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Scientiﬁ c session SMALL MAMMALS - Oncology and nutrition
Te st i cu l a r n eo p la s m s a re c o ns i d er e d u nc o mm o n i n d om estic
rabbits (Oryctolagus cuniculus), with interstitial cell tumors
(Leydig cell tumor)being one of the most commonly docu-
mented types.1,2,3 The reported age range is 3 and 9 years.
Bilateral tumor development has also been described as well
as a functional tumor resulting in associated gynecomastia.2,3
From submissions to a private pathology service, 56 rabbit
testicular tumors were identiﬁ ed. The age range was from
2 years to 12 years of age. Four tumors were bilateral. The
majority of tumors were diagnosed as interstitial cell tumors,
with a moderate number of seminomas, and rarely sertoli cell
tumors. A few granular cell tumors were identiﬁ ed and are an
important differential for interstitial cell tumors due to histo-
1. Flatt RE, Weisbroth SH. 1974. Interstitial cell tumor of the
testicle in rabbits: a report of two cases. Lab Anim Sci.
2. Roccabianca P, Ghisleni G, Scanziani E. 1999. Simultane-
ous seminoma and interstitial cell tumour in a rabbit with
a previous cutaneous basal cell tumour. J Comp Pathol.
3. Maratea KA, Ramos-Vara JA, Corriveau LA, Miller MA.
2007. Testicular interstitial cell tumor and gynecomastia
in a rabbit. Vet Pathol. 44(4):513-517.
4. Irizarry-Rovira AR, Lennox AM, Ramos-Vara JA. 2008.
Granular cell tumor in the testis of a rabbit: cytologic, his-
tologic, immunohistochemical, and electron micro-scopic
characterization. Vet Pathol. 45(1):73-7.
TESTICULAR TUMORS OF RABBITS:
Zoo/Exotic Pathology Service, Citrus Heights, United States