(Abstracted from Int Urogynecol J 2016;27:1137–1147)
Although the precise pathophysiology of bladder pain syndrome/interstitial cystitis (BPS/IC) is unclear, the underlying mechanism appears related to a defect in the urine-tissue barrier (the bladder’s protective mucous lining of glycosaminoglycans [GAG]). This defect has been documented in a subset of BPS/IC patients, and a favorable response
... [Show full abstract] to GAG-restoring agents has been reported.