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Mango Butter in Cosmetic Formulations

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Mango Butter in Cosmetic Formulations

... HE USE OF EXOTIC BUTTERS in skin care products is well known. 1 Usually obtained from tropical crops, exotic butters such as shea (Butyrospermum parkii), mango (Mangifera indica), sal (Shorea robusta) and mowrah (Madhuca latifolia), have many attributes that make them suitable for skin care products. 2 They are rich in symmetrical mono-unsaturated triglycerides which are solid or semi-solid at room temperature. They have narrow melting points and have appreciable viscosity and emulsion stability. ...
... Mango butter also has natural deflective properties against ultraviolet sunlight rays and hence is used as a sunscreen. Most often, the lipid is recommended by skin care professionals to smooth fine lines and wrinkles [9,10]. Though no pharmaceutical formulation has yet been reported with mango lipid, cosmeceuticals are being formulated with mango lipids for different purposes like foot cream, moisturizing cream, and sunscreen [11]. ...
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The naturally occurring lipids are non-toxic and biocompatible, hence suitable for pharmaceutical applications. The present study reports the application of mango lipid as a safe pharmaceutical excipient in the formulation of nanostructured lipid carriers (NLCs). The mango lipid was extracted by hot continuous percolation process using a Soxhlet apparatus and analyzed as per USP requirements by TLC and LC-MS. The safety profile of the lipid was studied by acute toxicity study in a rat model as per OECD guidelines. NLC formulation was developed with the physically modified mango lipid as the solid lipid and oleic acid as the liquid lipid by the modified emulsification technique. The compatibility of the lipid with other excipients was studied by differential scanning calorimetry (DSC) and FT-IR analysis. Cytotoxicity of the NLC formulation was studied with mouse brain endothelial cells (bEnd.3) by MTT assay. The TLC and LC-MS studies suggest that the mango lipid contains fatty acids composed of oleic acid (43.8% w/w), linoleic acid (3.6% w/w), stearic acid (43.2% w/w), palmitic acid (4.9% w/w), linolenic acid (2.3% w/w), and arachidic acid (2.2% w/w). The acute toxicity study and MTT assay suggest the safe use of the mango lipid at the cellular level in the living system. The spherical homogeneous nanometric NLCs were developed. DSC and FT-IR study confirm the compatibility of the lipid with the general components of the lipid nanoparticles. This work provides a new dimension to Mangifera indica L. lipid for its safe use in the development of novel lipid nanoformulations for drug delivery.
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Mango butter was explored as a functional, natural supplement and active skin ingredient in skin care formulations. A foot care cream was developed with mango butter to evaluate its medicinal value and protective function in skin repair. Qualitative comparison and clinical case studies of the product were carried out. Wound healing potential of foot care cream was investigated on the rat excision and incision wound models. Results of the clinical studies demonstrated complete repair of worn and cracked skin in all the human volunteers. Furthermore, foot care cream exhibited significant healing response in both the wound models. The project work could be concluded as establishment of high potential for mango butter to yield excellent emolliency for better skin protection. Improving the product features and medicinal functionality further validate mango butter as a specialty excipient in development of cosmeceuticals and has an immense value for its commercialization.
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