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Nutritional Studies on Promising plants for nephropathy treatment of Male Albino rats ــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــ
Abstract
The present work aimed to evaluate the effect of Almond nut, Sambucus herbs, Juniperus seeds, Grapefruit albedo& the combination of all (as 5 %) on reinopathic rats. For this purpose the study included about 35 rats about 150/ 200 (g) weight. Biological& chemical analysis of serum and histopathological investigation of internal organs were carried out. The experiment lasted for 4 weeks and eventually urine samples were collected for each rat for 24 hours and size measwredand estimated (creatThe present work aimed to evaluate the effect of Almond nut, Sambucusinine-urea-uric acid-protein-sodium-potassium). The weight of the rats and collect blood samples after collected fasting 12 hours and then serum separated to estimation of (creatinine-urea-uric acid-lipid profile-sodium-potassium-GPT-ALP-GOT). The weight of the internal organs (liver-kidney-heart-spleen-lung) determined and fixed in 10 % formalin for histopathological examinations. Finally a statistical analysis of all the data and was done. Introduction:
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Strategies that decrease postprandial glucose excursions, including digestive enzyme inhibition, and low glycemic index diets result in lower diabetes incidence and coronary heart disease (CHD) risk, possibly through lower postprandial oxidative damage to lipids and proteins. We therefore assessed the effect of decreasing postprandial glucose excursions on measures of oxidative damage. Fifteen healthy subjects ate 2 bread control meals and 3 test meals: almonds and bread; parboiled rice; and instant mashed potatoes, balanced in carbohydrate, fat, and protein, using butter and cheese. We obtained blood samples at baseline and for 4 h postprandially. Glycemic indices for the rice (38 +/- 6) and almond meals (55 +/- 7) were less than for the potato meal (94 +/- 11) (P < 0.003), as were the postprandial areas under the insulin concentration time curve (P < 0.001). No postmeal treatment differences were seen in total antioxidant capacity. However, the serum protein thiol concentration increased following the almond meal (15 +/- 14 mmol/L), indicating less oxidative protein damage, and decreased after the control bread, rice, and potato meals (-10 +/- 8 mmol/L), when data from these 3 meals were pooled (P = 0.021). The change in protein thiols was also negatively related to the postprandial incremental peak glucose (r = -0.29, n = 60 observations, P = 0.026) and peak insulin responses (r = -0.26, n = 60 observations, P = 0.046). Therefore, lowering postprandial glucose excursions may decrease the risk of oxidative damage to proteins. Almonds are likely to lower this risk by decreasing the glycemic excursion and by providing antioxidants. These actions may relate to mechanisms by which nuts are associated with a decreased risk of CHD.
Seven species of juniper grow in Azerbaijan. The examination of leaves and fruits of Juniperus oxycedrus L. growing in Azerbaijan was conducted. It was found that Juniperus oxycedrus L is widespread in Azerbaijan. The biologically active substances of Juniperus oxycedrus leaves have been studied. It was found that the main biologically active substances in leaves are flavonoids -1,61% and lipids -57,8%; in fruits - ethereal oil 1,2%. The flavonoid composites include luteolin, kaempferol, quercetine, izoquercitrin, rutin. They also possess the diuretic and anti-inflammation effects. Ethereal oil of fruits consist of 20 components, prevailing are alpha-beta-pinen, alpha-fellandren, alpha-terpineol and it also possesses high antimicrobial and antibacterial effect. Lipoid fraction includes tokoferols, karotinoids, xlorofils and lipoid acids: linol, linolen, olein, stearin and palmithin. There are also macroelements K,Ca, Mg,Na,and mikroelements Si, Fe, Al. It was found that the period of maximum accumulation of flavonoids in leaves and ethereal oil in fruit is in Autumn in the period of fruit maturation and ripening. Juniperus oxycedrus L is a good material for new antiseptic remedy. Flavonoids from the leaves of Juniperus oxycedrus L have anti-inflammatory and diuretic effect; fungicide, antimicrobial and antibacterial characteristics.
Sambucus nigra (elder) has been documented as a traditional treatment of diabetes. In the present study, an aqueous extract of elder (AEE, 1 g/L) significantly increased 2-deoxy-glucose transport, glucose oxidation and glycogenesis of mouse abdominal muscle in the absence of added insulin (2 x 2 factorial design). in acute 20-min tests, 0.25-1 g/L AEE evoked a stepwise stimulation of insulin secretion from clonal pancreatic beta-cells. The insulin releasing effect of AEE (0.5 g/L) was significantly potentiated by 16.7 mmol/L of glucose and significantly reduced by 0.5 mmol/L of diazoxide. AEE did not further enhance insulin secretion in cells stimulated by 10 mmol/L of L-alanine, 1 mmol/L of 3-isobutyl-1-methylxanthine or a depolarizing concentration of KCl (25 mmol/L). Prior exposure of clonal pancreatic beta-cells to AEE did not alter subsequent stimulation of insulin secretion induced by 10 mmol/L of L-alanine, thereby precluding a detrimental effect on cell viability. The insulinotropic action of AEE was partially dependent upon use of heat during extract preparation. Activity of AEE was heat-stable, acetone-insoluble and unaltered by prolonged exposure to acid/alkali (0.1 mol/L of HCl and NaOH). However, activity was significantly decreased 41% by dialysis to remove components with molecular mass <2000 Da. Sequential extraction with solvents revealed activity in both methanol and water fractions, indicating a cumulative effect of more than one extract constituent. Known constituents of elder, including lectin, rutin and the lipophilic triterpenoid (lupeol) and sterol (beta-sitosterol), did not stimulate insulin secretion. The results demonstrate the presence of insulin-releasing and insulin-like activity in the traditional antidiabetic plant, Sambucus nigra.
Short-term (4-9 weeks) human feeding trials have shown nut consumption to reduce serum total cholesterol (TC) and LDL-cholesterol (LDL). We hypothesized that individual levels of BMI, LDL, TC and triglycerides modify the cholesterol-lowering effect of almonds in a 24-week almond supplementation trial in a free-living population.
We performed secondary analysis on data from a previously published study. Using a sequential study design, all participants followed their habitual diets during the first six months (control), and then consumed an almond-supplemented diet (habitual + almonds) for another six months. 100 adults enrolled; 19 were lost to attrition. Those who completed the study were men (n = 43) and women (n = 38) with mean (SD) age 49.4 (13.6) years. During almond supplementation, we found statistically significant changes in TC (-0.22 mmol/L), LDL (-0.22 mmol/L), TC:HDL (-0.35), and LDL:HDL (-0.28) in participants with baseline LDL levels ≥ 3.30 mmol/L, but not among normocholesterolemic individuals. Direction and magnitude of change were similar among individuals with TC ≥ 5.20 mmol/L but not in the lower strata. Tests of interaction (diet × TC and diet × LDL) were significant. Reductions in the ratios TC:HDL, and LDL:HDL were significant among those with BMI < 25 kg/m(2), but not in heavier individuals; however, formal tests of interaction did not reach significance.
We provide strong evidence that the cholesterol-lowering effect of almonds is responsive among hypercholesterolemic individuals, and weak evidence that BMI modifies the effect of almonds on serum lipids.
From February 1986 to January 1988, samples of several processed Florida citrus juice products--frozen concentrated orange juice, orange juice from concentrate, pasteurized orange juice, grapefruit juice, and grapefruit juice from concentrate--were surveyed regularly during production. Samples were assayed for sodium, potassium, ascorbic acid, thiamin, calcium, iron, folic acid, phosphorus, magnesium, zinc, and copper primarily for the purpose of nutrition labeling. Means, standard deviations of the means, and maximum and minimum values of each nutrient are expressed in mg/6 fl oz for each product. In addition, the estimated percentage of the U.S. Recommended Daily Allowance (U.S. RDA) for each nutrient claimable at time of packing is given. (To be claimed on a nutrition label, a nutrient must occur at a minimum level of 2% of the U.S. RDA per serving, according to U.S. Food and Drug Administration [FDA] regulations.) The estimated percentage of the U.S. RDA claimable for ascorbic acid ranged from 90% to 100% in the orange juice products and was 70% for the grapefruit juice products. These juices are all considered significant sources of vitamin C. In the orange juice products, the percentage of the U.S. RDA for thiamin ranged from 6% to 8% and was 8% for folic acid. Significantly smaller amounts of each vitamin were noted in the grapefruit juices. Small but claimable levels of magnesium, calcium, copper, and phosphorus were found in one or more of the products tested. Neither zinc nor iron was found at the U.S. RDA minimum level of 2%. Significant amounts of potassium, for which there is no established U.S. RDA, were found in all the citrus juice products.(ABSTRACT TRUNCATED AT 250 WORDS)
In the recent time, several in vitro and in vivo studies have shown the inhibitory effect of grapefruit juice on metabolism of xenobiotics catalyzed by liver oxidative enzymes including cytochrome P450 izoenzymes. However, all these experiments were done with a single dose of grapefruit juice. The primary aim of this study was to evaluate if the chronical ingestion of grapefruit juice can cause enzyme activity alteration as well as a single dose. Three groups of male mice were used: the control group, the group which was administered 0.2 mL of grapefruit juice per os 10 days and the group which was administered single dose of 0.5 mL grapefruit juice per os 90 min. before the sacrificing. After the sacrificing of animals, liver was homogenized with appropriate buffer, and the activity of oxidative liver enzymes: xanthine oxidase (XOD), peroxidase (Px), catalase (CAT), lipid peroxidase (LPx), glutathion peroxidase (GSH-Px) and liver glutathion contents (GSH) were detected by standard methods. The results show that the enzyme activity of liver MFO was changed according to a single or multiple grapefruit juice ingestion. The grapefruit juice in a single oral dose significantly decreases the activity of xanthine oxidase, glutathion peroxidase, lipid peroxidase and liver glutathion contents, and has no effect on activity of catalase and peroxidase. The multiple grapefruit ingestion increases the activity of XOD, GSH-Px, LPx, Px and GSH, while the activity of CAT enzyme is unchanged. The chronical and single grapefruit ingestion has no effect on relative liver weight, but the liver protein content is significantly decreased after the multiple oral grapefruit juice ingestion.
An increased risk of nephrolithiasis has been associated with the ingestion of grapefruit juice in epidemiological studies. To our knowledge the basis of this effect of grapefruit juice has not been studied previously. We studied the effect of grapefruit juice consumption on urinary chemistry and measures of lithogenicity.
Ten healthy men and women between ages of 25 and 40 years participated. Each subject drank 240 ml. of tap water at least 3 times daily for 7 days during the control period. This period was followed by a second 7 days experimental period during which they drank 240 ml. of grapefruit juice 3 times daily. In each 7-day period urine was collected for 24 hours during the last 3 days. Urine chemical analysis was performed, supersaturations of calcium oxalate, calcium phosphate and uric acid were calculated and urinary lithogenicity was measured.
Urine volume and creatinine excretion were the same during the control and experimental periods. Grapefruit juice ingestion was associated with an increase in mean oxalate excretion plus or minus standard deviation of 41.1 +/- 9.2 to 51.9 +/- 12.0 mg. per 24 hours (p = 0.001) and in mean citrate excretion of 504.8 +/- 226.5 to 591.4 +/- 220.0 mg. per 24 hours (p = 0.01). There was no net change in the supersaturation or upper limit of metastability of calcium oxalate, calcium phosphate or uric acid. Crystal aggregation and growth inhibition by urinary macromolecules was not affected by grapefruit juice ingestion.
Offsetting changes in urine chemistry caused by the ingestion of grapefruit juice led to no net change in calculated supersaturation. No changes in lithogenicity were demonstrated. The results do not demonstrate an effect of grapefruit juice for increasing lithogenicity. The basis of the observations of epidemiological studies remain unexplained.
Alkalizing beverages are highly effective in preventing the recurrence of calcium oxalate (Ox), uric acid and cystine lithiasis. The aim of the present study was to evaluate the influence of grapefruit-juice and apple-juice consumption on the excretion of urinary variables and the risk of crystallization in comparison with orange juice. All investigations were carried out on nine healthy female subjects without any history of stone formation and aged 26-35 years. Each juice was tested in a 5 d study. During the study, the subjects received a standardized diet. Fluid intake of 2.75 litres was composed of 2.25 litres neutral mineral water, 0.4 litre coffee and 0.1 litre milk. On the fourth and fifth day 0.5 litre mineral water was partly substituted by 0.5 or 1.0 litre juice under investigation respectively. The influence on urinary variables was evaluated in 24 h urine samples. In addition, the BONN risk index of CaOx, relative supersaturation (RS)CaOx crystallization was determined. Due to an increased pH value and an increased citric acid excretion after consumption of each juice, the RSCaOx decreased statistically significantly (P<0.05) for grapefruit juice, but not significantly for orange and apple juice. The BONN risk index yielded a distinct decrease in the crystallization risk. We showed that both grapefruit juice and apple juice reduce the risk of CaOx stone formation at a magnitude comparable with the effects obtained from orange juice.
To study the effects of grapefruit and grapefruit products on body weight and metabolic syndrome, 91 obese patients were randomized to either placebo capsules and 7 ounces (207 mL) of apple juice, grapefruit capsules with 7 ounces (207 mL) of apple juice, 8 ounces (237 mL) of grapefruit juice with placebo capsule, or half of a fresh grapefruit with a placebo capsule three times a day before each meal. Metabolic syndrome parameters were measured at the beginning and end of 12 weeks. After 12 weeks, the fresh grapefruit group had lost 1.6 kg, the grapefruit juice group had lost 1.5 kg, the grapefruit capsule group had lost 1.1 kg, and the placebo group had lost 0.3 kg. The fresh grapefruit group lost significantly more weight than the placebo group (P < .05). A secondary analysis of those with the metabolic syndrome in the four treatment groups demonstrated a significantly greater weight loss in the grapefruit, grapefruit capsule, and grapefruit juice groups compared with placebo (P < .02). There was also a significant reduction in 2-hour post-glucose insulin level in the grapefruit group compared with placebo. Half of a fresh grapefruit eaten before meals was associated with significant weight loss. In metabolic syndrome patients the effect was also seen with grapefruit products. Insulin resistance was improved with fresh grapefruit. Although the mechanism of this weight loss is unknown it would appear reasonable to include grapefruit in a weight reduction diet.
Blologcal Evaluatin of some plants for trentment and supporting nephropathy Rats immunity" M. SC. Thesis, faculty of home economics
- A N Ali
Ali, A. N. (2011): "Blologcal Evaluatin of some plants for trentment and
supporting nephropathy Rats immunity" M. SC. Thesis, faculty of home
economics, minufiya university.
- C C Allsin
Allsin, c. c. (1974): cholesterol enzymatic colorimetric method J. of Clin.
Chem 20: 470
b: wikipedia org/ wiki/ sambucus
- Anon
Anon, 2012 b: wikipedia org/ wiki/ sambucus.
Methodology of protein evaluation. RAG. Nutr. Document R. 10 led 37 JUNE Meeting
- J A Campbell
Campbell, J. A. (1963) Methodology of protein evaluation. RAG. Nutr.
Document R. 10 led 37 JUNE Meeting, New york.
1959) evaluation of protein in food. I.A. method for the deterinination of protein efficiency ratio
- D G Chapman
- R Castilla
- J A Campbell
Chapman, D. G., castilla, R, and Campbell, J. A. (1959) evaluation of
protein in food. I.A. method for the deterinination of protein efficiency
ratio. Can. J. Biochem. Phosiol, 37: 679-686
) Carlton's Histoloical technique
- R A B Druy
Druy, R. A.B. and wallington E.A. (1980) Carlton's Histoloical technique.
influence of some vegetables, spices and herbs on the health status of kidneys As investigated using the experimental animals
- S M El-Moselhy
El-Moselhy, S. M. (2007): "influence of some vegetables, spices and herbs
on the health status of kidneys As investigated using the experimental
animals". M. SC. Thesis, faculty of home economics, minufiya university.
enzymatic colorimetric test of uric
- Prencipe Fossatti
Fossatti and prencipe (1980): enzymatic colorimetric test of uric. J. of clin.
Chem.., 28, 227.
Determination of HDL
- W T Fendewaid
Fendewaid, W. T. (1972): Determination of HDL. Clin. Chem.., 8: 499
) determination of HDL
- T Gordon
- M Amer
Gordon T. and Amer, M. (1977) determination of HDL J. med. 62: 707
Colorimetric method of total protein j. of clinical chemistry, Harper, row punilshers new york
- J B Henry
Henry, J. B. (1964) : Colorimetric method of total protein j. of clinical
chemistry, Harper, row punilshers new york. P. 181.