Background: Ultraviolet (UV) radiation has known as a major cause of photodamage, photoaging, and skin cancer as it involves in reactive oxygen species generation. Several natural antioxidants, including lycopene, have been suggested for photoprotection. However, the protective effect of lycopene on skin photodamage is still controversial. Objective: The objective of this study was to evaluate the protective effect of lycopene-rich product on skin photodamage. Materials and Methods: A systematic literature search was conducted in PubMed, Scopus, CINAHL, and Cochrane Library from inceptions to March 2018. Randomized placebo-controlled trials determining the effect of lycopene-rich products on photodamage in healthy volunteer were included in the study. Studies adding other antioxidants except carotenoids were excluded from the study. Risk of bias version 2.0 was used to assess the quality of included studies. Primary outcome was intensity of skin erythema formation. Meta-analysis was performed using random-effects model. Results: A total of four studies were included in this systematic review with a total of 99 participants. Only two studies were included in a meta-analysis. Lycopene-rich products with the lycopene content of 8–20 mg/day significantly reduced skin erythema formation, with mean difference of −2.35 units when compared to control (95% confidence interval; −3.65– −1.05, I2 = 0.0%). At molecular level, lycopene significantly inhibited UV radiation-induced expression of matrix metalloproteinase-1, heme oxygenase 1, and intercellular adhesion molecule 1 (ICAM-1) compared to olive or soybean oil (P < 0.05). Conclusions: Lycopene-rich products had a potential to be developed as a nutraceutical for photoprotection as it showed protective effects on skin photodamage. © 2018, Faculty of Pharmaceutical Sciences, Chulalongkorn University. All rights reserved.