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Safe Genes: Threshold Dependent Drives (Reciprocal Chromosomal Translocations and UDMel)

Presentation

Safe Genes: Threshold Dependent Drives (Reciprocal Chromosomal Translocations and UDMel)

Abstract

Presentation of our work: "Confinement and reversibility of threshold-dependent gene drive systems in spatially-explicit Aedes aegypti populations" (https://www.researchgate.net/publication/332380657_Confinement_and_reversibility_of_threshold-dependent_gene_drive_systems_in_spatially-explicit_Aedes_aegypti_populations); as part of the DARPA: "Safe Genes" project.
Threshold Dependent Drives
University of California, Berkeley
Héctor M. Sánchez C.
(John M. Marshall’s Lab)
What are Threshold Dependent Drives?
Translocations UDMEL
How do they differ from current approaches?
Time
Drive Frequency
Drive Frequency
Time
https://youtu.be/lNcIHcJYI_0?t=1:: [00:01-00:20]
MGDrivE: Mosquito Gene Drive Explorer
Fixation/Remediation
Simulation 1: Fixation/Remediation
Translocations
Fixation [10 releases]
https://youtu.be/lNcIHcJYI_0?t=22 :: [00:22-00:45]
Translocations VS UDMEL
Fixation [10 releases @ 25% coverage]
https://youtu.be/lNcIHcJYI_0?t=45 :: [00:45-00:45]
Translocations VS UDMEL
Remediation [10 releases]
https://youtu.be/lNcIHcJYI_0?t=70 :: [01:10-01:32]
Summary
Confinement
Simulation 2: Batch Migration
Translocations VS UDMEL
Batch Migration [5 migration events/day]
https://youtu.be/lNcIHcJYI_0?t=70 :: [02:30-02:55]
Summary
Data Needs/Surveillance
and
“Take Away”
Data needs/Surveillance
Life History Mosquito Movement
In a spatially explicit suburb setting, translocations is a good candidate
for a confineable and reversible way to spread disease-refractory
genes in Ae. aegypti populations.
“Take Home”
shorturl.at/mpvNT
sanchez.hmsc@berkeley.edu
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