Arrhythmias and Clinical EP
JACC March 12, 2019
Volume 73, Issue 9
U-SHAPED RELATIONSHIP BETWEEN CARBOHYDRATE INTAKE PROPORTION AND INCIDENT
Poster Hall, Hall F
Saturday, March 16, 2019, 10:00 a.m.-10:45 a.m.
Session Title: Arrhythmias and Clinical EP: Other 1
Abstract Category: 06. Arrhythmias and Clinical EP: Other
Presentation Number: 1123-310
Authors: Xiaodong Zhuang, Shaozhao Zhang, Huimin Zhou, Zhimin Du, Xinxue Liao, Cardiology Department, the First Afliated Hospital of
Sun Yat-Sen University, Guangzhou, People’s Republic of China, Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou,
People’s Republic of China
Background: We aim to assess the association of carbohydrate intake proportion and the risk of atrial fibrillation (AF) incident in
Atherosclerosis Risk in Communities (ARIC) study.
Methods: Participants free of AF were included. AF was ascertained from electrocardiograms, hospital discharge codes and death
certificates. Cox proportional hazards regression models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for
the association between carbohydrate intake proportion and incident AF.
Results: The average age was 54.2±5.8 years, and 45.3% were male for 13,852 participants. The carbohydrate intake proportion was
48.8±9.4%. During a median follow-up of 22.4 years, 1,892 cases of AF occurred. The HR for incident AF comparing the second and third
tertiles of carbohydrate intake proportion to the lowest tertile were 0.82 (95% CI 0.73-0.93) and 0.84 (95% CI 0.71-0.99) respectively.
Spline regression analysis showed a U-shaped relationship between carbohydrate intake and risk of AF incident (P < 0.005), with the
lowest observed risk associated with carbohydrate intake proportion of 39%-61%.
Conclusion: The restriction of carbohydrate intake increases AF incident in individuals with low and moderate carbohydrate intake. We
suggested that low carbohydrate diet as a popular way to lose weight may not be extensively recommended because of the increased risk
of incident AF.