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TESTICULAR TUMORS OF RABBITS: A SURVEY

  • April 2015
  • Conference: International Conference on Avian, Herpetological, and Exotic Mammal Medicine
  • At: Paris, France
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Drury Robb Reavill at Vin Veterinary information and academics
Drury Robb Reavill
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Abstract

STRUCTURE Testicular neoplasms are considered uncommon in domestic rabbits (Oryctolagus cuniculus), with interstitial cell tumors (Leydig cell tumor)being one of the most commonly documented types. 1,2,3 The reported age range is 3 and 9 years. Bilateral tumor development has also been described as well as a functional tumor resulting in associated gynecomastia. 2,3 From submissions to a private pathology service, 56 rabbit testicular tumors were identifi ed. The age range was from 2 years to 12 years of age. Four tumors were bilateral. The majority of tumors were diagnosed as interstitial cell tumors, with a moderate number of seminomas, and rarely sertoli cell tumors. A few granular cell tumors were identifi ed and are an important differential for interstitial cell tumors due to histo-logic similarities. 4 REFERENCES/CITATIONS 1. Flatt RE, Weisbroth SH. 1974. Interstitial cell tumor of the testicle in rabbits: a report of two cases. Lab Anim Sci. 24(4):682-685. 2. Roccabianca P, Ghisleni G, Scanziani E. 1999. Simultaneous seminoma and interstitial cell tumour in a rabbit with a previous cutaneous basal cell tumour. J Comp Pathol. 121(1):95-9. 3. Maratea KA, Ramos-Vara JA, Corriveau LA, Miller MA. 2007. Testicular interstitial cell tumor and gynecomastia in a rabbit. Vet Pathol. 44(4):513-517. 4. Irizarry-Rovira AR, Lennox AM, Ramos-Vara JA. 2008. Granular cell tumor in the testis of a rabbit: cytologic, his-tologic, immunohistochemical, and electron microscopic characterization. Vet Pathol. 45(1):73-7.
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Proceedings
452452
Scientifi c session SMALL MAMMALS - Oncology and nutrition
ABSTRACT STRUCTURE
Te st i cu l a r n eo p la s m s a re c o ns i d er e d u nc o mm o n i n d om estic
rabbits (Oryctolagus cuniculus), with interstitial cell tumors
(Leydig cell tumor)being one of the most commonly docu-
mented types.1,2,3 The reported age range is 3 and 9 years.
Bilateral tumor development has also been described as well
as a functional tumor resulting in associated gynecomastia.2,3
From submissions to a private pathology service, 56 rabbit
testicular tumors were identifi ed. The age range was from
2 years to 12 years of age. Four tumors were bilateral. The
majority of tumors were diagnosed as interstitial cell tumors,
with a moderate number of seminomas, and rarely sertoli cell
tumors. A few granular cell tumors were identifi ed and are an
important differential for interstitial cell tumors due to histo-
logic similarities.4
REFERENCES/CITATIONS
1. Flatt RE, Weisbroth SH. 1974. Interstitial cell tumor of the
testicle in rabbits: a report of two cases. Lab Anim Sci.
24(4):682-685.
2. Roccabianca P, Ghisleni G, Scanziani E. 1999. Simultane-
ous seminoma and interstitial cell tumour in a rabbit with
a previous cutaneous basal cell tumour. J Comp Pathol.
121(1):95-9.
3. Maratea KA, Ramos-Vara JA, Corriveau LA, Miller MA.
2007. Testicular interstitial cell tumor and gynecomastia
in a rabbit. Vet Pathol. 44(4):513-517.
4. Irizarry-Rovira AR, Lennox AM, Ramos-Vara JA. 2008.
Granular cell tumor in the testis of a rabbit: cytologic, his-
tologic, immunohistochemical, and electron micro-scopic
characterization. Vet Pathol. 45(1):73-7.
TESTICULAR TUMORS OF RABBITS:
A SURVEY
D. Reavill
Zoo/Exotic Pathology Service, Citrus Heights, United States
... In a review the age range for all tumors was from 2 years to 12 years. 68 As described in sporadic case reports, 8 tumors were bilateral and 2 were metastatic in this review. 68 Most of the tumors were diagnosed as granular cell tumors (GCT), with a fewer number of seminomas, and Sertoli cell tumors. ...
... 68 As described in sporadic case reports, 8 tumors were bilateral and 2 were metastatic in this review. 68 Most of the tumors were diagnosed as granular cell tumors (GCT), with a fewer number of seminomas, and Sertoli cell tumors. 68,69 Granular cell tumors have been recently better characterized and most tumors originally diagnosed as interstitial cell tumors have been reclassified as GCTs. ...
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The review covers select disease conditions most frequently described in aging rodents (rats, mice, hamsters, guinea pigs), rabbits, and ferrets. The conditions are categorized by general organ systems, infectious diseases, and neoplasms. Two data systems, the Veterinary Medical Teaching Hospital and Comparative Pathology Laboratory at the University of California, Davis and Zoo/Exotic Pathology Service, Citrus Heights, California were used in the determining disease conditions to describe.
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Granular Cell Tumor in the Testis of a Rabbit: Cytologic, Histologic, Immunohistochemical, and Electron Microscopic Characterization
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  • Feb 2008
An adult pet rabbit (Oryctolagus cuniculus) presented with a progressively enlarging left testicle. Because neoplasia was suspected, the testicle was removed. Pathologic evaluation (exfoliative cytology, histopathology, immunohistochemistry, electron microscopy) indicated that the tumor was an intratesticular granular cell tumor. Granular cell tumor has not been described in rabbits before and has not been described in the testes of animals or postnatal humans. Granular cell tumor should be included as a differential diagnosis of testicular tumors, particularly Leydig cell tumor, because of potential histologic similarities.
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Intertitial cell tumor of the testicle in rabbits: a report of two cases
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Two cases of interstitial cell tumors in the testicles of New Zealand white rabbits are reported. The affected rabbits were 5 and 7 yr old, and the lesions were bilateral and unilateral, respectively. The lesions in both cases were characterized by gross enlargement of the affected testicles with extensive necrosis within the neoplastic tissue. Cellular morphology was similar to that seen in the same tumor in dogs and other domestic animals.
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Simultaneous Seminoma and Interstitial Cell Tumour in a Rabbit with a Previous Cutaneous Basal Cell Tumour
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The development of spontaneous multiple tumours is a rare event in domestic rabbits. The diagnosis of a cutaneous basal cell tumour and the successive development of simultaneous bilateral testicular tumours with dissimilar histology (a seminoma and an interstitial cell tumour) are described in a vasectomized, crossbred dwarf rabbit, aged 6 years. Two cases of basalioma associated with uterine adenocarcinoma have been previously described in rabbits. A similar association between basal cell neoplasia and development of tumours (e.g., testicular and breast cancer) at cutaneous and non-cutaneous sites has been reported in man.
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Testicular Interstitial Cell Tumor and Gynecomastia in a Rabbit
Article
  • Aug 2007
Unilateral testicular interstitial (Leydig) cell tumor and gynecomastia were diagnosed in an adult male rabbit. The interstitial cell tumor was a well-circumscribed, 2-mm diameter, pale tan nodule composed of a uniform population of polygonal cells. Neoplastic interstitial cells exhibited diffuse, granular cytoplasmic staining with Melan A, a marker of steroid-producing cells in humans and dogs. Multiple subcutaneous masses in the caudal abdomen were associated with enlarged nipples and consisted of hyperplastic mammary gland tissue with proliferation of ducts and alveoli, marked lobule formation, and pseudolactational hyperplasia. Many epithelial cells lining the hyperplastic ducts and alveoli exhibited intense nuclear expression of progesterone receptor antigen, whereas myoepithelial cells showed strong nuclear staining for p63 antigen. This is the first report of concurrent interstitial cell tumor and gynecomastia in a rabbit and also the first description of gynecomastia in this species.
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