyperglycemia via control of starch breakdown. Eleven Ayurvedic Indian medicinal plants with known hypoglycemic properties were subjected to sequential solvent extraction and tested for α-amylase inhibition, in order to assess and evaluate their inhibitory potential on pancreatic α-amylase. Analysis of 91 extracts, showed that 10 exhibited strong Human Pancreatic Amylase (HPA) inhibitory potential. Of these, 6 extracts showed concentration dependent inhibition with IC(50) values, namely, cold and hot water extracts from Ficus bengalensis bark (4.4 and 125 μgmL(-1)), Syzygium cumini seeds (42.1 and 4.1 μgmL(-1)), isopropanol extracts of Cinnamomum verum leaves (1.0 μgmL(-1)) and Curcuma longa rhizome (0.16 μgmL(-1)). The other 4 extracts exhibited concentration independent inhibition, namely, methanol extract of Bixa orellana leaves (49 μgmL(-1)), isopropanol extract from Murraya koenigii leaves (127 μgmL(-1)), acetone extracts from C. longa rhizome (7.4 μgmL(-1)) and Tribulus terrestris seeds (511 μgmL(-1)). Thus, the probable mechanism of action of the above fractions is due to their inhibitory action on HPA, thereby reducing the rate of starch hydrolysis leading to lowered glucose levels. Phytochemical analysis revealed the presence of alkaloids, proteins, tannins, cardiac glycosides, flavonoids, saponins and steroids as probable inhibitory compounds.
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OBJECTIVE: To study the effect of shilajit (a herbomineral preparation) on blood glucose and lipid profile in euglycemic and alloxan-induced diabetic rats and its effects on the above parameters in combination with conventional antidiabetic drugs. MATERIAL AND METHODS: Diabetes was induced in albino rats by administration of a single dose of alloxan monohydrate 5% (125 mg/kg, i.p.). Effects of three different doses of shilajit (50, 100 and 200 mg/kg/day, orally), alone for 4 weeks and a combination of shilajit (100 mg/kg/day, orally) with either glibenclamide (5 mg/kg/day, orally) or metformin (0.5 g/kg/day, orally) for 4 weeks were studied on blood glucose and lipid profile. RESULTS: In the diabetic rats, all the three doses of shilajit produced a significant reduction in blood glucose levels and also produced beneficial effects on the lipid profile. The maximum effect was observed with the 100 mg/kg/day dose of shilajit. Combination of shilajit (100 mg/kg) with glibenclamide (5 mg/kg/day) or metformin (0.5 gm/kg/day) significantly enhanced the glucose-lowering ability and improvement in lipid profile than any of these drugs given alone. CONCLUSION: Shilajit is effective in controlling blood glucose levels and improves the lipid profile.
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Extracts of Caralluma attenuata are screened for their antihyperglycemic activity. Ethanol, chloroform and butanol extracts were tested on glucose loaded and alloxan-induced diabetic rats. In both tests, the butanol extract, at the oral dose of 250 mg/kg, has shown statistically significant and considerable antihyperglycemic activity.
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The fruit of Indian Eugenia jambolana have been shown to have therapeutic properties, but because the therapeutic potential of a plant is related to the geographic region in which the plant was grown and to the part of the plant used, we investigated Brazilian Eugenia jambolana fruit using the same preparation and experimental methods as have been used in India. The well-established metabolic cage model was used to evaluate the physiological and metabolic parameters associated with streptozotocin-induced diabetes in rats (n=10) which had been administered, by gavage, 50 mg per day of lyophilised Eugenia jambolana fruit-pulp extract for 41 days. We found that, compared to untreated controls, rats treated with the lyophilised fruit-pulp showed no observable difference in body weight, food or water intake, urine volume, glycaemia, urinary urea and glucose, hepatic glycogen, or on serum levels of total cholesterol, HDL cholesterol or triglycerides. No change was observed in the masses of epididymal or retroperitoneal adipose tissue or of soleus or extensor digitorum longus muscles. This lack of any apparent effect on the diabetes may be attributable to the regional ecosystem where the fruit was collected and/or to the severity of the induced diabetes.
  • Jln Sastry
  • Dravya Guna
  • Vijnana
Sastry JLN. Dravya Guna Vijnana. Vol-2., 2 nd ed. Varanasi: Chaukhambha Orientalia; 2005;p.788-90.