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Simultaneous determination of ramipril and felodipine using carbon paste electrode in micellar medium
Abstract
Simple, precise, inexpensive and sensitive voltammetric method was developed for simultaneous determination of Ramipril (RAM) and felodipine (FLD) mixture in drug substance, drug product and human urine using carbon paste electrode (CPE). Effect of different surfactants on peak current was studied in acetate buffer solution of pH 4.8. Sodium dodecyl sulphate (SDS) is the optimum surfactant based on the enhancement of the peak current. The peak current varied linearly over the concentration ranges from 5×10-5 mol L-1 to 8×10-4 mol L-1 for both drugs. The quantification limits were 1.78×10-5 and 1.94×10-5 mol L-1 and detections limits were 4.5×10-6 and 2.7×10-6 mol L-1 for RAM and FLD, respectively. The proposed voltammetric method was successfully applied to determine RAM and FLD mixture in drug product and human urine. The results of the proposed method were statistically compared with those of the reported method and showed no significant difference. Thus, it can be applied for quality control of both drugs.
The past few years have seen substantial development in electrochemical
sensors. The fundamental challenge in the construction of reliable analytical techniques
for the quantification of anti-inflammatory drugs has been conveniently overcome by
electrochemical methods. Voltammetric sensors have applications in biological,
environmental, and chemical structures. Owing to their high sensitivity, selectivity,
ease of preparation, and fast reaction, voltammetric sensors for detecting specific
biomolecules have received significant attention in recent years. Polarography, cyclic
voltammetry (CV), Differential Pulse Voltammetry (DPV), and Squarewave
Voltammetry (SWV) are examples of electrochemical techniques that are classified.
Non-steroidal anti-inflammatory drugs (NSAIDs) such as 4-amino antipyrine (4-AAP),
Indomethacin (IND), and Diclofenac (DCF) are widely used in the treatment of
inflammatory conditions such as musculoskeletal disorders, dental pain, menstrual
pain, postoperative pain, and migraines. This chapter discusses the details and usages
of the different voltammetric methods for the determination of NSAIDs.
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