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Research Article
Skin Appendage Disord
Frequency of the Types of Alopecia at Twenty-Two
Specialist Hair Clinics: A Multicenter Study
Sergio Vañó-Galván a David Saceda-Corralo a Ulrike Blume-Peytavi b Jose Cucchía c
Ncoza C. Dlova d Maria Fernanda Reis Gavazzoni Dias e Ramon Grimalt f Daniela Guzmán-Sánchez g
Matthew Harries h Anthony Ho i Susan Holmes j Jorge Larrondo k Anisa Mosam d
Rui Oliveira-Soares l, m Giselle M. Pinto n Bianca M. Piraccini o Rodrigo Pirmez p
Daniel De la Rosa Carrillo q Lidia Rudnicka r Jerry Shapiro i Rodney Sinclair s, t Antonella Tosti u
Ralph M. Trüeb v Annika Vogt b Mariya Miteva w
a Dermatology Department, Ramon y Cajal Hospital, University of Alcala, IRYCIS, Trichology Unit, Grupo Pedro Jaen Clinic,
Madrid, Spain; b Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany; c Private
Trichology Practice, Santa Ana Medical Center, Bogotá, Colombia; d Department of Dermatology, Nelson R Mandela School
of Medicine, University of KwaZulu-Natal, Durban, South Africa; e Fluminense Federal University – UFF, Niterói, Brazil;
f Dermatology Department, Universitat Internacional de Catalunya, Barcelona, Spain; g School of Medicine, Universidad de
Guadalajara, Guadalajara, Mexico; h The Dermatology Centre, University of Manchester, Salford Royal NHS Foundation Trust,
Salford, UK; i The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY,
USA; j Alan Lyell Centre for Dermatology, Queen Elizabeth University Hospital, Glasgow, UK; k Department of Dermatology,
Clínica Alemana de Santiago, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile; l Department
of Dermatology, Hospital Cuf Descobertas, Lisbon, Portugal; m Department of Dermatology, Hospital Cuf Torres Vedras,
Torres Vedras, Portugal; n Hair and Scalp Diseases, Outpatient Clinic, Division of Dermatology, Santa Casa de Misericórdia,
Porto Alegre, Brazil; o Division of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University
of Bologna, Bologna, Italy; p Department of Dermatology, Instituto de Dermatologia Professor Rubem David Azulay, Santa
Casa da Misericórdia do Rio de Janeiro, Rio de Janeiro, Brazil; q Department of Dermatology, Oslo University Hospital, Oslo,
Norway; r Department of Dermatology, Medical University of Warsaw, Warsaw, Poland; s Sinclair Dermatology, East Melbourne,
VIC, Australia; t Department of Medicine, University of Melbourne, Parkville, VIC, Australia; u University of Miami, Miami, FL,
USA; v Center for Dermatology and Hair Diseases Professor Trüeb, Wallisellen, Switzerland; w Department of Dermatology and
Cutaneous Surgery, University of Miami L. Miller School of Medicine, Miami, FL, USA
Received: November 5, 2018
Accepted: January 3, 2019
Published online: April 2, 2019
Sergio Vañó-Galván, MD, PhD
Dermatology Department, Ramon y Cajal Hospital
Carretera Colmenar Viejo km 9.100
ES–28034 Madrid (Spain)
E-Mail drsergiovano @ gmail.com
© 2019 S. Karger AG, Basel
E-Mail karger@karger.com
www.karger.com/sad
DOI: 10.1159/000496708
Keywords
Hair diseases · Alopecia · Androgenetic alopecia · Alopecia
areata · Frontal fibrosing alopecia · Telogen effluvium ·
Folliculitis decalvans · Lichen planopilaris · Epidemiology
Abstract
Background: The frequency of different types of alopecia is
not clearly reported in recent studies. Objective: To analyze
the frequency of the types of alopecia in patients consulting
at specialist hair clinics (SHC) and to assess for global varia-
tions. Methods: Multicenter retrospective study including
data from patients evaluated at referral SHC in Europe,
America, Africa and Australia. Results: A total of 2,835 pa-
tients (72.7% females and 27.3% males) with 3,133 diagno-
ses of alopecia were included (73% were non-cicatricial and
27% were cicatricial alopecias). In all, 57 different types of
alopecia were characterized. The most frequent type was an-
drogenetic alopecia (AGA) (37.7%), followed by alopecia
areata (AA) (18.2%), telogen effluvium (TE) (11.3%), frontal
fibrosing alopecia (FFA) (10.8%), lichen planopilaris (LPP)
(7.6%), folliculitis decalvans (FD) (2.8%), discoid lupus (1.9%)
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DOI: 10.1159/000496708
and fibrosing alopecia in a pattern distribution (FAPD) (1.8%).
There was a male predominance in patients with acne keloi-
dalis nuchae, dissecting cellulitis and FD, and female pre-
dominance in traction alopecia, central centrifugal cicatricial
alopecia, FFA, TE, FAPD and LPP. Conclusion: AGA followed
by AA and TE were the most frequent cause of non-cicatricial
alopecia, while FFA was the most frequent cause of cicatricial
alopecia in all studied geographical areas.
© 2019 S. Karger AG, Basel
Introduction
Androgenetic alopecia (AGA) is the most frequent
cause of hair loss in both genders [1–3], followed by alo-
pecia areata (AA) [4]. Regarding cicatricial alopecias, li-
chen planopilaris (LPP) has been described as the most
frequent cicatricial alopecia [5, 6]. However, most papers
published over recent years suggest that the incidence of
frontal fibrosing alopecia (FFA) may be increasing com-
pared with other types of cicatricial alopecias [7–9], al-
though this observation has not yet been confirmed in
large epidemiological studies. Some alopecias may have a
marked difference in their prevalence depending on the
geographical location and ethnicity (i.e., central centrifu-
gal cicatricial alopecia [CCCA] is typical of females with
African ancestry [7]); thus, a worldwide analysis of the
frequency of the different alopecias seen at specialist hair
clinics (SHC) may provide useful insights into disease ep-
idemiology. Regarding the healthcare setting, no data ex-
ist regarding possible disparities in the frequency of hair
disorders seen in private versus public centers.
There are no recent studies describing the frequency
of different types of alopecia among patients treated at
different SHC. The objective of this study was to analyze
the frequency of the different types of alopecia in patients
evaluated at SHC across the globe and to analyze the pos-
sible differences in frequencies between geographical ar-
eas, gender and age.
Methods
A multicenter retrospective study was designed, and local in-
stitutional review board approval was obtained. Data were collect-
ed at SHC in several countries between September 1st, 2017, and
November 30th, 2017. The referral centers were located in Austra-
lia, Brazil, Chile, Colombia, Germany, Italy, Mexico, Norway, Po-
land, Portugal, South Africa, Spain, Switzerland, USA and UK.
Each investigator included the following data: gender, age, setting
(private vs. public healthcare), first visit versus follow-up visit and
type of alopecia: AGA, telogen effluvium (TE), AA, FFA, LPP, dis-
coid lupus, folliculitis decalvans (FD), CCCA, traction alopecia,
dissecting cellulitis (DCS), acne keloidalis nuchae (AKN), fibros-
ing alopecia in a pattern distribution (FAPD), trichotillomania and
others including hair shaft disorders and hair weathering changes.
AA was subclassified into: patchy AA, ophiasis, diffuse AA, AA
incognita, alopecia totalis, alopecia universalis and beard AA. Each
investigator included data on a minimum of 100 consecutive pa-
tients consulting for any hair disorder in the study period. If a pa-
tient presented 2 or more concomitant alopecias, all were regis-
tered in the database.
The obtained data were anonymized and handled in accor-
dance with the European General Data Protection Regulation (EU
2016/679).
For all continuous variables, median and range were calcu-
lated, but for categorical variables, frequencies were reported.
The Mann-Whitney and χ2 tests were used to assess the statistical
significance of differences observed between groups for continu-
ous and categorical variables, respectively. p < 0.05 was consid-
ered statistically significant. For all statistical analyses, a software
package was used (SPSS 21.0; IBM Corp., Armonk, NY, USA).
Results
Results are summarized in Tables 1–3.
Demographic Data
In total, 2,835 patients were included (USA: n = 303,
Spain: n = 412, Mexico: n = 100, Chile: n = 137, Colombia:
n = 295, Norway: n = 100, Brazil: n = 312, Portugal: n =
100, Italy: n = 200, Germany: n = 100, Switzerland: n =
100, South Africa: n = 114, Australia: n = 107, UK: n = 202
and Poland: n = 253). 298 patients (10.5%) presented with
two concomitant types of alopecia. A total of 3,133 alope-
cia diagnoses with 57 different types of alopecia were re-
corded and showed the following distribution: 2,293 were
non-cicatricial alopecias (73.2%) while 840 were cicatri-
cial alopecias (26.8%). The median age of patients was
43.5 years (range 1–92 years), and 2,062 patients were fe-
males (72.7%) and 773 were males (27.3%). 915 (32.3%)
were evaluated as a first visit and 1,920 (67.7%) as a fol-
low-up visit, and 1,925 (67.9%) were seen in a private
healthcare setting, while 910 (32.1%) were seen in a pub-
lic healthcare setting.
Frequency in Alopecia by Type and Healthcare Setting
The most frequent type of alopecia was AGA (37.7%),
followed by AA (18.2%), TE (11.3%) and FFA (10.8%).
There were statistically significant differences in the fre-
quency of hair disorders depending on the healthcare set-
ting (Table 1). In the private healthcare setting, the most
frequent alopecia was AGA (48% of cases), followed by
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DOI: 10.1159/000496708
TE (14.6%), AA (13.6%) and FFA (8.5%). In the public
healthcare setting, the most frequent alopecia was AA
(28% of cases), followed by FFA (16%), AGA (14%) and
LPP (12%) (p = 0.003).
Frequency of Alopecia by Gender and Age
Regarding gender (Table 2), the most frequent alope-
cias in male patients were: AGA (48% of males), fol-
lowed by AA (25%), FD (6.9%), LPP (5%), TE (3.8%),
DCS (2.7%), FFA (1.9%), AKN (1.8%), discoid lupus
(0.9%) and FAPD (0.7%). The most frequent alopecias
in female patients were: AGA (34.2%), AA (15.7%), FFA
(14%), TE (13.5%), LPP (8.5%), discoid lupus (2.3%),
FAPD (2.2%), traction alopecia (1.9%), FD (1.4%) and
CCCA (1.3%).
The following alopecias were most frequent in male
patients: AKN (88% were males), DCS (76% were males),
FD (64% were males). A female predominance was ob-
served in: traction alopecia (98% were females), CCCA
(97% were females), FFA (95% were females), chronic
and acute TE (93 and 90% were females, respectively),
FAPD (89% were females), discoid lupus (88% were fe-
males) and LPP (83% were females).
Globally, male patients were younger than female pa-
tients (median age of 33 and 47 years, respectively; p <
0.001). Analyzing the different alopecias by the age of pa-
tients (Table 2), the youngest median age was observed in
patients with hair shaft disorders (14 years), followed by
patients with trichotillomania (25 years), AKN (32 years),
AA (32 years), DCS (37 years), FD (40 years) and AGA
(40 years). The oldest median age was observed in pa-
tients with FFA (60 years), FAPD (59 years), discoid lupus
(56 years) and LPP (54 years).
Non-Cicatricial Alopecia
The most frequent type of non-cicatricial alopecia was
AGA (51.5% of non-cicatricial alopecias), followed by AA
(24.9%) and TE (15.5%). Other types of alopecia such as
trichotillomania, hair shaft disorders, hair weathering,
syphilitic alopecia, scalp psoriasis, tinea capitis or anagen
effluvium were present in less than 3% of patients. The
most frequent hair shaft disorder was monilethrix (6 out of
12 patients), followed by trichorrhexis nodosa (3 out of 12
patients). Of the total of patients with AA (n = 568), the
most frequent subtype was patchy AA (62.1% of patients
diagnosed with AA), followed by alopecia totalis (16.6%),
alopecia universalis (9.5%), ophiasis (5.8%), diffuse AA
(4.1%), AA incognita (1.4%) and beard AA (0.5%).
Cicatricial Alopecia
Regarding cicatricial alopecias (n = 840, 26.8% of the
total of alopecias), FFA was the most frequent (40.1% of
cicatricial alopecias), followed by LPP (28.4%), FD
(10.5%), discoid lupus (7.1%), FAPD (6.8%), traction alo-
pecia (5.2%), CCCA (3.6%) and DCS (3.4%).
Other types of alopecia such as AKN, erosive pustular
dermatosis of the scalp, lamellar ichthyosis, permanent
post-chemotherapy alopecia, temporal triangular con-
Table 1. Frequency of hair disorders and differences by setting (private/public healthcare)
Type of alopecia Public setting, n (%) Private setting, n (%) Total, n (%)
Androgenetic alopecia 136 (14) 1,044 (48) 1,180 (37.7)
Alopecia areata 274 (28) 294 (13.6) 568 (18.2)
Telogen effluvium 38 (4) 317 (14.6) 355 (11.3)
Frontal fibrosing alopecia 152 (16) 185 (8.5) 337 (10.8)
Lichen planopilaris 118 (12) 121 (5.5) 239 (7.6)
Folliculitis decalvans 61 (6.3) 27 (1) 88 (2.8)
Discoid lupus 42 (4.3) 18 (<1) 60 (1.9)
FAPD 42 (4.3) 15 (<1) 57 (1.8)
Traction alopecia 10 (1.0) 34 (1.6) 44 (1.4)
CCCA 9 (1) 21 (1) 30 (1)
Dissecting cellulitis 12 (1) 17 (<1) 29 (0.9)
Acne keloidalis nuchae 13 (1.4) 4 (<1) 17 (0.5)
Trichotillomania 5 (<1) 7 (<1) 12 (0.4)
Hair shaft disorders 1 (<1) 11 (<1) 12 (0.4)
Other alopecias 47 (4.9) 48 (2.2) 95 (3)
Total 962 (30.7) 2,171 (69.3) 3,133 (100)
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DOI: 10.1159/000496708
genital alopecia, pemphigus-induced alopecia, Graham-
Little syndrome, alopecia mucinosa or coupe de sabre al-
opecia were present in less than 3% of patients.
Global Variations
The different frequency of alopecias in each continent
(Europe, America, Africa and Australia) was also ana-
lyzed (Table 3). We could not find any statistically sig-
nificant difference in the frequency of AGA, TE, FFA and
LPP. However, a higher frequency of some alopecias was
found in some continents: AA in Europe (23 vs. < 14% in
the rest of continents), traction alopecia in Africa (18 vs.
< 1% in the rest of continents), AKN in Africa (9 vs. < 1%
in the rest of continents), CCCA in Africa (6 vs. < 1% in
the rest of continents), FD in Africa (7.5 vs. < 3.5% in the
rest of continents) and FAPD in America (3.5 vs. < 2% in
Table 2. Differences in the frequency of hair disorders by gender and age
Type of alopecia Gender Median age (range), years
by gender total
Androgenetic alopecia (n = 1,180) male: 33% male: 33 (11–76) 40 (11–91)
female: 67% female: 45 (12–91)
Alopecia areata (n = 568) male: 36% male: 28 (1–63) 32 (1–82)
female: 64% female: 37 (3–82)
Acute telogen effluvium (n = 183) male: 10% male: 35 (18–65) 41 (9–76)
female: 90% female: 41 (9–76)
Chronic telogen effluvium (n = 172) male: 7% male: 31 (17–86) 42 (13–92)
female: 93% female: 43 (13–92)
Frontal fibrosing alopecia (n = 337) male: 5% male: 45 (31–70) 60 (31–89)
female: 95% female: 61 (31–89)
Lichen planopilaris (n = 239) male: 17% male: 43 (13–74) 54 (8–86)
female: 83% female: 56 (8–86)
Folliculitis decalvans (n = 88) male: 64% male: 40 (19–73) 40 (17–75)
female: 36% female: 41 (17–75)
Discoid lupus (n = 60) male: 12% male: 39 (27–58) 56 (19–81)
female: 88% female: 59 (19–81)
FAPD (n = 57) male: 11% male: 57 (24–73) 59 (21–82)
female: 89% female: 59 (21–82)
Traction alopecia (n = 44) male: 2% male: 44 (1 case) 41 (11–67)
female: 98% female: 40 (11–67)
CCCA (n = 30) male: 3% male: 56 (1 case) 47 (27–72)
female: 97% female: 46 (27–72)
Dissecting cellulitis (n = 29) male: 76% male: 33 (19–69) 37 (18–83)
female: 24% female: 57 (18–83)
Acne keloidalis nuchae (n = 17) male: 88% male: 32 (22–55) 32 (22–62)
female: 12% female: 51 (40–62)
Trichotillomania (n = 12) male: 42% male: 25 (14–41) 25 (8–41)
female: 58% female: 25 (8–35)
Hair shaft disorders (n = 12) male: 42% male: 15 (8–70) 14 (3–70)
female: 58% female: 4 (3–61)
Total (n = 3,133) male: 26.4% male: 33 (1–86) 43 (1–92)
female: 73.6% female: 47 (2–92)
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the rest of continents). Analyzing each continent by
countries, there were no significant differences in the fre-
quency of hair disorders. In the American continent, we
performed a subanalysis between North America (n =
352) and South America (n = 934). We found a statisti-
cally significant higher number of patients consulting for
these alopecias in North America: FFA (16% of patients
in North America vs. 8.4% of patients in South America,
p < 0.001), CCCA (2.8 vs. 0.5%, p = 0.002). On the con-
trary, more patients consulted for these alopecias in South
America: FAPD (4.7% of patients in South America vs.
0.3% of patients in North America, p < 0.001), discoid lu-
pus (4.3 vs. 0.3%, p < 0.001) and FD (2 vs. 0.3%, p = 0.014).
We did not find any statistically significant difference in
the age of the different alopecias between continents.
Discussion
This is the first multicenter study to analyze the fre-
quencies of the different types of alopecia in patients from
reference SHC in different continents. An understanding
of the frequency with which different types of alopecia are
seen in different geographical areas could provide useful
insights into disease epidemiology.
In concordance with previous studies [1–3, 10], AGA
was the most frequent cause of consultation in both gen-
ders. Male patients that consulted with AGA in our study
were younger than female patients (33 vs. 45 years, re-
spectively), similar to other studies [1]. This could be ex-
plained because female patients present two peaks of con-
sultation for AGA: early adults and menopause, while
male patients usually consult in the early adulthood.
The second most frequent global cause of consultation
in our study was AA. This was the most frequent type of
alopecia in the public healthcare setting. The median age
in patients with AA was 32 years, in accordance with pub-
lished studies (30–35 years) [4, 11, 12]. AA seems to affect
both genders equally [11], although in our study we found
a female predominance (64% females vs. 36% males),
probably because female patients tend to consult more
than male patients.
TE was the third most frequent cause of consultation,
with a clear female predominance, in concordance with
previous reports [13]. Other types of non-cicatricial alo-
pecia such as trichotillomania, tinea capitis or scalp pso-
riasis were less frequent. Monilethrix represented the
most frequent hair shaft disorder in our study.
Regarding gender, patients consulting with AKN, FD
and DCS were most frequently males, while patients
consulting with traction alopecia, CCCA, FFA, FAPD
and LPP were most frequently females, in accordance
with the literature [7, 9, 14–20]. The most frequent alo-
pecias in both genders were AGA followed by AA. Re-
markably, the third most frequent alopecia in male pa-
tients was FD, while in female patients was FFA, sup-
porting the already reported gender predominance in
both alopecias [9, 15].
Table 3. Differences in the frequency of hair disorders by continent
Type of alopecia Europe, n (%) America, n (%) Australia, n (%) Africa, n (%) Total, n (%)
Androgenetic alopecia 558 (35) 531 (41.2) 85 (69) 6 (4.5) 1,180 (37.6)
Alopecia areata 365 (22.9) 172 (13.3) 17 (14) 14 (10.5) 568 (18.2)
Telogen effluvium 175 (11) 175 (13.6) 0 5 (3.7) 355 (11.3)
Frontal fibrosing alopecia 177 (11) 134 (10.4) 9 (7.3) 17 (12.7) 337 (10.8)
Lichen planopilaris 115 (7.2) 93 (7.2) 3 (2.4) 28 (21) 239 (7.6)
Folliculitis decalvans 55 (3.4) 20 (2.5) 3 (2.4) 10 (7.5) 88 (2.8)
Discoid lupus 15 (1) 41 (3.2) 0 4 (3) 60 (1.9)
FAPD 11 (<1) 45 (3.5) 0 1 (1) 57 (1.8)
Traction alopecia 9 (<1) 10 (<1) 1 (<1) 24 (18) 44 (1.4)
CCCA 7 (<1) 15 (1) 0 8 (6) 30 (1)
Dissecting cellulitis 16 (1) 13 (1) 0 0 29 (0.9)
Acne keloidalis nuchae 3 (<1) 2 (<1) 0 12 (9) 17 (0.5)
Trichotillomania 6 (<1) 5 (<1) 0 1 (1) 12 (0.4)
Hair shaft disorders 8 (<1) 4 (<1) 0 0 12 (0.4)
Other alopecias 65 (4.1) 24 (1.9) 4 (3.3) 2 (1.5) 95 (3.0)
Total 1,592 (50.8) 1,286 (41) 122 (4) 133 (4.2) 3,133 (100)
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Regarding age, we also found similar results to previ-
ous reports [6, 9, 14–18, 21, 22] (youngest patients in
AKN, AA, DCS and FD, and oldest patients in FFA,
FAPD, discoid lupus and LPP).
The group of cicatricial alopecias represented the 27%
of patients consulting at SHC in our study, a significantly
higher percentage than the 7% published by Whiting in
2001 [22] or the 3% reported by Tan et al. in 2004 [21].
This difference may be explained by the increasing inci-
dence and improved diagnostic of FFA in the recent
years. In fact, FFA was the most frequent cause of cicatri-
cial alopecias in all the analyzed areas in our study, sup-
porting the apparent increasing incidence in the recent
years [9, 10, 23]. This finding would also support the con-
cept that environmental factors with worldwide distribu-
tion might play a role in the pathogenesis of FFA. An-
other interesting finding was the increasing number of
patients diagnosed with FAPD (57 cases, 6.8% of cicatri-
cial alopecias). This entity was described by Zinkernagel
and Trüeb in 2000 [18] and has been rarely reported in
other epidemiological studies [14, 21, 24, 25] being prob-
ably underdiagnosed. In our study, FAPD patients were
predominantly females (89%) with a median age of 59
years, which is in concordance with earlier reports
(Zinkernagel and Trüeb [18]: 19 patients, 79% females,
median age 60 years; Mardones et al. [26]: 12 cases, 70%
females, median age 48 years). In our opinion, FAPD
should be included in future classifications of cicatricial
alopecias.
We analyzed the differences in the frequency of hair
disorders depending on the healthcare setting private
versus public. Interestingly, AA and FFA were the most
frequent cause of consultation in SHC at public centers.
Besides the potentially great impact on quality of life of
these alopecias [27, 28], the symptomatic presentation
(FFA) or the requirement in some patients with AA for
complex therapies such as immunosuppressive drugs,
contact immunotherapy or corticosteroid injections
may explain the frequency of these alopecias at public
centers.
When we compared the frequency of alopecias by con-
tinents, we found results concordant with the literature
(traction alopecia, AKN, CCCA and FD more frequent in
Africa) [7, 14]. Interestingly, we found a higher frequency
of FFA in North America compared with South America,
with an opposite result for FAPD, which was more fre-
quent in South America. Another difference between
continents was the higher frequency of AA in European
patients compared to the rest of continents, a finding not
previously described in the literature to our knowledge.
Our study has some limitations. Firstly, the subgroups
of patients evaluated at SHC located in Australia and Af-
rica were small. Secondly, we did not include patients
evaluated in Asia. It should be noted that the presented
data in our study do not reflect the incidence or preva-
lence of alopecias, either in the general population, or in
the general practitioner setting, but the frequency of hair
disorders in patients seeking expert specialist hair opin-
ion or referred to tertiary centers. Thus, although the pre-
sented frequencies of alopecias should not be considered
as synonymous with “incidence” or “prevalence,” it does
provide valuable information on the current frequency of
hair disorders in patients consulting at specialist hair cen-
ters, which may be useful for clinicians and epidemiolo-
gists.
Conclusions
The most frequent type of alopecia evaluated at SHC
was AGA, followed by AA, TE and FFA. Patients con-
sulting with AKN, DCS and FD were predominantly
males, while patients consulting with traction alopecia,
CCCA, FFA, TE, FAPD and LPP were predominantly
females. FFA was the most frequent cicatricial alopecia
in all the studied geographical areas, followed by LPP
and FD.
A total of 57 different diagnoses of alopecia were per-
formed, showing the complexity of the diagnosis of hair
disorders. It highlights the importance of medical and
dermatologic evaluation in the management of patients
with hair loss.
Acknowledgements
A donation from Novartis (NF 516/2016) to the Dermatology
Department of Ramon y Cajal Hospital was used for financial sup-
port of statistical analysis and data management services.
We want to acknowledge Dr. Hudson Dutra for his help in the
acquisition of data.
Statement of Ethics
The study protocol was reviewed and approved by Ramon y
Cajal Ethical Committee.
Disclosure Statement
The authors declare no conflicts of interest.
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Frequency of the Types of Alopecia
7
Skin Appendage Disord
DOI: 10.1159/000496708
References
1 Salman KE, Altunay IK, Kucukunal NA, Cer-
man AA. Frequency, severity and related fac-
tors of androgenetic alopecia in dermatology
outpatient clinic: hospital-based cross-sec-
tional study in Turkey. An Bras Dermatol.
2017 Jan-Feb; 92(1): 35–40.
2 Gan DCC, Sinclair RD. Prevalence of male
and female pattern hair loss in Maryborough.
J Investig Dermatol Symp Proc. 2005 Dec;
10(3): 184-9.
3 Kaliyadan F, Nambiar A, Vijayaraghavan S.
Androgenetic alopecia: an update. Indian J
Dermatol Venereol Leprol. 2013 Sep-Oct;
79(5): 613–25.
4 Dainichi T, Kabashima K. Alopecia areata:
what’s new in epidemiology, pathogenesis, di-
agnosis, and therapeutic options? J Dermatol
Sci. 2017 Apr; 86(1): 3–12.
5 Headington JT. Cicatricial alopecia. Derma-
tol Clin. 1996 Oct; 14(4): 773–82. Available
from: http://www.ncbi.nlm.nih.gov/pubmed/
9238335
6 Otberg N, Wu WY, McElwee KJ, Shapiro J.
Diagnosis and management of primary cica-
tricial alopecia: part I. Skinmed. 2008 Jan-Feb;
7(1): 19-26.
7 Bolduc C, Sperling LC, Shapiro J. Primary cic-
atricial alopecia: other lymphocytic primary
cicatricial alopecias and neutrophilic and
mixed primary cicatricial alopecias. J Am
Acad Dermatol. 2016 Dec; 75(6): 1101–17.
8 Holmes S. Frontal Fibrosing Alopecia. Skin
Therapy Lett. 2016 Jul; 21(4): 5–7. Available
from: http://www.ncbi.nlm.nih.gov/pubmed/
27388531
9 Vañó-Galván S, Molina-Ruiz AM, Serrano-
Falcón C, Arias-Santiago S, Rodrigues-Barata
AR, Garnacho-Saucedo G, et al. Frontal fi-
brosing alopecia: a multicenter review of 355
patients. J Am Acad Dermatol. 2014 Apr;
70(4): 670–8.
10 Pindado-Ortega C, Saceda-Corralo D, Bu-
endía-Castaño D, Fernández-González P,
Moreno-Arrones ÓM, Fonda-Pascual P, et al.
Prescribing Habits for Androgenic Alopecia
among Dermatologists in Spain in 2017: A
Cross-Sectional Study. Actas Dermosifiliogr.
2018 Jul - Aug; 109(6): 536–42.
11 Strazzulla LC, Wang EH, Avila L, Lo Sicco K,
Brinster N, Christiano AM, et al. Alopecia
areata: disease characteristics, clinical evalua-
tion, and new perspectives on pathogenesis. J
Am Acad Dermatol. 2018 Jan; 78(1): 1–12.
12 Mirzoyev SA, Schrum AG, Davis MD, Torg-
erson RR. Lifetime incidence risk of alopecia
areata estimated at 2.1% by Rochester Epide-
miology Project, 1990-2009. J Invest Derma-
tol. 2014 Apr; 134(4): 1141–2.
13 García-Hernández MJ, Camacho FM. Chron-
ic telogen effluvium: incidence, clinical and
biochemical features, and treatment. Arch
Dermatol. 1999 Sep; 135(9): 1123–4. Available
from: http://www.ncbi.nlm.nih.gov/pubmed/
10490125
14 Bolduc C, Sperling LC, Shapiro J. Primary cic-
atricial alopecia: lymphocytic primary cicatri-
cial alopecias, including chronic cutaneous
lupus erythematosus, lichen planopilaris,
frontal fibrosing alopecia, and Graham-Little
syndrome. J Am Acad Dermatol. 2016 Dec;
75(6): 1081–99.
15 Vañó-Galván S, Molina-Ruiz AM, Fernán-
dez-Crehuet P, Rodrigues-Barata AR, Arias-
Santiago S, Serrano-Falcón C, et al. Folliculitis
decalvans: a multicentre review of 82 patients.
J Eur Acad Dermatol Venereol. 2015 Sep;
29(9): 1750–7.
16 Soares VC, Mulinari-Brenner F, Souza TE. Li-
chen planopilaris epidemiology: a retrospec-
tive study of 80 cases. An Bras Dermatol. 2015
Sep-Oct; 90(5): 666–70.
17 Segurado-Miravalles G, Camacho-Martínez
FM, Arias-Santiago S, Serrano-Falcón C, Ser-
rano-Ortega S, Rodrigues-Barata R, et al. Epi-
demiology, clinical presentation and thera-
peutic approach in a multicentre series of dis-
secting cellulitis of the scalp. J Eur Acad
Dermatol Venereol. 2017 Apr; 31(4):e199–
200.
18 Zinkernagel MS, Trüeb RM. Fibrosing alope-
cia in a pattern distribution: patterned lichen
planopilaris or androgenetic alopecia with a
lichenoid tissue reaction pattern? Arch Der-
matol. 2000 Feb; 136(2): 205–11.
19 Meinhard J, Stroux A, Lünnemann L, Vogt A,
Blume-Peytavi U. Lichen planopilaris: Epide-
miology and prevalence of subtypes - a retro-
spective analysis in 104 patients. J Dtsch Der-
matol Ges. 2014; 12(3): 229-235, 229-236.
20 Na K, Oh SH, Kim SK. Acne keloidalis nuchae
in Asian: A single institutional experience.
PLoS One. 2017; 12(12):e0189790.
21 Tan E, Martinka M, Ball N, Shapiro J. Prima-
ry cicatricial alopecias: clinicopathology of
112 cases. J Am Acad Dermatol. 2004 Jan;
50(1): 25–32.
22 Whiting DA. Cicatricial alopecia: clinico-
pathological findings and treatment. Clin
Dermatol. 2001 Mar-Apr; 19(2): 211–25.
Available from: http://www.ncbi.nlm.nih.
gov/pubmed/11397600
23 Lamb RC, Young D, Holmes S. Retrospective
review of diphencyprone in the treatment of
alopecia areata. Clin Exp Dermatol. 2016 Jun;
41(4): 352–8.
24 Griffin LL, Michaelides C, Griffiths CE, Paus
R, Harries MJ. Primary cicatricial alopecias: a
U.K. survey. Br J Dermatol. 2012 Sep; 167(3):
694–7.
25 Katoulis AC, Diamanti K, Sgouros D, Liakou
AI, Bozi E, Avgerinou G, et al. Is there a
pathogenetic link between frontal fibrosing
alopecia, androgenetic alopecia and fibrosing
alopecia in a pattern distribution? J Eur Acad
Dermatol Venereol. 2018 Jun; 32(6):e218–20.
26 Mardones F, Hott K, Martinez MC. Clinical
study of fibrosing alopecia in a pattern distri-
bution in a Latin American population. Int J
Dermatol. 2018 Feb; 57(2):e12–4.
27 Saceda-Corralo D, Pindado-Ortega C, More-
no-Arrones ÓM, Fernández-González P, Ro-
drigues-Barata AR, Jaén-Olasolo P, et al.
Health-Related Quality of Life in Patients
With Frontal Fibrosing Alopecia. JAMA Der-
matol. 2018 Apr; 154(4): 479–80.
28 Jun M, Keum DI, Lee S, Kim BJ, Lee WS.
Quality of Life with Alopecia Areata versus
Androgenetic Alopecia Assessed Using Hair
Specific Skindex-29. Ann Dermatol. 2018 Jun;
30(3): 388–91.
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